Article
Medicine, Research & Experimental
Mehboob Ali, David S. Zuzga, Giovanni M. Pitari
Summary: Differential phosphorylation of VASP at Ser157 and Ser239 plays a crucial role in modulating the clonogenic and migratory abilities of colorectal cancer cells. Specific manipulation of VASP phosphorylation at different serine residues can affect the malignant behavior of cancer cells. Moreover, cancer cells bearing phosphomutants targeting different VASP serine residues show distinct abilities in tumor formation and growth both in vitro and in vivo.
Review
Biochemistry & Molecular Biology
Anton Sergeevich Shakhov, Aleksandra Sergeevna Churkina, Anatoly Alekseevich Kotlobay, Irina Borisovna Alieva
Summary: This review summarizes information about the specific features of the centrosome and its relationship with the cell function of highly specialized cells. The participation of the centrosome in the functional activity of these cells, as well as its role as a universal regulatory and distribution center, controlling the dynamic morphology of animal cells, is discussed. The direct involvement of the centrosome in the performance of functions by specialized cells is also highlighted.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Priscilla Bianca de Oliveira, Gabriela Palma Zochio, Edileia Souza Paula Caetano, Maria Luiza Santos da Silva, Carlos Alan Dias-Junior
Summary: The study investigated the role of perivascular adipose tissue (PVAT)-derived hydrogen sulfide (H2S) in vasodilation in pregnancy hypertension-induced endothelial dysfunction. The results showed that PVAT-derived H2S stimulated with the amino acid L-cysteine may be an alternative method to induce vasorelaxation in endothelial dysfunction related to pregnancy hypertension.
Article
Multidisciplinary Sciences
Makiha Fukuda, Jitong Cai, Joel S. Bader, Jef D. Boeke
Summary: A synthetic biology approach to constructing an RNA-based genome expands our understanding of living things and opens avenues for technological advancement. Understanding the structure-function relationships of RNA sequences is critical for the precise design of an artificial RNA replicon.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Medicine, Research & Experimental
Shupeng Hu, Qiangzhong Pi, Xiudan Xu, Jianghong Yan, Yongzheng Guo, Wanying Tan, An He, Zhe Cheng, Suxin Luo, Yong Xia
Summary: This study investigates the role of eNOS in vascular dysfunction induced by sepsis. Increased phosphorylation of eNOS in early sepsis leads to decreased vasodilation, while decreased levels of eNOS in late sepsis result in diminished nitric oxide-dependent relaxation responses.
Review
Biochemistry & Molecular Biology
Felix Yemanyi, Kiran Bora, Alexandra K. Blomfield, Zhongxiao Wang, Jing Chen
Summary: The retina is a light-sensing tissue that relays information to the brain for vision. The blood-retinal barrier (BRB) contributes to maintaining homeostasis and protecting the retina from toxins. Disruption of the inner BRB (iBRB) can lead to conditions like retinal edema and vision loss. Understanding the mechanisms of iBRB formation, maintenance, and breakdown is crucial for potential therapeutic targets and drug delivery strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Stephen G. Young, Wenxin Song, Ye Yang, Gabriel Birrane, Haibo Jiang, Anne P. Beigneux, Michael Ploug, Loren G. Fong
Summary: GPIHBP1 is a crucial partner for LPL in lipolytic processing of lipoproteins, stabilizing LPL structure and preserving activity. It captures LPL and shuttles it to the capillary lumen. The AD of GPIHBP1 accelerates LPL binding, preserves LPL activity, and allows LPL to move across ECs.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Hang Zhou, Miao Li, Ruohe Zhao, Linlin Sun, Guang Yang
Summary: Poor sleep is associated with the risk of developing chronic pain. In a mouse model of neuropathic pain, cholinergic neurons in the basal forebrain are increasingly active during nonrapid eye movement (NREM) sleep. These neurons directly activate vasoactive intestinal polypeptide-expressing interneurons in the primary somatosensory cortex (S1), causing pain. The hyperactivity of these neurons is caused by inputs from the parabrachial nucleus (PB) driven by the injured peripheral nerves.
NATURE NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Yan-Fang Zheng, Xian Zhou, Dennis Chang, Deep Jyoti Bhuyan, Jie Ping Zhang, Wen-Zhen Yu, Xia-Sen Jiang, Sai Wang Seto, Seung Yeon Yeon, Jia Li, Chun Guang Li
Summary: The tri-culture neuroinflammation model established in this study mimics the microenvironment, cellular crosstalk and molecular events that occur during neuroinflammation, providing a robust in vitro model for studying neuroinflammation mechanisms and screening for potential therapeutics to treat various neurodegenerative diseases.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Cardiac & Cardiovascular Systems
Natalie R. Harris, Natalie R. Nielsen, John B. Pawlak, Amir Aghajanian, Krsna Rangarajan, D. Stephen Serafin, Gregory Farber, Danielle M. Dy, Nathan P. Nelson-Maney, Wenjing Xu, Disha Ratra, Sophia H. Hurr, Li Qian, Joshua P. Scallan, Kathleen M. Caron
Summary: This study reveals the essential role of VE-cadherin in the development and maintenance of cardiac lymphatics and its impact on lymphangiogenic signaling pathways. Surprisingly, despite the regression of cardiac lymphatics, Cdh5(flox/flox);Prox1CreER(T2) mice exhibited preserved cardiac function at baseline and after myocardial infarction compared with control mice. Mechanistically, loss of VE-cadherin leads to aberrant cellular internalization of VEGFR3, impairing downstream processes such as cellular proliferation.
CIRCULATION RESEARCH
(2022)
Article
Cell Biology
Yang Liu, Huiwen Wang, Han Zhang, Jun Wang, Qun Liu, Youkun Bi, Shaole Song, Xinlong Qiao, Keqi Zhu, Yanyun Wu, Guangju Ji
Summary: The mammalian heart has the ability to regenerate fully during the early postnatal period but loses this capacity after postnatal day 7. CUGBP1 is important for normal cardiac development, and it may also play a role in heart regeneration.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Fei-Yang Tzou, Tsu-Yi Su, Wan-Syuan Lin, Han-Chun Kuo, Yu-Lian Yu, Yu-Han Yeh, Chung-Chih Liu, Ching-Hua Kuo, Shu-Yi Huang, Chih-Chiang Chan
Summary: Disruption of sphingolipid homeostasis can lead to neurological disorders, with specific sphingolipid species modulating pathogenesis through mechanisms that remain unclear. DEGS1/ifc deficiency causes dihydroceramide accumulation, leading to Rac1 mislocalization and NOX-dependent neurodegeneration. The Rac1-NOX complex plays a crucial role in the accumulation of reactive oxygen species in the absence of DEGS1/ifc.
Article
Biochemistry & Molecular Biology
Nestor de la Visitacion, Inaki Robles-Vera, Javier Moleon, Cristina Gonzalez-Correa, Nazaret Aguilera-Sanchez, Marta Toral, Manuel Gomez-Guzman, Manuel Sanchez, Rosario Jimenez, Natividad Martin-Morales, Francisco O'Valle, Miguel Romero, Juan Duarte
Summary: Our study revealed the involvement of gut microbiota in hypertension through mechanisms including the increase of Th17 cells, endothelial dysfunction, vascular inflammation, and high blood pressure. By performing fecal microbiota transplantation, we found that the reduced populations of Sutterella and Anaerovibrio were associated with hypertension, and transplanting healthy microbiota to IMQ-treated mice could normalize these relative populations.
Review
Pharmacology & Pharmacy
Li Sun, Xuefang Li, Hui Luo, Huige Guo, Jie Zhang, Zhigang Chen, Fei Lin, Guoan Zhao
Summary: EZH2 is a catalytic subunit of polycomb repressor complex 2 and plays important roles in endothelial cell homeostasis. It represses gene expression through chromatin compaction by functionally methylating lysine 27 of histone H3. Studies have shown that EZH2 mediates the effects of environmental stimuli on endothelial functions, such as angiogenesis, endothelial barrier integrity, inflammatory signaling, and endothelial mesenchymal transition. This review aims to provide a concise summary of the roles EZH2 plays in endothelial function and explore its therapeutic potential in cardiovascular diseases.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Markus Waldeck-Weiermair, Shambhu Yadav, Jonas Kaynert, Venkata Revanth Thulabandu, Arvind K. Pandey, Fotios Spyropoulos, Taylor Covington, Apabrita Ayan Das, Christina Kruger, Thomas Michel
Summary: Statins have multiple protective effects on the cardiovascular system, including lowering cholesterol levels and antioxidant effects. Simvastatin, a statin drug, inhibits the production of oxidant H2O2 induced by histamine and vascular endothelial growth factor, and also regulates the localization of signaling protein Rac1.
