期刊
CARDIOVASCULAR RESEARCH
卷 85, 期 2, 页码 281-290出版社
OXFORD UNIV PRESS
DOI: 10.1093/cvr/cvp315
关键词
Endothelial function; Endothelial dysfunction; Ubiquitin; Proteasome
资金
- Deutsche Forschungsgemeinschaft [DFG STA567/4-1]
The ubiquitin-proteasome system (UPS) has been recognized as a key regulatory pathway in cardiovascular diseases. Although the role of this system in the pathogenesis of endothelial dysfunction remains largely unknown, available data suggest that proteasome activity is modified by mediators and processes-e.g. nitric oxide and oxidative stress-involved in the regulation of endothelial function. In addition, there is some evidence that the UPS itself modulates the activity of endothelial nitric oxide synthase, the key enzyme of vascular homeostasis, interacts with other vasoactive mediators involved in regulation of endothelial function, influences oxidative stress response in the vasculature, and thereby contributes to regulation of endothelial (dys)function. This review discusses the potential implications of the UPS in endothelial dysfunction.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据