Article
Hematology
Sean P. Heffron, Ada Weinstock, Bianca Scolaro, Shiyu Chen, Brian E. Sansbury, Greg Marecki, Christina C. Rolling, Hanane El Bannoudi, Tessa Barrett, James W. Canary, Matthew Spite, Jeffrey S. Berger, Edward A. Fisher
Summary: Platelet-conditioned media induces an anti-inflammatory, pro-resolving phenotype in macrophages. This effect is partially mediated by prostaglandin E2 stimulating the EP4 receptor on macrophages, leading to altered gene expression and function.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Plant Sciences
Kaiyang Lin, Xuedong Wang, Ji Li, Peng Zhao, Xiangwen Xi, Yi Feng, Li Yin, Jinwei Tian, Hulun Li, Xinxin Liu, Bo Yu
Summary: The study suggests that geraniin may have pharmacological activity in atherosclerosis by remodeling the gut microbiota, reducing plasma TMAO levels, alleviating vascular inflammation, and reducing atherosclerotic characteristics.
Article
Chemistry, Multidisciplinary
Xiaotong Li, Jiayi Gu, Qingqing Xiao, Ying Liu, Ping Zhou, Lifang Fan, Xiulian Zhang, Xiang Lu, Jun Wu, Zhengxia Liu, Wei He
Summary: In this study, a pH-sensitive liposome co-loaded with an anti-inflammatory agent and a plaque-collagen protector was developed for the treatment of atherosclerosis. The co-loaded system showed improved pharmacokinetics and effective accumulation in plaque, leading to efficient anti-atherosclerosis activities. The findings provide a potential guideline for clinical practice.
CHINESE CHEMICAL LETTERS
(2023)
Review
Biochemistry & Molecular Biology
Amin F. Majdalawieh, Aaram E. Eltayeb, Imad A. Abu-Yousef, Sarah M. Yousef
Summary: Sesamol, a compound found in sesame seeds and sesame oil, has been shown to have lipid-lowering and anti-atherogenic properties. It affects serum lipid levels by influencing fatty acid synthesis and oxidation, as well as cholesterol metabolism. This review provides a comprehensive summary of the hypolipidemic effects of sesamol, exploring its impact on serum lipid profiles and the molecular mechanisms involved. It highlights its ability to inhibit fatty acid synthesis, stimulate fatty acid oxidation, enhance cholesterol metabolism, and modulate macrophage cholesterol efflux.
Article
Hematology
Jamie Kane, Matthijs Jansen, Sebastian Hendrix, Laura A. Bosmans, Linda Beckers, Claudia van Tiel, Marion Gijbels, Noam Zelcer, Carlie J. de Vries, Philipp von Hundelshausen, Marc Vervloet, Ed Eringa, Anton J. Horrevoets, Niels van Royen, Esther Lutgens
Summary: The study demonstrates that treatment with anti-Gal-2 nanobodies can slow the progression of atherosclerosis, reduce plaque size, and modify the phenotype of plaque macrophages to an anti-inflammatory profile. These findings are significant for future therapeutic interventions targeting macrophages to promote arteriogenesis and reduce atherosclerosis.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Biochemistry & Molecular Biology
Victoria L. O'Morain, Jing Chen, Sue F. Plummer, Daryn R. Michael, Dipak P. Ramji
Summary: The Lab4b consortium of probiotics, containing four strains of lactic acid bacteria and bifidobacteria, demonstrates protective effects against atherosclerosis through various mechanisms. The study suggests that further research is needed in mouse models and clinical trials to explore the potential of Lab4b in preventing and treating atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Xinbo Zhang, Jeffrey G. McDonald, Binod Aryal, Alberto Canfran-Duque, Emily L. Goldberg, Elisa Araldi, Wen Ding, Yuhua Fan, Bonne M. Thompson, Abhishek K. Singh, Qian Li, George Tellides, Jose Ordovas-Montanes, Rolando Garcia Milian, Vishwa Deep Dixit, Elina Ikonen, Yajaira Suarez, Carlos Fernandez-Hernando
Summary: Desmosterol, the most abundant cholesterol biosynthetic intermediate in human coronary artery lesions, plays an essential role during atherogenesis by integrating with macrophage cholesterol metabolism and inflammatory activation to dampen inflammation and protect from disease progression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cardiac & Cardiovascular Systems
Alberto Canfran-Duque, Noemi Rotllan, Xinbo Zhang, Irene Andres-Blasco, Bonne M. Thompson, Jonathan Sun, Nathan L. Price, Marta Fernandez-Fuertes, Joseph W. Fowler, Diego Gomez-Coronado, William C. Sessa, Chiara Giannarelli, Robert J. Schneider, George Tellides, Jeffrey G. McDonald, Carlos Fernandez-Hernando, Yajaira Suarez
Summary: The accumulation of 25-hydroxycholesterol (25-HC) in human coronary atherosclerotic lesions accelerates atherosclerosis progression and promotes plaque instability through autocrine and paracrine actions. Macrophage-derived 25-HC intensifies the inflammatory response of lipid-loaded macrophages and inhibits smooth muscle cell migration within the plaque. These effects are independent of 25-HC-mediated modulation of transcriptional activity.
Review
Cell Biology
Alexander V. Blagov, Alexander M. Markin, Anastasia I. Bogatyreva, Taisiya V. Tolstik, Vasily N. Sukhorukov, Alexander N. Orekhov
Summary: This review summarizes the involvement of various cell populations, including immune cells and endothelial cells, in the pathogenesis of atherosclerosis. Among them, macrophages are of particular importance due to their diverse effects on atherogenesis and inflammation in atherosclerosis. The significance of different phenotypes of macrophages in the progression or regression of atherosclerosis is discussed, including their ability to become foam cells, the consequences of this event, and their ability to create a pro-inflammatory or anti-inflammatory environment through cytokine production at the site of atherosclerotic lesions. In addition, therapeutic strategies aimed at modulating macrophage activity are considered, providing useful ideas for future drug developments.
Article
Medicine, Research & Experimental
Acharya Balkrishna, Vivek Gohel, Nishit Pathak, Rani Singh, Meenu Tomer, Malini Rawat, Rishabh Dev, Anurag Varshney
Summary: Atherosclerosis is a major pathological process of cardiovascular diseases, which can begin early in life and remain silent before symptoms manifest. The formation of foamy macrophages due to dysregulated lipid metabolism is important in atherosclerotic plaque development. Current pharmacotherapy for atherosclerosis is limited, but "Lipidom" has shown potential with its antioxidant, lipid-lowering, and anti-inflammatory properties. This study aimed to characterize the pharmacological effects of "Lipidom" using experimental models.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Anna Kiepura, Kamila Stachyra, Rafal Olszanecki
Summary: This paper summarizes the evidence on the potential beneficial effects of FFAR4 stimulation in atherosclerosis, suggesting that one important mechanism may be the modulatory influence of FFAR4 on the phenotype of macrophages involved in atherogenesis.
Article
Polymer Science
Richard d'Arcy, Nicola Tirelli
Summary: Cross-linked micelles made of amphiphilic poly(ethylene glycol)-polysulfide block copolymers act as effective anti-inflammatory agents by scavenging ROS and inhibiting the production of inflammatory cytokines. Compared to self-assembled micelles, cross-linked micelles exhibit better stability, lower toxicity, and less damage to cells.
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2023)
Article
Cardiac & Cardiovascular Systems
Chuan Li, Lili Qu, Alyssa J. Matz, Patrick A. Murphy, Yongmei Liu, Ani W. Manichaikul, Derek Aguiar, Stephen S. Rich, David M. Herrington, David Vu, W. Craig Johnson, Jerome Rotter, Wendy S. Post, Anthony T. Vella, Annabelle Rodriguez-Oquendo, Beiyan Zhou
Summary: AtheroSpectrum, a computational program, identified a specific gene expression profile associated with inflammatory macrophage foam cells in atherosclerosis. By incorporating a subset of 30 genes with traditional risk factors, it was possible to accurately predict symptomatic atherosclerotic vascular disease.
Article
Biochemistry & Molecular Biology
Liyan Yu, Hongguang Liu, Xiaoxia Ma, Vidya Devanathadesikan Seshadri, Xuan Gao
Summary: The study found that Myrtenal has anti-atherosclerotic activity in high-fat diet-induced atherosclerosis rat models. Myrtenal-treated groups showed the ability to modulate the lipid metabolic pathway, reducing blood lipid levels and inflammatory cytokines.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Huiwen Liu, Honglan Wang, Qiyu Li, Yiwei Wang, Ying He, Xuejing Li, Chunyan Sun, Onder Ergonul, Fusun Can, Zhiqing Pang, Bo Zhang, Yu Hu
Summary: Chronic inflammation is critical in the onset and progression of atherosclerosis. Elevated levels of lipopolysaccharide (LPS) in the circulation system are correlated with the severity of atherosclerosis. This study focuses on using polymyxin covalently conjugated to PEGylated liposomes to adsorb LPS in the circulation system as a therapeutic target for atherosclerosis treatment.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Neurosciences
Wei Zhang, Jun-hua Gao, Zhao-fen Yan, Xi-yan Huang, Peng Guo, Li Sun, Zhuo Liu, Yang Hu, Li-jun Zuo, Shu-yang Yu, Chen-Jie Cao, Xiao-min Wang, Jau-shyong Hong
MOLECULAR NEUROBIOLOGY
(2018)
Article
Substance Abuse
Sheng-Yu Lee, Tzu-Yun Wang, Shiou-Lan Chen, Yun-Hsuan Chang, Po-See Chen, San-Yuan Huang, Nian-Sheng Tzeng, Liang-Jen Wang, I. Hui Lee, Kao Ching Chen, Yen Kuang Yang, Jau-Shyong Hong, Ru-Band Lu
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2018)
Article
Pharmacology & Pharmacy
Takuyu Hashiguchi, Sawako Shindo, Shih-Heng Chen, Jau-Shyong Hong, Masahiko Negishi
DRUG METABOLISM AND DISPOSITION
(2018)
Article
Biochemistry & Molecular Biology
Duy-Khanh Dang, Eun-Joo Shin, Dae-Joong Kim, Hai-Quyen Tran, Ji Hoon Jeong, Choon-Gon Jang, Ole Petter Ottersen, Seung-Yeol Nah, Jau-Shyong Hong, Toshitaka Nabeshima, Hyoung-Chun Kim
FREE RADICAL BIOLOGY AND MEDICINE
(2018)
Article
Immunology
Duy-Khanh Dang, Eun-Joo Shin, Dae-Joong Kim, Hai-Quyen Tran, Ji Hoon Jeong, Choon-Gon Jang, Seung-Yeol Nah, Jung Hwan Jeong, Jae Kyung Byun, Sung Kwon Ko, Guoying Bing, Jau-Shyong Hong, Hyoung-Chun Kim
JOURNAL OF NEUROINFLAMMATION
(2018)
Article
Medicine, General & Internal
Ching-Long Lai, Chun-Chung Lu, Hui-Ching Lin, Yueh-Feng Sung, Yi-Pin Wu, Jau-Shyong Hong, Giia-Sheun Peng
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2019)
Article
Neurosciences
Shih-Heng Chen, Yueh-Feng Sung, Esteban A. Oyarzabal, Yu-Mei Tan, Jeremy Leonard, Mingri Guo, Shuo Li, Qingshan Wang, Chun-Hsien Chu, Shiou-Lan Chen, Ru-Band Lu, Jau-Shyong Hong
MOLECULAR NEUROBIOLOGY
(2018)
Review
Clinical Neurology
Liyan Hou, Qiujuan Li, Liping Jiang, Hongyan Qiu, Chengyan Geng, Jau-Shyong Hong, Huihua Li, Qingshan Wang
FRONTIERS IN NEUROLOGY
(2018)
Article
Substance Abuse
Tzu-Yun Wang, Sheng-Yu Lee, Yun-Hsuan Chang, Shiou-Lan Chen, Po See Chen, Chun-Hsien Chu, San-Yuan Huang, Nian-Sheng Tzeng, I. Hui Lee, Kao Chin Chen, Yen Kuang Yang, Shih-Heng Chen, Jau-Shyong Hong, Ru-Band Lu
DRUG AND ALCOHOL DEPENDENCE
(2018)
Article
Neurosciences
Sheng Song, Lulu Jiang, Esteban A. Oyarzabal, Belinda Wilson, Zibo Li, Yen-Yu Ian Shih, Qingshan Wang, Jau-Shyong Hong
MOLECULAR NEUROBIOLOGY
(2019)
Correction
Neurosciences
Huan Li, Sheng Song, Yuan Wang, Chun Huang, Feng Zhang, Jie Liu, Jau-Shyong Hong
NEUROTOXICITY RESEARCH
(2019)
Article
Neurosciences
Huan Li, Sheng Song, Yuan Wang, Chun Huang, Feng Zhang, Jie Liu, Jau-Shyong Hong
NEUROTOXICITY RESEARCH
(2019)
Article
Genetics & Heredity
Yun-Hsuan Chang, Tzu-Yun Wang, Sheng-Yu Lee, Shiou-Lan Chen, Chih-Chun Huang, Po See Chen, Yen Kuang Yang, Jau-Shyong Hong, Ru-Band Lu
FRONTIERS IN GENETICS
(2018)
Article
Biochemistry & Molecular Biology
Ran Zhou, Shih-Heng Chen, Guorong Li, Hui-Ling Chen, YuXin Liu, Hung-Ming Wu, Yubao Wang, Jing Feng, Jau-Shyong Hong
CHEMICO-BIOLOGICAL INTERACTIONS
(2019)
Article
Neurosciences
Ru-Band Lu, Yun-Hsuan Chang, Sheng-Yu Lee, Tzu-Yun Wang, Shu-Li Cheng, Po-See Chen, Yen-Kuang Yang, Jau-Shyong Hong, Shiou-Lan Chen
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2020)