Review
Cell Biology
Michael Basler, Marcus Groettrup
Summary: The immunoproteasome is a special type of proteasome induced under inflammatory conditions, contributing to protein homeostasis in cells and involved in immune response, T cell expansion, and inflammatory diseases. Targeting the immunoproteasome has shown therapeutic effectiveness in cancer, autoimmune diseases, and transplantation in preclinical animal models.
Review
Cell Biology
Nuria Tubio-Santamaria, Frederic Ebstein, Florian H. Heidel, Elke Krueger
Summary: The ubiquitin-proteasome system (UPS) plays a crucial role in maintaining protein homeostasis, with inhibitors of the immunoproteasome showing potential as a targeted therapy for hematologic malignancies.
Review
Oncology
Grazia R. Tundo, Diego Sbardella, Francesco Oddone, Anna A. Kudriaeva, Pedro M. Lacal, Alexey A. Belogurov, Grazia Graziani, Stefano Marini
Summary: The immunoproteasome plays a crucial role in antigen presentation and its modulation presents promising research opportunities. Immunotherapy has shown significant advancements, however, a broader understanding of cancer cell antigen processing dynamics is still required for further improvements.
Review
Cell Biology
Satyendra Chandra Tripathi, Disha Vedpathak, Edwin Justin Ostrin
Summary: Cell-mediated immunity is driven by antigenic peptide presentation on major histocompatibility complex (MHC) molecules. Immunoproteasomes, with inducible activity by inflammatory stimuli, play central roles in cancer, autoimmunity, and inflammation by altering the catalytic activity of the proteasome.Understanding the roles of immunoproteasome in different cancers offers insights into developing targeted therapies.
Article
Cardiac & Cardiovascular Systems
Petra Kleinbongard, Helmut Raphael Lieder, Andreas Skyschally, Mouhamad Alloosh, Axel Goedecke, Sven Rahmann, Michael Sturek, Gerd Heusch
Summary: The study found that Ossabaw minipigs, despite having a genetic predisposition to develop a metabolic syndrome, were not responsive to cardioprotective interventions such as ischemic preconditioning.
BASIC RESEARCH IN CARDIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Boya Chen, Haiying Zhu, Bo Yang, Ji Cao
Summary: Immunoproteasome is a variant of proteasome optimized for producing antigenic peptides with higher binding affinity and plays a dual role in different types of cancer. It is involved in antigen presentation and degradation of proteins, including tumor suppressor proteins, contributing to tumor progression. Targeting immunoproteasome could be a potential therapeutic intervention in cancer treatment and understanding its role is crucial for cancer prevention and treatment.
ACTA PHARMACEUTICA SINICA B
(2023)
Review
Oncology
Priyanka S. Rana, James J. Ignatz-Hoover, James J. Driscoll
Summary: Proteasomes are complex protein-degrading machines that regulate the elimination of intracellular proteins. Immunoproteasomes are a specialized variant that degrade proteins in cells exposed to oxidative stress and inflammation. They can be targeted for therapeutic purposes in the treatment of cancer and infectious diseases.
Review
Cell Biology
Kanisa Davidson, Andrew M. Pickering
Summary: The proteasome is a large multi-subunit protease responsible for protein degradation. It plays critical roles in maintaining cellular homeostasis in neurons and modulating CREB signaling involved in long-term potentiation. The proteasome also promotes dendritic spine growth and affects memory, circadian rhythm, and glial function. Dysfunction of the proteasome is linked to aging and neurodegenerative diseases like ALS, Alzheimer's, Parkinson's, and Huntington's disease. The article discusses the proteasome's role in the nervous system and its contribution to brain aging and neurodegenerative disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Nabil Sayour, Gabor B. Brenner, Andras Makkos, Bernadett Kiss, Csenger Kovacshazi, Tamas G. Gergely, Sverre Groever Aukrust, Huimin Tian, Viktoria Zenkl, Kamilla Gomori, Tamara Szabados, Peter Bencsik, Andre Heinen, Rainer Schulz, Gary F. Baxter, Coert J. Zuurbier, Zoltan Voko, Peter Ferdinandy, Zoltan Giricz
Summary: In this study, RIPC was found to have no cardioprotective effect in rats, based on randomized and blinded in vivo studies in three study centres using different RIPC protocols. However, a systematic review and meta-analysis of in vivo rat models showed that RIPC could reduce infarct size by an average of 21.28%. These results highlight the need for more well-designed and well-reported studies to confirm these findings and develop clinically translatable cardioprotective interventions.
CARDIOVASCULAR RESEARCH
(2023)
Article
Nutrition & Dietetics
Luo-Luo Xu, Hui-Xiang Su, Pang-Bo Li, Hui-Hua Li
Summary: Ursolic acid (UA) prevents cardiac dysfunction induced by ischaemia/reperfusion (I/R) injury by activating immunoproteasome, reducing infarct size, myocyte apoptosis, and oxidative stress. UA supplementation can be a potential therapeutic strategy for cardiac ischaemic diseases.
Article
Multidisciplinary Sciences
Xiao Yang, Meihui Song, Ying Wang, Taicong Tan, Zhongyu Tian, Binyuan Zhai, Xuan Yang, Yingjin Tan, Yanding Cao, Shaojun Dai, Shunxin Wang, Liangran Zhang
Summary: This study identifies a molecular pathway for axis length regulation in meiotic cells. It shows that the cohesin regulator Pds5 interacts with proteasomes to regulate the ubiquitination level of chromosome proteins, which affects chromosome axis length. Two ubiquitin E3 ligases, SCF and Ufd4, are involved in this pathway. These findings contribute to our understanding of how Pds5 regulates meiotic chromosome organization and suggest a conserved regulatory mechanism in higher eukaryotes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Plant Sciences
Dania P. Lobaina, Roberto Tarazi, Tamara Castorino, Maite F. S. Vaslin
Summary: The ubiquitin-proteasome system (UPS) is crucial for maintaining cellular balance and plays a key role in DNA repair, gene transcription, and protein activation. Viruses often manipulate the UPS to maintain viral protein levels and evade host defenses. Understanding the mechanisms used by plant viruses to subvert host defenses is important for developing biotechnological approaches for viral resistance.
Article
Clinical Neurology
Huu Dat Nguyen, Young Eun Kim, Linh Thi Nhat Nguyen, In Hee Kwak, Yoon Kyoung Lee, Yun Joong Kim, Thanh Thi Hai Nguyen, Hong Ngoc Pham, Hyeo-il Ma
Summary: This study investigated the expression of immunoproteasome in Parkinson's disease (PD) and found that PSMB8 was significantly upregulated in the peripheral blood mononuclear cells of PD patients. The upregulation of PSMB8 was associated with disease severity. Additionally, abundant expression of PSMB8 was also observed in the brain of PD patients.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Laura Otero-Ortega, Elisa Alonso-Lopez, Maria Perez-Mato, Fernando Laso-Garcia, Mari Carmen Gomez-de Frutos, Luke Diekhorst, Maria Laura Garcia-Bermejo, Elisa Conde-Moreno, Blanca Fuentes, Maria Alonso de Lecinana, Eduardo Armada, Lorena Buiza-Palomino, Exuperio Diez-Tejedor, Maria Gutierrez-Fernandez
Summary: The study analyzed the content of circulating EVs in patients with IS and MI, finding common proteins and miRNAs as well as differences between the two groups. The research suggests a relationship between circulating EV content and the patient's disease state, with certain proteins and miRNAs participating in both diseases while others are specific to IS patients.
Article
Cardiac & Cardiovascular Systems
Judit Cubedo, Teresa Padro, Gemma Vilahur, Filippo Crea, Robert F. Storey, Jose Luis Lopez Sendon, Juan Carlos Kaski, Alessandro Sionis, Jordi Sans-Rosello, Estefania Fernandez-Peregrina, Alex Gallinat, Lina Badimon
Summary: This study found that circulating levels of glycosylated apolipoprotein J decrease significantly in the early phase of acute myocardial infarction, and lower levels are associated with increased rates of recurrent ischemic events and mortality in AMI patients after 6 months.
EUROPEAN HEART JOURNAL
(2022)