Article
Plant Sciences
Yan Wang, Hong Wu, Bin-Jie Gui, Jian Liu, Gen-Xiang Rong, Ran Deng, Yan-Hong Bu, Heng Zhang
Summary: The study found that geniposide can inhibit angiogenesis in rheumatoid arthritis and alleviate disease progression. The research also revealed the important role of SphK1, VEGF/VEGFR2, and S1P/S1PR1 signaling pathways in the effect of geniposide on synovial angiogenesis.
Review
Biochemistry & Molecular Biology
Yali Lai, Yue Tian, Xintong You, Jiangnan Du, Jianmei Huang
Summary: Many cardiovascular disorders are characterized by endothelial cell dysfunction, which is closely related to sphingolipid metabolism. Understanding the effects of sphingolipid metabolites and key enzymes on endothelial cells can provide insights into the pathogenesis of cardiovascular diseases and potential therapeutic targets.
LIPIDS IN HEALTH AND DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Xiaorui Wang, Wenwen Han, Yi Zhang, Yi Zong, Na Tan, Yan Zhang, Li Li, Chang Liu, Limei Liu
Summary: This study investigates the impact of an sEH inhibitor on renovascular endothelial dysfunction in hypertensive rats. The results show that the inhibitor effectively reverses the deleterious effects, such as increased blood pressure and reduced renal blood flow. Additionally, the study reveals the potential role of miR-155-5p in the development of vascular endothelial dysfunction in hypertension.
Article
Neurosciences
Wen Zeng, Qiaoling Lei, Jiao Ma, Shuqiang Gao, Rong Ju
Summary: This study investigated the biological effects of EPC-derived MVs on BMECs, showing that EPC-MVs can enhance BMEC viability, proliferation, migration, and tube formation. These results suggest the proangiogenic effect of EPC-derived MVs on BMECs, which holds potential applications in cell-free therapy for brain injury.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Food Science & Technology
Ho-Jeong Bang, Eunju Yoon, Sun Wook Kim, Mok-Ryeon Ahn
Summary: Benzyl caffeate significantly inhibits angiogenesis by inducing apoptosis and anti-proliferative effects on endothelial cells, showing potential antiangiogenic effects.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biochemistry & Molecular Biology
Yanyan Wang, Yun-Ling Tai, Grayson Way, Jing Zeng, Derrick Zhao, Lianyong Su, Xixian Jiang, Kaitlyn G. Jackson, Xuan Wang, Emily C. Gurley, Jinze Liu, Jinpeng Liu, Weidong Chen, Xiang-Yang Wang, Arun J. Sanyal, Phillip B. Hylemon, Huiping Zhou
Summary: This study investigated the role of hepatocyte-specific HuR in regulating hepatic lipid metabolism and found that HuR deficiency leads to increased hepatic lipid accumulation, inflammation, disrupted bile acid homeostasis, and enhanced liver fibrosis. Additionally, HuR was identified as a repressor of H19 expression, and the downregulation of H19 alleviated NAFLD in mice with HuR deficiency.
CELL AND BIOSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Ling-Wei Hii, Felicia Fei-Lei Chung, Chun-Wai Mai, Pei Yuen Ng, Chee-Onn Leong
Summary: SPHK1 is a conserved lipid enzyme that catalyzes the formation of S1P, and has been implicated in oncogenic functions, particularly in breast cancer. Recent evidence suggests a role for SPHK1 in regulating CSCs, indicating the therapeutic potential of targeting SPHK1 in refractory cancers enriched with CSCs.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Medicine, Research & Experimental
Caixia Zhou, Yashu Kuang, Qinyu Li, Yunhao Duan, Xiuxiang Liu, Jinnan Yue, Xiaoli Chen, Jie Liu, Yuzhen Zhang, Lin Zhang
Summary: This study demonstrates that EC-expressing S1pr2 tightly controls post-ischemic angiogenesis and blood flow perfusion recovery. The inhibition of S1pr2 can enhance post-ischemic angiogenesis and improve blood flow in peripheral artery disease, offering a novel therapeutic intervention.
Article
Biochemistry & Molecular Biology
Ewelina Jozefczuk, Piotr Szczepaniak, Tomasz Jan Guzik, Mateusz Siedlinski
Summary: The silencing of Sphk1 in neonatal mouse CMs was shown to enhance their postnatal maturation in both physiological and stress conditions, as evidenced by accelerated cell maturation, inhibition of proliferation, and induction of developmental pathways. This effect was further supported by the upregulation of the Akt signaling pathway and downregulation of Gsk3β, indicating physiological hypertrophy in the absence of Sphk1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Jeannette Rudzitis-Auth, Anika Christoffel, Michael D. Menger, Matthias W. Laschke
Summary: The inhibition of SPHK1 was found to significantly inhibit the development and vascularization of peritoneal endometriotic lesions, leading to reduced growth, cyst formation, microvessel density, and cell proliferation. In the dorsal skinfold chamber model, inhibition of SPHK1 resulted in smaller lesion size, lower functional microvessel density, smaller microvessel diameters, and reduced blood perfusion of the newly developing microvascular networks.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jiwang Chen, Angelia Lockett, Shuangping Zhao, Long Shuang Huang, Yifan Wang, Weiwen Wu, Ming Tang, Shahzaib Haider, Daniela Velez Rendon, Raheel Khan, Bing Liu, Nicholas Felesena, Justin R. Sysol, Daniela Valdez-Jasso, Haiyang Tang, Yang Bai, Viswanathan Natarajan, Roberto F. Machado
Summary: Sphingosine kinase 1 (SPHK1) and the sphingosine-1-phosphate (S1P) signaling pathway play important roles in pulmonary arterial hypertension (PAH). SPHK1 activates the YAP1 signaling pathway to promote the proliferation of pulmonary artery smooth muscle cells (PASMC) and pulmonary vascular remodeling. The YAP1 inhibitor, verteporfin, can attenuate PASMC proliferation, PH, and pulmonary vascular remodeling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Khem Raj Limbu, Rashmi Bhandari Chhetri, Yoon Sin Oh, Dong Jae Baek, Eun-Young Park
Summary: Pancreatic ductal adenocarcinoma (PDAC) is difficult to treat and resistant to conventional chemotherapy. This study found that the anthelmintic drug MBZ can inhibit cancer cell growth and migration by lowering S1P production and regulating related pathways and molecules.
Article
Cell Biology
Lu Gao, Weixian Chen, Lijun Li, Juanjuan Li, Wenyao Kongling, Yaoyang Zhang, Xueping Yang, Yanrong Zhao, Jie Bai, Fu Wang
Summary: Type H vessels play a role in osteogenesis and Epoxyeicostrioleic acids (EETs) contribute to vascular homeostasis. It is unclear whether increasing EETs with sEH inhibitor TPPU can enhance the coupling of angiogenesis and osteogenesis. In this study, TPPU was found to enhance osteogenic differentiation and promote bone growth and repair. Mechanistically, TPPU promoted cell proliferation and angiogenesis and increased the expression of certain factors involved in endothelial cell function. The results suggest that targeting EETs metabolic pathways can be a promising strategy for bone regeneration and repair.
CELL PROLIFERATION
(2023)
Article
Biochemistry & Molecular Biology
Jean-Philip Truman, Christian F. Ruiz, Magali Trayssac, Cungui Mao, Yusuf A. Hannun, Lina M. Obeid
Summary: This study reveals that under conditions of serine starvation, SK1 is degraded in a p53-independent manner, requiring the action of the proteasome. Overexpression of SK1 to compensate for its loss is detrimental to cell growth under serine deprivation, indicating that suppression of SK1 under these conditions is adaptive. The effects of SK1 suppression on intracellular reactive oxygen species were mimicked by D-erythro-sphingosine, suggesting that the accumulation of its substrate, sphingosine, is responsible for these effects.
Article
Biochemistry & Molecular Biology
Michael G. McCoy, Daniel Perez-Cremades, Nathan Belkin, Wenhui Peng, Bofang Zhang, Jingshu Chen, Madhur Sachan, A. K. M. Khyrul Wara, Rulin Zhuang, Henry S. Cheng, Mark W. Feinberg
Summary: This study demonstrates that a 4-miRNA cassette can reprogram vascular smooth muscle cells into endothelial cells, and these induced cells exhibit high similarity to native endothelial cells. Injected induced cells even restore blood flow faster than conventional endothelial cells in a mouse model, suggesting the potential of this approach for vascular disease therapy.
Article
Reproductive Biology
Nannan Kang, Huizhi Shan, Junxia Wang, Jie Mei, Yue Jiang, Jidong Zhou, Chenyang Huang, Hui Zhang, Mei Zhang, Xin Zhen, Guijun Yan, Haixiang Sun
Summary: CAPN7 negatively regulates decidualization of human endometrial stromal cells by hydrolyzing AKT1 and promoting its phosphorylation. Increased expression of CAPN7 in endometriosis suggests that dysregulation of CAPN7 may be a potential cause of endometriosis.
BIOLOGY OF REPRODUCTION
(2022)
Article
Endocrinology & Metabolism
Jiao Tian, Nannan Kang, Junxia Wang, Haixiang Sun, Guijun Yan, Chenyang Huang, Jie Mei
Summary: This study identified differentially expressed genes (DEGs) in the endometrium of patients with adenomyosis after GnRHa treatment, indicating significant changes in immune system-associated signal transduction. The highly expressed chemokine (C-C motif) ligand 21 (CCL21) in the eutopic endometrium after GnRHa treatment may be involved in improving endometrial receptivity in adenomyosis.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Xinyu Cai, Mei Zhang, Chenyang Huang, Yue Jiang, Jidong Zhou, Manlin Xu, Guijun Yan, Haixiang Sun, Na Kong
Summary: This study found that women with a history of GTD had a significantly lower live-birth rate during IVF/ICSI cycles, potentially due to the thinner endometrium and abnormal endometrial receptivity.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Andrology
Qiuling Yue, Lina Yu, Wenwen Liu, Jidong Zhou, Xuechun Hu, Yixun Liu, Xue Zhou, Limin Wu, Bo Xu, Xianhong Tong, Xiaohua Jiang, Guijun Yan, Shun Bai
Summary: Through studying the Homez mutant mice, it was found that the Homez gene does not play a crucial role in spermatogenesis and male fertility, but it does regulate the transcription of certain Zhx genes. This finding could prevent unnecessary duplicative work by other research groups.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2022)
Article
Materials Science, Ceramics
Meng Miao, Zhipeng Wang, Zhiming Guo, Guijun Yan, Jinfeng Xing
Summary: Researchers have developed a precursor ink for a lattice-matched methylammonium lead iodide solid sol of lead sulfide quantum dots (PbS-QDs/MAPbI3 solid sol) through ligand exchange. They then fabricated a high-performance uncooled photoconductive near-infrared sensor based on this solid sol using a simple dip coating method. This sensor exhibits outstanding overall performance in sensing near-infrared light with high external quantum efficiency, responsivity, detectivity, speed, linearity, and response retention rate.
CERAMICS INTERNATIONAL
(2023)
Article
Obstetrics & Gynecology
Na Kong, Jingyu Liu, Yue Jiang, Yingchun Zhu, Chunxue Zhang, Guijun Yan, Haixiang Sun, Chenyang Huang
Summary: This study aimed to investigate the effect of elevated serum progesterone (P) levels on the day of human chorionic gonadotropin (hCG) administration on the clinical pregnancy outcomes for embryos transferred at different stages of development. The results showed that when the serum P level on the hCG day was higher than 1.5 ng/mL, the clinical pregnancy rate (CPR) did not significantly decrease. There was no correlation between CPR and serum P level in cleavage-stage embryo transfer, but the CPR of blastocyst transfer decreased as serum P levels increased.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Article
Medicine, General & Internal
Xinyu Cai, Yue Jiang, Zhiwen Cao, Mei Zhang, Na Kong, Lina Yu, Yedong Tang, Shuangbo Kong, Wenbo Deng, Haibin Wang, Jianxin Sun, Lijun Ding, Ruiwei Jiang, Haixiang Sun, Guijun Yan
Summary: The expression of Mammalian sterile 20 (STE20)-like kinase 1 (Mst1) in the endometrium was decreased in women with recurrent implantation failure (RIF), but its activation promoted trophoblast-uterine epithelium adhesion. Nur77 facilitated trophoblast-uterine epithelium adhesion through the Mst1 signaling pathway and regulated embryo implantation by modulating integrin signaling. This study provides a new approach for assessing endometrial receptivity and treating implantation failure.
Article
Plant Sciences
Rudra Bhattarai, Hui Liu, Kadambot H. M. Siddique, Guijun Yan
Summary: This study compared two NIL pairs with the most contrasting performance in metribuzin treatment and different genetic backgrounds using RNA sequence analysis, identifying nine candidate genes underlying Qsns.uwa.4 A.2 responsible for metribuzin resistance. Quantitative RT-qPCR further validated the candidate genes, with TraesCS4A03G1099000 (nitrate excretion transporter), TraesCS4A03G1181300 (aspartyl protease), and TraesCS4A03G0741300 (glycine-rich proteins) identified as key factors for metribuzin resistance.
Article
Genetics & Heredity
Hui Zhang, Zhilong Wang, Quan Zhou, Zhiwen Cao, Yue Jiang, Manlin Xu, Jingyu Liu, Jidong Zhou, Guijun Yan, Haixiang Sun
Summary: This study found that the expression of INHBB is significantly reduced in women with recurrent implantation failure. The INHBB-ADCY1-mediated cAMP signaling pathway regulates decidualization in these patients.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Article
Environmental Sciences
Yajie Guan, Manlin Xu, Zhe Zhang, Chuanming Liu, Jidong Zhou, Fei Lin, Junshun Fang, Yang Zhang, Qiuling Yue, Xin Zhen, Guijun Yan, Haixiang Sun, Wenwen Liu
Summary: Circadian disturbance, caused by factors like shift employment and nighttime light pollution, is common in modern culture. This study investigated the effects of maternal circadian disruption before pregnancy on the reproductive health of offspring in mice. It was found that the female offspring exposed to constant light showed obesity, abnormal lipid metabolism, earlier puberty onset, impaired ovarian function, and downregulated expression of various genes involved in circadian rhythm and ovarian function. This study also identified altered immune responses as a potential mechanism for the damage to ovarian function.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Plant Sciences
Tanushree Halder, Hui Liu, Yinglong Chen, Guijun Yan, Kadambot H. M. Siddique
Summary: Identifying quantitative trait loci (QTL) for different root traits in bread wheat can help breeders develop climate-resilient and high-yielding wheat varieties. This study detected 14 QTL for eight root traits on nine wheat chromosomes and validated two QTL for shallow root depth and high root dry mass in independent populations. The identified QTL and candidate genes are valuable resources for future root trait improvement in wheat.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Endocrinology & Metabolism
Qingqing Shi, Chenyang Huang, Jingyu Liu, Yifan Li, Na Kong, Jie Mei, Xiaoyue Shen, Yanxin Sun, Feifei Lu, Haixiang Sun, Guijun Yan
Summary: Investigated the effects of hormone replacement therapy (HRT) alone or in combination with tamoxifen on patients with thin endometrium in frozen-thawed embryo transfer (FET) cycles. Found that while tamoxifen can significantly increase endometrial thickness, it may not improve the pregnancy outcomes of patients with thin endometrium.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemical Research Methods
Tanushree Halder, Elke Stroeher, Hui Liu, Yinglong Chen, Guijun Yan, Kadambot H. M. Siddique
Summary: Improving the root system of wheat is crucial for enhancing grain yield and climate resilience. This study identified proteins associated with root length and root mass in wheat using label-free quantitative proteomics. The findings revealed potential biomarkers that could be used for improving the root system of wheat.
JOURNAL OF PROTEOMICS
(2024)
Article
Agronomy
Guannan Liu, Dongcheng Liu, Aimin Zhang, Hui Liu, Md Sultan Mia, Daniel Mullan, Guijun Yan
Summary: This study identified a novel SNP and developed a highly efficient KASP marker for drought tolerance in wheat. The findings have significant implications for research on drought tolerance in wheat.
THEORETICAL AND APPLIED GENETICS
(2023)
Article
Agronomy
Guannan Liu, Daniel Mullan, Aimin Zhang, Hui Liu, Dongcheng Liu, Guijun Yan
Summary: Common wheat is an important crop, but markers and genes related to pre-harvest sprouting (PHS) resistance in white-grained wheat are limited. In this study, KASP markers and functional genes related to PHS resistance on wheat chromosome 3AL were identified using near isogenic lines and the 90K SNP chip. These markers and genes are valuable for high-throughput evaluation, marker-assisted selection, and understanding the genetic pathways controlling PHS.
