Article
Cardiac & Cardiovascular Systems
Abigayle B. Simon, Cassandra C. Derella, Marsha Blackburn, Jeffrey Thomas, Lawrence C. Layman, Matthew S. Nicholson, Jennifer Waller, Ahmed Elmarakby, Karim M. Saad, Ryan A. Harris
Summary: The study found that women with type 1 diabetes have higher levels of estradiol in the late follicular phase, leading to increased oxidative stress and endothelial dysfunction. The use of oral contraceptive pills appears to benefit endothelial function in patients with type 1 diabetes.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Multidisciplinary Sciences
Bernardete F. Melo, Jesus Prieto-Lloret, Marlene D. Cabral, Fatima O. Martins, Ines B. Martins, Joana F. Sacramento, Pedro Ruivo, Tania Carvalho, Silvia V. Conde
Summary: Type 2 diabetes (T2D) is associated with cardiovascular and pulmonary disease, but how it affects pulmonary endothelial function is not well understood. This study found that T2D progression differently affects endothelial function and vascular contractility in the aorta and pulmonary artery, associated with alterations in the nitrergic system and inflammatory pathways.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Zumra Kara, Berna Guven, Arzu Onay Besikci, Nuh Yildirim, Hikmet Altunay
Summary: The study aimed to investigate the beneficial effects of Ivabradine (IVA) on vascular function in diabetes, beyond its primary mechanism of action on heart rate reduction. The study found that IVA improved vascular function in diabetic rats, potentially through the support of HCN channels against the damaging effects of diabetes. These findings suggest that IVA may be a useful intervention to prevent diabetic cardiovascular dysfunction.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Yuichiro Iwamoto, Tomohiko Kimura, Fuminori Tatsumi, Toshitomo Sugisaki, Masato Kubo, Erina Nakao, Kazunori Dan, Ryo Wamata, Hideyuki Iwamoto, Kaio Takahashi, Junpei Sanada, Yoshiro Fushimi, Yukino Katakura, Masashi Shimoda, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto
Summary: Morphological changes in the pancreas of subjects with type 2 diabetes mellitus are associated with the progression of vascular complications.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Yukihito Higashi
Summary: Oxidative stress and chronic inflammation play a crucial role in the development of atherosclerosis, as vascular endothelial dysfunction leads to its progression and forms a vicious cycle with oxidative stress and inflammation.
Article
Endocrinology & Metabolism
Yueshu Wang, Yao Qin, Huilan Gu, Linyu Zhang, Jing Wang, Yiting Huang, Yuwen Shi, Qizhen Hu, Yang Chen, Yong Gu, Yun Shi, Yang Tao, Mei Zhang
Summary: This study found that Chinese patients with autoimmune type 1 diabetes have high residual beta-cell mass, suggesting potential implications for therapeutic strategies aimed at preserving and restoring beta-cell function.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Cardiac & Cardiovascular Systems
Ravi Retnakaran, Jiajie Pu, Chang Ye, Alexandra Emery, Caroline K. Kramer, Bernard Zinman
Summary: This study evaluated the effects of adding GLP1-RA exenatide or meal insulin lispro to basal glargine therapy on vascular function in early type 2 diabetes. The findings suggest that adding exenatide or lispro does not affect fasting endothelial function in patients with early type 2 diabetes.
CARDIOVASCULAR DIABETOLOGY
(2023)
Review
Multidisciplinary Sciences
Colin M. Dayan, Rachel E. J. Besser, Richard A. Oram, William Hagopian, Manu Vatish, Owen Bendor-Samuel, Matthew D. Snape, John A. Todd
Summary: Recent studies have shown that monitoring pancreatic islet autoantibodies and genetic risk assessment can identify most children who will develop T1D, with immunotherapy and primary prevention methods showing success in delaying disease progression. By shifting focus towards early diagnosis and b cell preservation, a future without daily insulin injections for children with T1D is anticipated.
Review
Biochemistry & Molecular Biology
Rachel L. Washburn, Karl Mueller, Gurvinder Kaur, Tanir Moreno, Naima Moustaid-Moussa, Latha Ramalingam, Jannette M. Dufour
Summary: Diabetes mellitus is a complex metabolic disease affecting one-third of the United States population, characterized by hyperglycemia. For patients with Type 1 diabetes, C-peptide may have potential therapeutic effects on various complications.
Article
Pharmacology & Pharmacy
Masashi Mukohda, Sho Nakamura, Kosuke Takeya, Akira Matsuda, Takanori Yano, Mihiro Seki, Risuke Mizuno, Hiroshi Ozaki
Summary: SLO affects vascular endothelial function, leading to vascular endothelial dysfunction mainly mediated by protein kinase Cb-induced phosphorylation of the eNOS inhibitory site. The study found that SLO can inhibit the hypotensive effect induced by acetylcholine, and in hypertensive rats, the immune response to SLO is more significant.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2021)
Article
Medicine, General & Internal
Karolina Nocun-Wasilewska, Danuta Zwolinska, Agnieszka Zubkiewicz-Kucharska, Dorota Polak-Jonkisz
Summary: This study found significantly higher concentrations of endothelial lesion markers in children with type 1 diabetes mellitus, which were positively correlated with disease duration, age, and BMI. Some markers showed linear correlations with the estimated glomerular filtration rate, suggesting their potential as prognostic factors for kidney dysfunction in children with type 1 diabetes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Kristina I. Bostrom, Xiaojing Qiao, Yan Zhao, Xiuju Wu, Li Zhang, Jocelyn A. Ma, Jaden Ji, Xinjiang Cai, Yucheng Yao
Summary: Endothelial-mesenchymal transition (EndMT) contributes to vascular calcification in diabetes mellitus. Inhibition of glycogen synthase kinase-3b (GSK3b) reduces vascular calcification by redirecting osteoblast-like cells derived from endothelial cells (ECs) back to the endothelial lineage in diabetic Ins2(Akita/wt) mice. The alterations in b-catenin and SMAD1 induced by GSK3b inhibition in the aortic endothelium of diabetic Ins2(Akita/wt) mice resemble those in Mgp(-/-) mice. These findings suggest that GSK3b inhibition reduces vascular calcification in diabetic arteries through a mechanism similar to that in Mgp(-/-) mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Priyal Dhawan, Sampara Vasishta, Aswath Balakrishnan, Manjunath B. Joshi
Summary: This review provides a comprehensive overview of how hyperglycemia in T2D reprograms endothelial epigenome and leads to vascular complications. It also discusses potential epidrugs that may ameliorate endothelial functions during T2D.
Article
Nutrition & Dietetics
Rosalind Baynham, Jet J. C. S. Veldhuijzen van Zanten, Paul W. Johns, Quang S. Pham, Catarina Rendeiro
Summary: The study shows that cocoa flavanols can counteract mental stress-induced endothelial dysfunction and improve peripheral blood flow during stress, suggesting that flavanol-rich dietary strategies can help protect vascular health during stress.
Review
Biochemistry & Molecular Biology
Yousef A. Al-Dashti, Roberta R. Holt, Carl L. Keen, Robert M. Hackman
Summary: Research on cardioprotective foods like dates is essential for addressing global public health needs. While animal studies show promising results, more human research is needed to fully understand the potential benefits of date fruit on vascular health. Conducting thorough clinical trials and assessing functional markers of vascular disease will provide valuable information for human health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cardiac & Cardiovascular Systems
Amit K. Dey, Jacob Groenendyk, Nehal N. Mehta, Evgenia Gourgari
CLINICAL CARDIOLOGY
(2019)
Article
Dermatology
Esther von Stebut, Kristian Reich, Diamant Thaci, Wolfgang Koenig, Andreas Pinter, Andreas Koerber, Tienush Rassaf, Ari Waisman, Venkatesh Mani, Denise Yates, Jennifer Frueh, Christian Sieder, Nima Melzer, Nehal N. Mehta, Tommaso Gori
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2019)
Article
Dermatology
Marilyn T. Wan, Drew A. Torigian, Abass Alavi, Judith Alvarez, Zelma C. Chiesa Fuxench, Megan H. Noe, Maryte Papadopoulos, Daniel B. Shin, Junko Takeshita, Thomas J. Werner, Nehal N. Mehta, Joel M. Gelfand
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Evgenia Gourgari, Junfeng Ma, Martin P. Playford, Nehal N. Mehta, Radoslav Goldman, Alan T. Remaley, Scott M. Gordon
CARDIOVASCULAR DIABETOLOGY
(2019)
Meeting Abstract
Cardiac & Cardiovascular Systems
Laboni H. Hoque, Amit Dey, Yuan Gu, Victoria Xin, Ruba Shalhoub, Runqiu Wang, Colin Wu, Tian Xin, Eileen Navarro Almario, Tejas Patel, Jerome Fleg, Anna Kettermann, Gyorgy Csako, George Sopko, Helena Sviglin, Gauri Dandi, Nuha Gani, Iffat Chowdhury, Keith Burkhart, Ana Szarfman, Sean Coady, Nehal Mehta, Frank Pucino, Yves Rosenberg, Ahmed Hasan
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2019)
Meeting Abstract
Cardiac & Cardiovascular Systems
Nuha Gani, Amit Dey, Victoria Xin, Runqiu Wang, Ruba Shalhoub, Colin Wu, Tian Xin, Eileen Navarro Almario, Tejas Patel, Jerome Fleg, Anna Kettermann, Gyorgy Csako, George Sopko, Helena Sviglin, Lawton Cooper, Laboni Hoque, Gauri Dandi, Iffat Chowdhury, Keith Burkhart, Karim Calis, Ana Szarfman, Nehal Mehta, Frank Pucino, Yves Rosenberg, Ahmed Hasan
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2019)
Article
Dermatology
Craig A. Elmets, Craig L. Leonardi, Dawn M. R. Davis, Joel M. Gelfand, Jason Lichten, Nehal N. Mehta, April W. Armstrong, Cody Connor, Kelly M. Cordoro, Boni E. Elewski, Kenneth B. Gordon, Alice B. Gottlieb, Daniel H. Kaplan, Arthur Kavanaugh, Dario Kivelevitch, Matthew Kiselica, Neil J. Korman, Daniela Kroshinsky, Mark Lebwohl, Henry W. Lim, Amy S. Paller, Sylvia L. Parra, Arun L. Pathy, Elizabeth Farley Prater, Reena Rupani, Michael Siegel, Benjamin Stoff, Bruce E. Strober, Emily B. Wong, Jashin J. Wu, Vidhya Hariharan, Alan Menter
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2019)
Editorial Material
Cardiac & Cardiovascular Systems
Yvonne Baumer, Nehal N. Mehta, Amit K. Dey, Tiffany M. Powell-Wiley, William A. Boisvert
EUROPEAN HEART JOURNAL
(2020)
Article
Dermatology
Matthew T. Patrick, Philip E. Stuart, Haihan Zhang, Qingyuan Zhao, Xianyong Yin, Kevin He, Xu-Jie Zhou, Nehal N. Mehta, John J. Voorhees, Michael Boehnke, Johann E. Gudjonsson, Rajan P. Nair, Samuel K. Handelman, James T. Elder, Dajiang J. Liu, Lam C. Tsoi
Summary: Psoriasis and type 2 diabetes share genetic components, with a causal relationship confirmed through Mendelian randomization. Trans-disease meta-analysis identified four genome-wide significant loci and revealed shared mechanisms between the two conditions.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Amit K. Dey, Heather L. Teague, Nicholas H. Adamstein, Justin A. Rodante, Martin P. Playford, Marcus Y. Chen, David A. Bluemke, Joel M. Gelfand, Paul M. Ridker, Nehal N. Mehta
Summary: The study shows that NLR is associated with psoriasis severity, hs-CRP, and NCB, and biologic therapy can reduce NLR over time and affect NCB.
JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY
(2021)
Review
Dermatology
Di Yan, Andrew Blauvelt, Amit K. Dey, Rachel S. Golpanian, Samuel T. Hwang, Nehal N. Mehta, Bridget Myers, Zhen-Rui Shi, Gil Yosipovitch, Stacie Bell, Wilson Liao
Summary: Psoriasis and psoriatic arthritis are not just diseases of the skin and joints, but rather immune dysfunction disorders caused by a combination of innate and environmental factors. Understanding the pathogenesis and systemic effects of psoriatic inflammation has led to the development of new and more effective treatments.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Alexander Sorokin, Nehal N. Mehta
CARDIOVASCULAR RESEARCH
(2022)
Editorial Material
Dermatology
Nehal N. Mehta, Joel M. Gelfand
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Review
Engineering, Biomedical
Eric Munger, John W. Hickey, Amit K. Dey, Mohsin Saleet Jafri, Jason M. Kinser, Nehal N. Mehta
Summary: Biological processes are complex, involving multicellular communication and function to maintain homeostasis. Machine learning is being increasingly used in atherosclerosis research to reveal complex relationships, enhance disease risk assessment, and improve understanding of plaque formation.
APL BIOENGINEERING
(2021)
Meeting Abstract
Dermatology
N. N. Mehta, M. G. Lebwohl, A. Peserico, E. Fumero, A. B. Gottlieb, A. M. Mendelsohn, J. Myers, J. Parno, S. J. Rozzo, A. Menter
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2019)