Review
Peripheral Vascular Disease
Stephane Laurent, Claudia Agabiti-Rosei, Rosa Maria Bruno, Damiano Rizzoni
Summary: Microcirculation and macrocirculation form a dangerous cross-link in hypertension, leading to vessel damage and elevated blood pressure. This vicious cycle can be reversed through pharmacological treatment.
Article
Peripheral Vascular Disease
Denise Marcon, Angela Tagetti, Claudia Piona, Alice Giontella, Stefano Bortolotti, Sara Bonafini, Lorenza Carletti, Anita Morandi, Maddalena Trombetta, Claudio Maffeis, Cristiano Fava
Summary: The study results suggest an independent association between central blood pressure and markers of subclinical arterial damage, highlighting the importance of hemodynamic factors in cardiovascular risk for patients with type 1 diabetes.
JOURNAL OF HYPERTENSION
(2022)
Article
Medical Laboratory Technology
Cathrine Munk Scheuer, Casper Duevang Tvarno, Charlotte Gils, Julie Dahl Ravn, H. David McIntyre, Dorte Moller Jensen, Peter Damm, Jeannet Kepp Bruun Lauenborg, Tine Dalsgaard Clausen, Martin Overgaard
Summary: A study found that there is variation in blood glucose measurements across different laboratories, which may affect the prevalence of gestational diabetes mellitus (GDM). Despite the small inter-laboratory bias in glucose measurements, the impact on GDM prevalence is considerable and may inappropriately affect clinical practice.
CLINICA CHIMICA ACTA
(2023)
Article
Endocrinology & Metabolism
Mengying Wang, Jie Huang, Tao Wu, Lu Qi
Summary: The study found that pulse wave arterial stiffness index (ASI) is positively associated with the risk of type 2 diabetes (T2D), while the association between pulse pressure (PP) and T2D shows a nonlinear J-shaped relationship. Additionally, the association between ASI and T2D is more pronounced among individuals with higher genetic susceptibility to T2D.
Article
Endocrinology & Metabolism
Mengying Wang, Jie Huang, Tao Wu, Lu Qi
Summary: Pulse wave arterial stiffness index (ASI) showed a dose-response association with type 2 diabetes (T2D), while pulse pressure (PP) displayed a nonlinear J-shaped association with T2D. Additionally, the association between ASI and T2D was partially strengthened by higher genetic susceptibility to T2D.
Article
Urology & Nephrology
Serena Low, Angela Moh, Su Fen Ang, Chin Leong Lim, Yan Lun Liu, Jiexun Wang, Keven Ang, Wern Ee Tang, Pek Yee Kwan, Ziliang Lim, Tavintharan Subramaniam, Chee Fang Sum, Su Chi Lim
Summary: Pulse pressure is associated with CKD progression, with high pulse pressure increasing the risk of renal function deterioration in patients. Measuring pulse pressure could serve as a simple, inexpensive, and readily available biomarker for renal decline in type 2 diabetes mellitus.
JOURNAL OF NEPHROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Nelson Wang, Katie Harris, Pavel Hamet, Stephen Harrap, Giuseppe Mancia, Neil Poulter, Bryan Williams, Sophia Zoungas, Mark Woodward, John Chalmers, Anthony Rodgers
Summary: The study found that cumulative systolic blood pressure load was associated with an increased risk of cardiovascular events and death in patients with type 2 diabetes, and provided better prediction compared to traditional blood pressure measures.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Chunlei Wu, Denhua Ma, Yu Chen
Summary: The study found that for every 1mmHg increase in pulse pressure difference, the incidence of type 2 diabetes mellitus increased by 0.3%. The risk of diabetes was lowest at a pulse pressure difference of about 35mmHg.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Zijian Wang, Xiaoran Li, Yichun Wang, Boyi Bao, Xiaosong Ding, Hongwei Li, Weiping Li
Summary: This study assessed the effect of pulse pressure (PP) at admission on long-term cardiac and all-cause mortality among elderly patients with type 2 diabetes mellitus (T2DM) admitted for acute coronary syndrome (ACS). The results showed that both high and low PP were significantly associated with increased cardiac and all-cause mortality, with a nadir at 50-59 mmHg.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Kosmas Margaritis, Georgia Margioula-Siarkou, Styliani Giza, Eleni P. Kotanidou, Vasiliki Regina Tsinopoulou, Athanasios Christoforidis, Assimina Galli-Tsinopoulou
Summary: Type-1 diabetes mellitus (T1DM) is a well-defined metabolic disorder characterized by hyperglycemia, with a growing incidence in children and adolescents. Recent discoveries of molecules like micro ribonucleic acids (miRNAs) and their interactions with T1DM have provided new insights into disease diagnosis. MiRNAs play a key role in T1DM pathogenesis by interfering with pancreatic b-cell function, insulin production and secretion, and are being studied as potential biomarkers for early diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Yang Wu, Haofei Hu, Jinlin Cai, Runtian Chen, Xin Zuo, Heng Cheng, Dewen Yan
Summary: This study explores the relationship between mean arterial pressure (MAP) and incident diabetes in Chinese adults. It finds that MAP is an independent predictor for a 5-year risk of incident diabetes, and the relationship between MAP and diabetes is non-linear. When MAP is below 100.333 mm Hg, MAP is closely positively related to diabetes.
Article
Peripheral Vascular Disease
Jean-Guillaume Dillinger, Charlotte Patin, Philippe Bonnin, Tiphaine Vidal-Trecan, Elise Paven, Jean-Francois Gautier, Jean-Pierre Riveline, Guy Amah, Patrick Henry
Summary: Analysis of brachial blood pressure in daily practice can help identify patients with diabetes mellitus at high risk for heart failure.
AMERICAN JOURNAL OF HYPERTENSION
(2022)
Article
Endocrinology & Metabolism
Andrew M. South, Joseph Rigdon, Saroja Voruganti, Jeanette M. Stafford, Dana Dabelea, Santica Marcovina, Amy K. Mottl, Cate Pihoker, Elaine M. Urbina, Elizabeth T. Jensen
Summary: This study investigated the association between uric acid levels and blood pressure and arterial stiffness in adolescents and young adults with type 1 diabetes. The results showed no significant relationship between uric acid and blood pressure or arterial stiffness in these patients. These findings support the results of clinical trials in older adults with diabetes, which show that lowering uric acid levels does not improve cardiovascular health.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, General & Internal
Libo Wang, Jonathan Harrison, Elizabeth Dranow, Nijat Aliyev, Lillian Khor
Summary: Point-of-care ultrasonography assessment of jugular venous pressure (JVP) is accurate and feasible in predicting elevated central venous pressure (CVP) in patients undergoing right heart catheterization, showing potential clinical application.
ANNALS OF INTERNAL MEDICINE
(2022)
Article
Peripheral Vascular Disease
Eirini Papadopoulou, Charalampos Loutradis, Glykeria Tzatzagou, Kalliopi Kotsa, Ioanna Zografou, Ioanna Minopoulou, Marietta P. Theodorakopoulou, Apostolos Tsapas, Asterios Karagiannis, Pantelis Sarafidis
Summary: The study showed that dapagliflozin significantly reduced 24-hour brachial and central blood pressure levels, as well as arterial stiffness parameters in patients with type-2 diabetes mellitus, contributing positively to cardiovascular benefits.
JOURNAL OF HYPERTENSION
(2021)
Article
Medicine, General & Internal
Paula Dmochowska, Maria Spyczak von Brzezinski, Jacek Zelazowski, Joanna Wojtkiewicz, Susanne Jung, Joanna M. Harazny
MEDICINA-LITHUANIA
(2019)
Article
Urology & Nephrology
Fabian Hammer, Uwe Malzahn, Julian Donhauser, Christoph Betz, Markus P. Schneider, Clemens Grupp, Nils Pollak, Stefan Stoerk, Christoph Wanner, Vera Krane, Susanne Berweck, Patrick Biggar, Christoph Blaser, Thomas Bochannek, Frank Breunig, Michael Brunner, Beatrix Bueschges-Seraphin, Stefan Buettner, Ahmet Cakmak, Thomas Doeltz, Mara Doerken, Kai-Uwe Eckardt, Heribert Fink, Stefan Fischer, Wolfgang Freisinger, Tilo Freiwald, Julian Gebhardt, Helmut Geiger, Ruediger Goetz, Jan Gossmann, Renate Hammerstingl, Joanna Harazny, Michael Heckel, Andrea Heyd-Schramm, Joachim Hoyer, Rolf Janka, Oliver Jung, Markus Ketteler, Christina Klaeffling, Claudius Kleinert, Marianne Kleinert, Arnfried Klingbeil, Thorsten Klink, Benjamin-Florian Koch, Judith Kosowski, Michael Leidig, Jens Lutz, Mohamed Marwan, Maria Moritz, Brigitte Moye, Holger Naujoks, Kai-Olaf Netzer, Ulrike Raff, Clemens Reichert, Imke Reimer, Jurij Ribel, Sophie Richter, Christian Ritter, Sarah Rudolf, Beate Schamberger, Michael Schmid, Thomas Schmiedeke, Andreas Schmitt, Heike Schneider, Reinhard Schneider, Cord Schneuzer, Markus Schoeffauer, Lothar Schramm, Sabine Schuetterle, Susanne Schwedler, Ewelina Sobkowiak, Daniel Sollinger, Frank Strutz, Sebastian Toncar, Vladimir Vasiljuk, Thomas Vogl, Thorsten Walther, Julia Weinmann-Menke, Bettina Wirth, Hendrick Witsch, Paul Wuermell, Raoul Zeltner, Josef Zimmermann
KIDNEY INTERNATIONAL
(2019)
Article
Peripheral Vascular Disease
Edyta Dabrowska, Joanna M. Harazny, Eliza Miszkowska-Nagorna, Adrian Stefanski, Beata Graff, Katarzyna Kunicka, Ewa Swierblewska, Agnieszka Rojek, Anna Szyndler, Jacek Wolf, Marcin Gruchala, Roland E. Schmieder, Krzysztof Narkiewicz
Review
Biochemistry & Molecular Biology
Paulina Dziamalek-Macioszczyk, Joanna M. Harazny, Tomasz Stompor
ACTA BIOCHIMICA POLONICA
(2019)
Article
Peripheral Vascular Disease
Maria Gosk-Przybylek, Adrian Doroszko, Piotr Dobrowolski, Ewa Warchol-Celinska, Joanna Harazny, Ewelina Binczyk, Katarzyna Szymanek, Mariola Peczkowska, Marek Kabat, Sadegh Toutounchi, Zbigniew Galazka, Barbara Gornicka, Jerzy Szaflik, Magdalena Januszewicz, Anna Klisiewicz, Piotr Hoffman, Jacques W. M. Lenders, Graeme Eisenhofer, Jacek P. Szaflik, Roland E. Schmieder, Aleksander Prejbisz, Andrzej Januszewicz
JOURNAL OF HYPERTENSION
(2020)
Article
Peripheral Vascular Disease
Edyta Dabrowska, Joanna M. Harazny, Eliza Miszkowska-Nagorna, Adrian Stefanski, Beata Graff, Katarzyna Kunicka, Ewa Swierblewska, Agnieszka Rojek, Anna Szyndler, Dariusz Gasecki, Jacek Wolf, Marcin Gruchala, Stephane Laurent, Roland E. Schmieder, Krzysztof Narkiewicz
MICROVASCULAR RESEARCH
(2020)
Article
Multidisciplinary Sciences
Susanne Jung, Agnes Bosch, Christian Ott, Dennis Kannenkeril, Thomas Dienemann, Joanna M. Harazny, Georg Michelson, Roland E. Schmieder
SCIENTIFIC REPORTS
(2020)
Review
Peripheral Vascular Disease
Urszula Szulc, Edyta Dabrowska, Janusz Pieczynski, Pawel Bialkowski, Krzysztof Narkiewicz, Roland E. Schmieder, Joanna Harazny
Summary: The assessment and monitoring of microcirculatory changes in arterial hypertension management is crucial, with a shift towards non-invasive methods focusing on the retinal vasculature. Various methods for measuring retinal microcirculation have been reviewed, with Scanning Laser Doppler Flowmetry being the most commonly used in studies of arterial hypertension, followed by Optical Coherence Tomography Angiography and retinal vasculature assessment software.
Article
Cardiac & Cardiovascular Systems
T. Hauser, V. Dornberger, U. Malzahn, S. J. Grebe, D. Liu, S. Stoerk, M. Nauck, N. Friedrich, M. Doerr, C. Wanner, V. Krane, F. Hammer
Summary: Spironolactone treatment did not significantly affect diastolic function parameters in hemodialysis patients, according to the study results.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2021)
Article
Peripheral Vascular Disease
Renata Cifkova, Joanna M. Harazny, Jan Bruthans, Peter Wohlfahrt, Alena Krajcoviechova, Vera Lanska, Julius Gelzinsky, Marketa Materankova, Stepan Mares, Jan Filipovsky, Otto Mayer, Roland E. Schmieder
Summary: This study aimed to establish reference values for major functional and structural parameters of retinal microcirculation in an urban population and found that juxtapapillary retinal capillary blood flow increases with age while vessel and luminal diameters decrease. Results revealed a close relationship between blood pressure and vascular remodeling of retinal arterioles, indicating an interaction between micro- and macro-vasculature.
MICROVASCULAR RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Susanne Jung, Julie Kolwelter, Agnes Bosch, Renata Cifkova, Joanna M. Harazny, Christian Ott, Stephan Achenbach, Roland E. Schmieder
Summary: Analysis of microvascular parameters in patients with congestive heart failure (CHF) revealed hypertrophic remodeling of retinal arterioles, with increased wall thickness, wall cross-sectional area, vessel and lumen diameter compared to age-matched controls. This suggests that microvascular structure and function assessed through scanning laser Doppler flowmetry (SLDF) may be a useful non-invasive method for monitoring microvascular damage in CHF patients and identifying potential new treatment targets for CHF therapies.
Article
Endocrinology & Metabolism
Dennis Kannenkeril, Susanne Jung, Joanna Harazny, Kristina Striepe, Christian Ott, Anke Dahlmann, Christoph Kopp, Mario Schiffer, Peter Linz, Armin M. Nagel, Michael Uder, Roland E. Schmieder
Summary: The study examined the association between tissue sodium content and vascular hypertrophic remodeling in patients with type 2 diabetes, finding significant correlations between sodium content in skin and muscle with vascular structural parameters. The results indicated that tissue sodium content is independently linked to hypertrophic vascular remodeling in type 2 diabetes.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Wojciech Matuszewski, Katarzyna Gontarz-Nowak, Joanna M. Harazny, Elzbieta Bandurska-Stankiewicz
Summary: The study aims to evaluate the morphological parameters of retinal arterioles in patients with type 1 diabetes mellitus (DM1). The results showed significant morphological changes in retinal vessels in DM1 patients without previously diagnosed diabetic retinopathy. These changes may be early indicators of cardiovascular risk.
Article
Peripheral Vascular Disease
Adrian Stefanski, Jacek Wolf, Joanna M. Harazny, Eliza Miszkowska-Nagorna, Bogumil Wolnik, Joanna Murawska, Krzysztof Narkiewicz, Roland E. Schmieder
Summary: Using scanning laser Doppler flowmetry, it was found that retinal capillary flow is increased in newly diagnosed diabetes patients compared to those with a disease duration exceeding 10 years, and gradually decreases with disease duration. Furthermore, structural changes in retinal arterioles are evident when the diabetes duration exceeds 10 years.
MICROVASCULAR RESEARCH
(2023)
Article
Medicine, Research & Experimental
Paulina Dziamalek-Macioszczyk, Joanna M. Harazny, Norbert Kwella, Pawet Wojtacha, Susanne Jung, Thomas Dienemann, Roland E. Schmieder, Tomasz Stompor
MEDICAL SCIENCE MONITOR
(2020)