Article
Multidisciplinary Sciences
Junyan Huo, Gan Zhang, Wenjing Wang, Wen Cao, Mengxia Wan, Tao Huang, Dongsheng Fan, Yu Fu
Summary: In this study, the bidirectional causal relationship between migraine and white matter lesions was explored using a two-sample mendelian randomization method. The analysis of a recent large-scale genome-wide association study data did not provide evidence for causality between white matter lesions and migraine.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Jasmin Annica Keller, Sigurdur Sigurdsson, Kelly Klaassen, Lydiane Hirschler, Mark A. A. van Buchem, Lenore J. J. Launer, Matthias J. P. van Osch, Vilmundur Gudnason, Jeroen H. J. M. de Bresser
Summary: This study aimed to investigate the association between the shape and volume of white matter hyperintensity (WMH) and the long-term risk of dementia in community-dwelling older adults. The results showed that an irregular shape of periventricular/confluent WMH, higher WMH volume, and higher deep WMH volume were associated with an increased risk of dementia.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Antoine Garnier-Crussard, Francois Cotton, Pierre Krolak-Salmon, Gael Chetelat
Summary: White matter hyperintensities (WMH) are vascular lesions frequently seen in older adults, but recent evidence suggests that non-vascular mechanisms, particularly in Alzheimer's disease (AD), may also contribute to WMH. This alternative hypothesis is supported by arguments from neuropathology, neuroimaging, fluid biomarkers, and genetics. The underlying mechanisms of AD-related WMH, such as neurodegeneration or neuroinflammation, are discussed, as well as the implications for AD diagnosis and management. Testing this hypothesis and addressing remaining challenges can improve personalized care for patients.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Ami Tsuchida, Philippe Boutinaud, Violaine Verrecchia, Christophe Tzourio, Stephanie Debette, Marc Joliot
Summary: White matter hyperintensities (WMHs) are markers of cerebral small vessel disease, associated with increased risk of stroke, dementia, and mortality. This study presents an automatic WMH segmentation tool based on deep learning, which can efficiently detect WMH with high accuracy.
HUMAN BRAIN MAPPING
(2023)
Article
Neuroimaging
Mahsa Dadar, Sawsan Mahmoud, Maryna Zhernovaia, Richard Camicioli, Josefina Maranzano, Simon Duchesne
Summary: There are distinct differences in WMH prevalence and distribution across different neurodegenerative disorders, as well as differences between sexes and asymmetry in WMH burden. The study found that women tend to have lower WMH burden compared to men and there are differences in WMH volumes between the left and right brain lobes.
NEUROIMAGE-CLINICAL
(2022)
Article
Cardiac & Cardiovascular Systems
Fatemeh Koohi, Eric L. Harshfield, Hugh S. Markus
Summary: White matter hyperintensities (WMHs) are a major risk factor for stroke and dementia, but their pathogenesis is not fully understood. This study investigated the contribution of conventional cardiovascular risk factors (CVRFs) to WMH volume. The results showed that only 32% of the variance in WMH volume was explained by CVRFs, and a significant portion of the variance remained unexplained. High blood pressure parameters accounted for 10.5% of the total variance.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Neurosciences
Yuki Oi, Masakazu Hirose, Hiroki Togo, Kenji Yoshinaga, Thai Akasaka, Tomohisa Okada, Toshihiko Aso, Ryosuke Takahashi, Matthew F. Glasser, Takuya Hayashi, Takashi Hanakawa
Summary: The study examined the application of surface-based brain MRI analysis technique in the older population and proposed a possible solution to the adverse effects of white matter hyperintensities on estimating cortical surfaces. The findings are important for identifying appropriate cortical surface biomarkers for aging and age-related neuropsychiatric disorders.
Article
Cardiac & Cardiovascular Systems
Adam de Havenon, Nethra R. R. Parasuram, Anna L. L. Crawford, Mercy H. H. Mazurek, Isha R. R. Chavva, Vineetha Yadlapalli, Juan E. E. Iglesias, Matthew S. S. Rosen, Guido J. J. Falcone, Seyedmehdi Payabvash, Gordon Sze, Richa Sharma, Steven J. J. Schiff, Basmah Safdar, Charles Wira, William T. T. Kimberly, Kevin N. N. Sheth
Summary: This study found that portable magnetic resonance imaging (pMRI) could successfully identify white matter hyperintensity (WMH) in the brain and be used in unconventional settings. The results suggest that pMRI may have a potential role in reducing disparities in neuroimaging.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Neurosciences
Xinxin Li, Yu Zhao, Jiyang Jiang, Jian Cheng, Wanlin Zhu, Zhenzhou Wu, Jing Jing, Zhe Zhang, Wei Wen, Perminder S. Sachdev, Yongjun Wang, Tao Liu, Zixiao Li
Summary: The study introduced a pipeline using deep fully convolutional network and ensemble models to automatically segment WMHs and estimate their volumes and locations, achieving the best performance among different methods in both research and clinical datasets. The model showed superior generalization ability when trained on the research dataset compared to the clinical dataset, highlighting its effectiveness in WMHs segmentation tasks.
HUMAN BRAIN MAPPING
(2022)
Article
Psychiatry
Antonio Terracciano, Bertin Cenatus, Xianghe Zhu, Selin Karakose, Yannick Stephan, Sofia Marcolini, Peter P. De Deyn, Martina Luchetti, Angelina R. Sutin
Summary: Neuroticism is associated with white matter hyperintensities, which partly mediate the association between neuroticism and cognitive function. This finding suggests that white matter integrity is a potential neurobiological pathway underlying the relationship between neuroticism and cognitive health.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Neurosciences
Hyun Ju Yang, Subin Lee, Myeong Ju Koh, Ho Kyu Lee, Bong Soo Kim, Ki Woong Kim, Joon Hyuk Park
Summary: The study found that a quarter of patients with very mild to moderate AD suffer from frailty, with the frailty group having significantly higher WMH volume compared to the robust group. Different types of WMH volume (total, juxtaventricular, and periventricular) were associated with frailty, while deep WMH volume was not.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Geriatrics & Gerontology
Shanshan Cao, Jiajia Nie, Jun Zhang, Chen Chen, Xiaojing Wang, Yuanyuan Liu, Yuting Mo, Baogen Du, Yajuan Hu, Yanghua Tian, Qiang Wei, Kai Wang
Summary: Our study found that CSVD patients with WMHs had reduced gray matter volume and functional connectivity in the cerebellum, which were associated with cognitive impairment. This suggests that the cerebellum may have a crucial role in modulating cognitive function in CSVD patients with WMHs.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neuroimaging
Angela C. C. Jochems, Susana Munoz Maniega, Maria del C. Valdes Hernandez, Gayle Barclay, Devasuda Anblagan, Lucia Ballerini, Rozanna Meijboom, Stewart Wiseman, Adele M. Taylor, Janie Corley, Francesca M. Chappell, Ellen V. Backhouse, Michael S. Stringer, David Alexander Dickie, Mark E. Bastin, Ian J. Deary, Simon R. Cox, Joanna M. Wardlaw
Summary: Based on the data from the Lothian Birth Cohort 1936, the study found that there are longitudinal associations between lateral ventricle and white matter hyperintensities (WMH) volumes, which are influenced by factors such as age, blood pressure, total brain volume, and gender. The changes in ventricular and WMH volumes are moderately correlated, but their underlying processes are not fully overlapping.
NEUROIMAGE-CLINICAL
(2022)
Article
Neurosciences
Mahsa Dadar, Olivier Potvin, Richard Camicioli, Simon Duchesne
Summary: The study investigated the impact of white matter hyperintensities (WMHs) on FreeSurfer gray matter (GM) structure volumes, finding higher overlaps of WMHs with GM volumes in several brain structures for participants with higher WMH volumes. Uncorrected caudate volumes increased with age, with no difference between cognitively healthy individuals and probable Alzheimer's disease patients. However, after correcting for WMHs, caudate volumes decreased with age and Alzheimer's disease patients had lower caudate volumes than cognitively healthy individuals. The presence of WMHs can lead to systematic inaccuracies in GM segmentations and change clinical associations, affecting cognitive performance assessments.
HUMAN BRAIN MAPPING
(2021)
Article
Clinical Neurology
Yan Fu, Yan Sun, Zhi-Bo Wang, Dan-Dan Zhang, Lan Tan, Jian-Feng Feng, Wei Cheng, Jin-Tai Yu
Summary: This study used the American Heart Association's Life's Simple 7 (LS7) metric to define cardiovascular and brain health and found that ideal LS7 cardiovascular health factors are associated with both macrostructural and microstructural markers of brain health. The results suggest that better LS7 profiles are linked to better brain health.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Transplantation
Peter Rossing
Summary: The KDIGO guideline on Diabetes Management in Chronic Kidney Disease provides comprehensive care recommendations for patients with diabetes and CKD, focusing on glycemic control and new treatment options.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Transplantation
Luis M. Ruilope, Bertram Pitt, Stefan D. Anker, Peter Rossing, Csaba P. Kovesdy, Roberto Pecoits-Filho, Pablo Pergola, Amer Joseph, Andrea Lage, Nicole Mentenich, Markus F. Scheerer, George L. Bakris
Summary: This analysis suggests that finerenone protects against kidney disease progression and cardiovascular events in patients with T2D and early or late-stage CKD.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Transplantation
Jennifer B. Green, Amy K. Mottl, George Bakris, Hiddo J. L. Heerspink, Johannes F. E. Mann, Janet B. McGill, Masaomi Nangaku, Peter Rossing, Charlie Scott, Alain Gay, Rajiv Agarwal
Summary: This study aims to investigate the efficacy of dual therapy with finerenone and an SGLT2i in reducing chronic kidney disease and type 2 diabetes. The results will provide important insights for improving treatment methods for kidney disease and cardiovascular risks.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Peripheral Vascular Disease
Rajiv Agarwal, Luis M. Ruilope, Gema Ruiz-Hurtado, Hermann Haller, Roland E. Schmieder, Stefan D. Anker, Gerasimos Filippatos, Bertram Pitt, Peter Rossing, Marc Lambelet, Christina Nowack, Peter Kolkhof, Amer Joseph, George L. Bakris
Summary: Finerenone, a selective nonsteroidal mineralocorticoid receptor antagonist, was found to reduce 24-hour, daytime, and nighttime systolic blood pressure in patients with chronic kidney disease and type 2 diabetes.
JOURNAL OF HYPERTENSION
(2023)
Article
Cardiac & Cardiovascular Systems
Gerasimos Filippatos, Stefan D. Anker, Phyllis August, Andrew J. S. Coats, James L. Januzzi, Boris Mankovsky, Peter Rossing, Luis M. Ruilope, Bertram Pitt, Pantelis Sarafidis, John R. Teerlink, Chris J. Kapelios, Martin Gebel, Meike Brinker, Amer Joseph, Andrea Lage, George Bakris, Rajiv Agarwal
Summary: This study investigated the causes of mortality in patients with chronic kidney disease and type 2 diabetes. The findings showed that Finerenone significantly reduced the risk of all-cause and cardiovascular mortality in T2D patients across different stages of CKD, and particularly in preventing cardiovascular-related deaths and sudden cardiac death.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Endocrinology & Metabolism
Viktor Rotbain Curovic, Nete Tofte, Morten Lindhardt, Katarina Adamova, Stephan J. L. Bakker, Joachim Beige, Joline W. J. Beulens, Andreas L. Birkenfeld, Gemma Currie, Christian Delles, Ingo Dimos, Lidmila Francova, Marie Frimodt-Moller, Peter Girman, Ruediger Goeke, Tine W. Hansen, Tereza Havrdova, Adriaan Kooy, Gozewijnw D. Laverman, Harald Mischak, Gerjan Navis, Giel Nijpels, Marina Noutsou, Alberto Ortiz, Aneliya Parvanova, Frederik Persson, John R. Petrie, Piero L. Ruggenenti, Femke Rutters, Ivan Rychlik, Justyna Siwy, Goce Spasovski, Marijn Speeckaert, Matias Trillini, Petra Zuerbig, Heiko von der Leyen, Peter Rossing
Summary: This study examines the relationship between baseline diabetic retinopathy (DR) and the risk of developing microalbuminuria, kidney function decline, and cardiovascular events (CVEs) in type 2 diabetes patients. The results show that the presence of DR is associated with an increased risk of developing microalbuminuria and CVEs, but not kidney function decline.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2023)
Article
Endocrinology & Metabolism
Jens Christian Laursen, Christian Stevns Hansen, Marco Bordino, Marie Frimodt-Moller, Tine Willum Hansen, Luciano Bernardi, Per-Henrik Groop, Peter Rossing
Summary: This study explored the association between baroreflex sensivity and blood oxygen saturation (SpO2) in type 1 diabetes and various degrees of microvascular disease. It was found that higher baroreflex sensitivity was associated with higher SpO2 in type 1 diabetes. Compared with non-diabetic controls, type 1 diabetes patients had lower baroreflex sensitivity and lower SpO2. Therefore, hypoxia could be a therapeutic target in type 1 diabetes.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2023)
Article
Medicine, General & Internal
Marie Moller, Rikke Borg, Iain Bressendorff, Lisbeth N. Fink, Eva Gravesen, Karina Haar Jensen, Torben Hansen, Dorrit Krustrup, Frederik Persson, Peter Rossing, Frederikke E. Sembach, Anne C. B. Thuesen, Ditte Hansen
Summary: Diabetic kidney disease is a severe complication of diabetes, and a kidney biopsy is the only way to accurately diagnose it. This study aims to investigate the prevalence of diabetic kidney disease in individuals with type 2 diabetes and explore potential targets for individualized treatment through in-depth molecular analysis of kidney tissue samples.
Article
Cardiac & Cardiovascular Systems
Glenn M. Chertow, Ricardo Correa-Rotter, Priya Vart, Niels Jongs, John J. V. McMurray, Peter Rossing, Anna Maria Langkilde, C. David Sjostrom, Robert D. Toto, David C. Wheeler, Hiddo J. L. Heerspink
Summary: In the DAPA-CKD trial, dapagliflozin was found to reduce the risk of kidney and cardiovascular events in patients with chronic kidney disease and albuminuria. The treatment effect of dapagliflozin was consistent regardless of baseline cardiovascular medication use.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Endocrinology & Metabolism
Viktor Rotbain Curovic, Morten B. Houlind, Marjolein Y. A. M. Kroonen, Niels Jongs, Emilie H. Zobel, Tine W. Hansen, Juliette Tavenier, Jesper Eugen-Olsen, Gozewijn D. Laverman, Adriaan Kooy, Frederik Persson, Peter Rossing, Hiddo J. L. Heerspink
Summary: The effect of four different drug classes on suPAR levels in people with type 1 and type 2 diabetes was evaluated. The study showed no overall effect of the drugs on suPAR levels, but individualized treatment significantly reduced suPAR levels.
DIABETES OBESITY & METABOLISM
(2023)
Letter
Endocrinology & Metabolism
Jens Christian Laursen, Viktor Rotbain Curovic, Marjolein Y. A. M. Kroonen, Niels Jongs, Emilie H. Zobel, Tine W. Hansen, Marie Frimodt-Moller, Gozewijn D. Laverman, Adriaan Kooy, Frederik Persson, Hiddo J. L. Heerspink, Christian Stevns Hansen, Peter Rossing
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Peter Rossing, Stefan D. D. Anker, Gerasimos Filippatos, Bertram Pitt, Luis M. M. Ruilope, Liana K. K. Billings, Jennifer B. B. Green, Daisuke Koya, Ofri Mosenzon, Kevin M. M. Pantalone, Christiane Ahlers, Andrea Lage, Robert Lawatscheck, Andrea Scalise, George L. L. Bakris
Summary: This study aimed to assess the impact of finerenone on the risk of cardiovascular and kidney outcomes in patients with chronic kidney disease and type 2 diabetes, regardless of obesity. A post hoc analysis of a pooled dataset evaluated the association between waist circumference (WC), composite cardiovascular and kidney outcomes, and the effects of finerenone. The findings revealed that finerenone significantly reduced the risk of cardiovascular and kidney outcomes in the high-risk waist circumference group.
DIABETES OBESITY & METABOLISM
(2023)
Article
Urology & Nephrology
Lesley A. Inker, Hocine Tighiouart, Ogechi M. Adingwupu, Michael G. Shlipak, Alessandro Doria, Michelle M. Estrella, Marc Froissart, Vilmundur Gudnason, Anders Grubb, Roberto Kalil, Michael Mauer, Peter Rossing, Jesse Seegmiller, Josef Coresh, Andrew S. Levey
Summary: New CKD-EPI and EKFC eGFR equations have sufficient accuracy for clinical practice. Differences in performance across subgroups reflect diversity in source populations and use of variables. Using eGFR equations with both cystatin C and creatinine can improve accuracy and uniformity of GFR estimation.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Yeli Wang, Ogechi M. Adingwupu, Michael G. Shlipak, Alessandro Doria, Michelle M. Estrella, Marc Froissart, Vilmundur Gudnason, Anders Grubb, Roberto Kalil, Michael Mauer, Peter Rossing, Jesse Seegmiller, Josef Coresh, Andrew S. Levey, Lesley A. Inker
Summary: This study found that the combination of cystatin C and creatinine provides the most accurate estimates of glomerular filtration rate, especially when eGFRcr and eGFRcys are discordant.
Review
Urology & Nephrology
Tobias Bomholt, Dea Kofod, Kirsten Norgaard, Peter Rossing, Bo Feldt-Rasmussen, Mads Hornum
Summary: CGM provides more detailed measurements of mean sensor glucose, glucose variability, and time in ranges, which can overcome the limitations of HbA1c in dialysis patients. It has the potential to improve glycemic control and detect hypoglycemia. However, the long-term use of CGM in the dialysis population has not been evaluated and practical burden and cost may be a limitation.