Article
Medicine, General & Internal
Aroa Tardaguila-Garcia, Francisco Javier Alvaro-Afonso, Marta Garcia-Madrid, Mateo Lopez-Moral, Irene Sanz-Corbalan, Jose Luis Lazaro-Martinez
Summary: The aim of this study was to compare the healing time in patients with diabetic foot osteomyelitis based on clinical signs of infection, blood parameter variations, radiological signs, and treatment received. A total of 116 patients were included in the study, and the results showed that except for eosinophils with higher values (p = 0.004), there was no significant association between clinical signs of infection, increased blood parameters, radiological signs and healing time.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Endocrinology & Metabolism
Mona Mohamed Ibrahim Abdalla, Jaiprakash Mohanraj, Sushela Devi Somanath
Summary: The global burden of diabetic foot ulcers (DFUs) is a significant public health concern, affecting millions of people worldwide. One promising therapeutic approach is the use of adiponectin, a hormone primarily produced and secreted by adipose tissue, which has demonstrated anti-inflammatory and anti-atherogenic properties and potential therapeutic applications in the treatment of DFUs.
WORLD JOURNAL OF DIABETES
(2023)
Article
Thermodynamics
Kwun Ting Lau, Shahid Ali Khan, Dongxu Ji, Chika Michael Eze, Hui Cheng, Jiyun Zhao
Summary: In this study, a comprehensive model for supercritical Nusselt number correlations was developed through preliminary analysis and empirical modeling. The dataset was validated and the study revealed the correlation with the minimum RMSPE value. This provides valuable insights into the empirical modeling of supercritical Nusselt number correlations.
INTERNATIONAL COMMUNICATIONS IN HEAT AND MASS TRANSFER
(2023)
Article
Dermatology
Juan Lin, Xinxin Mo, Yejun Yang, Chao Tang, Jia Chen
Summary: This meta-analysis found that diabetic subjects with foot ulcer wounds had significantly lower vitamin D levels and higher prevalence of vitamin D deficiency and severe vitamin D deficiency compared with non-ulcerated diabetic subjects.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jaideep Mahendra, Little Mahendra, Dhana Divya, Paavai Ilango, Nalini Devarajan, Abirami Thanigaimalai
Summary: This study evaluates and compares the levels of lipocalin, adiponectin, and periodontal viruses in generalized periodontitis patients with and without diabetes mellitus. The results show that patients with diabetes and periodontitis have higher prevalence of EBV and CMV, as well as decreased levels of adiponectin, indicating an aggravation of the diabetic status among periodontitis patients and reinforcing the Periodontitis-DM continuum.
Article
Surgery
Miska Vuorlaakso, Juha Kiiski, Tapani Salonen, Matti Karppelin, Mika Helminen, Ilkka Kaartinen
Summary: Early wound and ischemia management is crucial for preventing severe consequences in patients with DFI. Older age, low glomerular filtration rate, major amputation, and high C-reactive protein are associated with lower postoperative survival rates.
FRONTIERS IN SURGERY
(2021)
Article
Dermatology
Haiting Chen, Ting Xiao, Ling Zhang, Ning Liu, Xia Liang, Tuodi Li, Jinying Wang, Yaozhong Peng, Yanping Liu, Jiali Xu
Summary: This meta-analysis study examined the effect of ultrasound-supported wound debridement (USSD) in diabetic foot ulcer (DFU) patients. The findings showed that USSD had a greater impact on wound healing compared to standard care and placebo.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Antonino Tuttolomondo, Alessandro Del Cuore, Alessandro La Malfa, Alessandra Casuccio, Mario Daidone, Carlo Domenico Maida, Domenico Di Raimondo, Tiziana Di Chiara, Maria Grazia Puleo, Rosario Norrito, Giovanni Guercio, Antonio Pinto
Summary: Patients with diabetic foot complications have worse cardiovascular risk profiles, higher levels of endothelial dysfunction, and an altered sympathovagal balance compared to patients with diabetes without foot complications. This study aimed to evaluate the sympathovagal balance in patients with diabetic foot and control subjects, and explore the correlation of HRV parameters with inflammatory markers and endothelial dysfunction indices. The results showed differences in HRV indices between patients with diabetic foot and healthy controls, indicating a relationship between parasympathetic dysfunction and vascular complications in diabetic foot patients.
CARDIOVASCULAR DIABETOLOGY
(2021)
Review
Endocrinology & Metabolism
Zulfiqarali G. Abbas, Andrew J. M. Boulton
Summary: The prevalence of diabetes mellitus is increasing globally with the greatest potential increases expected in Africa. The rise in diabetes complications, particularly related to diabetic foot disease, is associated with rapid demographic, sociocultural, and economic transitions. Efforts are needed to address the growing complications of diabetic foot ulcers in Africa through education, prevention programs, and increased recognition of the clinical and public health implications of diabetic foot disease by African governments.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Medicine, General & Internal
Kanwal Ijaz, Muhammad Luqman Ali Bahoo, Sobia Niaz, Hafiz Usman Ahmad
Summary: This study compared the levels of glycated albumin and angiopoietin-2 in type-two diabetics with and without diabetic retinopathy, and found higher levels of glycated albumin and angiopoietin-2 in the diabetic retinopathy group.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Chemistry, Analytical
Jose Torreblanca Gonzalez, Beatriz Gomez-Martin, Ascension Hernandez Encinas, Jesus Martin-Vaquero, Araceli Queiruga-Dios, Alfonso Martinez-Nova
Summary: Diabetic foot syndrome poses risks of ulceration, neuropathy, ischemia, and infection, which can lead to foot amputation if not treated properly. Research has shown a correlation between increased skin temperature and asymmetries between corresponding areas on both feet. Developing a smart device to regulate the temperature of diabetic patients in the preulceration phase may be an effective prevention method.
Article
Rheumatology
V Pulito-Cueto, S. Remuzgo-Martinez, F. Genre, J. Calvo-Alen, E. Aurrecoechea, I Llorente, A. Triguero-Martinez, R. Blanco, J. Llorca, E. Ruiz-Lucea, N. Rivera Garcia, O. Gualillo, R. Lopez-Mejias, S. Castaneda, M. A. Gonzalez-Gay
Summary: This study evaluated the short-term effect of anti-IL-6 receptor tocilizumab on adiponectin levels in rheumatoid arthritis patients, finding no significant impact. Obesity was associated with decreased adiponectin levels, while adiponectin levels were negatively correlated with various metabolic factors and positively correlated with HDL-cholesterol levels.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)
Article
Medicine, General & Internal
Matevz Kastrin, Vilma Urbancic Rovan, Igor Frangez
Summary: Bioactive Glass S53P4 shows promising outcomes in ulcer surgery, suitable for treating osteomyelitis, and serves as a safe bone substitute biomaterial.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Infectious Diseases
Yasmeen Abouelhassan, Andrew J. Fratoni, Ashley K. Shepard, David P. Nicolau, Tomefa E. Asempa
Summary: This study assessed the pharmacokinetics of tebipenem in healthy subjects and patients with diabetic foot infection, and found that tebipenem demonstrated excellent distribution into skin and soft tissue.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Ronald W. Kartika, Idrus Alwi, Franciscus D. Suyatna, Em Yunir, Sarwono Waspadji, Suzzana Immanuel, Todung Silalahi, Saleha Sungkar, Jusuf Rachmat, Mirta Hediyati Reksodiputro, Saptawati Bardosono
Summary: This study demonstrated the superior role of combined A-PRF and thorn HA as an adjunctive therapy in treating DFUs by promoting angiogenesis and reducing inflammation pathways. Using A-PRF and thorn HA accelerates wound healing process and increases granulation tissue compared to using A-PRF alone.
Review
Biochemistry & Molecular Biology
Renata Riolo, Riccardo De Rosa, Irene Simonetta, Antonino Tuttolomondo
Summary: Human nutrition is a new science based on biochemistry and the effects of food constituents. Ancient medicine believed in the medicinal properties of food, with Hippocrates stating that a balanced diet could help maintain health. Understanding molecular nutrition and the interaction between nutrients and DNA can lead to the formulation of diets where food acts as both food and medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Mariano Catello Di Donna, Giuseppe Cucinella, Giulia Zaccaria, Giuseppe Lo Re, Agata Crapanzano, Sergio Salerno, Vincenzo Giallombardo, Giulio Sozzi, Anna Fagotti, Giovanni Scambia, Antonio Simone Lagana, Vito Chiantera
Summary: Complete cytoreductive surgery is crucial for women with advanced ovarian cancer, and laparoscopic score assessment provides high accuracy in predicting optimal cytoreduction. Radiologic and laparotomic scoring assessments showed lower accuracy in predicting complete cytoreduction. Integrating laparoscopic evaluation as part of the treatment decision-making process is necessary for accurately selecting treatment strategies in advanced ovarian cancer patients.
Review
Biology
Muhammad Ali, Viviana Benfante, Alessandro Stefano, Anthony Yezzi, Domenico Di Raimondo, Antonino Tuttolomondo, Albert Comelli
Summary: Polyphenols, which are natural organic substances found in fruits, vegetables, and spices, have gained attention due to their effectiveness in preventing and managing various diseases, including cancer and rheumatoid arthritis (RA). They interact with receptors and membranes, modulate signal cascades, and interact with enzymes related to CD and RA. These actions provide evidence for their use in pharmaceutical treatments. This review focuses on the pathways modulated by polyphenols in CD and RA and emphasizes their antioxidant properties.
Article
Medicine, Legal
Ilaria Viola, Maria Chiara Terranova, Giuseppe Lo Re, Giovanni De Lisi, Gregorio Serra, Emiliano Maresi, Sergio Salerno
Summary: The case report highlights the utility of post-mortem computed tomography (PMCT) in detecting signs of live birth in a deceased baby, comparing the findings with standard autopsies and histological examinations. The report describes a case of a newborn who was thrown out of a fifth-floor window onto a footpath, while the mother hid immediately after giving birth. PMCT revealed aerated lung parenchyma, severe lung distress, air in the airways without any fluid, and air in the upper gastrointestinal tract, indicating no resuscitation measures were performed on the baby at delivery. Multiple skull fractures and degeneration of cerebral parenchyma were also detected. All these findings were confirmed by conventional autopsies, histological, and immunohistochemical examinations, highlighting the usefulness of PMCT in distinguishing live births from stillbirths.
FORENSIC SCIENCE INTERNATIONAL
(2023)
Editorial Material
Biochemistry & Molecular Biology
Antonino Tuttolomondo
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Biochemistry & Molecular Biology
Antonino Tuttolomondo, Irene Simonetta
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Vittoriano Della Corte, Gaetano Pacinella, Federica Todaro, Rosaria Pecoraro, Antonino Tuttolomondo
Summary: Natriuretic peptides are a complex molecular network with pleiotropic effects on various organs and tissues, primarily maintaining cardiovascular homeostasis and regulating water-salt balance. Increasing knowledge of their receptors, molecular mechanisms, and discovery of new peptides has led to a better understanding of their physiological and pathophysiological roles, with potential therapeutic applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Francesca Giudice, Sergio Salerno, Giuseppe Badalamenti, Gianluca Muto, Antonio Pinto, Massimo Galia, Francesco Prinzi, Salvatore Vitabile, Giuseppe Lo Re
Summary: Gastrointestinal stromal tumors (GISTs) are common intestinal tumors that arise from the interstitial cells of Cajal in the gastrointestinal tract. Usually asymptomatic, especially small tumors may be incidentally found on abdominal CT scans. The discovery of receptor tyrosine kinase inhibitors has changed the outcome of patients with high-risk GISTs.
SEMINARS IN ULTRASOUND CT AND MRI
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Giuseppe Lo Re, Giuseppe Cucinella, Giulia Zaccaria, Agata Crapanzano, Sergio Salerno, Antonio Pinto, Antonio Lo Casto, Vito Chiantera
Summary: Cervical cancer is the fourth most common cancer in women, divided into squamous cell carcinoma and adenocarcinoma. Disease extent and metastases determine prognosis. Accurate tumor staging is crucial for treatment planning. The FIGO and TNM classifications are commonly used for patient classification and treatment guidance. MRI plays a crucial role in classifying patients and is important for diagnosis and treatment planning.
SEMINARS IN ULTRASOUND CT AND MRI
(2023)
Review
Chemistry, Multidisciplinary
Giuseppe Miceli, Giuliana Rizzo, Maria Grazia Basso, Elena Cocciola, Andrea Roberta Pennacchio, Chiara Pintus, Antonino Tuttolomondo
Summary: Identifying atherosclerotic disease is crucial for diagnosing the large artery atherosclerosis ischemic stroke subtype and selecting the right therapeutic strategy. Classification of plaque and estimation of cardiovascular risk are essential for preventing future cerebral ischemic events. Non-invasive imaging studies such as CT angiography, MRI, and ultrasound are commonly used to detect arterial plaque. Artificial intelligence (AI) can provide solutions for tissue characterization and classification of carotid artery plaque through analyzing complex data and using automated algorithms.
APPLIED SCIENCES-BASEL
(2023)
Review
Biochemistry & Molecular Biology
Giuseppe Miceli, Maria Grazia Basso, Giuliana Rizzo, Chiara Pintus, Elena Cocciola, Andrea Roberta Pennacchio, Antonino Tuttolomondo
Summary: The correct recognition of ischemic stroke etiology is crucial for effective treatment and prevention of recurrence. However, identifying the cause is often challenging, relying on clinical features and diagnostic exams. AI models can enhance sensitivity in identifying main causes of ischemic stroke, such as carotid stenosis, atrial fibrillation, and small vessel disease. This review aims to provide overall knowledge on the most effective AI models in the differential diagnosis of ischemic stroke according to the TOAST classification. Our results show that AI is a useful tool for subtyping acute stroke patients and clarifying the etiology of undetermined ischemic stroke, particularly identifying cardioembolic sources.
Article
Health Care Sciences & Services
Giuseppe Davide Albano, Giovanni Scalzo, Ginevra Malta, Maria Puntarello, Alberto Alongi, Donatella Piscionieri, Giuseppe Francesco Lo Re, Sergio Salerno, Stefania Zerbo, Antonina Argo
Summary: The investigation of bone injuries is crucial in forensic medicine, especially when dealing with charred or dismembered human remains. This study presents the analysis of two cases of different bone injuries and the techniques used to differentiate relevant pathology findings. PMCT was effective in distinguishing thermal bone lesions from traumatic lesions, while the stereomicroscope provided better characterization and evaluation of shear injuries. Rapid techniques such as PMCT and stereomicroscopy are valuable for investigating bone injuries in forensic cases.
Review
Biochemistry & Molecular Biology
Vittoriano Della Corte, Federica Todaro, Marco Cataldi, Antonino Tuttolomondo
Summary: This review article analyzes serum biomarkers associated with atherosclerosis and explores the potential utility of incorporating them in clinical decision-making.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Antonio Lo Casto, Giacomo Spartivento, Viviana Benfante, Riccardo Di Raimondo, Muhammad Ali, Domenico Di Raimondo, Antonino Tuttolomondo, Alessandro Stefano, Anthony Yezzi, Albert Comelli
Summary: The purpose of this investigation was to evaluate the diagnostic performance of two convolutional neural networks (CNNs) in analyzing the relationship between the lower third molar (MM3) and the mandibular canal (MC) in panoramic images, and to compare it with that of an inexperienced observer. The CNN algorithms achieved higher diagnostic accuracy, sensitivity, specificity, and positive predictive value (PPV) compared to the inexperienced observer. This study demonstrated the potential use of deep CNN architecture in identifying and evaluating the contact between MM3 and MC in panoramic pictures.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sabrina Maria Milo, Patrizia Toia, Federico Midiri, Luigi D'Alessandro, Giulia Sollami, Aldo Panci, Vincenzo Pernice, Francesco Violante, Khalil Fattouch, Giuseppe Cutaia, Giuseppe Salvaggio, Giuseppe Lo Re, Emanuele Grassedonio, Massimo Galia, Ludovico La Grutta
Summary: The aim of this study was to evaluate the prevalence of early complications after TAVI and their correlation with the Calcium Score (CS) of the aortic valve, aorta, and ilio-femoral arteries derived from pre-procedural CT. A retrospective review was conducted on 226 patients undergoing CT for pre-TAVI evaluation. The results showed that aortic valve and vascular CS could help predict post-TAVI early complications.
