Article
Biochemical Research Methods
Zerin Alimajstorovic, Susan P. Mollan, Olivia Grech, James L. Mitchell, Andreas Yiangou, Mark Thaller, Hannah Lyons, Matilde Sassani, Senali Seneviratne, Thomas Hancox, Andris Jankevics, Lukas Najdekr, Warwick Dunn, Alexandra J. Sinclair
Summary: This study utilized metabolomic analysis to compare the cerebrospinal fluid and serum of patients with idiopathic intracranial hypertension (IIH) with control subjects. The results revealed differential metabolic pathways in IIH patients, which normalized after treatment. These pathways were associated with clinical measures and provide initial insights into the pathogenesis of IIH.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Health Care Sciences & Services
Rosa R. L. C. Thielmann, Ciska Hoving, Jochen W. L. Cals, Rik Crutzen
Summary: This study aimed to investigate the effects of online access to medical records on patient empowerment, informed decision-making, and the patient-provider relationship. The results showed that users were more likely than nonusers to believe that online access to medical records would increase their participation in healthcare, improve their relationship with their general practitioner, and facilitate informed decision-making. Overall, online access to medical records has the potential to empower patients and enhance informed decision-making, but the effects are small.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Medicine, Research & Experimental
Qingqing Hou, Shiming Zhang, Yuan Li, Huanjun Wang, Dan Zhang, Dongmei Qi, Yunlun Li, Haiqiang Jiang
Summary: This study aimed to investigate the association of lipid metabolites, circadian genes, and lipid metabolism associated genes in spontaneously hypertensive rats. Through lipidomics and gene expression analysis, it was found that SHR exhibited significant differences in lipid metabolites levels compared to WKY, as well as disturbances in circadian and lipid metabolism associated gene expressions. Moreover, a strong association between the levels of lipid metabolites and circadian genes and lipid metabolism associated genes was identified.
Article
Multidisciplinary Sciences
Brandon Theodorou, Cao Xiao, Jimeng Sun
Summary: The paper proposes HALO, a Hierarchical Autoregressive Language Model, for generating high-fidelity longitudinal electronic health records (EHR) data. HALO maintains statistical properties and enables machine learning modeling without privacy concerns.
NATURE COMMUNICATIONS
(2023)
Article
Computer Science, Interdisciplinary Applications
Alan D. Kaplan, Uttara Tipnis, Jean C. Beckham, Nathan A. Kimbrel, David W. Oslin, Benjamin H. McMahon, M. V. P. Suicide Exemplar Workgroup MVP Suicide Exemplar Workgroup
Summary: In this study, an unsupervised probabilistic model is proposed to address the heterogeneity and irregular sampling of longitudinal Electronic Health Record (EHR) data. It captures the nonlinear relationships between variables and can be used to evaluate the likelihood of risk for depression based on data from the United States Veterans Health Administration.
JOURNAL OF BIOMEDICAL INFORMATICS
(2022)
Article
Computer Science, Information Systems
Amanda B. Zheutlin, Luciana Vieira, Ryan A. Shewcraft, Shilong Li, Zichen Wang, Emilio Schadt, Susan Gross, Siobhan M. Dolan, Joanne Stone, Eric Schadt, Li Li
Summary: This study developed a novel approach for predicting postpartum hemorrhage and identified clinical feature thresholds that can guide intrapartum monitoring for PPH risk. The results suggest that the model has the potential to reduce PPH morbidity and mortality through early detection and prevention.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2021)
Article
Medicine, General & Internal
Mark M. Mitsnefes, Mitchell Maltenfort, Michelle R. Denburg, Joseph T. Flynn, Julia Schuchard, Bradley P. Dixon, Hiren P. Patel, Donna Claes, Kimberley Dickinson, Yong Chen, Caroline Gluck, Mary Leonard, Priya S. Verghese, Christopher B. Forrest
Summary: This study examined the feasibility of using real-world office blood pressure data obtained from electronic health records to generate age-, sex- and height-specific blood pressure percentiles for children. The results showed that the blood pressure percentiles generated from the real-world data were consistent with the current clinical practice guidelines. This suggests that real-world electronic health records data can be used for blood pressure management in children.
Article
Computer Science, Information Systems
Alison Callahan, Vladimir Polony, Jose D. Posada, Juan M. Banda, Saurabh Gombar, Nigam H. Shah
Summary: The study introduces a paradigm for scalable time-aware clinical data search and presents a search engine called ACE that uses a temporal query language. ACE allows users to perform complex temporal searches across various clinical data types quickly and efficiently.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2021)
Article
Chemistry, Medicinal
Xialin Zhu, Qingqing Hou, Ling Zhang, Danyang Wang, Zhenhua Tian, Yuecheng Liu, Yu Wang, Yunlun Li, Haiqiang Jiang
Summary: Hypertension is a progressive metabolic disease characterized by circadian regulation of lipid metabolism disorder. This study found that isorhynchophylline (IRP) can improve lipid metabolism rhythm disorder by regulating specific genes, providing a potential treatment strategy for hypertension.
PHYTOTHERAPY RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
John F. Kingrey, Christine Y. Zhou, Bhavinkumar Dalal, Jean M. Elwing
Summary: A survey was conducted among pulmonary hypertension (PH) providers to evaluate the type and frequency of patient assessment methods employed following PAH diagnosis. The results showed that current clinical practice patterns in the monitoring of PAH patients are variable and do not necessarily align with guideline-based practices, indicating the need for further research and improved guidelines.
Article
Health Care Sciences & Services
Dawn Heisey-Grove, Cheryl Rathert, Laura E. McClelland, Kevin Jackson, Jonathan P. DeShazo
Summary: The study explores how patient and staff characteristics influence the content of secure messages. They found that factors such as age, gender, race, and staff profession impact the type of messages exchanged. Understanding these differences can help in addressing disparities in healthcare outcomes.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Chemistry, Medicinal
Parisa Shoaei-Hagh, Farzaneh Kamelan Kafi, Sara Najafi, Mansoureh Zamanzadeh, Alireza Heidari Bakavoli, Javad Ramezani, Samira Soltanian, Javad Asili, Hossein Hosseinzadeh, Saeid Eslami, Zhila Taherzadeh
Summary: The study evaluated the efficacy, safety, and utility of Nigella sativa seeds oil as a complementary treatment for hypertension, glucose control, and lipid metabolism. Results showed that the use of N. sativa seeds oil as an adjunct to common medications exhibited significant antihypertensive effects and beneficial effects on glucose control and lipid metabolism in hypertensive patients.
PHYTOTHERAPY RESEARCH
(2021)
Article
Endocrinology & Metabolism
Raziel Rojas-Rodriguez, Lori Lyn Price, Jessica Somogie, Sylvie Hauguel-deMouzon, Satish C. Kalhan, Patrick M. Catalano
Summary: Maternal lipid metabolism during pregnancy, especially in late pregnancy, is highly correlated with neonatal adiposity. Late pregnancy basal and clamp glycerol turnover (GLYTO) are significantly associated with neonatal adiposity and explain around 40% of the variation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
James Baligeh Walter Russell, Theresa Ruba Koroma, Santigie Sesay, Sallieu Kabay Samura, Sulaiman Lakoh, Ansumana Bockarie, Onome Thomas Abir, Joseph Sam Kanu, Joshua Coker, Abdul Jalloh, Victor Conteh, Sorie Conteh, Mohamed Smith, Othman Z. Mahdi, Durodami R. Lisk
Summary: This study aimed to investigate the prevalence of cardiometabolic risk factors (CMRFs), target organ damage (TOD) and its associated factors among adults in Freetown, Sierra Leone. The study found high prevalence of CMRFs such as hypertension, diabetes mellitus, dyslipidemia, obesity, smoking, and alcohol consumption, as well as target organ damage including left ventricular hypertrophy (LVH) and chronic kidney disease (CKD). The findings highlight the need for interventions to improve cardiometabolic health screening and management in Sierra Leonean population.
Article
Medicine, General & Internal
Heming Wu, Zhikang Yu, Qingyan Huang
Summary: This study investigated the serum lipid profiles of Hakka patients with hypertension in southern China. The results showed variations in dyslipidaemia among different age and sex groups, with a higher prevalence in non-elderly patients and higher levels of TG, TC, and LDL-C in female patients.
Article
Pharmacology & Pharmacy
Keiko Yamazaki, Yasuo Takahashi, Kotoe Teduka, Tomohiro Nakayama, Yayoi Nishida, Satoshi Asai
BMC PHARMACOLOGY & TOXICOLOGY
(2019)
Article
Pharmacology & Pharmacy
Michiko Ishii, Yukimoto Ishii, Tomohiro Nakayama, Yasuo Takahashi, Satoshi Asai
DRUG METABOLISM AND PHARMACOKINETICS
(2020)
Article
Pharmacology & Pharmacy
Yayoi Nishida, Yasuo Takahashi, Kotoe Tezuka, Hayato Akimoto, Tomohiro Nakayama, Satoshi Asai
BMC PHARMACOLOGY & TOXICOLOGY
(2020)
Article
Genetics & Heredity
Kazuyoshi Ishigaki, Masato Akiyama, Masahiro Kanai, Atsushi Takahashi, Eiryo Kawakami, Hiroki Sugishita, Saori Sakaue, Nana Matoba, Siew-Kee Low, Yukinori Okada, Chikashi Terao, Tiffany Amariuta, Steven Gazal, Yuta Kochi, Momoko Horikoshi, Ken Suzuki, Kaoru Ito, Satoshi Koyama, Kouichi Ozaki, Shumpei Niida, Yasushi Sakata, Yasuhiko Sakata, Takashi Kohno, Kouya Shiraishi, Yukihide Momozawa, Makoto Hirata, Koichi Matsuda, Masashi Ikeda, Nakao Iwata, Shiro Ikegawa, Ikuyo Kou, Toshihiro Tanaka, Hidewaki Nakagawa, Akari Suzuki, Tomomitsu Hirota, Mayumi Tamari, Kazuaki Chayama, Daiki Miki, Masaki Mori, Satoshi Nagayama, Yataro Daigo, Yoshio Miki, Toyomasa Katagiri, Osamu Ogawa, Wataru Obara, Hidemi Ito, Teruhiko Yoshida, Issei Imoto, Takashi Takahashi, Chizu Tanikawa, Takao Suzuki, Nobuaki Sinozaki, Shiro Minami, Hiroki Yamaguchi, Satoshi Asai, Yasuo Takahashi, Ken Yamaji, Kazuhisa Takahashi, Tomoaki Fujioka, Ryo Takata, Hideki Yanai, Akihide Masumoto, Yukihiro Koretsune, Hiromu Kutsumi, Masahiko Higashiyama, Shigeo Murayama, Naoko Minegishi, Kichiya Suzuki, Kozo Tanno, Atsushi Shimizu, Taiki Yamaji, Motoki Iwasaki, Norie Sawada, Hirokazu Uemura, Keitaro Tanaka, Mariko Naito, Makoto Sasaki, Kenji Wakai, Shoichiro Tsugane, Masayuki Yamamoto, Kazuhiko Yamamoto, Yoshinori Murakami, Yusuke Nakamura, Soumya Raychaudhuri, Johji Inazawa, Toshimasa Yamauchi, Takashi Kadowaki, Michiaki Kubo, Yoichiro Kamatani
Article
Medicine, General & Internal
Satoshi Takeuchi, Yasuo Takahashi, Satoshi Asai
Article
Pharmacology & Pharmacy
Hayato Akimoto, Yasuo Takahashi, Satoshi Asai
Summary: The study found that fenofibrate and bezafibrate did not have a significant association with the risk of diabetic retinopathy in patients with type 2 diabetes and dyslipidemia. However, poor control of HbA1c levels and high LDL-C levels increased the risk of DR. Controlling LDL-C levels and HbA1c levels is more important in preventing DR in patients with type 2 diabetes and dyslipidemia than the selection of fibrates.
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
(2021)
Article
Pharmacology & Pharmacy
Hayato Akimoto, Takuya Nagashima, Kimino Minagawa, Takashi Hayakawa, Yasuo Takahashi, Satoshi Asai
Summary: This study identified associations between broad-spectrum antibiotics and other drugs with an increased risk of DILI, as well as new potential signals of drugs causing hepatotoxicity such as mosapride and L-carbocisteine. These findings highlight the importance of further causality assessment for potential hepatotoxic drugs.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2021)
Article
Genetics & Heredity
Saori Sakaue, Masahiro Kanai, Yosuke Tanigawa, Juha Karjalainen, Mitja Kurki, Seizo Koshiba, Akira Narita, Takahiro Konuma, Kenichi Yamamoto, Masato Akiyama, Kazuyoshi Ishigaki, Akari Suzuki, Ken Suzuki, Wataru Obara, Ken Yamaji, Kazuhisa Takahashi, Satoshi Asai, Yasuo Takahashi, Takao Suzuki, Nobuaki Shinozaki, Hiroki Yamaguchi, Shiro Minami, Shigeo Murayama, Kozo Yoshimori, Satoshi Nagayama, Daisuke Obata, Masahiko Higashiyama, Akihide Masumoto, Yukihiro Koretsune, Kaoru Ito, Chikashi Terao, Toshimasa Yamauchi, Issei Komuro, Takashi Kadowaki, Gen Tamiya, Masayuki Yamamoto, Yusuke Nakamura, Michiaki Kubo, Yoshinori Murakami, Kazuhiko Yamamoto, Yoichiro Kamatani, Aarno Palotie, Manuel A. Rivas, Mark J. Daly, Koichi Matsuda, Yukinori Okada
Summary: The study conducted deep-phenotype genome-wide association studies in BioBank Japan, identifying approximately 5,000 new loci and improving the resolution of the genomic map of human traits. By decomposing matrices of phenome-wide summary statistics, responsible variants and biological mechanisms underlying current disease classifications across populations were pinpointed.
Article
Multidisciplinary Sciences
Yasuo Takahashi, Keiko Yamazaki, Yoichiro Kamatani, Michiaki Kubo, Koichi Matsuda, Satoshi Asai
Summary: This study identified a novel genetic locus associated with resistant hypertension in the Japanese population, as well as several loci with suggestive associations. The findings also highlighted biological processes related to resistant hypertension, emphasizing the importance of the nervous system in this condition.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Takuya Nagashima, Takashi Hayakawa, Hayato Akimoto, Kimino Minagawa, Yasuo Takahashi, Satoshi Asai
Summary: By conducting a triangulation study, we found that mirtazapine, fluvoxamine, and milnacipran are less likely to cause hyponatremia compared to other antidepressants.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Pharmacology & Pharmacy
Hayato Akimoto, Takuya Nagashima, Kimino Minagawa, Takashi Hayakawa, Yasuo Takahashi, Satoshi Asai
Summary: This study used machine-learning algorithms to investigate the synergistic interaction between two drugs on the risk of abnormal elevation of serum ALT in Japanese adult patients. The combination of diclofenac and famotidine appeared to increase the risk of abnormal elevation of serum ALT in the real world.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Keiko Yamazaki, Chikashi Terao, Atsushi Takahashi, Yoichiro Kamatani, Koichi Matsuda, Satoshi Asai, Yasuo Takahashi
Summary: Resistant hypertension refers to uncontrolled blood pressure despite the use of multiple antihypertensive drugs. The pathogenesis of resistant hypertension is still unclear, although genetic factors may play a significant role.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Rheumatology
Noboru Kitamura, Hitomi Kobayashi, Yosuke Nagasawa, Kaita Sugiyama, Hiroshi Tsuzuki, Yutaka Tanikawa, Natsumi Ikumi, Yuito Okada, Yasuo Takahashi, Satoshi Asai, Naoto Tamura, Michihiro Ogasawara, Toshio Kawamoto, Ryohei Kuwatsuru, Hiromichi Tamaki, Genki Kidoguchi, Mutsuto Tateishi, Makiko Kimura, Yuichi Mochida, Kengo Harigane, Takayuki Shimazaki, Takao Koike, Kazuhide Tanimura, Hiroshi Kataoka, Koichi Amano, Hidekata Yasuoka, Masami Takei
Summary: This study aimed to identify risk factors for relapse after MTX dose reduction in RA patients receiving GLM/MTX combination therapy. The results showed that patients with a history of cardiovascular disease, gastrointestinal disease, liver disease, or prior NSAIDs-use had a higher risk of relapse after MTX reduction.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Health Care Sciences & Services
Takashi Hayakawa, Takuya Nagashima, Hayato Akimoto, Kimino Minagawa, Yasuo Takahashi, Satoshi Asai
Summary: This study aimed to investigate the nonlinear relationship between the administration period and cumulative dose of benzodiazepines, the duration of related disorders, and the risk of incident dementia. The hazard model was extended using multiple-kernel learning, and various statistical techniques were applied to analyze the data extracted from electronic medical records. The results showed significant nonlinear risk variations over 2-4 years due to the duration of insomnia and anxiety disorders, as well as the administration period of short-acting benzodiazepines. After adjusting for confounding factors, there were no significant risk associations with long-term use of benzodiazepines.
Article
Pharmacology & Pharmacy
Hayato Akimoto, Kotoe Tezuka, Yayoi Nishida, Tomohiro Nakayama, Yasuo Takahashi, Satoshi Asai
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2019)