Article
Anesthesiology
Lisa Q. Rong, Antonino Di Franco, Mohammed Rahouma, Arnaldo Dimagli, Aneri Patel, Alexandra J. Lopes, Maria Walline, June Chan, David Chadow, Roberto Perezgrovas Olaria, Giovanni Soletti Jr, Jiwon Kim, Richard B. Devereux, Kane O. Pryor, Leonard N. Girardi, Jonathan W. Weinsaft, Mario Gaudino
Summary: Intraoperative left ventricular diastolic dysfunction is closely associated with postoperative atrial fibrillation. Patients who develop postoperative atrial fibrillation are more likely to have abnormal left ventricular diastolic function. Baseline abnormal left ventricular diastolic function and pericardiotomy intervention are independently associated with postoperative atrial fibrillation.
Article
Veterinary Sciences
Luis Lobo, Joana Esteves-Guimaraes, Pedro Oliveira, Luis Salazar, Andre Pereira, Ana Patricia Fontes-Sousa
Summary: This study evaluated maternal left ventricular systo-diastolic function in pregnant bitches using conventional and TDI echocardiography. The results show increased cardiac output and heart rate in late gestation, with improved systolic function and decreased diastolic function.
VETERINARY SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Lina Su, Xiaodi Yan, Yongmei Pan, Songna Yang
Summary: This study aimed to investigate the impact of daily physical activity on tissue Doppler indices of left ventricular diastolic function. The results demonstrated that moderate-high-intensity daily physical activity was associated with improved septal e', suggesting that it could potentially ameliorate left ventricular diastolic dysfunction.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Pediatrics
Kevin Le Duc, Thameur Rakza, Jean Benoit Baudelet, Mohamed Riadh Boukhris, Sebastien Mur, Ali Houeijeh, Laurent Storme
Summary: This study aimed to evaluate the application of Tissue Doppler Imaging in assessing right and left cardiac function in newborn infants with pulmonary hypertension. The results showed that newborn infants with pulmonary hypertension have marked right ventricular diastolic dysfunction, while left ventricular function is normal. Therefore, we propose that the severity of respiratory failure is related to the degree of right ventricular diastolic dysfunction.
FRONTIERS IN PEDIATRICS
(2023)
Article
Endocrinology & Metabolism
Dandan Peng, Zhenqiu Yu, Mingwei Wang, Junping Shi, Lei Sun, Yuanyuan Zhang, Wenbin Zhao, Chen Chen, Jiake Tang, Chunyi Wang, Jie Ni, Wen Wen, Jingjie Jiang
Summary: This study reveals that metabolic dysfunction-associated fatty liver disease (MAFLD) is associated with left ventricular diastolic dysfunction (LVDD) and cardiac remodeling, especially in patients with diabetes, overweight/obesity, and moderate-to-severe hepatic steatosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Dogac Oksen, Muzaffer Aslan, Emre Ozmen, Yunus Emre Yavuz
Summary: This study showed that ranolazine had positive effects on left ventricular diastolic functions and repolarization parameters in patients with coronary slow flow.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Paolo Formenti, Silvia Coppola, Laura Massironi, Giacomo Annibali, Francesco Mazza, Lisa Gilardi, Tommaso Pozzi, Davide Chiumello
Summary: This study aimed to evaluate the presence of diastolic dysfunction in mechanically ventilated ARDS patients and found those with diastolic dysfunction had higher lung edema and worse outcomes, but the impact on oxygenation and respiratory mechanics was not significant.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Walid Nachar, Nolwenn Merlet, Foued Maafi, Teodora Mihalache-Avram, Melanie Mecteau, Danielle Gelinas, Yanfen Shi, Mathieu Brodeur, Sonia Alem, Lucie Blondeau, Marieve Cossette, Marie-Claude Guertin, David Rhainds, David Busseuil, Eric Rheaume, Jean-Claude Tardif
Summary: Through different experimental models, the study showed that the therapeutic effect of ApoA-I mimetic on LVDD without AVS is not significant, indicating that the previously observed improvements in LVDD may be caused by the improvement in AVS.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Hematology
Parul Rai, Victoria I. I. Okhomina, Guolian Kang, Hugo R. R. Martinez, Jane S. S. Hankins, Vijaya Joshi
Summary: Cardiac abnormalities in sickle cell anemia include diastolic dysfunction, which is associated with high morbidity and early mortality. This study evaluated the effects of disease-modifying therapies on diastolic function and found that hydroxyurea and erythrocyte transfusions did not improve diastolic parameters over a 2-year period.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Medicine, General & Internal
Qingsha Hou, Fang Yan, Xudong Dong, Huanling Liu, Jie Wu, Jiao Li, Yunchuan Ding
Summary: This study assessed fetal ventricular diastolic function in GDM using conventional and Dual-gate Doppler methods, finding that fetal right ventricular function is crucial for early detection of diastolic dysfunction. Significant differences in E/e' ratios were observed between the GDM and control groups.
Article
Anesthesiology
Eckhard Mauermann, Stefaan Bouchez, Thierry Bove, Michael Vandenheuvel, Patrick Wouters
Summary: This study confirms that TEE modestly underestimates E-TDI' but not to a clinically relevant extent. While E-TDI' in the DTG is not a promising alternative, the future role for speckle tracking-based early diastolic strain rate is unknown.
ANESTHESIA AND ANALGESIA
(2021)
Article
Endocrinology & Metabolism
Marijana Tadic, Jelena Suzic-Lazic, Vladan Vukomanovic, Cesare Cuspidi, Sanja Ilic, Vera Celic
Summary: This study evaluated cardiorespiratory fitness in type 2 diabetic patients with different levels of left ventricular diastolic dysfunction (LVDD). The findings showed that LVDD significantly impacted functional capacity in diabetic patients, with parameters such as left ventricular hypertrophy and diastolic function being affected.
ACTA DIABETOLOGICA
(2021)
Article
Anesthesiology
Ylva Stenberg, Ylva Rhodin, Anne Lindberg, Roman Aroch, Magnus Hultin, Jakob Wallden, Tomi Myrberg
Summary: The study showed that a simplified approach using tissue Doppler e'-velocities can be used to identify left ventricular diastolic dysfunction pre-operatively, but together with E/e' ratio the severity of dysfunction may be overestimated.
BMC ANESTHESIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Kok Han Chee, Kok Leng Tan, Ibrahim Luqman, Shahrizal Shudim Saiful, Yee Yean Chew, Karuthan Chinna, Alexander Tong Boon Tan
Summary: The study revealed a high prevalence of asymptomatic left ventricular diastolic dysfunction among patients with type 2 diabetes mellitus without prior known cardiovascular disease. Older age, insulin therapy, and Chinese ethnicity were identified as risk factors for left ventricular diastolic dysfunction in this population.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xinli Guo, Chao Gong, Rizhen Song, Ke Wan, Yuchi Han, Yucheng Chen
Summary: The study aimed to validate the diagnostic ability and accuracy of first-pass perfusion cardiac magnetic resonance parameters in assessing left ventricular diastolic dysfunction in patients with left heart disease. Results showed that pulmonary transit time and pulmonary transit beat were identified as independent predictors of diastolic dysfunction in these patients, with pulmonary transit time presenting the best diagnostic performance. These findings suggest that pulmonary transit time could be a non-invasive quantitative surrogate marker for detecting and evaluating diastolic dysfunction in left heart disease patients.
EUROPEAN RADIOLOGY
(2022)
Review
Clinical Neurology
Christos S. Katsouras, Michail I. Papafaklis, Sotirios Giannopoulos, Theodoros Karapanayiotides, Georgios Tsivgoulis, Lampros K. Michalis
Summary: Numerous observational studies have shown a decline in cerebro-/cardiovascular admissions during the early phase of the COVID-19 pandemic, but recent studies suggest that the overall decrease is smaller than initially reported. The main cause of this decline is believed to be collateral damage from the COVID-19 outbreak, including the effects of imposed measures such as social distancing and self-isolation. However, there may also be a smaller true decline in CV events due to a lack of triggers associated with acute syndromes. It is important to prepare healthcare systems for a potential increase in CV hospitalizations in the future.
JOURNAL OF CLINICAL NEUROLOGY
(2023)
Article
Urology & Nephrology
Davide Bolignano, Marta Greco, Pierangela Presta, Anila Duni, Caterina Vita, Ethymios Pappas, Maria Mirabelli, Lampros Lakkas, Katerina K. Naka, Antonio Brunetti, Daniela Patrizia Foti, Michele Andreucci, Giuseppe Coppolino, Evangelia Dounousi
Summary: Chronic HD patients with severe cardiac alterations have a higher risk of death and adverse CV outcomes. Imbalanced expression of certain miRNAs is related to pathological cardiac remodeling and worse CV outcomes. In this study, circulating levels of miRNA 30a-5p, 23a-3p, and 451a were found to be lower in HD patients and correlated with the severity of cardiac dysfunction. These miRNAs may serve as predictors of worse clinical outcomes.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Lampros Lakkas, Katerina K. Naka, Aris Bechlioulis, Anila Duni, Maria Moustakli, Olga Balafa, Ioanna Theodorou, Christos S. Katsouras, Evangelia Dounousi, Lampros K. Michalis
Summary: This study aimed to compare myocardial strain, echocardiographic indices, and coronary flow reserve (CFR) in younger and older CKD patients. The findings showed that younger CKD patients had impaired coronary microcirculation and left ventricular diastolic function, while myocardial strain abnormalities were not observed. These issues worsened with aging in CKD patients. The study suggests that assessing coronary microcirculation and ventricular function may be important in younger CKD patients.
ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES
(2023)
Review
Biochemistry & Molecular Biology
Konstantinos C. Siaravas, Christos S. Katsouras, Chrissa Sioka
Summary: Radiotherapy may be used alone or in combination with chemotherapy for cancer treatment, and it has various mechanisms of radiation-induced cardiac toxicities. This systematic review summarizes the known mechanisms, dosage values, and timeline of cardiovascular toxicities after radiation therapy. The findings can be used for the assessment of cardiovascular risk factors and the development of screening programs for cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Alexia Alexandraki, Elisavet Papageorgiou, Marina Zacharia, Kalliopi Keramida, Andri Papakonstantinou, Carlo M. Cipolla, Dorothea Tsekoura, Katerina Naka, Ketti Mazzocco, Davide Mauri, Manolis Tsiknakis, Georgios C. Manikis, Kostas Marias, Yiola Marcou, Eleni Kakouri, Ifigenia Konstantinou, Maria Daniel, Myria Galazi, Effrosyni Kampouroglou, Domen Ribnikar, Cameron Brown, Georgia Karanasiou, Athos Antoniades, Dimitrios Fotiadis, Gerasimos Filippatos, Anastasia Constantinidou
Summary: Cancer therapy-related cardiac dysfunction (CTRCD) is a pressing medical issue in breast cancer patients receiving specific treatments, and traditional biomarkers lack reliability in predicting CTRCD. Clinical studies are exploring new biomarkers as potential indicators and predictors of CTRCD. This systematic review aims to summarize human studies on traditional and novel biomarkers for early detection and prediction of CTRCD in breast cancer patients undergoing cardiotoxic-cancer therapies.
Article
Biochemistry & Molecular Biology
Anila Duni, Athanasios Kitsos, Aris Bechlioulis, Georgios S. Markopoulos, Lampros Lakkas, Gerasimos Baxevanos, Michail Mitsis, George Vartholomatos, Katerina K. Naka, Evangelia Dounousi
Summary: This study investigated differences in circulating immune cells between type 2 cardiorenal syndrome (CRS-2) patients and CKD patients without cardiovascular disease (CVD). The results showed that CRS-2 patients had higher levels of proinflammatory cells and T regulatory cells, as well as lower levels of lymphocytes and natural killer cells compared to CKD patients. Decreased lymphocytes, T-lymphocytes, and increased proinflammatory cells were associated with mortality. CD4+ T-lymphocytes independently predicted fatal cardiovascular events in the CRS-2 cohort.
Article
Health Care Sciences & Services
Paraskevi Zotou, Aris Bechlioulis, Spyridon Tsiouris, Katerina K. Naka, Xanthi Xourgia, Konstantinos Pappas, Lampros Lakkas, Aidonis Rammos, John Kalef-Ezra, Lampros K. Michalis, Andreas Fotopoulos
Summary: Myocardial perfusion imaging via single-photon emission computed tomography (SPECT MPI) is a well-established method for diagnosing coronary artery disease (CAD). However, the role of SPECT MPI in predicting major cardiovascular events remains uncertain. In this study, the presence of extensive perfusion defects in SPECT MPI was found to be independently associated with mortality at 1 year in high-risk patients with suspected stable CAD.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Savvas Kyriakidis, George Rigas, Vassiliki Kigka, Dimitris Zaridis, Georgia Karanasiou, Panagiota Tsompou, Gianna Karanasiou, Lampros Lakkas, Sotirios Nikopoulos, Katerina K. K. Naka, Lampros K. K. Michalis, Dimitrios I. I. Fotiadis, Antonis I. I. Sakellarios
Summary: Diagnosis of coronary artery disease relies mainly on invasive imaging modalities such as X-ray angiography, intravascular ultrasound (IVUS), and optical coherence tomography (OCT), with computed tomography coronary angiography (CTCA) as a non-invasive alternative. This study presents a novel tool for reconstructing 3D coronary arteries and characterizing plaques using these imaging modalities. Image processing and deep learning algorithms were used to determine lumen and adventitia borders, plaque properties, and strut detection. The tool combines X-ray angiography with IVUS/OCT analysis for hybrid 3D reconstruction, and uses a 3D level set approach for CTCA image processing. The tool was evaluated for efficiency and usability, achieving high agreement with manual annotations and a high System Usability Scale (SUS) score of 0.89, indicating excellent usability.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Vasileios Bouratzis, Christos Katsouras, Lampros Lakkas, Aris Bechlioulis, Lampros K. Michalis
EUROPEAN HEART JOURNAL-CASE REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Christos Ballas, Lampros Lakkas, Olga Kardakari, Athanasios Konstantinidis, Konstantinos Exarchos, Stavroula Tsiara, Konstantinos Kostikas, Katerina K. Naka, Lampros K. Michalis, Christos S. Katsouras
Summary: This study evaluated non-conventional markers of right ventricular dysfunction in patients with acute pulmonary embolism. The results showed that a majority of patients had abnormal right ventricular function, which was associated with clinical and biochemical prognostic indices.
Article
Biology
Matthaios Didagelos, Vlasis Ninios, Charalampos Kakderis, Lampros Lakkas, Antonios Kouparanis, Dimitrios Nikas, Katerina K. Naka, Aidonis Rammos, Thomas Zegkos, Vasileios Kamperidis, Ilias Ninios, Sotirios Evangelou, Dimitrios G. Tsalikakis, Lampros Michalis, Antonios Ziakas
Summary: The study evaluated outcomes at 2 years after TAVI with the Portico valve for patients with severe aortic stenosis. The results showed that TAVI with the Portico valve is an effective and safe solution for high-risk surgical patients with severe aortic stenosis.
Article
Biology
Aidonis Rammos, Aris Bechlioulis, Petros Kalogeras, Chris J. Watson, Pietro Salvo, Tommaso Lomonaco, Olga Kardakari, Evanthia E. Tripoliti, Yorgos Goletsis, Dimitris I. Fotiadis, Christos S. Katsouras, Lampros K. Michalis, Katerina K. Naka
Summary: This study found that saliva NT-proBNP correlates with serum values in patients with acute decompensated HF, but cannot differentiate between HF and other causes of dyspnea.
Article
Biochemistry & Molecular Biology
Anila Duni, Marta Greco, Pierangela Presta, Roberta Arena, Ethymios Pappas, Lampros Lakkas, Katerina K. Naka, Antonio Brunetti, Daniela Patrizia Foti, Michele Andreucci, Giuseppe Coppolino, Evangelia Dounousi, Davide Bolignano
Summary: Patients undergoing chronic hemodialysis (HD) are at high risk of cardiovascular (CV) events, but risk prediction in this population is challenging. Recent research has shown that circulating miRNA 122-5p is related to the onset and progression of CV disease. This study found that HD patients had lower levels of circulating miRNA 122-5p compared to healthy controls. ALT, E/e', and CRP were identified as independent predictors of miRNA 122-5p levels. Additionally, higher baseline levels of circulating miRNA 122-5p predicted a significantly increased risk of composite endpoint occurrence in HD patients.