Article
Biochemistry & Molecular Biology
Tauqeer Hussain Mallhi, Momina Shahid, Kanwal Rehman, Yusra Habib Khan, Abdullah Salah Alanazi, Nasser Hadal Alotaibi, Muhammad Sajid Hamid Akash, Muhammad Hammad Butt
Summary: Myocardial infarction (MI) is a cardiovascular disease caused by coronary artery blockage, leading to cardiac muscle death. The etiology of MI involves environmental, occupational, and genetic factors. Previous studies have shown that different variants of the MTHFR gene are responsible for MI by impacting folate and homocysteine metabolism. This study focuses on investigating the genetic polymorphism of MTHFR C677T (rs1801133) and its association with MI in the presence of diabetes mellitus (DM) as a risk factor. The study found that the T/T homozygous genotype of MTHFR C677T (rs1801133) was significantly associated with MI in patients with DM as a risk factor.
Editorial Material
Medicine, General & Internal
Lynne W. Stevenson, Andrew P. DeFilippis
Summary: The evolution of the fight-or-flight response system is to help humans deal with acute physiological threats, which are now less common than chronic cardiovascular stress. The study shows that pharmacologic inhibition of RAAS improves chronic heart failure and the natriuretic peptide system provides a counterbalance to RAAS. Neprilysin, a key neutral endopeptidase, degrades a variety of peptides including natriuretic peptides and angiotensin II.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Multidisciplinary Sciences
Weronika Wargocka-Matuszewska, Katarzyna Fiedorowicz, Anna Rugowska, Karolina Bednarowicz, Agnieszka Zimna, Lukasz Cheda, Paulina Hamankiewicz, Krzysztof Kilian, Michal Fiedorowicz, Monika Drabik, Natalia Rozwadowska, Zbigniew Rogulski, Maciej Kurpisz
Summary: This study utilized in vivo imaging techniques to monitor the effects of stem cell transplantation in mice with myocardial infarction, showing that transplanted stem cells survived and proliferated over a 5-week period, improving cardiac metabolic and hemodynamic parameters.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Andreas Carlsson, Anna-Lotta Irewall, Anna Graipe, Anders Ulvenstam, Thomas Mooe, Joachim oegren
Summary: This prospective cohort study explores the long-term outcomes after ischemic stroke (IS) and transient ischemic attack (TIA) and identifies factors associated with new events. The study finds that IS patients have a higher risk of major adverse cardiovascular events (MACE) and cardiovascular death compared to TIA patients. Factors such as age, kidney failure, prior IS, prior acute myocardial infarction (AMI), congestive heart failure, and impaired functional status are associated with an increased risk of MACE.
SCIENTIFIC REPORTS
(2023)
Article
Pediatrics
Clemens Kamrath, Joachim Rosenbauer, Alexander J. Eckert, Angeliki Pappa, Felix Reschke, Tilman R. Rohrer, Kirsten Moenkemoeller, Michael Wurm, Kathrin Hake, Klemens Raile, Reinhard W. Holl
Summary: This study aimed to quantify the relative risk of diabetic ketoacidosis in children with newly diagnosed type 1 diabetes in 2020 and examine its association with regional COVID-19 incidence. The findings indicate a significant increase in ketoacidosis frequency compared to expected rates during certain months in 2020, with a positive association between regional COVID-19 incidence and ketoacidosis risk in the first half of the year. However, this association was not observed in the second half of 2020.
Article
Pharmacology & Pharmacy
H. -M Hou, X. -J Qin, H. -Y Zhao
Summary: This study investigated the relationship between homocysteine levels and MTHFR C677T polymorphisms with acute ischemic vascular events and focused on the differential effects of the MTHFR C677T polymorphisms on the burden and location of AMI and ACI. The results showed that homocysteine levels were associated with MTHFR C677T polymorphisms and acute ischemic vascular events, but did not differentially affect the burden and location of AMI and ACI.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Emergency Medicine
Nart Zafer Baytugan, Aziz i nan Celik, Tahir Bezgin, Metin Cagdas
Summary: SGLT-2 inhibitors are oral antidiabetic agents that inhibit renal SGLT-2 receptors and increase urinary glucose excretion. We present a case of severe euglycemic DKA complicated with ST-segment elevation myocardial infarction following SGLT-2 inhibitor therapy. Atypical presentation of ketoacidosis without hyperglycemia can delay diagnosis and may result in catastrophic complications. Quick diagnosis, appropriate assessment, and effective treatment protocols ensure successful resolution of euglycemic DKA.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Samuel Heuts, Can Gollmann-Tepekoeylue, Ellen J. S. Denessen, Jules R. Olsthoorn, Jamie L. R. Romeo, Jos G. Maessen, Arnoud W. J. van't Hof, Otto Bekers, Ola Hammarsten, Leo Poelzl, Johannes Holfeld, Nikolaos Bonaros, Iwan C. C. van der Horst, Sean M. Davidson, Matthias Thielmann, Alma M. A. Mingels
Summary: The use of biomarkers in diagnosing myocardial infarction is well-established, but their value in identifying postoperative myocardial infarction after coronary artery bypass grafting is less understood. The release mechanisms of cardiac biomarkers, such as cTn, after CABG are not fully understood, making interpretation of postoperative increases in cTn concentrations complicated. Future studies are needed to determine the prognostic influence of biomarker release in general and postoperative myocardial infarction in particular.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Liangpeng Li, Wenbin Fu, Xue Gong, Zhi Chen, Luxun Tang, Dezhong Yang, Qiao Liao, Xuewei Xia, Hao Wu, Chao Liu, Miao Tian, Andi Zeng, Lin Zhou, Pedro A. Jose, Ken Chen, Wei Eric Wang, Chunyu Zeng
Summary: The study aims to investigate the role of GRK4 in the pathogenesis and progression of myocardial infarction (MI). Results showed that GRK4 expression was increased in the heart after MI, and overexpression of GRK4 aggravated cardiac infarction and dysfunction while specific gene knockout ameliorated these effects. GRK4 inhibited autophagy and promoted cardiomyocyte apoptosis, effects mediated by HDAC4 phosphorylation and a decrease in beclin-1 expression, leading to greater impairment of cardiac function in MI patients carrying the GRK4 A486V variant.
EUROPEAN HEART JOURNAL
(2021)
Article
Medicine, General & Internal
Yong Hoon Kim, Ae-Young Her, Seung-Woon Rha, Cheol Ung Choi, Byoung Geol Choi, Ji Bak Kim, Soohyung Park, Dong Oh Kang, Ji Young Park, Sang-Ho Park, Myung Ho Jeong
Summary: Using a new-generation drug-eluting stent, the study compared the 2-year clinical outcomes of patients with diabetes mellitus (DM) and non-DM concomitant with a non-ST-segment elevation myocardial infarction (NSTEMI) and an ST-segment elevation myocardial infarction (STEMI) who underwent percutaneous coronary intervention. The results showed higher non-CD rates in patients with DM and higher CD rates in patients without DM in the NSTEMI group.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Li-Ping Zhu, Wei-Lan Yin, Lei Peng, Xiao-Hong Zhou, Peng Zhou, Shu-Xia Xuan, Ying Luo, Chen Chen, Bin Cheng, Jin-Duan Lin, Yan-Mei Liu, Feng-Jun Tan, Wei-Guo Yin
Summary: The study revealed a correlation between the Glu504Lys polymorphism in the ALDH2 gene and myocardial infarction (MI), with the genotype GA/AA being an independent risk factor for MI. Alcohol consumption, high myoglobin levels, and low levels of high-density lipoprotein cholesterol were also significantly associated with a higher incidence of MI.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Cosmin Tirdea, Sorin Hostiuc, Horatiu Moldovan, Alexandru Scafa-Udriste
Summary: Acute myocardial infarction is still a leading cause of death globally. This review aims to compile information on genes associated with AMI and conducted a big data analysis. It identified 28 genes that are closely associated with an increased risk for AMI, including LTA, LGALS2, LDLR, and APOA5.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Dehui Liu, Shangrong Zou, Guangnan Li, Qiyu Zhang, Chunlin Chen, Cuizhi Li, Huafeng Song, Shaoxian Chen, Jiawen Wang, Yueheng Wu, Youbin Liu
Summary: Acute myocardial infarction is a leading cause of death worldwide, and its pathological mechanisms are not fully understood. This study found that UCP2 plays a protective role after myocardial infarction, and its mechanism involves the upstream microRNA-762 and downstream DRP1-dependent mitochondrial fission.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cell Biology
Bridget Simonson, Mark Chaffin, Matthew C. Hill, Ondine Atwa, Yasmine Guedira, Harshit Bhasin, Amelia W. Hall, Sikander Hayat, Simon Baumgart, Kenneth C. Bedi, Kenneth B. Margulies, Carla A. Klattenhoff, Patrick T. Ellinor
Summary: Using single-nucleus RNA sequencing and computational analysis, the cellular and molecular signature of ischemic cardiomyopathy (ICM) was investigated. The study revealed alterations in the cellular composition of the ischemic heart, with decreased cardiomyocytes and increased proportions of lymphatic, angiogenic, and arterial endothelial cells in ICM patients. Furthermore, increased LAMININ signaling from endothelial cells and similarities in transcriptional changes were observed between ICM, hypertrophic, and dilated cardiomyopathies, which may help identify potential drug targets for end-stage heart failure.
Article
Pharmacology & Pharmacy
Yihai Liu, Mingyue Wu, Jiamin Xu, Biao Xu, Lina Kang
Summary: The study demonstrated that the SGLT2 inhibitor empagliflozin could improve cardiac remodeling in early myocardial infarction of non-diabetic mice by reducing cardiomyocyte apoptosis, oxidative stress, and restoring mitochondrial membrane potential. The activation of AMP-activated protein kinase (AMPK) signaling pathway may mediate the cardioprotective role of empagliflozin.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Evelyn M. Templeton, Moritz Lasse, Torsten Kleffmann, Leigh J. Ellmers, Suetonia C. Palmer, Trent Davidson, Nicola J. A. Scott, John W. Pickering, Christopher J. Charles, Zoltan H. Endre, Vicky A. Cameron, A. Mark Richards, Miriam T. Rademaker, Anna P. Pilbrow
Summary: One-quarter of patients with acute decompensated heart failure (ADHF) experience acute kidney injury (AKI), which is associated with increased long-term mortality. Currently, there is a critical need to identify early and real-time markers of AKI in ADHF; however, protein biomarkers with sufficient diagnostic or prognostic performance have not been widely adopted in clinical practice. This study aimed to identify novel protein biomarkers of AKI associated with ADHF by quantifying changes in protein abundance in the kidneys using a sheep model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Gilbert Thomas-Black, Andrada Dumitrascu, Hector Garcia-Moreno, Julie Vallortigara, Julie Greenfield, Barry Hunt, Susan Walther, Mackenzie Wells, David R. Lynch, Hugh Montgomery, Paola Giunti
Summary: This study aimed to understand the motivations and barriers for trial participation among patients with progressive ataxias. The results showed that balance problems and ambulation were the most important symptoms to be addressed. Potential benefits to self and others were common motivations for participation. Concerns about side effects and travel burden were reasons for non-participation. Drug repurposing trials and intrathecal drug administration were found to be popular among participants.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Editorial Material
Physiology
Mike Tipton, Hugh Montgomery
EXPERIMENTAL PHYSIOLOGY
(2022)
Article
Medicine, General & Internal
Siegfried Karl Wagner, Fintan Hughes, Mario Cortina-Borja, Nikolas Pontikos, Robbert Struyven, Xiaoxuan Liu, Hugh Montgomery, Daniel C. Alexander, Eric Topol, Steffen Erhard Petersen, Konstantinos Balaskas, Jack Hindley, Axel Petzold, Jugnoo S. Rahi, Alastair K. Denniston, Pearse A. Keane
Summary: Retinal signatures of systemic disease are being revealed through high-resolution ophthalmic imaging and advanced modelling. However, progress is limited due to the lack of large labelled datasets. This study aims to link longitudinal multimodal retinal imaging with systemic disease data to identify hidden retinal signatures for earlier detection and risk management of life-threatening conditions.
Editorial Material
Medicine, General & Internal
[Anonymous]
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Article
Multidisciplinary Sciences
Mel Ramasawmy, Yi Mu, Donna Clutterbuck, Marija Pantelic, Gregory Y. H. Lip, Christina van der Feltz-cornelis, Dan H. Wootton, Nefyn H. Williams, Hugh Montgomery, Rita Mallinson Cookson, Emily Attree, Mark Gabbay, Melissa A. Heightman, Nisreen A. Alwan, Amitava Banerjee, Paula Lorgelly
Summary: This study aims to understand the healthcare and experiences of individuals with Long Covid and evaluate the inequalities in care. A mixed methods approach will be used to collect qualitative and quantitative data to describe the patients' condition and care costs, as well as explore their experiences during the care process.
Article
Critical Care Medicine
Hugh Montgomery, F. D. Richard Hobbs, Francisco Padilla, Douglas Arbetter, Alison Templeton, Seth Seegobin, Kenneth Kim, Jesus Abraham Simon Campos, Rosalinda H. Arends, Bryan H. Brodek, Dennis Brooks, Pedro Garbes, Julieta Jimenez, Gavin C. K. W. Koh, Kelly W. Padilla, Katie Streicher, Rolando M. Viani, Vijay Alagappan, Menelas N. Pangalos, Mark T. Esser
Summary: This study evaluated the safety and efficacy of tixagevimab-cilgavimab in preventing severe COVID-19 or death in non-hospitalized adults. The results showed that a single dose of tixagevimab-cilgavimab significantly reduced the risk of progression to severe COVID-19 or death, with favorable safety.
LANCET RESPIRATORY MEDICINE
(2022)
Article
Medicine, General & Internal
Ismita Chhetri, Julie E. A. Hunt, Jeewaka R. Mendis, Lui G. Forni, Justin Kirk-Bayley, Ian White, Jonathan Cooper, Karthik Somasundaram, Nikunj Shah, Stephen D. Patterson, Zudin A. Puthucheary, Hugh E. Montgomery, Benedict C. Creagh-Brown
Summary: Muscle wasting is a significant problem in ICU-AW patients, affecting 40% of patients and causing long-term physical disability. The application of repetitive vascular occlusion stimulus (RVOS) has shown potential in limiting muscle atrophy and improving clinical outcomes in ICU patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cell Biology
Zoe Ward, Sebastian Schmeier, John Pearson, Vicky A. Cameron, Chris M. Frampton, Richard W. Troughton, Rob N. Doughty, A. Mark Richards, Anna P. Pilbrow
Summary: We developed a short-read RNA-Seq protocol to detect mRNAs, lncRNAs, and circRNAs in plasma for the discovery of novel markers for coronary artery disease (CAD) and heart failure (HF). We found that circulating levels of multiple coding and non-coding transcripts were altered in association with CAD, including several mitochondrial mRNAs. These findings suggest that circulating levels of these transcripts could potentially be used to identify asymptomatic individuals with established CAD before an acute coronary event.
Article
Infectious Diseases
Ali Heydari, Nick D. Kim, Patrick J. Biggs, Jacqui Horswell, Gerty J. H. P. Gielen, Alma Siggins, Matthew D. Taylor, Collette Bromhead, Barry R. Palmer
Summary: The accumulation of heavy metals in agricultural soil from superphosphate fertilisers can cause soil bacteria to develop resistance to heavy metals and antibiotics. This study investigated the co-selection of heavy metal and antibiotic resistance in uncontaminated soil incubated with cadmium, zinc, and mercury for 6 weeks. The microbial communities exposed to heavy metals were found to differ significantly from the control group across various taxonomic levels.
Review
Medicine, General & Internal
Daniel Watkin, Hugh Montgomery, Ned Gilbert-Kawai
Summary: This article summarizes the 2022 European Society of Cardiology guidelines on cardiovascular assessment and management of patients undergoing non-cardiac surgery, highlighting the importance of physicians' involvement in perioperative care and potential impacts of heart disease on surgical patients' risk of complications.
BRITISH JOURNAL OF HOSPITAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Jaap Mandema, Hugh Montgomery, Louis Dron, Shuai Fu, Estelle Russek-Cohen, Christina Bromley, Samer Mouksassi, Amy Lalonde, Aaron Springford, Larry Tsai, Phil Ambery, Doug Mcnair, Nawab Qizilbash, Stuart Pocock, Nevine Zariffa
Summary: Rapid and robust strategies that include large randomized controlled trials (RCTs) and well-designed observational real-world studies (RWS) are necessary to evaluate the efficacy and effectiveness of pharmacotherapeutic interventions in future pandemics. The results of a study analyzing the data from COVID-19 RCTs and RWS suggest that large RCTs provide more accurate conclusions about the clinical benefits of treatments, while RWS tend to yield more varied results. Therefore, in future pandemics, prioritizing large RCTs, improving the design and data matching of RWS, enhancing reporting standards, and promoting access to patient-level data are crucial for evaluating therapies.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Article
Infectious Diseases
F. D. Richard Hobbs, Hugh Montgomery, Francisco Padilla, Jesus Abraham Simon-Campos, Kenneth Kim, Douglas Arbetter, Kelly W. Padilla, Venkatesh Pilla Reddy, Seth Seegobin, Katie Streicher, Alison Templeton, Rolando M. Viani, Eva Johnsson, Gavin C. K. W. Koh, Mark T. Esser
Summary: This study evaluated the effects of AZD7442 on adult outpatients with COVID-19. It found that AZD7442 reduced the risk of death and hospitalization, and improved symptom severity.
INFECTIOUS DISEASES AND THERAPY
(2023)
Article
Environmental Sciences
Sophie van Hamelsveld, Farideh Jamali-Behnam, Izzie Alderton, Brigitta Kurenbach, Andrew W. Mccabe, Barry R. Palmer, Maria J. Gutierrez-Gines, Louise Weaver, Jacqui Horswell, Louis A. Tremblay, Jack A. Heinemann
Summary: The widespread use of emerging contaminants may worsen antibiotic resistance, as these contaminants have been found to alter bacterial responses to antibiotics and increase the spread of antimicrobial resistance genes. The study investigated the effects of nine emerging contaminants on antibiotic resistance and gene transfer, and found that the observed effects varied at different antibiotic concentrations.
EMERGING CONTAMINANTS
(2023)
Article
Biochemistry & Molecular Biology
Sumeet Manandhar, Amy Scott-Thomas, Michael Harrington, Priyanka Sinha, Anna Pilbrow, Arthur Mark Richards, Vicky Cameron, Madhav Bhatia, Stephen T. Chambers
Summary: This study measured the concentrations of hydrogen sulfide (H2S) and substance P (SP) in the peripheral blood of patients with Escherichia coli or Klebsiella pneumoniae bacteraemia. The study found that the concentrations of H2S and SP varied with the site of infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)