期刊
CARDIOLOGY JOURNAL
卷 20, 期 5, 页码 453-463出版社
VIA MEDICA
DOI: 10.5603/CJ.2013.0130
关键词
arterial baroreceptors; autonomic dysfunction; baroreflex sensitivity; cardiovascular autonomic neuropathy; diabetes mellitus
资金
- Polish Ministry of Higher Education and Science [5808/B/T01/2010/38]
Diabetes mellitus (DM) is a disease of increasing incidence and prevalence. Arterial baroreceptors are stretch-sensitive receptors, which in a reflex manner are involved in the homeostatic control of arterial blood pressure. Diabetic subjects have depressed baroreflex sensitivity (BRS), although the exact pathomechanisms are unclear. In this review, we discuss the features, clinical and prognostic implications of reduced BRS for diabetic patients and the potential involvement of cardiovascular autonomic neuropathy and atherosclerosis. Finally, we demonstrate evidence on interventions (e.g. pioglitazone, alpha-lipoic acid, leptin, fluvastatin, physical training etc.) which could improve BRS and ameliorate cardiovascular autonomic dysfunction in diabetic patients.
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