Article
Biochemistry & Molecular Biology
Paolo Cameli, Elena Pordon, Miriana d'Alessandro, Maria Laura Marzi, Lucrezia Galasso, Cesare Biuzzi, Laura Bergantini, Elena Bargagli, Sabino Scolletta, Federico Franchi
Summary: This study evaluated the performance of serum MR-proADM as a prognostic biomarker in hospitalized COVID-19 patients. It showed that MR-proADM levels were higher in non-survivors and those requiring respiratory support. The combination of MR-proADM, KL-6, and IL-6 improved the accuracy of predicting death or ICU admission.
Article
Clinical Neurology
Ali A. El-Solh, Yolanda Lawson, Parveen Attai
Summary: This study found that the combination of PTSD and insomnia is associated with a higher risk of major adverse cardiovascular events (MACEs) compared to either condition alone.
Article
Psychology, Clinical
David S. Krantz, Lisa M. Shank, Jeffrey L. Goodie
Summary: Evidence indicates that PTSD is a significant risk factor for CVD, and understanding it as a systemic disorder is crucial for reducing cardiovascular risk associated with PTSD. Further research is needed to test the applicability and implications of this perspective.
Article
Neurosciences
Shlomo Sragovich, Michael Gershovits, Jacqueline C. K. Lam, Victor O. K. Li, Illana Gozes
Summary: The study aimed to determine if somatic mutations in brain diseases present in blood samples for potential diagnostics. It found a high number of cytoskeletal-mutated genes when comparing with autism, intellectual disability, cytoskeleton, inflammation, and DNA repair databases. Additionally, more putative high impact mutated genes specific to PTSD-symptom cohorts were identified, highlighting the importance of tumor necrosis factor in these cohorts.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Carina A. Martin, Rany Vorn, Martin Schrieber, Chen Lai, Sijung Yun, Hyung-Suk Kim, Jessica Gill
Summary: The study compared DNA methylation patterns in patients with physical trauma and identified genes related to PTSD and MDD. These epigenetic changes could be used as potential biomarkers for predicting the onset of PTSD or MDD following traumatic events.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Health Care Sciences & Services
Fernando Ramasco Rueda, Antonio Planas Roca, Rosa Mendez Hernandez, Angels Figuerola Tejerina, Eduardo Tamayo Gomez, Carlos Garcia Bernedo, Emilio Maseda Garrido, Natalia F. F. Pascual Gomez, Olga de la Varga-Martinez
Summary: The study aimed to determine the association between preoperative serum levels of MR-ProADM and the need for organic support after abdominal cancer surgery, as well as identify the predictive value of preoperative MR-ProADM. The results showed that elevated preoperative MR-ProADM levels were associated with the need for postoperative organic support, indicating the potential use of MR-ProADM as a biomarker for perioperative risk assessment.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Christiaan H. Vinkers, Elbert Geuze, Sanne J. H. van Rooij, Mitzy Kennis, Remmelt R. Schur, Danny M. Nispeling, Alicia K. Smith, Caroline M. Nievergelt, Monica Uddin, Bart P. F. Rutten, Eric Vermetten, Marco P. Boks
Summary: This study showed that successful treatment of PTSD is associated with significant changes in DNA methylation of certain genes, such as ZFP57. The longitudinal evidence suggests that ZFP57 methylation plays a role in both the development and successful treatment of deployment-related PTSD.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Jimeng Li, Lei Tong, Bettina C. Schock, Li-Li Ji
Summary: Post-traumatic stress disorder (PTSD) is closely related to neuroinflammation, which plays a key role in the pathogenesis of PTSD. Activation of immune cells and changes in inflammatory markers in the brain are involved in neuroinflammation. Understanding the mechanisms of neuroinflammation in PTSD is crucial for studying the disorder.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Biology
Konstantina Skolariki, Aristidis G. Vrahatis, Marios G. Krokidis, Themis P. Exarchos, Panagiotis Vlamos
Summary: Post-traumatic stress disorder (PTSD) is a complex psychological disorder that is influenced by factors such as dysregulated hypothalamic-pituitary-adrenal (HPA) axis, neurotransmitter imbalances, and genetic variations. Understanding the intricate gene networks and their interactions is vital for comprehending the underlying mechanisms of PTSD.
Article
Psychiatry
Yoki L. Mertens, Antje Manthey, Anika Sierk, Henrik Walter, Judith K. Daniels
Summary: The current study aimed to identify the neural correlates of acute post-traumatic dissociation using the script-driven imagery paradigm in combination with functional magnetic resonance imaging. The study found enhanced activation in the cerebellum, occipital gyri, supramarginal gyrus and amygdala during trauma recall. However, none of the derived clusters correlated significantly with dissociative symptoms.
Article
Behavioral Sciences
Cecilia A. A. Hinojosa, Michael B. B. VanElzakker, Navneet Kaur, Julia M. M. Felicione, Meredith E. E. Charney, Eric Bui, Luana Marques, Paul Summergrad, Scott L. L. Rauch, Naomi M. M. Simon, Lisa M. M. Shin
Summary: Trauma-focused psychotherapy is the main treatment for PTSD, but a significant number of patients still have symptoms after treatment. This study used fMRI to examine brain responses before and after treatment and found that decreased amygdala activation and increased prefrontal cortex activation during fearful facial expressions, as well as decreased amygdala activation over time, were associated with greater reduction in PTSD symptoms. These findings suggest that changes in brain responses to repeated stimuli may be potential predictors of response to exposure therapies.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Ravi Philip Rajkumar
Summary: Post-Traumatic Stress Disorder (PTSD) is a chronic psychiatric disorder that has been linked to an increased risk of neurodegenerative disorders, such as Alzheimer's dementia and Parkinson's disease. This study aimed to identify biomarkers associated with the development of neurodegenerative disorders in PTSD patients. The results showed that biomarkers like cortical thinning, white matter integrity disruption, genetic polymorphisms, immune-inflammatory alterations, vitamin D deficiency, metabolic syndrome, and parasomnias are significantly associated with PTSD and may predict an increased risk of subsequent neurodegenerative disorders.
Article
Clinical Neurology
Michael W. Weiner, Danielle Harvey, Susan M. Landau, Dallas P. Veitch, Thomas C. Neylan, Jordan H. Grafman, Paul S. Aisen, Ronald C. Petersen, Clifford R. Jack, Duygu Tosun, Leslie M. Shaw, John Q. Trojanowski, Andrew J. Saykin, Jacqueline Hayes, Charles De Carli
Summary: The study found no significant association between TBI and/or PTSD and biomarker-defined AD. Veterans with TBI and/or PTSD had poorer cognitive status, which may be attributed to other comorbid pathologies.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Inbal Reuveni, Noa Herz, Tuvia Peri, Shaul Schreiber, Yuval Harpaz, Ruth Geisser, Omer Bonne, Abraham Goldstein
Summary: This study investigated the oscillatory brain activity of PTSD patients during recollection and imagination of traumatic memories using magnetoencephalography (MEG). The results showed that PTSD patients exhibited a distinct neural pattern in response to trauma scripts compared to healthy trauma-exposed individuals.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Roland von Kaenel, Rebecca E. Meister-Langraf, Claudia Zuccarella-Hackl, Hansjoerg Znoj, Aju P. Pazhenkottil, Jean-Paul Schmid, Juergen Barth, Ulrich Schnyder, Mary Princip
Summary: Changes in cardiac symptoms after acute coronary syndrome (ACS) are associated with changes in post-traumatic stress disorder (PTSD) symptoms.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Jonathan C. Hsu, Douglas Darden, Maylene Alegre, Ulrika Birgersdotter-Green, Gregory K. Feld, Kurt S. Hoffmayer, Frederick Han, David Krummen, Farshad Raissi, Gordon Ho, Pam R. Taub, Marcus A. Urey, Eric Adler
Summary: This study aimed to determine the effects of closed loop stimulation (CLS) rate-adaptive pacing on functional capacity in patients with heart failure with reduced ejection fraction (HFrEF) and chronotropic incompetence (CI) implanted with cardiac resynchronization therapy (CRT) devices. The results showed equivalent results in terms of heart rate response, peak oxygen uptake, and walking distance in patients using CLS and standard accelerometer settings.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2021)
Article
Virology
Abby C. Lee, Grant Castaneda, Wei Tse Li, Chengyu Chen, Neil Shende, Jaideep Chakladar, Pam R. Taub, Eric Y. Chang, Weg M. Ongkeko
Summary: This study aimed to characterize similarities in dysregulated immune pathways between patients with cardiovascular diseases (CVDs) and COVID-19 patients to understand why CVD patients are more vulnerable to severe COVID-19. The researchers found significant overlap of cytokine- and inflammasome-related gene expression profiles between CVD patients and COVID-19 patients, with cardiomyopathy patients exhibiting the most similar immune landscape to COVID-19 patients. Additionally, COVID-19 patients showed greater upregulation of cytokine- and inflammasome-related genes compared to CVD patients.
Article
Medicine, General & Internal
Emily N. C. Manoogian, Adena Zadourian, Hannah C. Lo, Nikko R. Gutierrez, Azarin Shoghi, Ashley Rosander, Aryana Pazargadi, Xinran Wang, Jason G. Fleischer, Shahrokh Golshan, Pam R. Taub, Satchidananda Panda
Summary: This study aims to investigate the feasibility and efficacy of 10-hour time-restricted eating (TRE) on health parameters related to cardiometabolic disease risks among career firefighters. The Healthy Heroes Study is a randomized controlled trial with 150 firefighters over 1 year, aiming to evaluate the impact of TRE on blood glucose, body weight, body composition, biomarkers, sleep, and mood. Results will be disseminated through peer-reviewed manuscripts, reports, and presentations.
Article
Cardiac & Cardiovascular Systems
Rebecca A. Ocher, Erika Padilla, Jonathan C. Hsu, Pam R. Taub
Summary: This case report describes a 32-year-old female patient who showed improvement in POTS after COVID-19 infection. Her post-viral workup revealed normalization of catecholamine levels and significant symptomatic improvement in heart rate.
CASE REPORTS IN CARDIOLOGY
(2021)
Article
Psychiatry
Laura S. Redwine, Suzi Hong, Jordan Kohn, Claudia Martinez, Barry E. Hurwitz, Meredith A. Pung, Kathleen Wilson, Christopher Pruitt, Barry H. Greenberg, Paul J. Mills
Summary: This study aimed to investigate the role of systemic inflammation in reduced cognitive functioning in patients with early-stage heart failure and determine its associations with other cardiovascular risk factors. The results showed that CRP levels were negatively related to cognitive function in patients with heart failure, independent of cardiovascular disease and psychological risk factors.
PSYCHOSOMATIC MEDICINE
(2022)
Article
Nutrition & Dietetics
Iwona Swiatkiewicz, Salvatore Di Somma, Ludovica De Fazio, Valerio Mazzilli, Pam R. Taub
Summary: This study compared intensive CR and standard CR programs, finding that intensive CR, with a specialized plant-based diet, stress management, and social support, had significant effects on improving cardiometabolic and psychosocial outcomes.
Article
Medicine, General & Internal
Nikita Mittal, Ariel Portera, Pam Taub
Summary: A middle-aged woman was diagnosed with postural orthostatic tachycardia syndrome based on clinical symptoms, elevated norepinephrine levels, and positive tilt-table test. Conventional treatments were ineffective, but the patient improved after receiving methylated B vitamins for her heterozygous catechol-O-methyltransferase Val158Met polymorphism.
Article
Geriatrics & Gerontology
Jordan N. Kohn, Judith D. Lobo, Emily A. Troyer, Kathleen L. Wilson, Gavrila Ang, Amanda L. Walker, Christopher Pruitt, Meredith A. Pung, Laura S. Redwine, Suzi Hong
Summary: This study compared the effectiveness of 12 weeks of community-based, in-person, group Tai Chi (TC) and Health Education (HAP-E) in improving health and wellbeing in older adults with hypertension and promoting psychological resilience during COVID-19. The results showed that both TC and HAP-E improved health and wellbeing, but TC had a greater impact on improving mental health. The follow-up surveys during COVID-19 revealed declines in health and wellbeing, with smaller declines in the TC arm, indicating increased resilience.
AGING & MENTAL HEALTH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sophie You, Evan M. Masutani, Marcus T. Alley, Shreyas S. Vasanawala, Pam R. Taub, Joy Liau, Anne C. Roberts, Albert Hsiao
Summary: This study assessed the feasibility of using deep learning for image-based background phase error correction in 4D flow MRI and compared its effectiveness to manual correction. The results showed that the automated correction method reduced bias and variance in flow measurements, achieving comparable results to manual correction.
Article
Oncology
Sylvia L. Crowder, Rachel Sauls, Laura Redwine, Michael Nieder, Omar Albanyan, Hassaan Yasin, Farhad Khimani, Marilyn Stern
Summary: This study aimed to identify the needs, interests, and preferences of AYA HSCT patients in mindfulness and quality of life, in order to develop a mindfulness-based stress reduction intervention. The results suggest that a mindfulness-based intervention can be beneficial in reducing physiological stress and improving quality of life in AYA HSCT patients.
Article
Pharmacology & Pharmacy
Tommy T. Chiou, Kimberly Tomasi, Pam R. Taub, Michael J. Wilkinson
Summary: We presented an early experience with inclisiran in an academic lipid clinic, administered by healthcare professionals. The study showed variations in approval rates among different insurance types, with Medicare beneficiaries having higher approval rates compared to non-Medicare insurance holders. The findings suggest the need for increased accessibility of inclisiran, particularly for younger patients with non-Medicare insurance.
JOURNAL OF CLINICAL LIPIDOLOGY
(2023)
Article
Psychology, Developmental
Marilyn Stern, Diana Rancourt, Sandra Soca Lozano, Acadia W. Buro, Heewon L. Gray, Carmen Rodriguez, Rocio Bailey, Laura Redwine
Summary: This study examined the feasibility and acceptability of using community health workers to deliver a health promotion program integrating mindfulness strategies for stress reduction to underserved Latino families in rural communities. The results showed that the program was feasible and acceptable, and had positive effects on reducing parental stress and promoting mindful eating.
JOURNAL OF PEDIATRIC PSYCHOLOGY
(2023)
Article
Geriatrics & Gerontology
Jordan N. Kohn, Judith D. Lobo, Emily A. Troyer, Gavrila Ang, Kathleen L. Wilson, Amanda L. Walker, Chad Spoon, Christopher Pruitt, Lize Tibirica, Meredith A. Pung, Laura S. Redwine, Suzi Hong
Summary: This study compared the effects of Tai Chi practice and Healthy Aging Education on frailty in older adults with hypertension. The results showed that Tai Chi practice significantly decreased frailty and increased the odds of clinically meaningful improvement.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Acadia W. Buro, Kevin Roman Candelaria, Rocio Bailey, Frances Luna, Alexandra Albizu-Jacob, Marilyn Stern, Laura Redwine
Summary: The COVID-19 pandemic has had a disproportionate impact on rural Latino communities, leading to low rates of vaccination and testing. This qualitative study examined the barriers and strategies that affect COVID-19 vaccination and testing uptake in these communities. Key barriers included fear, lack of control, misinformation, lack of accessibility, and institutional/policy issues, while strategies for improvement included faith, self-care, and community and family resilience. Recommendations for future pandemic responses in rural Latino communities include multiple levels of intervention, involvement of trusted community members, and fair and consistent policies.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Cardiac & Cardiovascular Systems
Cameron K. Ormiston, Erika Padilla, David T. Van, Christine Boone, Sophie You, Anne C. Roberts, Albert Hsiao, Pam R. Taub
Summary: This case series is the first to report a three-way association between POTS, EDS, and MTS. Two patients experienced significant improvement in their POTS symptoms and quality of life after undergoing MTS treatment. Patients with EDS should be evaluated for possible POTS and pelvic venous complications.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2022)