Review
Cardiac & Cardiovascular Systems
He Jiao, Jinghui Li, Yunpeng Bai, Zhigang Guo
Summary: This study compared the outcomes of sequential and individual saphenous vein grafts in coronary artery bypass grafting. The results showed that sequential grafts had higher rates of graft failure and long-term mortality, but also an increased risk of perioperative repeat revascularization. Based on the study, the selection of surgical techniques should be based on patients and surgeons.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
David P. Taggart, Yulia Gavrilov, George Krasopoulos, Cha Rajakaruna, Joseph Zacharias, Ravi De Silva, Keith M. Channon, Thomas Gehrig, Terrence John Donovan, Ivar Friedrich
Summary: This study investigated the effect of external stents on the progression of saphenous vein graft disease. The results showed that external stenting improved the patency scales of saphenous vein grafts and significantly reduced intimal hyperplasia area and thickness.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Davide Maselli, Gloria Garoffolo, Giada Andrea Cassanmagnago, Rosa Vono, Matthijs S. Ruiter, Anita C. Thomas, Paolo Madeddu, Maurizio Pesce, Gaia Spinetti
Summary: Mechanical stress promotes molecular phenotypic switching of saphenous vein progenitors and increases their responsiveness to extracellular environment alterations.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Maura Brioschi, Erica Gianazza, Daniele Andreini, Saima Mushtaq, Laura Cavallotti, Fabrizio Veglia, Calogero C. Tedesco, Gualtiero Colombo, Mauro Pepi, Gianluca Polvani, Elena Tremoli, Alessandro Parolari, Cristina Banfi
Summary: Coronary artery bypass graft (CABG) surgery is the preferred treatment for patients with complex multivessel coronary artery disease, but graft occlusion still occurs in a significant proportion. This study found that the preoperative level of mercaptoalbumin (HSA-SH) is independently associated with graft occlusion within 5 years after CABG.
Article
Cardiac & Cardiovascular Systems
Mario Gaudino, Katia Audisio, Antonino Di Franco, John H. Alexander, Paul Kurlansky, Andreas Boening, Joanna Chikwe, P. J. Devereaux, Anno Diegeler, Arnaldo Dimagli, Marcus Flather, Andre Lamy, Jennifer S. Lawton, Derrick Y. Tam, Wilko Reents, Mohamed Rahouma, Leonard N. Girardi, David L. Hare, Stephen E. Fremes, Umberto Benedetto
Summary: Based on the pooled analysis of 4 large coronary bypass surgery trials, the use of radial artery was associated with better clinical outcomes compared to saphenous vein graft and right internal thoracic artery.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Mario Gaudino, Katia Audisio, Antonino Di Franco, John H. Alexander, Paul Kurlansky, Andreas Boening, Joanna Chikwe, P. J. Devereaux, Anno Diegeler, Arnaldo Dimagli, Marcus Flather, Andre Lamy, Jennifer S. Lawton, Derrick Y. Tam, Wilko Reents, Mohamed Rahouma, Leonard N. Girardi, David L. Hare, Stephen E. Fremes, Umberto Benedetto
Summary: The use of radial artery in coronary bypass surgery showed better clinical outcomes compared to saphenous vein graft and right internal thoracic artery, based on a pooled analysis of four large trials.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Masafumi Ono, Shigetaka Kageyama, Neil O'Leary, Mohammed S. El-Kurdi, Jochen Reinoehl, Eric Solien, Richard W. Bianco, Mirko Doss, Bart Meuris, Renu Virmani, Martijn Cox, Yoshinobu Onuma, Patrick W. Serruys
Summary: This study demonstrates the feasibility and effectiveness of a novel biorestorative graft in an ovine coronary artery bypass graft model, suggesting its potential as an alternative to saphenous vein grafts. These findings could pave the way for the first-in-man trial of using this new material for coronary artery bypass graft patients who struggle with harvesting SVGs.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Review
Cardiac & Cardiovascular Systems
Mario Gaudino, Irbaz Hameed, N. Bryce Robinson, Yongle Ruan, Mohamed Rahouma, Ajita Naik, Viola Weidenmann, Michelle Demetres, Derrick Y. Tam, David L. Hare, Leonard N. Girardi, Giuseppe Biondi-Zoccai, Stephen E. Fremes
Summary: This study conducted a network meta-analysis to compare the angiographic patency rates of various conduits used in coronary bypass surgery. The results showed that radial artery and no-touch saphenous vein grafts were associated with significantly lower graft occlusion rates compared to conventionally harvested saphenous vein, with radial artery ranking as the best conduit.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Cardiac & Cardiovascular Systems
Alistair Royse, Justin Ren, Colin Royse, David H. Tian, Stephen Fremes, Mario Gaudino, Umberto Benedetto, Y. Joseph Woo, Andrew B. Goldstone, Piroze Davierwala, Michael Borger, Michael Vallely, Christopher M. Reid, Rodolfo Rocha, David Glineur, Juan Grau, Richard Shaw, Hugh Paterson, Doa El-Ansary, Stuart Boggett, Nilesh Srivastav, Zulfayandi Pawanis, David Canty, Rinaldo Bellomo
Summary: The study suggests that avoiding the use of saphenous vein grafts in total arterial revascularization (TAR) surgery can reduce patients' late survival rate and has a positive impact on reducing all-cause mortality.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Review
Medicine, General & Internal
Giovanni Soletti, Arnaldo Dimagli, Lamia Harik, Gianmarco Cancelli, Roberto Perezgrovas-Olaria, Talal Alzghari, Michele Dell'Aquila, Jordan Leith, Sabrina Castagnini, Christopher Lau, Leonard N. Girardi, Mario Gaudino
Summary: The Venous External SupporT (VEST) device significantly reduces intimal hyperplasia (IH) in saphenous vein grafts (SVGs), but does not decrease the need for repeat revascularization or reduce graft occlusion events.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Muhammad Owais Khan, Justin S. Tran, Han Zhu, Jack Boyd, Rene R. Sevag Packard, Ronald P. Karlsberg, Andrew M. Kahn, Alison L. Marsden
Summary: Biomechanical forces may play a key role in saphenous vein graft disease after coronary artery bypass graft surgery. Computational fluid dynamic modeling has the potential to identify high-risk patients who may benefit from more aggressive medical therapy and closer surveillance. Further studies are needed to develop clinically available tools for predicting SVG failure post-CABG.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2021)
Review
Medicine, General & Internal
Huiru Chen, Zilan Wang, Ke Si, Xiaoxiao Wu, Hanyu Ni, Yanbing Tang, Wei Liu, Zhong Wang
Summary: This study evaluated the efficacy of external stenting for SVGs in CABG and found that it significantly reduced intimal hyperplasia area and thickness, improved lumen uniformity, and did not increase SVG failure rate.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Multidisciplinary Sciences
T. Girao-Silva, M. H. Fonseca-Alaniz, J. C. Ribeiro-Silva, J. Lee, N. P. Patil, L. A. Dallan, A. B. Baker, M. C. Harmsen, J. E. Krieger, A. A. Miyakawa
Summary: High stretch conditions induce dysfunction in human saphenous vein endothelial cells, characterized by reduced NO bioavailability, increased inflammatory adhesion molecule expression, and elevated cell adhesion. Additionally, high stretch leads to actin remodeling and increased oxidative stress, which can be alleviated by pre-treatment with antioxidants.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Eleonora Mezzetti, Aniello Maiese, Federica Spina, Fabio Del Duca, Alessandra De Matteis, Marco Di Paolo, Raffaele La Russa, Emanuela Turillazzi, Vittorio Fineschi
Summary: Saphenous vein graft (SVG) is a cardiac surgical practice that creates a cardiac bypass in cases of coronary artery obstruction. This paper presents a rare case of SVG aneurysmal rupture that occurred 24 h after surgery. A systematic review of the literature was also conducted to provide a general overview.
Article
Medicine, General & Internal
Lars Saemann, Lena Wernstedt, Sabine Pohl, Markus Stiller, Jan Willsch, Britt Hofmann, Gabor Veres, Andreas Simm, Gabor Szabo
Summary: This study found that endothelial function of saphenous vein grafts decreases with age in patients treated with coronary artery bypass grafting. Age should be taken into consideration when maintaining grafts.
JOURNAL OF CLINICAL MEDICINE
(2023)