期刊
CARDIOLOGY IN REVIEW
卷 20, 期 1, 页码 38-44出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/CRD.0b013e31822c5380
关键词
vitamin D; calcitriol; 1,25-dihydroxyvitamin D; vitamin D insufficiency
Vitamin D is a fat-soluble vitamin that is naturally found in very few foods, is added to others, and is available as a dietary supplement. It is produced endogenously when ultraviolet light strikes the skin. Recent epidemiologic and experimental evidence has suggested that low vitamin D levels may play a role in various cardiovascular conditions, including coronary artery disease, congestive heart failure, valvular calcification, stroke, hypertension, and cognitive decline. Low vitamin D may lead to vascular smooth muscle cell proliferation, endothelial cell dysfunction, vascular and myocardial cell calcification, and increased inflammation. However, the data supporting a cardioprotective effect of vitamin D supplementation are very weak, and the large, controlled clinical trials now in progress should resolve this issue.
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