Dietary compound isoliquiritigenin targets GRP78 to chemosensitize breast cancer stem cells via β-catenin/ABCG2 signaling

Grp78 as a therapeutic target for refractory head–neck cancer with CD24−CD44+ stemness phenotype

(2013) C-C Chiu et al.   CANCER GENE THERAPY

Inhibitory effects of isoliquiritigenin on the migration and invasion of human breast cancer cells

(2013) Kai-Lee Wang et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Tumor-Initiating Cells and FZD8 Play a Major Role in Drug Resistance in Triple-Negative Breast Cancer

(2013) S. Yin et al.   MOLECULAR CANCER THERAPEUTICS

Isoliquiritigen Enhances the Antitumour Activity and Decreases the Genotoxic Effect of Cyclophosphamide

(2013) Hong Zhao et al.   MOLECULES

Pharmacokinetics, biodistribution and bioavailability of isoliquiritigenin after intravenous and oral administration

(2013) Hua Qiao et al.   PHARMACEUTICAL BIOLOGY

Dietary Compound Isoliquiritigenin Inhibits Breast Cancer Neoangiogenesis via VEGF/VEGFR-2 Signaling Pathway

(2013) Zhiyu Wang et al.   PLoS One

The Molecular Chaperone GRP78/BiP in the Development of Chemoresistance: Mechanism and Possible Treatment

(2013) Corinna Roller et al.   Frontiers in Pharmacology

Genetic and Pharmacologic Inhibition of β-Catenin Targets Imatinib-Resistant Leukemia Stem Cells in CML

(2012) Florian H. Heidel et al.   Cell Stem Cell

Defining the Benefits of Neoadjuvant Chemotherapy for Breast Cancer

(2012) Anne F. Schott et al.   JOURNAL OF CLINICAL ONCOLOGY

c-Kit mediates chemoresistance and tumor-initiating capacity of ovarian cancer cells through activation of Wnt/β-catenin–ATP-binding cassette G2 signaling

(2012) W K Chau et al.   ONCOGENE

Acute Inducible Ablation of GRP78 Reveals Its Role in Hematopoietic Stem Cell Survival, Lymphogenesis and Regulation of Stress Signaling

(2012) Shiuan Wey et al.   PLoS One

GRP78 Knockdown Enhances Apoptosis via the Down-Regulation of Oxidative Stress and Akt Pathway after Epirubicin Treatment in Colon Cancer DLD-1 Cells

(2012) Yu-Jia Chang et al.   PLoS One

Colon cancer cells expressing cell surface GRP78 as a marker for reduced tumorigenicity

(2012) Britta Hardy et al.   CELLULAR ONCOLOGY

Mammalian target of rapamycin regulates isoliquiritigenin-induced autophagic and apoptotic cell death in adenoid cystic carcinoma cells

(2011) Gang Chen et al.   APOPTOSIS

The wnt/β-catenin signaling pathway: A potential therapeutic target in the treatment of triple negative breast cancer

(2011) Taj D. King et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Adenosine-Derived Inhibitors of 78 kDa Glucose Regulated Protein (Grp78) ATPase: Insights into Isoform Selectivity

(2011) Alba T. Macias et al.   JOURNAL OF MEDICINAL CHEMISTRY

Implications of cancer stem cell theory for cancer chemoprevention by natural dietary compounds

(2011) Yanyan Li et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Identification of Direct Protein Targets of Small Molecules

(2010) Brett Lomenick et al.   ACS Chemical Biology

In Situ Identification of Putative Cancer Stem Cells by Multiplexing ALDH1, CD44, and Cytokeratin Identifies Breast Cancer Patients with Poor Prognosis

(2010) Veronique Neumeister et al.   AMERICAN JOURNAL OF PATHOLOGY

Wnt/β-Catenin Pathway Activation Is Enriched in Basal-Like Breast Cancers and Predicts Poor Outcome

(2010) Andrey I. Khramtsov et al.   AMERICAN JOURNAL OF PATHOLOGY

β-Catenin Mediates the Establishment and Drug Resistance of MLL Leukemic Stem Cells

(2010) Jenny Yeung et al.   CANCER CELL

Targeting Wnt Signaling: Can We Safely Eradicate Cancer Stem Cells?

(2010) F. Takahashi-Yanaga et al.   CLINICAL CANCER RESEARCH

A Wnt-ow of Opportunity: Targeting the Wnt/β-Catenin Pathway in Breast Cancer

(2010) Jenifer R. Prosperi et al.   CURRENT DRUG TARGETS

Isoliquiritigenin induces G2 and M phase arrest by inducing DNA damage and by inhibiting the metaphase/anaphase transition

(2009) Iha Park et al.   CANCER LETTERS

Circulating tumor cells with a putative stem cell phenotype in peripheral blood of patients with breast cancer

(2009) Panayiotis A. Theodoropoulos et al.   CANCER LETTERS

Side population and cancer stem cells: Therapeutic implications

(2009) Lidia Moserle et al.   CANCER LETTERS

Association of Breast Cancer Stem Cells Identified by Aldehyde Dehydrogenase 1 Expression with Resistance to Sequential Paclitaxel and Epirubicin-Based Chemotherapy for Breast Cancers

(2009) T. Tanei et al.   CLINICAL CANCER RESEARCH

Target identification using drug affinity responsive target stability (DARTS)

(2009) B. Lomenick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isoliquiritigenin 2′-methyl ether induces growth inhibition and apoptosis in oral cancer cells via heme oxygenase-1

(2009) Young-Man Lee et al.   TOXICOLOGY IN VITRO

Critical Role of the Stress Chaperone GRP78/BiP in Tumor Proliferation, Survival, and Tumor Angiogenesis in Transgene-Induced Mammary Tumor Development

(2008) D. Dong et al.   CANCER RESEARCH

Analysis of ABCG2 expression and side population identifies intrinsic drug efflux in the HCC cell line MHCC-97L and its modulation by Akt signaling

(2008) Chen Hu et al.   CARCINOGENESIS

Isoliquiritigenin inhibits migration and invasion of prostate cancer cells: possible mediation by decreased JNK/AP-1 signaling

(2008) Gyoo Taik Kwon et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Isoliquiritigenin Inhibits Tumor Growth and Protects the Kidney and Liver Against Chemotherapy-Induced Toxicity in a Mouse Xenograft Model of Colon Carcinoma

(2008) Chang Ki Lee et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

APC Is Essential for Targeting Phosphorylated β-Catenin to the SCFβ-TrCP Ubiquitin Ligase

(2008) YunYun Su et al.   MOLECULAR CELL