Article
Endocrinology & Metabolism
Angela Lamarca, D. Mark Pritchard, Thomas Westwood, Georgios Papaxoinis, Daisuke Nonaka, Sobhan Vinjamuri, Juan W. Valle, Prakash Manoharan, Wasat Mansoor
NEUROENDOCRINOLOGY
(2018)
Article
Oncology
C. Rao, A. Stewartz, A. P. Martin, B. Collins, D. M. Pritchard, T. Athanasiou, A. Sun Myint
Article
Oncology
Arthur Sun Myint, Fraser McLean Smith, Simon Gollins, Helen Wong, Christopher Rao, Karen Whitmarsh, Raj Sripadam, Paul Rooney, Michael Hershman, D. Mark Pritchard
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2018)
Article
Multidisciplinary Sciences
Awad Mahalhal, Jonathan M. Williams, Sophie Johnson, Nicholas Ellaby, Carrie A. Duckworth, Michael D. Burkitt, Xuan Liu, Georgina L. Hold, Barry J. Campbell, D. Mark Pritchard, Chris S. Probert
Article
Biochemistry & Molecular Biology
Sophie Reade, Jonathan M. Williams, Raphael Aggio, Carrie A. Duckworth, Awad Mahalhal, Rachael Hough, D. Mark Pritchard, Chris S. Probert
Article
Biochemistry & Molecular Biology
Awad Mahalhal, Michael D. Burkitt, Carrie A. Duckworth, Georgina L. Hold, Barry J. Campbell, David Mark Pritchard, Chris S. Probert
Summary: Long-term alterations in dietary iron affect gut microbiota signatures but do not exacerbate chronic colitis, while exacerbating acute colitis. More research is needed to understand the impact of iron supplementation on inflammatory bowel disease. The change in microbiome in colitis patients may be due to increased luminal iron, rather than the colitis itself.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Toxicology
Lawrence Howell, Rosalind E. Jenkins, Stephen Lynch, Carrie Duckworth, B. Kevin Park, Christopher Goldring
Summary: Hepatic organoids are a promising in vitro model that show potential for drug metabolism and detoxification. Global proteomic analysis revealed similarity to liver tissue and increased expression of drug-metabolizing enzymes in differentiated organoids. Further experimentation is needed to fully understand their use in modeling drug-induced liver injury.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Gastroenterology & Hepatology
Jonathon Snook, Neeraj Bhala, Ian L. P. Beales, David Cannings, Chris Kightley, Robert Ph Logan, D. Mark Pritchard, Reena Sidhu, Sue Surgenor, Wayne Thomas, Ajay M. Verma, Andrew F. Goddard
Summary: Iron deficiency anaemia is a major global cause of disease burden, diagnosed through blood testing and treated with iron replacement therapy. Causes include poor diet and gastrointestinal pathologies, with endoscopy and radiological scanning used for diagnosis and assessment in some cases.
Article
Nutrition & Dietetics
Awad Mahalhal, Alessandra Frau, Michael D. Burkitt, Umer Z. Ijaz, Christopher A. Lamb, John C. Mansfield, Stephen Lewis, D. Mark Pritchard, Chris S. Probert
Summary: This study demonstrates differential and unique influences of ferric maltol and ferrous sulphate supplements on intestinal microbiota. FS treatment led to an increase in five genera, but FM was not associated with any measurable change. The severity of DSS-induced colitis was greater with FSS than FMS.
Review
Gastroenterology & Hepatology
Jan Bornschein, D. Mark Pritchard
Summary: The discovery of Helicobacter pylori infection in 1984 revolutionized the management of upper gastrointestinal diseases. However, over time, some clinical practices adopted after the discovery have become less appropriate. Careful testing for H. pylori infection remains crucial, especially in patients with peptic ulcers.
FRONTLINE GASTROENTEROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Carrie A. Duckworth
Summary: The intestinal tract is lined by a single layer of epithelium that requires an active and controlled stem cell population for rapid renewal to maintain a physical barrier and efficient absorption. Specialized epithelial cells derived from adult intestinal stem cells play a crucial role in intestinal homeostasis. The mechanisms controlling ISC abundance, longevity, and activity are regulated by various cell populations and signaling pathways in the ISC niche.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2021)
Letter
Gastroenterology & Hepatology
D. Mark Pritchard, Robert Logan
Article
Endocrinology & Metabolism
Francesco Panzuto, John Ramage, D. Mark Pritchard, Marie-Louise F. van Velthuysen, Joerg Schrader, Nehara Begum, Anders Sundin, Massimo Falconi, Dermot O'Toole
Summary: The aim of this guidance paper is to provide practical guidance for specialists in the diagnosis and management of well-differentiated gastric and duodenal neuroendocrine tumours (NETs) by updating the previous ENETS guidelines. Type II gastric NETs, neuroendocrine carcinomas (NECs), and functioning duodenal NETs are not covered in this paper as they will be discussed in other ENETS guidance papers.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Review
Gastroenterology & Hepatology
Mohid S. Khan, D. Mark Pritchard
Summary: This article provides an overview of neuroendocrine tumours (NETs), emphasizing the importance of assessment, treatment, and prognosis, as well as the role of gastroenterologists.
FRONTLINE GASTROENTEROLOGY
(2022)
Article
Physiology
Hanan M. Garalla, Nantaporn Lertkowit, Laszlo Tiszlavicz, Zita Reisz, Chris Holmberg, Rob Beynon, Deborah Simpson, Akos Varga, Jothi Dinesh Kumar, Steven Dodd, David Mark Pritchard, Andrew R. Moore, Andras I. Rosztoczy, Tibor Wittman, Alec Simpson, Graham J. Dockray, Andrea Varro
PHYSIOLOGICAL REPORTS
(2018)