Article
Oncology
Wei Li, Yingying Yang, Menghang Yang, Nan Song, Ziwei Wan, Qing Lu, Jingyun Shi
Summary: This study analyzed the clinicopathologic, radiologic, and prognostic characteristics of primary lung mucinous adenocarcinomas (LMAs) based on radiologic classification. Patients with pure-solid and part-solid types had good prognoses, while those with pneumonic type had poor prognoses.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Genetics & Heredity
Yufei Wang, Chen Zhang, Chengyue Ji, Wenli Jin, Xin He, Shunzhi Yu, Renhua Guo
Summary: Recent studies have identified different molecular subtypes of LUAD associated with cuproptosis-related genes, showing different prognoses. Patients with high cuproptosis scores had higher somatic mutation frequency and stemness scores, while patients with low cuproptosis scores had more immune infiltration and better prognosis. The cuproptosis score may serve as a promising biomarker to guide immunotherapy in LUAD.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Ryo Fujikawa, Yuji Muraoka, Jumpei Kashima, Yukihiro Yoshida, Kimiteru Ito, Hirokazu Watanabe, Masahiko Kusumoto, Shun-ichi Watanabe, Yasushi Yatabe
Summary: This study analyzed the clinicopathologic, genotypic, and prognostic features of 781 patients with invasive nonmucinous adenocarcinoma of the lung using the new grading system proposed by the Pathology Committee. Grade 3 tumors were associated with younger age, male sex, higher smoking dose, aggressive features, and showed distinct radiological and genotypic characteristics compared to grade 1 or 2 tumors. The study suggested that preoperative variables can be used to predict grade 3 tumors.
JOURNAL OF THORACIC ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Shize Pan, Congkuan Song, Heng Meng, Ning Li, Donghang Li, Bo Hao, Zilong Lu, Qing Geng
Summary: The present study comprehensively examined the transcriptional and genetic alteration of cuproptosis-related genes (CRGs) in lung adenocarcinoma (LUAD), and identified their potential functions in the tumor microenvironment, clinicopathological characteristics, drug sensitivity, and prognosis. A cuproptosis-related gene score (CRG_score) was developed and validated, and its clinical application and predictive value in combination with TNM stage were established.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Rosario Distefano, Giovanni Nigita, Patricia Le, Giulia Romano, Mario Acunzo, Patrick Nana-Sinkam
Summary: Post-transcriptional modifications in miRNA molecules have provided new insights into cancer biology and potential cancer biomarkers. In this study, we analyzed the profiles of canonical and non-canonical miRNAs in lung cancer patients of different races. We identified distinct post-transcriptional modifications in lung cancer tissues, indicating the relevance of miRNA isoforms as potential biomarkers. Concurrent profiling of canonical and non-canonical miRNAs may help identify additional biological pathways and biomarkers in lung cancer.
Article
Genetics & Heredity
Jingchen Zhang, Xujian He, Jia Hu, Tong Li
Summary: Lung adenocarcinoma (LUAD) is a common malignant tumor with poor prognosis due to individual biological heterogeneity. This study investigates the potential connection between necroptosis-related genes (NRGs) and LUAD. The results show that the expression of NRGs is associated with patient prognosis and immune activation, providing a new approach to predict patient survival and therapeutic benefits for LUAD.
FRONTIERS IN GENETICS
(2022)
Article
Genetics & Heredity
Yuchu Zhang, Libing Shen, Qili Shi, Guofang Zhao, Fajiu Wang
Summary: This study analyzed the APA profiles in patients with lung adenocarcinoma (LUAD) using multi-omics data, identified two key regulators CPSF2 and CPEB3, and suggested their potential as prognostic genes in LUAD. Additionally, four LUAD subtypes based on different APA factor expression patterns showed distinct clinical outcomes and oncogenic features related to tumor microenvironment.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Sujing Jiang, Mingshu Xiao, Yueli Shi, Yongfang Wang, Zhiyong Xu, Kai Wang
Summary: In this study, we established a risk model based on N7-methylguanosine(m7G)-related miRNAs for lung adenocarcinoma (LUAD) and divided patients into high-risk or low-risk subgroups. We constructed a nomogram for predicting overall survival (OS) and analyzed the oxidative stress-related genes, immune landscape, and drug response profile of the subgroups. Our findings provide new insights into the molecular mechanisms of m7G in LUAD and offer a novel risk model for predicting prognosis and guiding therapeutic regimens.
Article
Oncology
Bokyung Ahn, Shinkyo Yoon, Deokhoon Kim, Sung -Min Chun, Goeun Lee, Hyeong-Ryul Kim, Se Jin Jang, Hee Sang Hwang
Summary: This study evaluated the clinicopathologic and genomic characteristics associated with high-grade patterns (HGPs) in lung adenocarcinoma (LUAD). Results showed that higher HGP subclasses were associated with male gender, advanced stage tumors, lymphovascular invasion, and higher frequencies of genetic alterations.
Article
Biochemistry & Molecular Biology
Chia-Hsin Liu, Shu-Hsuan Liu, Yo-Liang Lai, Yi-Chun Cho, Fang-Hsin Chen, Li-Jie Lin, Pei-Hua Peng, Chia-Yang Li, Shu-Chi Wang, Ji-Lin Chen, Heng-Hsiung Wu, Min-Zu Wu, Yuh-Pyng Sher, Wei-Chung Cheng, Kai -Wen Hsu
Summary: Lung cancer is a leading cause of cancer-related deaths worldwide, and a specific panel of miRNAs has been identified as potential predictors of 5-year overall survival in lung adenocarcinoma patients.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Immunology
Yongting Liu, Yanhong Ouyang, Ziyang Feng, Zhaohui Jiang, Jiayao Ma, Xin Zhou, Changjing Cai, Ying Han, Shan Zeng, Shanshan Liu, Hong Shen
Summary: In this study, the correlation between RASGRP2 and immune infiltration and malignant features in lung adenocarcinoma (LUAD) was investigated. The results showed that decreased RASGRP2 was associated with worse clinical parameters and prognosis in LUAD patients. Further experiments revealed that RASGRP2 was involved in lymphocyte activation and leukocyte adhesion, and was positively correlated with the infiltration of various immune cells, immunoregulators, and chemokines.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biology
Andrea Mogavero, Paolo Bironzo, Luisella Righi, Alessandra Merlini, Federica Benso, Silvia Novello, Francesco Passiglia
Summary: Lung cancer is a common and deadly disease, with the 2021 WHO classification providing an updated categorization of lung adenocarcinomas and highlighting rare histological types. Rare variants of lung cancer are challenging to diagnose, but advances in mutational profiling and next-generation sequencing offer hope for better therapeutic options in the future. This review aims to summarize current knowledge on rare adenocarcinoma subtypes, providing clinicians with updated information to guide their practice.
Article
Cell Biology
Xingchen Fan, Xuan Zou, Cheng Liu, Shuang Peng, Shiyu Zhang, Xin Zhou, Jun Zhu, Wei Zhu
Summary: This study aimed to identify critical miRNA-mRNA regulation pairs contributing to lung adenocarcinoma (LUAD) pathogenesis. Through analysis of miRNA and mRNA expression data, potential regulation pairs were identified and their diagnostic value and biological functions were confirmed. The study also analyzed the expression and clinical characteristics of these regulation pairs under different conditions.
Article
Oncology
Ferdinandos Skoulidis
Summary: Transcriptional profiling identified three robust subtypes of nonsquamous non-small cell lung cancer, regardless of initiating oncogenic driver events. Differential sensitivity to MEK 1/2 inhibitors was reported among the subtypes, and an interaction involving the mucinous subtype, STKII/LKBI genomic alterations, and inferior clinical outcomes with atezolizumab in the OAK clinical trial was identified.
CLINICAL CANCER RESEARCH
(2021)
Article
Immunology
Young Wha Koh, Bumhee Park, Se Hee Jung, Jae-Ho Han, Seokjin Haam, Hyun Woo Lee
Summary: We investigated the distribution of immune cell types and the response to PD-1/PD-L1 inhibitors according to EGFR mutation profile in lung adenocarcinoma. The results showed that EGFR wild-type carcinomas had higher numbers of certain immune cells compared to EGFR mutant carcinomas, and EGFR rare variants were predicted to have a better response to PD-1/PD-L1 inhibitors. Therefore, EGFR rare mutation form could be a potential target for PD-1/PD-L1 inhibitor therapy in lung adenocarcinoma.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Allergy
Taimu Yamaguchi, Ayami Nomura, Atsushi Matsubara, Takayoshi Hisada, Yoshinori Tamada, Tatsuya Mikami, Mizuri Ishida
Summary: This study investigated the correlation between gut microbial diversity and sensitization to major inhaled allergens. It was found that decreased gut microbiota diversity is associated with allergic symptoms. Additionally, the relationship between bacterial composition in sensitized individuals and the onset of allergy symptoms was examined.
ALLERGOLOGY INTERNATIONAL
(2023)
Article
Medicine, Research & Experimental
Yota Tatara, Hiromi Yamazaki, Fumiki Katsuoka, Mitsuru Chiba, Daisuke Saigusa, Shuya Kasai, Tomohiro Nakamura, Jin Inoue, Yuichi Aoki, Miho Shoji, Ikuko N. Motoike, Yoshinori Tamada, Katsuhito Hashizume, Mikio Shoji, Kengo Kinoshita, Koichi Murashita, Shigeyuki Nakaji, Masayuki Yamamoto, Ken Itoh
Summary: Through multiomics analysis of peripheral blood in patients with mild cognitive impairment (MCI), it was found that hsa-miR-4455 is the best biomarker for predicting MCI. The study revealed the association of a subset of T cells and the GCN pathway with MCI. This multiomics approach improves the diagnostic accuracy for MCI and provides insights into changes in peripheral blood.
CURRENT RESEARCH IN TRANSLATIONAL MEDICINE
(2023)
Letter
Pathology
Tomoaki Naka, Taiki Hashimoto, Teruhiko Yoshida, Yasushi Yatabe, Shigeki Sekine
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Editorial Material
Oncology
Masaya Yotsukura, Yuji Muraoka, Yukihiro Yoshida, Kazuo Nakagawa, Kouya Shiraishi, Takashi Kohno, Yasushi Yatabe, Shun-ichi Watanabe
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Mako Nagayoshi, Asahi Hishida, Tomonori Shimizu, Yasufumi Kato, Yoko Kubo, Rieko Okada, Takashi Tamura, Jun Otonari, Hiroaki Ikezaki, Megumi Hara, Yuichiro Nishida, Isao Oze, Yuriko N. Koyanagi, Yohko Nakamura, Miho Kusakabe, Rie Ibusuki, Keiichi Shibuya, Sadao Suzuki, Takeshi Nishiyama, Teruhide Koyama, Etsuko Ozaki, Kiyonori Kuriki, Naoyuki Takashima, Yasuyuki Nakamura, Sakurako Katsuura-Kamanos, Kokichi Arisawa, Masahiro Nakatochi, Yukihide Momozawa, Kenji Takeuchi, Kenji Wakai, J-MICC Study group
Summary: This study found that higher BMI in the Japanese population is causally associated with various cardiometabolic traits including high blood pressure, triglycerides, uric acid, low high-density-lipoprotein cholesterol, and eGFR. However, there was no significant association between genetic risk scores for BMI and individual-level cardiometabolic traits.
JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mika Iwai, Taisuke Kajino, Masahiro Nakatochi, Kiyoshi Yanagisawa, Yasuyuki Hosono, Hisanori Isomura, Yukako Shimada, Motoshi Suzuki, Ayumu Taguchi, Takashi Takahashi
Summary: In this study, a novel lncRNA called TILR was identified as a constitutive negative regulator of p53 expression, playing a role in the development of lung cancer. It was found that TILR interacts with the protein PCBP2 and binds to p53 mRNA, leading to the suppression of p53 expression and activation of downstream genes involved in apoptosis. Furthermore, TILR was shown to be involved in a positive feedback loop with p53 and Fanconi anemia pathway genes. These findings highlight the importance of TILR in regulating p53 expression and apoptosis in lung cancer.
Review
Oncology
Saori Mishima, Yoichi Naito, Kiwamu Akagi, Naomi Hayashi, Akira Hirasawa, Tomoro Hishiki, Ataru Igarashi, Masafumi Ikeda, Shigenori Kadowaki, Hiroaki Kajiyama, Motohiro Kato, Hirotsugu Kenmotsu, Yasuhiro Kodera, Keigo Komine, Takafumi Koyama, Osamu Maeda, Mitsuru Miyachi, Hiroshi Nishihara, Hiroyuki Nishiyama, Shouichi Ohga, Wataru Okamoto, Eiji Oki, Shigeru Ono, Masashi Sanada, Ikuo Sekine, Tadao Takano, Kayoko Tao, Keita Terashima, Katsuya Tsuchihara, Yasushi Yatabe, Takayuki Yoshino, Eishi Baba
Summary: The development of novel antitumor agents and biomarkers has improved survival in different tumor types. Immune checkpoint inhibitors have shown efficacy in patients with TMB-H solid tumors, leading to the need for guidelines prioritized for these patients. This guideline provides recommendations for properly testing TMB and selecting patients who can benefit from immunotherapy.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Yora Nindita, Masahiro Nakatochi, Rie Ibusuki, Ippei Shimoshikiryo, Daisaku Nishimoto, Keiichi Shimatani, Toshiro Takezaki, Hiroaki Ikezaki, Masayuki Murata, Megumi Hara, Yuichiro Nishida, Takashi Tamura, Asahi Hishida, Mako Nagayoshi, Rieko Okada, Keitaro Matsuo, Hidemi Ito, Haruo Mikami, Yohko Nakamura, Takahiro Otani, Sadao Suzuki, Teruhide Koyama, Etsuko Ozaki, Kiyonori Kuriki, Naoyuki Takashima, Naoko Miyagawa, Kokichi Arisawa, Sakurako Katsuura-Kamano, Yukihide Momozawa, Michiaki Kubo, Kenji Takeuchi, Kenji Wakai
Summary: The study evaluated the population-based impact of smoking, drinking, and genetic factors on low HDL-C levels using data from the J-MICC Study. The findings showed that smoking, drinking, and certain genetic variants were associated with HDL-C levels, but there was no significant gene-environment interaction. The population-based impact of the genetic factor CETP rs3764261 was higher than that of smoking and lower than that of drinking.
JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Clinical Neurology
Ryoichi Nakamura, Genki Tohnai, Masahiro Nakatochi, Naoki Atsuta, Hirohisa Watanabe, Daisuke Ito, Masahisa Katsuno, Akihiro Hirakawa, Yuishin Izumi, Mitsuya Morita, Takehisa Hirayama, Osamu Kano, Kazuaki Kanai, Nobutaka Hattori, Akira Taniguchi, Naoki Suzuki, Masashi Aoki, Ikuko Iwata, Ichiro Yabe, Kazumoto Shibuya, Satoshi Kuwabara, Masaya Oda, Rina Hashimoto, Ikuko Aiba, Tomohiko Ishihara, Osamu Onodera, Toru Yamashita, Koji Abe, Kouichi Mizoguchi, Toshio Shimizu, Yoshio Ikeda, Takanori Yokota, Kazuko Hasegawa, Fumiaki Tanaka, Kenji Nakashima, Ryuji Kaji, Jun-ichi Niwa, Manabu Doyu, Chikashi Terao, Shiro Ikegawa, Koki Fujimori, Shiho Nakamura, Fumiko Ozawa, Satoru Morimoto, Kazunari Onodera, Takuji Ito, Yohei Okada, Hideyuki Okano, Gen Sobue
Summary: In this study, three novel loci (FGF1, THSD7A, and LRP1) were identified to be associated with the survival of sporadic ALS patients. Decreased mRNA expression of FGF1 and THSD7A were also observed, which correlated with reduced viability of induced pluripotent stem cell-derived motor neurons from ALS patients.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Letter
Oncology
Yu Okubo, Yasushi Yatabe
JOURNAL OF THORACIC ONCOLOGY
(2023)
Article
Oncology
Yao Liang, Osamu Maeda, Kazushi Miyata, Mitsuro Kanda, Dai Shimizu, Shizuki Sugita, Tohru Okada, Junji Ito, Mariko Kawamura, Shunichi Ishihara, Masahiro Nakatochi, Masahiko Ando, Yasuhiro Kodera, Yuichi Ando
Summary: The feasibility of global standard chemoradiotherapy followed by surgery in patients with esophageal cancer was assessed in this study. The study conducted at Nagoya University Hospital reviewed the outcomes of patients who received global standard chemoradiotherapy followed by surgery compared to those who received lower drug doses. The results showed that the global standard regimen was associated with more severe adverse events but no significant difference in resection rate or complications.
MOLECULAR AND CLINICAL ONCOLOGY
(2023)
Review
Oncology
Tony Kiat Hon Lim, Ferdinandos Skoulidis, Keith M. Kerr, Myung-Ju Ahn, Joshua R. Kapp, Fernando A. Soares, Yasushi Yatabe
Summary: KRAS is the most commonly mutated oncogene in advanced NSCLC, and the approval of KRAS G12C-selective inhibitors has made it a druggable target. Real-world evidence shows geographic differences in KRAS G12C prevalence, and co-mutations with other genes are also common. Testing and reporting of KRAS G12C should be included in routine biomarker testing before first-line therapy.
Article
Cardiac & Cardiovascular Systems
Takaki Akamine, Kazuo Nakagawa, Kimiteru Ito, Hirokazu Watanabe, Masaya Yotsukura, Yukihiro Yoshida, Yasushi Yatabe, Masahiko Kusumoto, Shun-Ichi Watanabe
Summary: We evaluated the potential of preoperative fluorine-18-fluorodeoxyglucose positron emission tomography to predict invasive thymic epithelial tumours in patients with computed tomography-defined clinical stage I thymic epithelial tumours <5 cm in size who are generally considered to be candidates for minimally invasive approaches.
INTERDISCIPLINARY CARDIOVASCULAR AND THORACIC SURGERY
(2023)
Review
Cell Biology
Keith M. Kerr, Lukas Bubendorf, Fernando Lopez-Rios, Farah Khalil, Sinchita Roy-Chowdhuri, Philippe Joubert, Arndt Hartmann, Elena Guerini-Rocco, Yasushi Yatabe, Paul Hofman, Wendy A. Cooper, Sanja Dacic
Summary: Many patients with non-small cell lung cancer do not receive guideline-recommended, biomarker-directed therapy. Optimized tissue management is crucial for the protection and utilization of limited tissue resources, enabling accurate molecular profiling and treatment selection.
Review
Oncology
Shinkichi Takamori, Yasushi Yatabe, Atsushi Osoegawa, Keiju Aokage, Hiroshige Yoshioka, Tomohiro Miyoshi, Takahiro Mimae, Makoto Endo, Aritoshi Hattori, Masaya Yotsukura, Tetsuya Isaka, Mitsuhiro Isaka, Tomohiro Maniwa, Ryu Nakajima, Shun-ichi Watanabe, Lung Canc Surgical Study Grp LCSSG, Japan Clinical Oncology Grp JCOG
Summary: Salivary gland-type lung tumors (SGT), primarily mucoepidermoid carcinoma and adenoid cystic carcinoma, are rare and present with symptoms of bronchial obstruction. Surgical resection with lymphadenectomy is recommended, and radiation therapy varies by subtype. The diagnosis and treatment of SGT remain challenging.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2023)