Article
Gastroenterology & Hepatology
Yu-Jie Zhou, Xiao-Fan Lu, Huimin Chen, Xin-Yuan Wang, Wenxuan Cheng, Qing-Wei Zhang, Jin-Nan Chen, Xiao-Yi Wang, Jing-Zheng Jin, Fang-Rong Yan, Haoyan Chen, Xiao-Bo Li
Summary: This study used single-cell transcriptomics to investigate serrated lesions in the colon and found that there were redox imbalances in the epithelial cell clusters, which were tumor-promoting. Additionally, specific epithelial cell clusters in serrated lesions displayed distinct molecular features, and the immune environment underwent alterations.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Surgery
Swati Sonal, Vikram Deshpande, David T. Ting, Azfar Neyaz, Amaya Pankaj, Martin S. Taylor, Anne M. Dinaux, Lieve G. J. Leijssen, Chloe Boudreau, David L. Berger
Summary: This study compared the expression of molecular markers between infiltrating tumor border configuration (ITBC) and pushing tumor border configuration (PTBC) in colorectal cancer patients using tissue microarray. The results showed that ITBC tumors had lower expression of immune components, lower rates of BRAFV600E mutation, and deficient MMR proteins compared to PTBC tumors. However, in MMR-proficient tumors, there were no differences in the expression of molecular markers except for lower expression of PDL1 immune cells.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2023)
Article
Multidisciplinary Sciences
Amjad Alharbi, Haifa Bin Dokhi, Ghadir Almuhaini, Futoon Alomran, Emad Masuadi, Nouf Alomran
Summary: KRAS mutations were common among Saudi CRC patients, while BRAF mutations were low. The presence of KRAS mutation did not impact survival. Age at diagnosis and gender were significant factors affecting survival time.
Article
Oncology
Aina Kunitomo, Akira Ouchi, Koji Komori, Takashi Kinoshita, Yusuke Sato, Tetsuya Abe, Seiji Ito, Tsuyoshi Sano, Yasuhiro Shimizu
Summary: This study aimed to evaluate the clinical significance of surgical intervention for isolated peritoneal metastases (PM) from colorectal cancer (CRC), with a particular focus on the timing of PM. The results showed that patients who underwent radical resection of PM had better survival compared with those who received palliative chemotherapy, especially for metachronous PM. Therefore, surgical intervention should be considered for isolated metachronous PM when radical resection is feasible.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Gastroenterology & Hepatology
Carla Satorres, Maria Garcia-Campos, Marco Bustamante-Balen
Summary: Serrated lesions are precursor lesions of colorectal cancer, with the serrated pathway likely responsible for up to 30% of cases. Multiple molecular mechanisms are involved, including MAPK pathway alterations, CpG island methylation, and microsatellite instability. Further research is needed to clarify the precise roles of alterations in the serrated pathway and develop specific prevention and therapeutic strategies.
Article
Oncology
Hanna Elomaa, Maarit Ahtiainen, Sara A. Vayrynen, Shuji Ogino, Jonathan A. Nowak, Marjukka Friman, Olli Helminen, Erkki-Ville Wirta, Toni T. Seppala, Jan Bohm, Markus J. Makinen, Jukka-Pekka Mecklin, Teijo Kuopio, Juha P. Vayrynen
Summary: This study evaluated the prognostic significance of tumour cell-T cell co-localisation and T cell densities in colorectal cancer patients. The findings showed that high T cell proximity score was associated with longer cancer-specific survival, indicating the potential of spatial measurement of T cell infiltrates as a novel, robust tumour-immune biomarker.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Qianhao Meng, Jian Zhao, Yuanyuan Yu, Ke Wang, Jing Ren, Chang Xu, Yusheng Wang, Guangyu Wang
Summary: For patients with BRAF V600E-mutated advanced colorectal cancer (CRC), there was no significant difference in overall survival (OS) and progression-free survival (PFS) between those treated with chemotherapy alone and those treated with chemotherapy combined with targeted therapy. Surgical treatment of the primary tumor and the presence of liver metastasis may serve as independent prognostic indicators for these patients.
Article
Medicine, General & Internal
Bahar Saberzadeh-Ardestani, Jeremy C. Jones, Joleen M. Hubbard, Robert R. McWilliams, Thorvardur R. Halfdanarson, Qian Shi, Mohamad Bassam Sonbol, Jonathan Ticku, Zhaohui Jin, Frank A. Sinicrope
Summary: This cohort study found clinically significant prolongation of survival in older patients with dMMR mCRC who received first-line pembrolizumab monotherapy in routine clinical practice. Liver metastasis was associated with poorer survival compared to nonliver metastasis, indicating the importance of metastatic site in survival outcome.
Article
Oncology
Sebastian Stintzing, Kathrin Heinrich, David Tougeron, Dominik Paul Modest, Ingo Schwaner, Jan Eucker, Rudolf Pihusch, Martina Stauch, Florian Kaiser, Christoph Kahl, Meinolf Karthaus, Christian Mueller, Christof Burkart, Anke Reinacher-Schick, Stefan Kasper-Virchow, Ludwig Fischer von Weikersthal, Beate Krammer-Steiner, Gerald Wolfgang Prager, Julien Taieb, Volker Heinemann
Summary: This clinical trial investigated the efficacy of triplet chemotherapy combined with either cetuximab or bevacizumab in previously untreated BRAF(V600E)-mutant metastatic colorectal cancer (mCRC) patients. The results showed that bevacizumab-based chemotherapy remains the preferable first-line treatment for patients with BRAF(V600E)-mutant mCRC.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Oncology
Hiroyuki Takeda, Yu Sunakawa
Summary: BRAF mutations are an important poor prognostic factor in mCRC, but greater understanding of patient characteristics through genomic classification allows for more ideal treatment strategies.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ahmad Machmouchi, Laudy Chehade, Sally Temraz, Ali Shamseddine
Summary: Targeted monoclonal antibody therapy against EGFR is a leading treatment for mCRC. However, resistance due to KRAS and BRAF mutations has emerged. Cells with these mutations overexpress GLUT1 and SVCT2, leading to intracellular vitamin C transport and cell death. High dose vitamin C shows promise in overcoming EGFR resistance in mCRC with wild KRAS mutation and in patients with KRAS and BRAF mutations, but more clinical trials are needed.
Review
Oncology
Phimmada Hatthakarnkul, Jean A. Quinn, Amna Ahmed Mohemmd Matly, Aula Ammar, Hester C. van Wyk, Donald C. McMillan, Joanne Edwards
Summary: The study found a significant association between high-grade tumour budding and mutated KRAS or MSS/pMMR, which may be useful for predicting outcomes in colorectal cancer patients.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Review
Oncology
Junjia Liu, Hao Xie
Summary: This review explores the characteristics, clinical relevance, and treatment possibilities of BRAF non-V600 mutations in colorectal cancer, filling in existing knowledge gaps. Understanding the intricacies of these mutations can help healthcare professionals and researchers develop personalized treatment strategies to improve patient care.
Article
Oncology
Mackenzie L. Davenport, John B. Echols, Austin D. Silva, Joshua C. Anderson, Philip Owens, Clayton Yates, Qing Wei, Shuko Harada, Douglas R. Hurst, Mick D. Edmonds
Summary: miR-31 demonstrates oncogenic properties in specific subtypes of lung cancer, highlighting its potential as a therapeutic target in these subtypes.
Article
Genetics & Heredity
Peter W. Eide, Seyed H. Moosavi, Ina A. Eilertsen, Tuva H. Brunsell, Jonas Langerud, Kaja C. G. Berg, Bard I. Rosok, Bjorn A. Bjornbeth, Arild Nesbakken, Ragnhild A. Lothe, Anita Sveen
Summary: Gene expression-based subtypes of colorectal cancer have clinical significance, but the representativeness of primary tumors and consensus molecular subtypes (CMS) for metastatic cancers remains unclear. Metastases exhibit decreased CMS1/CMS3 signals and increased CMS4 signals, influenced by the microenvironment. The majority of classified metastases are CMS2 or CMS4, with subtype switching and inter-metastatic CMS heterogeneity being common.
NPJ GENOMIC MEDICINE
(2021)
Article
Medicine, General & Internal
Yoji Takeuchi, Katsuhiro Mabe, Yuichi Shimodate, Shinji Yoshii, Shinya Yamada, Mineo Iwatate, Takuji Kawamura, Kinichi Hotta, Koji Nagaike, Nobuaki Ikezawa, Tomoaki Yamasaki, Yoriaki Komeda, Satoshi Asai, Yasuhiro Abe, Takuji Akamatsu, Yuko Sakakibara, Hisatomo Ikehara, Yuzuru Kinjo, Takashi Ohta, Yoko Kitamura, Takashi Shono, Takuya Inoue, Yoshio Ohda, Nozomu Kobayashi, Tokuma Tanuma, Ryu Sato, Taku Sakamoto, Naohiko Harada, Akiko Chino, Hideki Ishikawa, Masanori Nojima, Toshio Uraoka, Kenta Hamada, Satoki Shichijo, Yasushi Yamasaki, Minoru Kato, Yusuke Tonai, Hiroyoshi Iwagami, Masamichi Arao, Hiroko Nakahira, Taro Iwatsubo, Shunntaro Inoue, Kenji Matsuno, Kentaro Nakagawa, Masayasu Ohmori, Noriko Matsuura, Akira Maekawa, Takashi Kanesaka, Koji Higashino, Noriya Uedo, Ryu Ishihara, Motowo Mizuno, Mio Matsumoto, Daisuke Miyamoto, Shigetsugu Tsuji, Yasushi Sano, Sachiyo Komai, Kenichiro Imai, Masafumi Naito, Yuichi Yoshida, Kiyonori Yuguchi, Hirokazu Sasakawa, Naoki Dan, Ayako Sakai, Yuichi Satomoto, Maria Taniguchi, Masao Hanafusa, Sasaki Kazunari, Bensuleiman Yahaya, Myojo Satoshi, Takuo Kado, Hiroko Nebiki, Yuhei Sakata, Yu Yasui, Akie Kimura, Hiroshi Kashida, Toshiharu Sakurai, Tomoyuki Nagai, Mitsunari Yamada, Masashi Kono, Kazuki Okamoto, Eisuke Akamine, Naoki Fujimoto, Takumi Ichinona, Eisuke Nakao, Kotaro Takeshita, Yuki Kano, Kenji Matsuo, Taro Nakamichi, Haruaki Naneta, Hayato Hirashima, Yasuki Nakatani, Yoshiyuki Harada, Maiko Ikenouchi, Keijirou Okada, Takuya Yamada, Ayaka Shoji, Seiya Kato, Sho Suzuki, Shinjiro Yamaguchi, Kohei Fukumoto, Takaaki Kishino, Hideto Shimokobe, Tomoko Kitaichi, Daiki Maeda, Yoshitaka Kadowaki, Jun Konishi, Maki Konno, Hirofumi Naito, Motohiko Kato, Hideki Mori
ANNALS OF INTERNAL MEDICINE
(2019)
Article
Gastroenterology & Hepatology
Yuichiro Suzuki, Tokuma Tanuma, Masanori Nojima, Gota Sudo, Masakazu Akahonai, Hidetaka Hamamoto, Hironori Aoki, Taku Harada, Akio Katanuma, Hiroshi Nakase
GASTROINTESTINAL ENDOSCOPY
(2020)
Article
Oncology
H. Igarashi, H. Taniguchi, K. Nosho, K. Ishigami, H. Koide, K. Mitsuhashi, K. Okita, I. Takemasa, K. Imai, H. Nakase
CLINICAL & TRANSLATIONAL ONCOLOGY
(2020)
Article
Biochemical Research Methods
Masaki Suzuki, Atsushi Muroi, Masanori Nojima, Ayumi Numata, Hirotaka Takasaki, Rika Sakai, Tomoyuki Yokose, Yohei Miyagi, Naohiko Koshikawa
PROTEOMICS CLINICAL APPLICATIONS
(2020)
Article
Surgery
Shuhei Miura, Yoshihiko Kurimoto, Ryushi Maruyama, Takahiko Masuda, Yohsuke Yanase, Yutaka Iba, Masanori Nojima, Akira Yamada
ANNALS OF VASCULAR SURGERY
(2020)
Article
Oncology
Yasushi Adachi, Masanori Nojima, Mitsuru Mori, Ryogo Himori, Toshiyuki Kubo, Hiro-O Yamano, Yingsong Lin, Kenji Wakai, Akiko Tamakoshi
CANCER PREVENTION RESEARCH
(2020)
Correction
Genetics & Heredity
Tsuneo Ikenoue, Masami Arai, Chikashi Ishioka, Takeo Iwama, Satoshi Kaneko, Nagahide Matsubara, Yoshihiro Moriya, Tadashi Nomizu, Kokichi Sugano, Kazuo Tamura, Naohiro Tomita, Teruhiko Yoshida, Kenichi Sugihara, Hiromu Naruse, Kiyoshi Yamaguchi, Masanori Nojima, Yusuke Nakamura, Yoichi Furukawa
JOURNAL OF HUMAN GENETICS
(2020)
Article
Multidisciplinary Sciences
Muneyoshi Futami, Keisuke Suzuki, Satomi Kato, Saori Ohmae, Yoshio Tahara, Masanori Nojima, Yoichi Imai, Takayuki Mimura, Yoshihiro Watanabe, Arinobu Tojo
Article
Oncology
Yasush Adachi, Masanori Nojima, Mitsuru Mori, Toshiyuki Kubo, Noriyuki Akutsu, Yasushi Sasaki, Hiroshi Nakase, Yingsong Lin, Youichi Kurozawa, Kenji Wakai, Akiko Tamakoshi
Summary: This study analyzed the association between serum sFas levels and the incidence of liver cancer. The results showed that high levels of sFas were associated with an increased risk of liver cancer. These findings suggest that sFas may serve as a biomarker for assessing liver cancer risk.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Anesthesiology
Aya Watahabe, Naoki Shimada, Hiroto Ishiki, Noriko Fujiwara, Masanori Nojima, Arinobu Tojo
Summary: Younger age and pancreatic cancer are associated with higher requirements of fentanyl patch in terminally ill cancer patients. Patients with pancreatic cancer require more frequent adjustment of the medication dosage near death.
JOURNAL OF PAIN & PALLIATIVE CARE PHARMACOTHERAPY
(2023)
Article
Public, Environmental & Occupational Health
Noriko Fujiwara, Naoki Shimada, Masanori Nojima, Keisuke Ariyoshi, Norie Sawada, Motoki Iwasaki, Shoichiro Tsugane
Summary: This study identified factors associated with home death in Japan, including being unmarried, unemployed male, and having a high drinking level in male. Cardiovascular disease, cerebrovascular disease, and external factors were significantly associated with home death, while the risk of home death for cancer patients tended to be lower.
JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Kenji Watanabe, Masanori Nojima, Hiroshi Nakase, Toshiyuki Sato, Minoru Matsuura, Nobuo Aoyama, Taku Kobayashi, Hirotake Sakuraba, Masakazu Nishishita, Kaoru Yokoyama, Motohiro Esaki, Fumihito Hirai, Masakazu Nagahori, Sohachi Nanjo, Teppei Omori, Satoshi Tanida, Yoshihiro Yokoyama, Kei Moriya, Atsuo Maemoto, Osamu Handa, Naoki Ohmiya, Kiichiro Tsuchiya, Shinichiro Shinzaki, Shingo Kato, Toshio Uraoka, Hiroki Tanaka, Noritaka Takatsu, Atsushi Nishida, Junji Umeno, Masanao Nakamura, Yoshiyuki Mishima, Mikihiro Fujiya, Kenji Tsuchida, Sakiko Hiraoka, Makoto Okabe, Takahiko Toyonaga, Katsuyoshi Matsuoka, Akira Andoh, Yoshio Hirota, Tadakazu Hisamatsu, J COMBAT Study Grp
Summary: The degree of immune response to COVID-19 vaccination in IBD patients varies. Most IBD patients showed a sufficient immune response, while some had persistently low response. Factors such as age and medication were associated with the immune response.
JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Immunology
Motoki Amai, Masanori Nojima, Yoshikazu Yuki, Hiroshi Kiyono, Fumitaka Nagamura
Summary: To assess safety in vaccine development, stricter grading scales are required. However, concern exists that their strictness may lead to an overestimation of some adverse events. An analysis of a phase I clinical trial of a preventive vaccine revealed that the occurrence of certain adverse events differed when assessed using FDA grading scale compared to reference intervals. The criteria for hypernatremia and hypokalemia were lower and higher, respectively, than most standards.
Article
Oncology
Yasushi Adachi, Masanori Nojima, Mitsuru Mori, Hiro-o Yamano, Yasushi Sasaki, Hiroshi Nakase, Yingsong Lin, Kenji Wakai, JACC Study
Summary: The findings suggest that serum SOD activity is inversely correlated with the risk of colorectal carcinoma, particularly in men and individuals with rectal cancer or left-sided CRC.
CANCER EPIDEMIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Tomoya Iida, Daisuke Hirayama, Naoki Minami, Minoru Matsuura, Kohei Wagatsuma, Kentaro Kawakami, Kanna Nagaishi, Masanori Nojima, Hiroki Ikeuchi, Seiichi Hirota, Ryutaro Shirakawa, Hisanori Horiuchi, Hiroshi Nakase
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2020)