Review
Cell Biology
Bo Chen, Ke Ning, Ming-li Sun, Xin-an Zhang
Summary: Osteoarthritis (OA) is a chronic disease characterized by the degeneration of articular cartilage. The Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway plays a vital role in the progression of OA. This review focuses on the role and mechanism of JAK2/STAT3 signaling in cartilage degradation, subchondral bone dysfunction, and synovial inflammation, as well as recent therapeutic approaches targeting this pathway for OA treatment.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Environmental Sciences
Jou-Chun Chou, Fu-Kong Lieu, Donald Ming-Tak Ho, Heng-Yi Shen, Po-Han Lin, Sindy Hu, Shyi-Wu Wang, Ho Lin, Paulus S. Wang
Summary: This study revealed that PRL promotes NSCLC cell proliferation by upregulating GHR and JAK2/STAT3/VEGF pathway. NSCLC cells secrete PRL and GHR is the key receptor for PRL-induced cell proliferation.
Article
Oncology
Yan Zhuang, Yue Ma, Sunshun Yan, Bing Zhao, Shuling Wu, Qianwen Zhang, Xiaoying Huang, Haiyang Zhao, Chengguang Zhao, Zhiguo Liu, Lehe Yang
Summary: Cyy260 has concentration- and time-dependent inhibitory effect on NSCLC cells while being less toxic to normal cells. It regulates apoptosis through intracellular and extracellular apoptotic pathways, and induces cell cycle arrest to inhibit cell proliferation. Further molecular mechanism analysis revealed the involvement of the JAK2/STAT3 signaling pathway in the antitumor effect of Cyy260.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Oncology
Yong Teng, Reid Loveless, Elayne M. Benson, Li Sun, Austin Y. Shull, Chloe Shay
Summary: The study reveals that SHOX2 is strongly associated with poor distant metastasis-free survival in breast cancer patients, and its inactivation suppresses breast tumor growth and metastasis in mice. SHOX2 directly activates WASF3 gene in breast cancer cells by activating STAT3 and recruiting it to the WASF3 promoter, promoting metastatic potential. Targeting the SHOX2-STAT3-WASF3 signaling axis may represent a valuable alternative strategy for combating breast cancer metastasis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Ka Lung Cheung, Anbalagan Jaganathan, Yuan Hu, Feihong Xu, Alannah Lejeune, Rajal Sharma, Cristina I. Caescu, Jamel Meslamani, Adam Vincek, Fan Zhang, Kyung Lee, Nilesh Zaware, Amina Abdul Qayum, Chunyan Ren, Mark H. Kaplan, John Cijiang He, Huabao Xiong, Ming-Ming Zhou
Summary: This study uncovers a previously unrecognized mechanism of self-directed cell type-specific regulation of the master transcription factor Stat3 through its own transcriptional target Hipk2 in Th17 cell differentiation. These findings provide insights into the regulation of Th17 cell immune functions and suggest a therapeutic strategy for developing targeted therapies for Th17-associated inflammatory disorders.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Medicine, Research & Experimental
Jiangtao Zhou, Jing Hou, Jun Wang, Jiajing Wang, Jianping Gao, Yun'e Bai
Summary: The study explored the role of Brusatol (BR) in human laryngeal squamous carcinoma cells (Hep-2) using in vitro and in vivo approaches. It was found that BR could inhibit the viability, migration, and invasion of Hep-2 cells without significant toxicity to normal cells. Mechanistically, BR induced cell apoptosis and suppressed cell proliferation by blocking cells in S phase. Additionally, BR was shown to inhibit the protein expression levels of epithelial-mesenchymal transition (EMT) related markers.
Article
Medicine, Research & Experimental
Na-Na Yang, Jing-Wen Yang, Yang Ye, Jin Huang, Lu Wang, Yu Wang, Xin-Tong Su, Ying Lin, Fang-Ting Yu, Si-Ming Ma, Ling-Yu Qi, Lu-Lu Lin, Li-Qiong Wang, Guang-Xia Shi, Hong-Ping Li, Cun-Zhi Liu
Summary: The study investigated how electroacupuncture stimulation at the hindlimb region ameliorates inflammation in postoperative ileus (POI). Results showed that electroacupuncture suppressed intestinal inflammation and promoted gastrointestinal motility by activating the alpha 7 nicotinic acetylcholine receptor (alpha 7nAChR)-mediated JAK2/STAT3 signaling pathway in macrophages. Furthermore, hindlimb region stimulation inhibited the expression of GABA(A) receptor in dorsal motor nucleus of vagal (DMV) neurons, leading to suppression of inflammation via vagal efferent output.
Article
Cell Biology
M. T. Longhi, L. E. Silva, M. Pereira, M. Magalhaes, J. Reina, F. N. L. Vitorino, B. M. Gumbiner, J. P. C. da Cunha, N. Cella
Summary: The study identified that the PI3K-Akt and JAK2-STAT3 pathways are involved in regulating EGF-induced maspin nuclear accumulation in MCF-10A cells, while the MAP kinase pathway is not. Cell-cell contact also plays a role in determining Maspin subcellular localization. Proteomic and interactome analyses suggest that Maspin may have effects on post-transcriptional and translation regulation, protein folding, and cell-cell adhesion.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Chemistry, Multidisciplinary
Hyun-Soo Park, Joo-Hui Han, Jeong Won Park, Do-Hyung Lee, Keun-Woo Jang, Miji Lee, Kyung-Sun Heo, Chang-Seon Myung
Summary: The study found that sodium propionate (SP) inhibits proliferation and induces apoptosis in breast cancer cells by inhibiting JAK2/STAT3 signaling, increasing ROS levels, and activating p38 MAPK.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Plant Sciences
Liangrong Wu, Chenchen Qian, Weiqi Zhang, Mengyun Shi, Xiuxiu Chen, Yi Wang, Feng Lin
Summary: This study found that ginkgetin inhibits the proliferation and induces apoptosis of ovarian cancer cells. It also reduces the migration and invasion of these cells. The anti-tumor effects of ginkgetin are associated with the inhibition of JAK2/STAT3 and MAPK pathways and SIRT1 protein expression, making it a potential candidate for the treatment of ovarian cancer.
Review
Immunology
Teklie Mengie Ayele, Zelalem Tilahun Muche, Awgichew Behaile Teklemariam, Achenef Bogale Kassie, Endeshaw Chekol Abebe
Summary: The JAK2/STAT3 signaling pathway plays a crucial role in regulating various biological processes such as cell proliferation, differentiation, apoptosis, and immune system control. Aberrantly activated JAK2/STAT3 is associated with the development and metastasis of various tumors, while the JAK3/STAT3 pathway shows promise as a potential therapeutic target in solid tumor treatment.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Neurosciences
Yi Zhong, Bo Yin, Yingze Ye, Omar Y. A. T. Dekhel, Xiaoxing Xiong, Zhihong Jian, Lijuan Gu
Summary: The JAK2/STAT3 signaling pathway plays a crucial role in ischemic stroke by regulating inflammatory response, apoptosis, oxidative stress, and angiogenesis.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yujie Li, Jie Wei, Yao Sun, Wenqian Zhou, Xiaoya Ma, Jinping Guo, Huan Zhang, Tianbo Jin
Summary: The study aimed to identify new biomarkers for detecting breast cancer through bioinformatic analyses and experimental validation. DLGAP5, identified as a potential biomarker, was found to have an impact on cell proliferation, migration, invasion, and cell cycle in breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Xuhui Fan, Haotian Fu, Ni Xie, Hangcheng Guo, Tiantian Fu, Yunfeng Shan
Summary: The study revealed that panaxadiol significantly inhibited proliferation and induced apoptosis in human pancreatic cancer cells, as well as suppressed the migration of pancreatic cancer cells, suggesting its potential as an anti-tumor agent for pancreatic cancer treatment.
Article
Biology
Chunqiu Xiong, Bingbing Yan, Suhua Xia, Fei Yu, Jingjing Zhao, Hua Bai
Summary: This study demonstrated the anticancer effects of Tilianin in PA-1 cells through its ability to significantly decrease cell viability and induce apoptosis.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Oncology
Liwei Lang, Reid Loveless, Juan Dou, Tiffany Lam, Alex Chen, Fang Wang, Li Sun, Jakeline Juarez, Zhaohui Steve Qin, Nabil F. Saba, Chloe Shay, Yong Teng
Summary: Targeting mitochondrial oncoproteins presents a new concept for effective cancer therapeutics. In this study, the researchers focused on ATAD3A and its impact on head and neck squamous cell carcinoma (HNSCC). They found that ATAD3A is highly expressed in HNSCC tissues and cell lines, and loss of ATAD3A expression suppresses HNSCC cell growth and leads to tumor regression. Mechanistically, they discovered that ATAD3A interacts with ERK1/2 in the mitochondria of HNSCC cells and this interaction is essential for the activation of mitochondrial ERK1/2 signaling. Most importantly, they showed that targeting ATAD3A in combination with RAS inhibitor treatment has a more significant tumor suppression effect. These findings highlight the potential of ATAD3A and RAS signaling as targets for HNSCC therapeutics.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Chloe S. Lalonde, Yong Teng, Barbara A. Burtness, Robert L. Ferris, Rafi Ahmed, Nabil F. Saba
Summary: This article provides an overview of the necessary elements to eliminate oropharyngeal squamous cell carcinoma, including improved vaccine uptake, universal vaccination effort, and implementation of novel therapeutics to cure existing disease.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Oncology
Nabil F. Saba, Pooja Vijayvargiya, Jan B. Vermorken, Juan P. Rodrigo, Stefan M. Willems, Nina Zidar, Remco de Bree, Antti Maekitie, Greg T. Wolf, Athanassios Argiris, Yong Teng, Alfio Ferlito
Summary: Therapies for squamous cell carcinomas of the head and neck are evolving rapidly, with the inclusion of immunotherapy and anti-angiogenic therapies. This review article explores the utility of anti-VEGF therapies on SCCHN and its interaction with the immune environment. The correlation between VEGF and the progression of SCCHN is strong, with nearly 90% of these cancers expressing VEGF.
Review
Biochemistry & Molecular Biology
Mehdi Sanati, Samaneh Aminyavari, Hamid Mollazadeh, Ali Motamed-Sanaye, Bahram Bibak, Elmira Mohtashami, Yong Teng, Amir R. R. Afshari, Amirhossein Sahebkar
Summary: This research reviewed the literature to assess the connection between metformin's anticancer properties and the development of glioblastoma multiforme (GBM). The comprehensive review found that metformin not only inhibits tumor growth by activating the AMPK pathway, but also induces cell apoptosis, inhibits cell proliferation and metastasis, and enhances chemo-radio-sensitizing behavior against GBM through other mechanisms. Further research is needed to explore the potential of metformin-based therapeutics for GBM and the challenges they may face.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Oncology
Lixia Gao, Fan Yang, Dianyong Tang, Zhigang Xu, Yan Tang, Donglin Yang, Deping Sun, Zhongzhu Chen, Yong Teng
Summary: This study reveals that ENO2 is highly expressed in head and neck squamous cell carcinoma (HNSCC) and promotes cell proliferation and glycolysis by controlling PKM2 protein stability and nuclear translocation. Treatment with the ENO inhibitor AP-III-a4 significantly induces HNSCC remission in a preclinical mouse model.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Fan Yang, Chloe Shay, Marin Abousaud, Chris Tang, Yamin Li, Zhaohui Qin, Nabil F. Saba, Yong Teng
Summary: This study analyzes immune-related adverse events (irAEs) associated with seven FDA-approved immune checkpoint inhibitors (ICIs) in cancer treatment, revealing the pattern of toxicity burden among patients. The findings highlight that irAEs related to anti-PD-1 ICIs require fewer hospital care resources compared to anti-PD-L1 and anti-CTLA-4 ICIs. Age and sex have specific impacts on tissue and organ toxicities of ICIs.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Hongchen Yan, Tianci Zhou, Yongsheng Wang, Zhengcheng Liu, Ilyas Ali, Le Sheng, Qiang Jiang, Tao Li, Minghui Xiang, Ping Li, Wei Zhang, Yong Teng, Honglin Li, Yang Liu, Yafei Cai
Summary: Streptococcus agalactiae is a major pathogen causing mastitis in animals, but its specific pathogenic mechanisms and regulatory factors are largely unknown. Our study revealed that the downregulation of CDK5RAP3 in mastitis caused by S. agalactiae triggers inflammasome activation and inhibits autophagolysosome degradation, leading to inflammation and cell death. This study sheds light on the interaction between autophagy and immune responses and provides new insights for the development of clinical drugs to cure S. agalactiae mastitis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Editorial Material
Biochemistry & Molecular Biology
Yong Teng
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Jianqiang Yang, Yong Teng
Summary: Cancer stem cells (CSCs) are important seeds for tumor development and progression. Exosomes derived from CSCs play a significant role in various aspects of cancer. Understanding the characteristics and function of CSC-derived exosomes can potentially lead to the development of new clinical tools and therapies for cancer treatment.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Fanghui Chen, Le Sheng, Tianci Zhou, Li Yan, Reid Loveless, Honglin Li, Yong Teng, Yafei Cai
Summary: Ufl1 and Ufbp1 play a role in preventing liver fibrosis, steatohepatitis and hepatocellular carcinoma (HCC) development by inhibiting the mTOR pathway.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Nabil F. Saba, Conor E. Steuer, Asari Ekpenyong, Ashley McCook-Veal, Kelly Magliocca, Mihir Patel, Nicole C. Schmitt, William Stokes, James E. Bates, Soumon Rudra, Jill Remick, Mark McDonald, Marin Abousaud, Aik Choon Tan, Muhammad Zaki Hidayatullah Fadlullah, Ritu Chaudhary, Jameel Muzaffar, Kedar Kirtane, Yuan Liu, Georgia Z. Chen, Dong M. Shin, Yong Teng, Christine H. Chung
Summary: PD-1 therapy is standard treatment for recurrent metastatic head and neck squamous cell carcinoma. The combination of Pembrolizumab and Cabozantinib shows promising clinical activity. Further research is needed.
Review
Oncology
Nabil F. F. Saba, Saagar Pamulapati, Bhamini Patel, Mayur Mody, Primoz Strojan, Robert Takes, Antti A. A. Maekitie, Oded Cohen, Pia Pace-Asciak, Jan B. B. Vermorken, Carol Bradford, Arlene Forastiere, Yong Teng, Andreas Wieland, Alfio Ferlito
Summary: Head and neck cancer (HNC) is a common malignancy, with oropharyngeal squamous cell carcinoma (OPSCC) being the majority of cases. The incidence of HPV-related OPSCC, caused by human papillomavirus (HPV), is increasing rapidly. Immunotherapy has shown promise in managing recurrent and metastatic HNC, leading to interest in its application for HPV-related OPSCC. This review focuses on the immune characteristics and potential for immunotherapy in this virus-driven cancer.
Review
Biochemistry & Molecular Biology
Yong Teng, Lixia Gao, Antti A. Makitie, Ewa Florek, Agata Czarnywojtek, Nabil F. Saba, Alfio Ferlito
Summary: This review discusses the relationship between ferroptosis and head and neck cancer treatment, including its conceptual framework, mechanism, functional aspects, and implications for tumor therapy. In addition, strategies for improving the efficacy of head and neck cancer treatment through modulation of ferroptosis are summarized.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Hakjoo Lee, Tae Jin Lee, Chad A. Galloway, Wenbo Zhi, Wei Xiao, Karen L. de Mesy Bentley, Ashok Sharma, Yong Teng, Hiromi Sesaki, Yisang Yoon
Summary: This study reveals that OPA1 is dispensable in the liver and its deletion induces a mitohormesis response that protects the liver from drug toxicity and enhances liver resilience.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Liwei Lang, Fanghui Chen, Yamin Li, Chloe Shay, Fan Yang, Hancai Dan, Zhuo G. Chen, Nabil F. Saba, Yong Teng
Summary: Radiotherapy is essential for the treatment of head and neck squamous cell carcinoma (HNSCC), but radioresistance remains a major obstacle. This study shows that radioresistant HNSCC cells exhibit increased aggressiveness and that upregulation of c-Met phosphorylation is a critical mechanism for radioresistance. The study also reveals that c-Met exacerbates radioresistance-associated aggressiveness, but its genetic knockdown and pharmacologic inactivation suppress it. Mechanistically, c-Met upregulation promotes the expression of PLXDC2, which leads to epithelial-mesenchymal transition (EMT) induction and enrichment of cancer stem cells (CSCs), resulting in radioresistance. Depletion of PLXDC2 overcomes c-Met-mediated radioresistance. Therapeutically, the addition of a selective c-Met inhibitor to radiation induces tumor shrinkage and limits tumor metastasis in a mouse model. These findings provide insights into radioresistance-associated aggressiveness and suggest a potential therapeutic strategy for HNSCC patients.
CANCER RESEARCH COMMUNICATIONS
(2023)