Hypoxia upregulates CD147 through a combined effect of HIF-1α and Sp1 to promote glycolysis and tumor progression in epithelial solid tumors

HAb18G/CD147 promotes epithelial–mesenchymal transition through TGF-β signaling and is transcriptionally regulated by Slug

(2011) J Wu et al.   ONCOGENE

CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors

(2011) R. Le Floch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Receptor Activator of NF- B Ligand Enhances Breast Cancer-Induced Osteolytic Lesions through Upregulation of Extracellular Matrix Metalloproteinase Inducer/CD147

(2010) N. Rucci et al.   CANCER RESEARCH

Transcription factor Sp1 regulates expression of cancer-associated molecule CD147 in human lung cancer

(2010) Ling-Min Kong et al.   CANCER SCIENCE

Co-expression of CD147/EMMPRIN with monocarboxylate transporters and multiple drug resistance proteins is associated with epithelial ovarian cancer progression

(2010) Hongmin Chen et al.   CLINICAL & EXPERIMENTAL METASTASIS

Promoter hypomethylation up-regulates CD147 expression through increasing Sp1 binding and associates with poor prognosis in human hepatocellular carcinoma

(2010) Ling-Min Kong et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Hypoxia responsive gene expression is mediated by various subsets of transcription factors and miRNAs that are determined by the actual oxygen availability

(2010) Francesco Licausi et al.   NEW PHYTOLOGIST

Upregulation of HAb18G/CD147 in activated human umbilical vein endothelial cells enhances the angiogenesis

(2009) Yanke Chen et al.   CANCER LETTERS

Hyaluronan, CD44, and Emmprin Regulate Lactate Efflux and Membrane Localization of Monocarboxylate Transporters in Human Breast Carcinoma Cells

(2009) Mark G. Slomiany et al.   CANCER RESEARCH

The prognostic value of CD147/EMMPRIN is associated with monocarboxylate transporter 1 co-expression in gastric cancer

(2009) Céline Pinheiro et al.   EUROPEAN JOURNAL OF CANCER

CD147 silencing inhibits lactate transport and reduces malignant potential of pancreatic cancer cells in in vivo and in vitro models

(2009) W Schneiderhan et al.   GUT

HAb18G (CD147), a cancer-associated biomarker and its role in cancer detection

(2009) Yu Li et al.   HISTOPATHOLOGY

Mitochondrial Lactate Oxidation Complex and an Adaptive Role for Lactate Production

(2009) TAKESHI HASHIMOTO et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis

(2009) X. Xia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

A novel mode of action of YC-1 in HIF inhibition: stimulation of FIH-dependent p300 dissociation from HIF-1 

(2008) S. H. Li et al.   MOLECULAR CANCER THERAPEUTICS

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE

Upregulation of EMMPRIN after permanent focal cerebral ischemia

(2007) Wei Zhu et al.   NEUROCHEMISTRY INTERNATIONAL