Perturbed replication induced genome wide or at common fragile sites is differently managed in the absence of WRN

Aberrant chromosome morphology in human cells defective for Holliday junction resolution

(2011) Thomas Wechsler et al.   NATURE

The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest

(2010) Julia M. Sidorova et al.   CELL CYCLE

Delineation of WRN helicase function with EXO1 in the replicational stress response

(2010) Monika Aggarwal et al.   DNA REPAIR

ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery

(2010) Francesca Ammazzalorso et al.   EMBO JOURNAL

WRN mutations in Werner syndrome patients: genomic rearrangements, unusual intronic mutations and ethnic-specific alterations

(2010) Katrin Friedrich et al.   HUMAN GENETICS

Molecular Cooperation between the Werner Syndrome Protein and Replication Protein A in Relation to Replication Fork Blockage

(2010) Amrita Machwe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

(2010) Yoshitami Hashimoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Werner Syndrome Helicase/Exonuclease Processes Mobile D-Loops through Branch Migration and Degradation

(2009) Patricia L. Opresko et al.   PLoS One

Werner syndrome helicase activity is essential in maintaining fragile site stability

(2008) Livia Maria Pirzio et al.   JOURNAL OF CELL BIOLOGY

Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway

(2008) Annapaola Franchitto et al.   JOURNAL OF CELL BIOLOGY

Cleavage of Stalled Forks by Fission Yeast Mus81/Eme1 in Absence of DNA Replication Checkpoint

(2007) Benoît Froget et al.   MOLECULAR BIOLOGY OF THE CELL