Oncrasin targets the JNK-NF-κB axis to sensitize glioma cells to TNFα-induced apoptosis

Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNFα)-induced apoptosis through SIRT1 inhibition

(2012) D Dixit et al.   Cell Death & Disease

Targeting inflammation-induced transcription factor activation: an open frontier for glioma therapy

(2011) Ellora Sen   DRUG DISCOVERY TODAY

Suppression of MMP-2 Attenuates TNF-α Induced NF-κB Activation and Leads to JNK Mediated Cell Death in Glioma

(2011) Divya Kesanakurti et al.   PLoS One

Antitumor Activity of a Novel Oncrasin Analogue Is Mediated by JNK Activation and STAT3 Inhibition

(2011) Wei Guo et al.   PLoS One

Bicyclic triterpenoid Iripallidal induces apoptosis and inhibits Akt/mTOR pathway in glioma cells

(2010) Nitin Koul et al.   BMC CANCER

NF-κB and STAT3 signaling in glioma: targets for future therapies

(2010) George P Atkinson et al.   Expert Review of Neurotherapeutics

Ras regulates interleukin-1β-induced HIF-1α transcriptional activity in glioblastoma

(2010) Vivek Sharma et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Jnk signaling pathway-mediated regulation of Stat3 activation is linked to the development of doxorubicin resistance in cancer cell lines

(2009) Ju-Hwa Kim et al.   BIOCHEMICAL PHARMACOLOGY

Persistently Activated Stat3 Maintains Constitutive NF-κB Activity in Tumors

(2009) Heehyoung Lee et al.   CANCER CELL

Release of HMGB1 in Response to Proapoptotic Glioma Killing Strategies: Efficacy and Neurotoxicity

(2009) M. Candolfi et al.   CLINICAL CANCER RESEARCH

Manumycin inhibits STAT3, telomerase activity, and growth of glioma cells by elevating intracellular reactive oxygen species generation

(2009) Deobrat Dixit et al.   FREE RADICAL BIOLOGY AND MEDICINE

HDAC inhibitor, scriptaid, induces glioma cell apoptosis through JNK activation and inhibits telomerase activity

(2009) Vivek Sharma et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation

(2009) D. J. Gough et al.   SCIENCE

Identification of a Small Molecule with Synthetic Lethality for K-Ras and Protein Kinase C Iota

(2008) W. Guo et al.   CANCER RESEARCH

Constitutively Activated STAT3 Frequently Coexpresses with Epidermal Growth Factor Receptor in High-Grade Gliomas and Targeting STAT3 Sensitizes Them to Iressa and Alkylators

(2008) H.-W. Lo et al.   CLINICAL CANCER RESEARCH

Ebselen sensitizes glioblastoma cells to Tumor Necrosis Factor (TNFα)-induced apoptosis through two distinct pathways involving NF-κB downregulation and Fas-mediated formation of death inducing signaling complex

(2008) Vivek Sharma et al.   INTERNATIONAL JOURNAL OF CANCER

Induction of inflammatory and immune responses by HMGB1–nucleosome complexes: implications for the pathogenesis of SLE

(2008) Vilma Urbonaviciute et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Involvement of miltefosine-mediated ERK activation in glioma cell apoptosis through Fas regulation

(2008) Richa Tewari et al.   JOURNAL OF NEUROCHEMISTRY

The ING4 Tumor Suppressor Attenuates NF- B Activity at the Promoters of Target Genes

(2008) S. Nozell et al.   MOLECULAR AND CELLULAR BIOLOGY

High mobility group protein B1 enhances DNA repair and chromatin modification after DNA damage

(2008) S. S. Lange et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA