Article
Nutrition & Dietetics
Jining Yang, Xinxin Guo, Tianyou Li, Yingquan Xie, Dawei Wang, Long Yi, Mantian Mi
Summary: Sulforaphane (SFN) can protect the liver from exhaustive exercise (EE)-induced damage by reducing lactate dehydrogenase (LDH), creatine kinase (CK), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) levels. SFN intervention also attenuates liver tissue abnormalities, oxidative stress injury, and inflammation. Liver transcriptomic analysis shows that SFN affects differentially expressed genes involved in glucose and lipid metabolism.
Article
Cell Biology
Hyoungnae Kim, Mi Ra Yu, Haekyung Lee, Soon Hyo Kwon, Jin Seok Jeon, Dong Cheol Han, Hyunjin Noh
Summary: Research has shown that MSCs from patients with CKD exhibit reduced proliferation, accelerated senescence, and increased DNA damage compared to healthy MSCs, but these changes were significantly reduced after metformin treatment. Metformin enhances the paracrine action of CKD MSCs, leading to lower expression of inflammatory and fibrotic markers in kidney cells co-cultured with metformin-treated MSCs. Furthermore, metformin-treated CKD MSCs effectively reduce inflammation and fibrosis in diseased kidneys, suggesting a therapeutic benefit in targeting accelerated senescence of CKD MSCs.
Article
Medicine, Research & Experimental
Ya-jun Hou, Dawei Li, Weiqi Wang, Leilei Mao, Xiaoyan Fu, Baoliang Sun, Cundong Fan
Summary: This study evaluated the anticancer effects and mechanism of NT157 against human glioma growth, and found that NT157 alone inhibited glioma cell growth by regulating cell cycle, promoting apoptosis, and inducing DNA damage and dysfunction of signaling pathways. Combined treatment with TRAIL further enhanced apoptosis by upregulating DR5 and inducing DNA damage.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Wei Zhao, Ying Duan, Hong-Mei Li, Shengying Li, Yuemao Shen, Youming Zhang, Yue-zhong Li, Ya-Jie Tang
Summary: This study preliminarily disclosed the intrinsic regularity between different types of heterocycle-substituted DMEP derivative compounds and their antitumor activity mechanisms, including inducing severe DNA damage and promoting cell cycle arrest.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Environmental Sciences
Eva Ari Wahyuni, Chien Yi Chen, Huery Nuo Wu, Chih-Ching Chien, Ssu-Ching Chen
Summary: Propolis can alleviate oxidative DNA damage induced by 4-ABP by removing ROS and inhibiting CYP2E1 expression, but it does not induce DNA repair enzymes. However, it can still protect cells from DNA damage.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Yun Ji, Yu He, Ying Yang, Zhaolai Dai, Zhenlong Wu
Summary: This study evaluated the protective effects of hydroxyproline (Hyp) on 4-hydroxy-2-nonenal (4-HNE)-induced oxidative stress in pig intestinal epithelial cells. The results showed that Hyp could attenuate cell apoptosis, DNA damage, and changes in oxidative stress-related molecules. Furthermore, the enhanced expression of Kruppel-like factor 4 (KLF4) may be involved in the protective effects of Hyp.
Article
Cell Biology
Yihong Li, Huadong Fan, Fuqiang Yuan, Lanhai Lu, Jie Liu, Wenke Feng, Huang-Ge Zhang, Shao-Yu Chen
Summary: The study found that ethanol exposure leads to downregulation of anti-apoptotic genes and increased DNMT activity in human NCCs, while sulforaphane (SFN) can prevent ethanol-induced apoptosis by inhibiting DNMT activity and restoring gene expression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Plant Sciences
Jessica Gasparello, Elisabetta D'Aversa, Chiara Papi, Laura Gambari, Brunella Grigolo, Monica Borgatti, Alessia Finotti, Roberto Gambari
Summary: Sulforaphane may modulate the inflammatory response by inhibiting key molecules IL-6 and IL-8 involved in the COVID-19 cytokine storm, potentially controlling the hyperinflammatory state associated with SARS-CoV-2 infection.
Article
Multidisciplinary Sciences
Makoto Isono, Kazuki Okubo, Takako Asano, Akinori Sato
Summary: The combination of gemcitabine and the ATR inhibitor AZD6738 showed efficacy in inhibiting bladder cancer cell viability, colony formation, and promoting apoptosis. Mechanistically, AZD6738 interfered with CHK1 and hindered the repair of DNA damage induced by gemcitabine.
Article
Environmental Sciences
Jessica C. S. Rabelo, Alex L. Hanusch, Lazaro Wender O. de Jesus, Lorena A. Mesquita, Fernanda C. Franco, Raquel A. Silva, Simone M. T. Saboia-Morais
Summary: The study showed that exposure to the cyanotoxin cylindrospermopsin (CYN) led to genotoxic effects in the brain, liver, blood cells, and erythrocytes of P. reticulata. The findings suggest potential harm of CYN to aquatic organisms and human health.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Cell Biology
Marina Rodriguez-Munoz, Martina Serrat, David Soler, Anna Genesca, Teresa Anglada
Summary: Chromosome bridges in cancer cells are often formed and may break during mitosis, with a direct correlation between the distance between bridge kinetochores and bridge breakage. The mechanisms responsible for chromosome bridge breakage during mitosis may depend on the separation between the bridge kinetochores. Previous studies have suggested mechanical stress or biochemical digestion as possible causes of bridge breakage in interphase cells, suggesting a multifactorial model for bridge breakage.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Ho Man Tang, C. Conover Talbot, Ming Chiu Fung, Ho Lam Tang
Summary: Researchers described a comprehensive dataset containing time-course mRNA expression profiles for the reversal of ethanol-induced apoptosis in mouse liver cells. By comparing this dataset with others, key regulators governing reversal of apoptosis and other reversible cell death processes can be identified.
Article
Cell Biology
Qiongyu Yan, Bin Zhang, Xi Ling, Bin Zhu, Shenghui Mei, Hua Yang, Dongjie Zhang, Jiping Huo, Zhigang Zhao
Summary: This study reveals the role of CTLA-4 as an immunomodulator in the DNA damage response. It activates ATM by binding to the ATM inhibitor protein 2A, exacerbates DNA damage response, and induces cell apoptosis. This provides important insights into the mechanisms by which T cells maintain immune function under high-stress conditions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Environmental Sciences
Yan-Ning Chen, Yu-Hsuan Chan, Jun-Ping Shiau, Ammad Ahmad Farooqi, Jen-Yang Tang, Kuan-Liang Chen, Ching-Yu Yen, Hsueh-Wei Chang
Summary: This study demonstrates that MLN4924, a neddylation inhibitor, has the potential to be an effective anti-oral-cancer agent by inhibiting proliferation and inducing apoptosis in oral cancer cells while having fewer cytotoxic effects on normal cells.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Oncology
Shiyu Wang, Yanan Wang, Xiangnan Liu, Yongbin Yang, Sufang Wu, Yuan Liu
Summary: This study investigated the radiotherapy sensitization mechanism in cervical cancer through the exploration of Sulforaphane (SFN) as a potential sensitizer. SFN treatment inhibited the survival of cervical cancer cells and resulted in the suppression of the homologous recombination pathway, thereby enhancing the sensitivity of radiotherapy. LATS2 was identified as a downstream target of SFN treatment and played a crucial role in the SFN-facilitated radiotherapy sensitization.
Article
Oncology
Lu Yang, Yun Li, Arup Bhattacharya, Yuesheng Zhang
Article
Oncology
Lu Yang, Yun Li, Arup Bhattacharya, Yuesheng Zhang
Article
Multidisciplinary Sciences
Lu Yang, Yun Li, Arup Bhattacharya, Yuesheng Zhang
NATURE COMMUNICATIONS
(2017)
Review
Biochemical Research Methods
Zhidan Chen, Yuesheng Zhang, Paul Vouros
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2018)
Article
Oncology
Marilyn L. Kwan, Lawrence H. Kushi, Kim N. Danforth, Janise M. Roh, Isaac J. Ergas, Valerie S. Lee, Kimberly L. Cannavale, Teresa N. Harrison, Richard Contreras, Ronald K. Loo, David S. Aaronson, Charles P. Quesenberry, David Tritchler, Nirupa R. Ghai, Virginia P. Quinn, Christine B. Ambrosone, Yuesheng Zhang, Li Tang
CANCER CAUSES & CONTROL
(2019)
Article
Oncology
Yun Li, Zhidan Chen, Joseph D. Paonessa, Walter Meinl, Arup Bhattacharya, Hansruedi Glatt, Paul Vouros, Yuesheng Zhang
Article
Cell Biology
Lu Yang, Yun Li, Arup Bhattacharya, Yuesheng Zhang
SCIENCE TRANSLATIONAL MEDICINE
(2019)
Review
Pharmacology & Pharmacy
Yuesheng Zhang
Summary: HER2-positive breast cancer is a common cancer type that is often treated with HER2 inhibitors. However, drug resistance frequently develops, limiting the effectiveness of treatment. Emerging therapeutics are being explored to overcome drug resistance in this subset of breast cancer.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Food Science & Technology
Zinian Wang, Marilyn L. Kwan, Rachel Pratt, Janise M. Roh, Lawrence H. Kushi, Kim N. Danforth, Yuesheng Zhang, Christine B. Ambrosone, Li Tang
FOOD SCIENCE & NUTRITION
(2020)
Article
Biology
Lu Yang, Yun Li, Arup Bhattacharya, Yuesheng Zhang
Summary: Yang et al. discovered a mechanism to reactivate mutant p53 as a tumor suppressor by disrupting its binding to peptidase D, leading to posttranslational modifications, refolding, and restoration of tumor suppressor activities. This finding suggests a new therapeutic approach for a wide range of human tumors by inhibiting cancer cell growth through the reactivation of mutant p53's tumor suppressor functions.
COMMUNICATIONS BIOLOGY
(2021)
Article
Oncology
Lu Yang, Arup Bhattacharya, Yun Li, Sandra Sexton, Xiang Ling, Fengzhi Li, Yuesheng Zhang
Summary: Resistance to EGFR inhibitors in colorectal cancer is primarily due to the inability of the inhibitors to downregulate their target. The combination treatment with PEPDG278D overcomes this resistance.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Food Science & Technology
Zinian Wang, Chengjian Tu, Rachel Pratt, Thaer Khoury, Jun Qu, Jed W. Fahey, Susan E. McCann, Yuesheng Zhang, Yue Wu, Alan D. Hutson, Christine B. Ambrosone, Stephen B. Edge, Helen H. Cappuccino, Kazuaki Takabe, Jessica S. Young, Li Tang
Summary: This study confirms the anti-cancer activities of dietary isothiocyanates (ITCs) from cruciferous vegetables in breast cancer patients. The results show that these substances can alter the expression of tumor biomarkers, supporting their potential beneficial roles in breast cancer prognosis.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Oncology
Dongbo Xu, Li Wang, Kyle Wieczorek, Yali Zhang, Zinian Wang, Jianmin Wang, Bo Xu, Prashant K. Singh, Yanqing Wang, Xiaojing Zhang, Yue Wu, Gary J. Smith, Kristopher Attwood, Yuesheng Zhang, David W. Goodrich, Qiang Li
Summary: Immune checkpoint inhibitors are standard care for some advanced bladder cancer patients, but many do not respond. A novel preclinical model developed in this study showed mixed responses to anti-PD-1 immunotherapy, with responder tumors having higher macrophage infiltration, suggesting a potential role for the innate immune microenvironment in regulating ICI treatment responses.
Article
Nutrition & Dietetics
Zinian Wang, Marilyn L. Kwan, Reina Haque, Maciej Goniewicz, Rachel Pratt, Valerie S. Lee, Janise M. Roh, Isaac J. Ergas, Kimberly L. Cannavale, Ronald K. Loo, David S. Aaronson, Charles P. Quesenberry, Yuesheng Zhang, Christine B. Ambrosone, Lawrence H. Kushi, Li Tang
Summary: This study aimed to investigate the associations between dietary iso-thiocyanates (ITCs) intake and the prognosis of non-muscle-invasive bladder cancer (NMIBC). The results showed that dietary ITC intake was associated with an increased risk of late recurrence in NMIBC patients. Urinary ITC metabolites and higher plasma concentrations of ITC-albumin adducts were associated with a reduced risk of late recurrence and disease progression. Increasing dietary ITC exposure through cruciferous vegetable intake could be a promising strategy to attenuate recurrence and progression risks in NMIBC patients.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Review
Pharmacology & Pharmacy
Yuesheng Zhang
Summary: EGFR is a receptor tyrosine kinase that can be activated by ligand binding, overexpression, or mutation. Various EGFR inhibitors have been developed for cancer treatment, but they only show efficacy in a few types of cancers and drug resistance is common. It has been increasingly recognized that EGFR also possesses noncanonical kinase-independent oncogenic functions, which may play a crucial role in cancer resistance to EGFR inhibitors.
PHARMACOLOGICAL REVIEWS
(2023)