期刊
CARBOHYDRATE RESEARCH
卷 372, 期 -, 页码 9-14出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2012.09.015
关键词
Brassica rapa ssp campestris; Sucrose 3,3 ',4 '-triisovalerate; Sucrose 6,3 ',4 '-triisovalerate; Ethanone-1-C-beta-D-glucopyranoside; 3,7-Anhydro-1-deoxy-D-glycero-D-gulo-2-octulose; Reactive oxygen species
资金
- Next-Generation Bio-Green 21 Program [PJ008020]
- Rural Development Administration, Republic of Korea
Phytochemical investigation of the roots of Brassica rapa ssp. campestris led to the isolation of three new carbohydrate derivatives, namely sucrose 3,3 ',4 '-triisovalerate (2), sucrose 6,3 ',4 '-triisovalerate (3), and ethanone-1-C-beta-D-glucopyranoside (3,7-anhydro-1-deoxy-D-glycero-D-gulo-2-octulose, 6), along with four known carbohydrate derivatives, 2,6,3 ',4 '-tetraisovalerate (1), ethyl beta-D-glucopyranoside (4), n-butyl b-D-fructofuranoside (5), and n-pentyl b-D-fructofuranoside (7), which were initially isolated from plants of the Brassica genus. Structures of the isolated compounds were established by spectroscopic analyses, including UV, IR, MS, and NMR. All of the isolated carbohydrate derivatives were evaluated to determine their effect on ROS production and glutamate-induced cell death in HT-22 cells. Compound 6 showed the most significant ROS reduction and a protective effect with IC50 values of 69.4 +/- 3.8 mu M and 4.96 +/- 0.32 mu M, respectively, which were equivalent to those of the positive control, Trolox. (C) 2012 Elsevier Ltd. All rights reserved.
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