期刊
CARBOHYDRATE RESEARCH
卷 344, 期 17, 页码 2399-2405出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2009.09.002
关键词
Pyrimidine; Glucopyranosyl thiourea; Glucopyranosyl isothiocyanate; Microwave-assisted method
资金
- Scientific Research Fund-Hanoi National University [QGTD.08.03]
Some 2-amino-4,6-diarylpyrimidines 2 have been prepared from substituted benzylideneacetophenones and guanidine hydrochloride in the presence of alkali by conventional heating in alcoholic medium and microwave heating in solvent-free conditions. N-(2,3,4,6-Tetra-O-acetyl-beta-D-glucopyranosyl)-N'-(4',6'-diarylpyrimidin-2'-yl)thioureas 4 have been synthesized by reaction of per-O-acetylated glucopyranosyl isothiocyanate 1 and substituted 2-amino-4,6-diarylpyrimidines 2. Two different methods have been used, namely, refluxing in anhydrous dioxane and solvent-free microwave-assisted coupling. The second procedure afforded higher yields in much shorter reaction times. The compounds 2 and 4 were tested for their antibacterial and antifungal activities in vitro against Staphylococcus epidermidis, Enterobacter aerogenes and Candida albicans by disc diffusion method. (C) 2009 Elsevier Ltd. All rights reserved.
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