期刊
CARBOHYDRATE RESEARCH
卷 343, 期 18, 页码 3085-3095出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2008.09.014
关键词
Sulfated heterorhamnan; Chemical structure; Antiviral activity; Green seaweed; Gayralia oxysperma; Ulvales
资金
- Fundacao Araucaria/CNPq-Brasil (PRONEX-Carboidratos)
- MCT/CNPq/MS-SCTIE-DECIT/CT-Saude [554671/2006-9]
- Universidad de Buenos Aires, Agencia
- Nacional para la Promocion Cientifica y Tecnologica
- Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
- National Research Council of Brazil (CNPq)
- CONICET (Argentina)
A homogeneous sulfated heterorhamnan was obtained by aqueous extraction, then by ultrafiltration from the green seaweed Gayralia oxysperma. Besides a-L-rhamnose it contains glucuronic and galacturonic acids, xylose and glucose. The structure was established by methylation analyses of the carboxyl-reduced, carboxyl-reduced/desulfated, carboxyl-reduced/Smith-degraded, and carboxyl-reduced/Smith-degraded/desulfated products and 1D, 2D NMR spectroscopy analyses. The heterorhamnan backbone is constituted by 3- and 2-linked rhamnosyl units (1.00:0.80), the latter being similar to 50% substituted at C-3 by side chains containing 2-sulfated glucuronic and galacturonic acids and xylosyl units. The 3- and 2-linked rhamnosyl units are unsulfated (20%), disulfated (16%), and mostly monosulfated at C-2 (27%) and C-4 (37%). The branched and sulfated heterorhamnan had high and specific activity against herpes simplex virus. (C) 2008 Elsevier Ltd. All rights reserved.
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