Article
Biochemistry & Molecular Biology
Meiyu Cui, Xiaohong Li, Lihua Geng, Ning Wu, Jing Wang, Zhenzhen Deng, Zhi Li, Quanbin Zhang
Summary: This study compared the immunomodulatory activities of six different fucoidans from Saccharina japonica and found that the molecular weight and chemical composition of fucoidans affect their binding ability to SRs and immunomodulatory effects. Additionally, several variants of SR-A as ligands in fucoidans were confirmed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Sunisa Khongthong, Yongyuth Theapparat, Natthrit Roekngam, Chinnapatch Tantisuwanno, Michael Otto, Pipat Piewngam
Summary: Sulfated galactans (SG) isolated from G. fisheri, particularly SG-1, with an estimated molecular mass of 100 kDa, activate murine macrophages via the dectin-1 signaling pathway, enhancing nitric oxide secretion and mRNA levels of pro-inflammatory cytokines. Treatment with G. fisheri SG-1 displays immune-stimulatory activities comparable to or surpassing lipopolysaccharide treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Agriculture, Multidisciplinary
Xue-Ying Li, Yu-Jing Wang, Shun Chen, Li-Hua Pan, Qiang-Ming Li, Jian-Ping Luo, Xue-Qiang Zha
Summary: The present study demonstrated that LJP61A significantly reduced the lesion burden in atherosclerotic mice and alleviated lipid deposition in Ox-LDL-stimulated macrophages. Moreover, LJP61A enhanced autophagy-mediated macrophage polarization, leading to reduced inflammation and atherosclerosis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Igor A. Schepetkin, Marina G. Danilets, Anastasia A. Ligacheva, Evgenia S. Trofimova, Natalia S. Selivanova, Evgenii Yu. Sherstoboev, Sergei V. Krivoshchekov, Ekaterina I. Gulina, Konstantin S. Brazovskii, Liliya N. Kirpotina, Mark T. Quinn, Mikhail V. Belousov
Summary: Polysaccharides extracted from Saussurea plants have immunomodulatory activity, inducing nitric oxide production and activating cytokine secretion. These polysaccharides exert therapeutic effects by regulating leukocyte functions.
Article
Nutrition & Dietetics
Jiamei Cui, Yunpeng Wang, Eunyoung Kim, Chongyu Zhang, Guiguo Zhang, Yunkyoung Lee
Summary: This study investigated the structural characteristics and bioactivities of a novel long-chain LJPS derived from Laminaria japonica. The LJPS was found to consist of various monomer residues and was a multi-branched, long-chain macromolecule with highly branched and helix domains. The LJPS exhibited no toxicity to mouse macrophage cells and showed biphasic immuno-modulating capacity.
FRONTIERS IN NUTRITION
(2022)
Article
Food Science & Technology
Zhidong Liu, Zhifang Liu, Laihao Li, Junjie Zhang, Qiancheng Zhao, Na Lin, Wenzhu Zhong, Mei Jiang
Summary: This study evaluated the immunomodulatory effect of the polysaccharide from Sinonovacula constricta on RAW264.7 cells. The results showed that the polysaccharide enhanced the immune function of the cells and regulated the signaling pathways.
FOOD SCIENCE & NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Haitao Fan, Meng Sun, Jie Li, Shuofeng Zhang, Guangzhong Tu, Kechun Liu, Qing Xia, Yanyan Jiang, Bin Liu
Summary: A new polysaccharide, named SP800201, was isolated from Saposhnikoviae Radix. The polysaccharide consisted of monosaccharides including Gal, GalA, Ara, and Rha. Both cell and zebrafish experiments demonstrated the immunomodulatory activity of SP800201.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Food Science & Technology
Jiankuan Li, Yan Wang, Jiaojiao Ji, Lingya Cao, Yune Bai, Jianping Gao
Summary: The research identified a glucan named CPC from the roots of Codonopsis pilosula, with a structure of 1,4-linked alpha-D-glucose backbone and 1,6-linked beta-D-glucose branched chains. Additionally, CPC exhibited significant induction on immune-related indicators, indicating its potential benefits for regulating human immune health.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Agricultural Engineering
Zhi Huang, Min-Hua Zong, Wen-Yong Lou
Summary: This study investigated the structural features and immunomodulatory activities of a polysaccharide (MSCP1) from Millettia Speciosa Champ (M. speciose). MSCP1 was found to have a high molecular weight and consist of glucose and xylose. In vitro experiments showed that MSCP1 significantly enhanced macrophage activity and increased the release of nitric oxide and cytokines, suggesting its potential as an immunomodulatory agent.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Wen-Na Zhang, Li-Li Gong, Zhong-Bo Zhou, Min Sun, Yuan-Yuan Li, Jing-Wen Sun, Yan Chen
Summary: In this study, a new polysaccharide fraction HLP-1 was extracted from the fruiting bodies of Helvella leucopus and its structure and functions were investigated. The results indicated that HLP-1 had the potential to enhance immunity and could be applied in functional foods.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Lingrong Wen, Yueming Jiang, Xuesong Zhou, Huimin Bi, Bao Yang
Summary: Soybean peptides are functional foods with health benefits, with their structure playing a key role in determining these benefits. By identifying peptide structure and evaluating immunomodulatory activity, soybean peptides were found to facilitate macrophage proliferation.
Article
Food Science & Technology
Ruoxin Chen, Jingxiang Xu, Weihao Wu, Yuxi Wen, Suyue Lu, Hesham R. El-Seedi, Chao Zhao
Summary: This review explores the structure-activity relationship of polysaccharides, highlighting the contributions of molecular weight, monosaccharide composition, functional groups, types of glycoside bonds, conformation, and branching degrees to immunostimulatory activity. However, the limited purity and heterogeneity of polysaccharides pose challenges to studying their structure-activity relationships.
CURRENT RESEARCH IN FOOD SCIENCE
(2022)
Article
Plant Sciences
Meenakshi Bhardwaj, Sugumar Mani, R. Malarvizhi, Veeresh Kumar Sali, Hannah R. Vasanthi
Summary: The study showed that a sulfated polysaccharide extracted from marine algae has significant immunomodulatory effects in experimental rats, reducing systemic inflammation and possessing antioxidant and anti-inflammatory potential.
Review
Biotechnology & Applied Microbiology
Quang Nhat Tran, Il Tae Kim
Summary: Saccharina japonica, also known as Laminaria japonica or Phaeophyta japonica, has long been recognized as food and medicine in some Asian countries. Recently, it has also been considered a promising biofuel feedstock for energy and environmental solutions. This review focuses on the advances in bio-hydrogen production from S. japonica and discusses the future developments in this field.
FERMENTATION-BASEL
(2023)
Article
Engineering, Marine
Shanshan Wang, Yongwei Yan, Hao Qian, Jie Li, Tao Liu, Zhaolan Mo
Summary: This study investigated the dynamics of planktonic microbial community and its correlation with the environment during the seedling production stage of Saccharina japonica. The microbial richness was found to increase and positively correlate with light intensity and contents of NO3- and PO43-. The study also observed a clear temporal succession of the community and identified dominant taxa. The findings expanded our understanding of the planktonic microbial community in response to S. japonica cultivation.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2022)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)