Review
Polymer Science
Ioana A. A. Duceac, Sergiu Coseri
Summary: Chitosan is a unique polysaccharide with amine groups naturally occurring in its structure, making it a polycation suitable for preparing polyelectrolyte complexes or imine bonds gels. Hydrogels have advantages such as quick gelation, no need for crosslinking agents, and self-healing and injectability properties, which are of great importance in various applications.
Article
Biochemistry & Molecular Biology
Jonas Simon, Lukas Fliri, Janak Sapkota, Matti Ristolainen, Stephen A. Miller, Michael Hummel, Thomas Rosenau, Antje Potthast
Summary: The reductive amination of dialdehyde cellulose (DAC) with 2-picoline borane was investigated for its potential in producing bioderived thermoplastics. The effects of different side chains on the reaction were examined using microcrystalline cellulose as a model compound. The obtained insights were then applied to study the thermal properties of high-molecular-weight thermoplastics generated from 39%-oxidized softwood kraft pulp.
Article
Chemistry, Applied
Jonas Simon, Lukas Fliri, Felix Drexler, Markus Bacher, Janak Sapkota, Matti Ristolainen, Michael Hummel, Antje Potthast, Thomas Rosenau
Summary: Periodate oxidation of cellulose to produce dialdehyde cellulose (DAC) has attracted increasing attention in sustainable materials development. However, there is a large variation in the proposed preparation and work-up protocols, decreasing comparability and causing reproducibility problems. This study critically examined and compared two prevalent work-up protocols, glycol quenching and filtration/washing. The findings suggest that simple washing protocols are recommended instead of glycol quenching to prevent side reactions and organic contaminations.
CARBOHYDRATE POLYMERS
(2023)
Article
Materials Science, Paper & Wood
Martin Chewe Sichinga, Timothy Kline, M. A. Whitehead, Theo G. M. van de Ven
Summary: The development of an environmentally sensitive and cost-effective method for producing multi-functionalized cellulose fibers has led to the synthesis of imine carboxymethyl dialdehyde modified cellulose fibers (ICDAMF). This approach allows for the integration of desirable functional groups, such as carboxyl groups for gel formation and aldehyde groups for covalent adsorption of diamine dyes. The ICDAMF has potential use in textiles, where it can prevent the leaching of dyes and reduce environmental pollution.
Article
Materials Science, Paper & Wood
Mohamed Hasanin, Amr H. Hashem, Ahmed A. El-Rashedy, Samir Kamel
Summary: New amino heterocyclic cellulose derivatives were prepared and showed potential antimicrobial and antitumor activities. Molecular dynamics study revealed the selective targeting of ATP binding pocket residues by these compounds, providing a structure basis for understanding c-Kit kinase auto-inhibition.
Article
Biochemistry & Molecular Biology
Yang Xu, Yongjian Xu, Wenhuan Deng, Hao Chen, Jianhua Xiong
Summary: A comparative study on the extraction of Dialdehyde cellulose nanocrystals (DCNC) using NaIO4 pre-oxidation and synchronous oxidation was conducted. It was found that ring-liked and rod-liked DCNC with different micromorphology and oxidation degree can be obtained through optimized deep eutectic solvent treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Paper & Wood
Jonas Simon, Lukas Fliri, Flavia Froehlich, Janak Sapkota, Matti Ristolainen, Michael Hummel, Thomas Rosenau, Antje Potthast
Summary: Borohydride reduction of dialdehyde cellulose is a promising strategy for producing bio-based dialcohol cellulose. However, degradation of the polymer backbone limits its practical applications. This study aimed to optimize the reduction process by adjusting reaction time, pH, and reagent stoichiometry to suppress degradation reactions. The degree of oxidation significantly affects the yields and molecular weights of the dialcohol cellulose products, with a leveling-off effect at higher oxidation degrees. Increasing the amount of sodium borohydride can minimize chain scissions, while lowering the pH slows down degradation but affects conversion of aldehyde functionalities. This study provides insights into side reactions during borohydride reduction of dialdehyde cellulose and the chemistry of the dialdehyde cellulose/dialcohol cellulose system.
Article
Biochemistry & Molecular Biology
Peter N. Kariuki, Yasothai Arjunan, Usharani Nagarajan, Swarna V. Kanth
Summary: Through a four-step process, native tapioca starch was converted into dialdehyde tapioca starch (DTS) with ideal properties for various applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Jonas Simon, Otgontuul Tsetsgee, Nohman Arshad Iqbal, Janak Sapkota, Matti Ristolainen, Thomas Rosenau, Antje Potthast
Summary: The properties of dialdehyde celluloses are highly dependent on the aldehyde content, and the current methods for determining the aldehyde content lack simplicity and speed. This study proposes a new approach using near-infrared and Fourier-transform infrared spectroscopy, combined with partial least squares regression, to quickly and reliably predict the aldehyde content of dialdehyde celluloses.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Hamidreza Mozafari, Mohammad Hojjatoleslamy, Mohammadreza Mohammadizadeh
Summary: The Zodo gum exudated by Amygdalus scoparia spach was chemically modified through periodate oxidation to produce dialdehyde Zodo gum (DZG). Factors such as sodium periodate volume, temperature, pH, and time were considered in modifying the properties of Zodo gum. Optimal conditions were determined for the production of different samples with varying dialdehyde content, with H-1-C-13 NMR, FTIR, and rheological parameters used to evaluate the results.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Multidisciplinary
Jonas Simon, Inge Schlapp-Hackl, Janak Sapkota, Matti Ristolainen, Thomas Rosenau, Antje Potthast
Summary: In this study, the glass transition temperature (Tg) of dialdehyde cellulose derivatives was successfully tailored by adjusting the degree of oxidation and introducing different side chains, providing a strategy for developing sustainable thermoplastics.
Article
Biochemistry & Molecular Biology
Elahe Nosouhian, Mohammad Hojjatoleslamy, Mohammad Goli, Maryam Jafari, Hossein Kiani
Summary: This study utilized response surface methodology (RSM) to determine the optimal point of basil seed oxidation by considering temperature, pH, and time as factors. The resulting dialdehyde basil seed gum (DBSG) was analyzed and its physicochemical properties were determined. The study found that the optimal conditions for producing DBSG with the highest aldehyde percentage and viscosity were a pH of 3, temperature of 45 degrees C, and a time of 3 hours. Further analysis revealed the formation of dialdehyde groups and over-oxidation in some samples, which could impact their industrial applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Ksenia A. Sapozhnikova, Evgeny L. Gulyak, Vladimir A. Brylev, Vsevolod A. Misyurin, Sergey D. Oreshkov, Anastasiya V. Alexeeva, Dmitry Yu. Ryazantsev, Maria A. Simonova, Ekaterina V. Ryabukhina, Galina P. Popova, Nataliya A. Tikhonova, Natalia A. Lyzhko, Alexander E. Barmashov, Andrey V. Misyurin, Alexey V. Ustinov, Vera A. Alferova, Vladimir A. Korshun
Summary: A universal approach to construct antibody-drug conjugates (ADCs) has been developed by oxidizing glycans and utilizing ligation and cycloaddition reactions for conjugation. This method allows for the synthesis of cytotoxic conjugates targeting tumor-associated antigens. The conjugates showed varying cytotoxicity in vitro, with one specific conjugate demonstrating activity against PRAME-expressing cancer cell lines, making it the first reported PRAME-targeting ADC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Jingfeng Zhao, Yuhang Chen, Chucheng Shao, Jiang Liu, Genyu Zhu, Xuefeng Zhou
Summary: By using classical molecular dynamics simulations, it was demonstrated that the atomic bonds in the interconnecting zones (i-zones) of Zr55Cu35Al10 alloy became loose and formed free volumes when the temperature approached the glass transition temperature (Tg). The separation of clusters by free volume networks resulted in the conversion of the solid amorphous structure into a supercooled liquid state, leading to a significant reduction in strength and a transition from limited plastic deformation to superplasticity.
SCIENTIFIC REPORTS
(2023)
Article
Polymer Science
Cong Du, Xin Ning Zhang, Tao Lin Sun, Miao Du, Qiang Zheng, Zi Liang Wu
Summary: The study introduces a series of poly(acrylamide-co-methacrylic acid) hydrogels with moderate water contents and excellent mechanical properties, synthesized by free-radical copolymerization. The mechanical properties of the hydrogels vary with the feeding molar fraction of acrylamide. Gels with a molar fraction of 0.2-0.35 exhibit high toughness and stability in water due to dense hydrogen bonds and high segment rigidity.
Article
Radiology, Nuclear Medicine & Medical Imaging
Hana Dobsicek Trefna, Saul Llacer Navarro, Fredrik Lorentzon, Tiina Nypelo, Anna Strom
Summary: Tissue mimicking phantom materials with thermal and dielectric equivalence are crucial for microwave diagnostics and treatment. By using nanocellulose in gelatin stabilized emulsions to mimic fat tissue, the study showed promising results in reducing the temperature dependence of moduli and meeting quality assurance guidelines, indicating the potential for development in microwave diagnostics and treatment.
BIOMEDICAL PHYSICS & ENGINEERING EXPRESS
(2021)
Article
Biochemistry & Molecular Biology
Vishnu Arumughan, Tiina Nypelo, Merima Hasani, Anette Larsson
Summary: This study investigates the effect of Ca2+ ions on the properties of CMC solutions and their impact on cellulose nanofibers (CNFs). The presence of Ca2+ was found to facilitate multichain association of CMC chains and increase the hydrodynamic diameter. The study suggests that the adsorption of CMC at high concentrations of CaCl2 is mainly governed by changes in solution properties rather than changes in the cellulose surface.
Article
Chemistry, Applied
Robin Nilsson, Martina Olsson, Gunnar Westman, Aleksandar Matic, Anette Larsson
Summary: This study investigated the effects of side chain structures on the glass transition temperature and water interactions in cellulose esters. The results showed that the glass transition temperature decreased with increased side chain length, and the solubility and penetration of water in the cellulose esters decreased as well.
CARBOHYDRATE POLYMERS
(2022)
Article
Polymer Science
Roujin Ghaffari, Henrik Almqvist, Robin Nilsson, Gunnar Liden, Anette Larsson
Summary: This study investigated the diffusion of kraft lignin molecules through model cellulose membranes of varying pore sizes. The results showed that small pore sizes enable the diffusion of small molecules while hindering the transport of larger molecules or clusters. This study provides important insights into the mass transfer events in pulping processes.
Article
Engineering, Chemical
Ruchi Aggarwal, Anjali Kumari Garg, Deepika Saini, Sumit Kumar Sonkar, Amit Kumar Sonker, Gunnar Westman
Summary: Cellulose nanocrystals (CNCs) with good adsorption capacity were synthesized by acid hydrolysis of microcrystalline cellulose (MCC) and characterized for their chemical composition and functionality. Sulfated CNCs showed effective removal of toxic dyes and high adsorption capacity, demonstrating potential for industrial application.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2022)
Review
Agriculture, Multidisciplinary
Felix Abik, Chonnipa Palasingh, Mamata Bhattarai, Shaun Leivers, Anna Strom, Bjorge Westereng, Kirsi S. Mikkonen, Tiina Nypelo
Summary: Holistic utilization of all wood biomass is crucial for efficient forest resource use. Wood hemicelluloses, structurally similar to those from crops, have potential as food ingredients, but their applications are limited. This review explores the extraction processes, properties, and potential gastrointestinal effects of wood hemicelluloses, as well as the regulatory approval process and current applications in the food industry.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Patric Elf, Husamettin Deniz Ozeren, Per A. A. Larsson, Anette Larsson, Lars Wagberg, Robin Nilsson, Poppy Thanaporn Chaiyupatham, Mikael S. S. Hedenqvist, Fritjof Nilsson
Summary: The development of wood-based thermoplastic polymers that can replace synthetic plastics is environmentally important. This study used molecular dynamics simulations and experiments to investigate the influence of ring opening on the properties of dialcohol cellulose and how temperature and water affect these properties. The simulations showed that ring opening had a higher impact on providing molecular mobility at high temperatures, which was also observed in experiments. This opening had the strongest effect on processability above the glass transition temperature and in wet conditions, and it also lowered the glass transition temperature. The results demonstrate the valuable use of molecular dynamics in developing wood-based materials with optimal thermoplastic properties.
Article
Oncology
Mattia De Lazzari, Anna Strom, Laura Farina, Nuno P. Silva, Sergio Curto, Hana Dobsicek Trefna
Summary: Background phantoms mimicking human tissue properties are crucial for the development and quality assurance of equipment used in Hyperthermia Treatment. A fat-mimicking material based on glycerol-in-oil emulsion stabilized with ethylcellulose was proposed and its properties were assessed. The phantom demonstrated equivalent dielectric and thermal properties to fat tissue, with good mechanical stability. It was proven suitable for quality assurance procedures, although further investigation is needed for electrical heating devices.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2023)
Article
Chemistry, Multidisciplinary
Sylwia Wojno, Amit Kumar Sonker, Jelka Feldhusen, Gunnar Westman, Roland Kadar
Summary: Nonlinear material parameters are more sensitive than linear viscoelastic parameters to the onset of weakly interconnected networks in cellulose nanocrystal(CNC) isotropic suspensions. All surface-modified CNC suspensions resulted in isotropic gels. The length of the grafted chains and the degree of branching were the primary factors influencing the nonlinear material response.
Article
Chemistry, Multidisciplinary
Alexander Riddell, Jonna Hynynen, Francisco Baena-Moreno, Abdenour Achour, Gunnar Westman, Jim Parkas, Diana Bernin
Summary: The conversion of lignin into valuable chemical products is important for sustainable biorefineries. Photochemical methods offer the potential for efficient and selective lignin depolymerization. In this study, the effects of the photosensitizer benzophenone on the photochemical conversion of lignin and 2-(benzyloxy)phenol were investigated. The results showed differences in the reactions with and without benzophenone, indicating the formation of different products. Depolymerization of lignin into smaller fragments was confirmed using diffusion NMR, with or without the photosensitizer.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Nanoscience & Nanotechnology
Ruchi Aggarwal, Anjali Kumari Garg, Vishrant Kumar, Harshita Jonwal, Sonia Sethi, Srushti Gadiyaram, Sumit Kumar Sonkar, Amit Kumar Sonker, Gunnar Westman
Summary: A two-step viable synthetic approach for quick and energy-efficient acid-based charring is explained to produce self-passivated fluorescent water-soluble CD (wsCD) from sustainable microcrystalline cellulose (MCC) materials. The wsCD solution exhibits blue emission under UV-light and has a fluorescence quantum yield of approximately 6%. The wsCD are used for selective sensing of ofloxacin (OFLX) and have shown mild antifungal activity.
ACS APPLIED NANO MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Amit Kumar Sonker, Shizhao Xiong, Ruchi Aggarwal, Martina Olsson, Arnita Spule, Seyedehsan Hosseini, Sumit Kumar Sonkar, Aleksandar Matic, Gunnar Westman
Summary: This study presents an efficient method for exfoliating MoS2 in water and using it as an electrode material. The MoS2 is exfoliated through sonication with sulfated cellulose nanocrystals, resulting in a stable water suspension. The exfoliated MoS2 is then used in a zinc battery electrode, demonstrating a Coulombic efficiency of 90%. The success of exfoliation is confirmed by Raman and transmission electron microscopy.
ACS APPLIED NANO MATERIALS
(2023)
Article
Materials Science, Composites
Seyedehsan Hosseini, Robin Nilsson, Anna Strom, Anette Larsson, Gunnar Westman
Summary: Alkyl ketene dimers (AKDs) modify thermomechanical pulp (TMP) fibers, improving their compatibility and flow properties with polypropylene (PP) in composite materials.
POLYMER COMPOSITES
(2023)
Article
Chemistry, Physical
Roujin Ghaffari, Vishnu Arumughan, Anette Larsson
Summary: This study examines the effects of ions on the adsorption and mass transfer behavior of lignin molecules. The results show that highly hydrated sulfate ions at high concentrations decrease the mass transfer rate of lignin, while less hydrated nitrate ions increase lignin's adsorption onto the cellulose surface.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2024)
Article
Nanoscience & Nanotechnology
Parveen Kumar Deralia, Aline Maire du Poset, Anja Lund, Anette Larsson, Anna Strom, Gunnar Westman
Summary: Developing flexible materials for packaging and stretchable electronic applications from polysaccharide-based polymers contributes to the transition to a circular bioeconomy. By exploring the relationship between structural composition, thermal processing, and thermomechanical properties of arabinoxylan-based thermoplastics, this study provides insights into the development of bio-based products for various applications. The superior elongation of the AX thermoplastic films and the impact of molar substitution and T-g on the properties highlight the potential for utilizing polysaccharide-based polymers in engineering bio-based materials.
ACS APPLIED BIO MATERIALS
(2021)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)