Article
Pharmacology & Pharmacy
Peng Deng, Ge Sun, Jie Zhao, Kaitai Yao, Miaomiao Yuan, Lizeng Peng, Longfei Mao
Summary: Cervical cancer is a significant cause of cancer-related death and a major public health problem in many countries. In this study, 14 erlotinib-linked 1,2,3-triazole compounds were designed, synthesized, and evaluated for their anti-tumor activity against cervical cancer. Results showed that six of these compounds exhibited remarkable inhibitory activity against human cervical cancer cells in vitro. Additionally, three of the compounds induced apoptosis and cell cycle arrest in the cancer cells. These findings suggest that the erlotinib-linked 1,2,3-triazole compounds have potential as effective anticancer agents against cervical cancer.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Renata Maria Costa Souza, Lilian Maria Lapa Montenegro Pimentel, Laryssa Kathleen Mendonca Ferreira, Valeria Rego Alves Pereira, Aline Caroline Da Silva Santos, Willyenne Marilia Dantas, Carla Jasmine Oliveira Silva, Ramayana Morais De Medeiros Brito, Jose Lucas Andrade, Valter Ferreira De Andrade-Neto, Ricardo Toshio Fujiwara, Lilian Lacerda Bueno, Valdemiro Amaro Silva Junior, Lindomar Pena, Celso Amorim Camara, Brijesh Rathi, Ronaldo Nascimento De Oliveira
Summary: This study evaluated the antimalarial activities of 2-amino-1,4-naphthoquinone derivatives (containing 1,2,3-triazole) in both in vitro and in vivo models. The results showed that two compounds exhibited antimalarial activity, suggesting their potential value in drug discovery platform.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Zhong-jie Xu, Ying-jie Zhou, Jia-hao Wang, Long-fei Mao, Wei Li, Gui-qing Xu
Summary: In this study, acenaphthylene was used as the raw material to synthesize a series of novel 1,8-naphthalimide-1,2,3-triazole derivatives, which were then tested for their anti-tumor activities. Compound 5e exhibited good activity against H1975 lung cancer cells, with an IC50 of 16.56 mu M.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Emer M. Foyle, Nicholas G. White
Summary: The use of 1,2,3-triazole and triazolium motifs to construct anion templated supramolecular structures has grown rapidly over the past decade, enabling a range of complex structures to be synthesized, especially in areas such as foldamers, polymers, and interlocked systems.
CHEMISTRY-AN ASIAN JOURNAL
(2021)
Article
Agriculture, Multidisciplinary
Xue Yin, Lili Wang, Shaoli Liu, Yahui Li
Summary: This study synthesized and evaluated the fungicidal activity of 27 distinct 2-Ar-substituted-1,2,3-triazole derivatives. Twelve of them showed better performance than the positive control in the fungal test, indicating their potential as novel antifungal agents. Further investigation is warranted to explore their antifungal mechanisms and potential as lead compounds.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Oriol Bosch-Sanz, Yvette Rabada, Xevi Biarnes, Javier Pedreno, Luis Caveda, Mercedes Balcells, Jordi Martorell, David Sanchez-Garcia
Summary: Fibrinolysis is a natural process that removes fibrin deposits to ensure blood fluidity. Excessive fibrinolytic activity can cause complications in surgery or trauma. Current antifibrinolytic drugs require high doses and have side effects, limiting their use in patients with renal impairment. This study synthesized a series of compounds and identified a candidate with higher specificity and lower dosage. Molecular docking and dynamics analysis revealed the importance of 1,2,3-triazole in the activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Fernanda Valerio Lopes, Pedro Henrique Fazza Stroppa, Juliane Aparecida Marinho, Roberta Reis Soares, Lara de Azevedo Alves, Priscila Vanessa Zabala Capriles Goliatt, Clarice Abramo, Adilson David da Silva
Summary: This study evaluated the antimalarial activity of triazole derivatives, with compound 5 showing promising potential for further development in antimalarial chemotherapy. In vitro and in vivo studies showed that compound 5 had significant parasitemia suppression and minimal cytotoxicity, making it a leading candidate for future research in antimalarial drug development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Han Luo, Yong-Feng Lv, Hong Zhang, Jiang-Miao Hu, Hong-Mei Li, Shou-Jin Liu
Summary: A new series of mollugin-1,2,3-triazole derivatives were synthesized using a copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition reaction, and most of them demonstrated cytotoxicity on five human cancer cell lines, with compounds 14 and 17 showing significant cytotoxicity across all five cancer cell lines.
Article
Agriculture, Multidisciplinary
Cristiane Aparecida Franco, Toshik Iarley da Silva, Marlon Gomes Dias, Bruno Wesley Ferreira, Bianca Lana de Sousa, Guilherme Mateus Bousada, Robert Weingart Barreto, Boniek Gontijo Vaz, Gesiane da Silva Lima, Marcelo Henrique dos Santos, Jose Antonio Saraiva Grossi, Eduardo Vinicius Vieira Varejao
Summary: A series of tyrosol 1,2,3-triazole derivatives were synthesized and tested for phytotoxic activity on wild poinsettia, fleabane, and tropical spiderwort. While none of the compounds showed activity against two of the weed species, they exhibited strong phytotoxic effects on wild poinsettia, indicating their potential use as tools for managing this competitive weed in agricultural lands.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Physical
Hima Bindhu Joolakanti, Ramanjaneyulu Kamepalli, Jeevanreddy Miryala, Satyanarayana Battu
Summary: The study identified a series of N-(3-((1H-1,2,3-triazol-4-yl)methoxy)phenyl)acetamide derivatives as potential compounds targeting Estrogen Receptor Alpha, with excellent bioactivity demonstrated in cell experiments.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Biochemistry & Molecular Biology
Lijie Wei, Haishan Sui, Jingjing Zhang, Zhanyong Guo
Summary: A novel inulin derivative (3) bearing 1,2,3-triazole and diphenyl phosphate was successfully synthesized using CuAAC Click chemistry, showing significantly enhanced antioxidant activity compared with inulin. In vitro evaluation revealed strong radical scavenging abilities of the derivative, particularly against hydroxyl radicals and superoxide radicals. The synthetic strategy may offer an effective approach for preparing new inulin antioxidant biomaterials.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Organic
Tomas Horsten, Flip de Jong, Dries Theunissen, Mark Van der Auweraer, Wim Dehaen
Summary: This study explored the potential of 1,2,3-triazolium salts for the formation of water-soluble chromophores. The synthesis of water-soluble 1,2,3-triazolium BOPAHY dyes was achieved by a metal-free pathway.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Mauricio Alcolea Palafox, Nataliya P. Belskaya, Lozan T. Todorov, Irena P. Kostova
Summary: In this study, a 1,2,3-triazole derivative with potential anticancer activity was used as a ligand to form a complex with the lanthanum(III) ion. The molecular structure and vibrational spectra of the complex were analyzed using computational methods and compared to experimental data. The best method for predicting the structure was found to be M06-2X with the Lanl2mb basis set. Additionally, the antioxidant activity and mechanisms of the complex were investigated.
Article
Agriculture, Multidisciplinary
Angela Maria Almeida Lima, Robson Ricardo Teixeira, Willian Bucker Moraes, Matheus Ricardo Rocha, Arlan Figueiredo Carvalho Moraes, Samela Cansi Gomes, Poliana Rodrigues Gazolla, Silma Francielle Silva, Vagner Tebaldi Queiroz, Victor Rocha Fonseca, Wanderson Romao, Pedro Alves Bezerra Morais, Valdemar Lacerda, Lucas Magalha de Abreu, Fabricio Marques Oliveira, Osmair Vital de Oliveira, Adilson Vidal Costa
Summary: This study describes the preparation and fungicidal activity evaluation of 12 glycerol derivatives bearing 1,2,3-triazole fragments. The results showed that the glycerol derivatives significantly inhibited conidial germination of Asperisporium caricae, the etiological agent of papaya black spot. Compound 4c exhibited the most active inhibitory effect and improved the severity of black spots on papaya fruits.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Joao Vitor da Silva Rodrigues, Poliana Aparecida Rodrigues Gazolla, Iago da Cruz Pereira, Roberto Sousa Dias, Italo Esposti Poly da Silva, John Willians Oliveira Prates, Isabela de Souza Gomes, Sabrina de Azevedo Silveira, Adilson Vidal Costa, Fabricio Marques de Oliveira, Alex Ramos de Aguiar, Cynthia Canedo da Silva, Robson Ricardo Teixeira, Sergio Oliveira de Paula
Summary: This article describes the preparation of a series of 1,2,3-triazole compounds derived from the natural product vanillin and evaluates their antiviral activity against the Zika virus. One compound (compound 8) demonstrated effective inhibition of the virus and blocked infection in vitro by acting on the viral particle. These findings are significant for the development of new chemical agents to treat Zika syndrome.
ANTIVIRAL RESEARCH
(2023)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)