Article
Biotechnology & Applied Microbiology
Gen Li, Yin Zhang, Jiezhou Wu, Renhao Yang, Qi Sun, Yidong Xu, Bo Wang, Ming Cai, Yang Xu, Chengyu Zhuang, Lei Wang
Summary: This study explores the effects and mechanism of adipose stem cells-derived exosomes (ADSCs-Exos) and ADSCs-Exos modified tissue engineering scaffold on bone defect repair. The results demonstrate that ADSCs-Exos promote the proliferation, migration, and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), and ADSCs-Exos modified scaffold enhances the repair of BMSCs and bone defects both in vitro and in vivo.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Samira Tajvar, Afra Hadjizadeh, Saeed Saber Samandari
Summary: Successful bone tissue engineering requires 3D scaffolds with controllable properties tailored to specific clinical applications. Scaffold degradation, which must match the rate of host tissue regeneration, has been identified as a major challenge. This review focuses on the degradation mechanisms and approaches used to control the degradation rate of bone scaffold materials.
INTERNATIONAL BIODETERIORATION & BIODEGRADATION
(2023)
Review
Chemistry, Applied
Chuntao Chen, Weixiao Ding, Heng Zhang, Lei Zhang, Yang Huang, Mengmeng Fan, Jiazhi Yang, Dongping Sun
Summary: This article provides a review of the research advancement and applications of BC-based biomaterials in the field of biomedicine. It includes the modifications and generation of BC-based composites using nanotechnology. The preparation methods and potential applications of these materials are summarized and discussed in detail, with a focus on important factors such as degradation and pore structure characteristic. Furthermore, the challenges and potential advances in future development are also discussed.
CARBOHYDRATE POLYMERS
(2022)
Review
Chemistry, Medicinal
Teerawat Sukpaita, Suwabun Chirachanchai, Atiphan Pimkhaokham, Ruchanee Salingcarnboriboon Ampornaramveth
Summary: This review provides an overview of chitosan-based biomaterials for bone tissue engineering and their applications in treating bone defects. The focus is on the characteristics of chitosan, scaffold fabrication processes, advantages and disadvantages, and future directions in the field.
Review
Biotechnology & Applied Microbiology
Zimu Mao, Baoshi Fan, Xinjie Wang, Ximeng Huang, Jian Guan, Zewen Sun, Bingbing Xu, Meng Yang, Zeyi Chen, Dong Jiang, Jiakuo Yu
Summary: The use of tissue engineering scaffold, especially biomaterials, has shown significant effectiveness in tendon-bone healing and can be enhanced by biological interventions. Current research is mainly focused on animal models, calling for further clinical trials to explore the full potential of these approaches in clinical practice.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Helida Gomes de Oliveira Barud, Robson Rosa da Silva, Marco Antonio Costa Borges, Guillermo Raul Castro, Sidney Jose Lima Ribeiro, Hernane da Silva Barud
Summary: Bacterial cellulose (BC) is a natural polymer with biocompatibility and low cost, making it suitable for various biomedical applications such as artificial blood vessels and wound dressings. Despite its wide applicability in biomedicine, there is a lack of updated scientific reports on its dental applications, which have great potential for further exploration.
Review
Biotechnology & Applied Microbiology
V. K. Anupama Devi, Anjaneyulu Udduttula, Amit Kumar Jaiswal
Summary: Biomedical uses for natural polysaccharides of marine origin, including fucoidan derived from brown algae, are gaining popularity. Despite being less researched compared to other biomaterials, fucoidan is more accessible and cost-effective. This review provides an overview of its history, sources, and characteristics, with a focus on its application in bone tissue engineering. The global research status of fucoidan, especially for bone tissue engineering, is examined, making this study a comprehensive manual for understanding its research status.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Igor Rzhepakovsky, Sergey Piskov, Svetlana Avanesyan, Marina Sizonenko, Lyudmila Timchenko, Oxana Anfinogenova, Andrey Nagdalian, Andrey Blinov, Evgeniya Denisova, Stanislav Kochergin, Sergey Kubanov, Magomed Shakhbanov, Mohammad Ali Shariati, Mohammad S. Mubarak
Summary: Pure and porous bacterial cellulose scaffolds were synthesized using Medusomyces gisevii Sa-28 bacterial strain. Modification with gelatin increased the biocompatibility and solubility of the scaffolds. The scaffolds exhibited uniform distribution of pores, promoting new blood vessel growth and collagen fiber formation. The results suggest that these scaffolds can be used for engineering hard and soft tissues.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Nanoscience & Nanotechnology
Lijia Cheng, Shoma K. Suresh, Hongyan He, Ritu Singh Rajput, Qiyang Feng, Saravanan Ramesh, Yuzhuang Wang, Sasirekha Krishnan, Serge Ostrovidov, Gulden Camci-Unal, Murugan Ramalingam
Summary: Recent advancements in 3D printing technology show great potential in fabricating scaffolds and implants for biomedical applications, particularly in bone repair and regeneration. The integration of different living cells in 3D constructs made from conventional biomaterials can create artificial bone grafts capable of regenerating damaged tissues. Various conventional and nanomaterials have been utilized in the production of 3D-printed scaffolds for bone tissue engineering applications.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Polymer Science
Banafsheh Safari, Marziyeh Aghazadeh, Leila Roshangar, Ayuob Aghanejad, Soodabeh Davaran
Summary: This study reports the fabrication and evaluation of a bioactive hybrid scaffold collagen/P-PCL for bone tissue engineering. The scaffold showed biocompatibility, osteoconductivity, and osteoinductivity, supporting the proliferation and differentiation of AD-MSCs.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Polymer Science
Mark-Jefferson Buer Boyetey, Selorm Torgbo, Prakit Sukyai
Summary: Bio-based biomaterials, such as bacterial cellulose (BC) and hydroxyapatite (HA), show promise for bone tissue engineering due to their renewable nature and bioactivity. This review discusses the biosynthesis and modification of BC, as well as the use of bioceramics like HA to enhance its properties. The application of growth factors and immobilization strategies are also explored for their potential in improving bioactivity. Additionally, the development of modern additive manufacturing techniques like 3D bioprinting holds great potential for tailor-made materials in tissue engineering.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Agricultural Engineering
Chotiwit Sriwong, Suwimon Boonrungsiman, Prakit Sukyai
Summary: Biocomposite cellulose-based scaffolds combined with hydroxyapatite were successfully developed from sugarcane bagasse for tissue engineering. The scaffolds showed appropriate porosity and low degradation rate. Cell viability, proliferation, and differentiation experiments demonstrated that the cellulose combined HA scaffolds promoted the growth and differentiation of bone cells. The results indicated that sugarcane bagasse-derived cellulose is an ideal material for bone scaffolding applications.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Review
Biochemistry & Molecular Biology
Pawel Dec, Andrzej Modrzejewski, Andrzej Pawlik
Summary: The treatment of bone defects is a major challenge in modern clinical practice due to the increased incidence of bone disease. Biomaterials play a crucial role in bone tissue engineering and their selection is a key issue in designing tissue scaffolds for patient-specific regeneration. This article provides a comprehensive literature review of existing and novel biomaterials, highlighting their advantages and disadvantages for bone defect regeneration. The materials are categorized into organic, inorganic, and synthetic polymers, considering current trends in the field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biotechnology & Applied Microbiology
Jiang-Nan Fu, Xing Wang, Meng Yang, You-Rong Chen, Ji-Ying Zhang, Rong-Hui Deng, Zi-Ning Zhang, Jia-Kuo Yu, Fu-Zhen Yuan
Summary: This article reviews the advances in osteochondral tissue engineering and discusses various strategies including scaffold design, material types, fabrication techniques, and functional properties. Although there are still challenges and difficulties, research in this field is of great importance for repairing OC defects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Rui-Chian Tang, Lily Shang, Philip O. Scumpia, Dino Di Carlo
Summary: Researchers have developed a novel crescent-shaped hydrogel scaffold with a microporous structure that allows for improved cell infiltration and expansion. With the use of microfluidic fabrication, the size of the cavities in the scaffold can be adjusted, leading to enhanced cellular network formation in vitro and in vivo. The results suggest that this new scaffold has the potential for superior functionality in tissue engineering applications.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Multidisciplinary
Sanming Hu, Zhijun Shi, Weiwei Zhao, Li Wang, Guang Yang
COMPOSITES PART B-ENGINEERING
(2019)
Article
Materials Science, Characterization & Testing
Saba Gul, Nasrullah Shah, Muhammad Balal Arain, Nida Rahman, Touseef Rehan, Mazhar Ul-Islam, Muhammad Wajid Ullah, Guang Yang
Article
Materials Science, Biomaterials
Ana M. R. Rebelo, Yang Liu, Changqing Liu, Karl-Herbert Schaefer, Monika Saumer, Guang Yang
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2019)
Editorial Material
Biotechnology & Applied Microbiology
Ronan R. McCarthy, Muhammad Wajid Ullah, Eujin Pei, Guang Yang
TRENDS IN BIOTECHNOLOGY
(2019)
Article
Oncology
Suliman Khan, Muhammad Wajid Ullah, Rabeea Siddique, Yang Liu, Ismat Ullah, Mengzhou Xue, Guang Yang, Hongwei Hou
FRONTIERS IN ONCOLOGY
(2019)
Review
Biotechnology & Applied Microbiology
Ronan R. McCarthy, Muhammad Wajid Ullah, Peter Booth, Eujin Pei, Guang Yang
BIOTECHNOLOGY ADVANCES
(2019)
Article
Biochemistry & Molecular Biology
Mazhar Ul-Islam, Fazli Subhan, Salman Ul Islam, Shaukat Khan, Nasrullah Shah, Sehrish Manan, Muhammad Wajid Ullah, Guang Yang
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2019)
Article
Engineering, Biomedical
Raju Panday, Ahmed Mohammed Elamin Abdalla, Miao Yu, Xiaohong Li, Chenxi Ouyang, Guang Yang
JOURNAL OF BIOMATERIALS APPLICATIONS
(2020)
Article
Immunology
Ayman Ahmad Al Kraiem, Yingchun Zeng, Xixiang Huo, Kun Yang, Fand Al Kraiem, Jingliang Qin, Yujun Cui, Biao Kan, Meiying Yan, Guang Yang, Tie Chen
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2019)
Article
Materials Science, Biomaterials
Xiaohong Li, Xiongfa Ji, Kun Chen, Xi Yuan, Zehua Lei, Muhammad Wajid Ullah, Jun Xiao, Guang Yang
Summary: The study developed a new drug delivery system with high drug loading and sustained release capabilities, which showed excellent biocompatibility and efficient drug loading for potential treatment of hepatocellular carcinoma.
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Engineering, Biomedical
Lin Mao, Li Wang, Mingyue Zhang, Muhammad Wajid Ullah, Li Liu, Weiwei Zhao, Ying Li, Abeer Ahmed Qaed Ahmed, Haoyan Cheng, Zhijun Shi, Guang Yang
Summary: The multifunctional nanocomposite hydrogels based on bacterial cellulose, gelatin, and selenium nanoparticles showed excellent antibacterial, antioxidant, and anti-inflammatory capabilities, as well as promising wound healing performance in a rat full-thickness defect model. The hydrogels demonstrated superior mechanical properties, good swelling ability, flexibility, biodegradability, and biocompatibility, making them a great potential wound dressing for preventing infection and accelerating skin regeneration in clinic.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Engineering, Biomedical
Xiaohong Li, Xiongfa Ji, Kun Chen, Muhammad Wajid Ullah, Basen Li, Jiameng Cao, Lin Xiao, Jun Xiao, Guang Yang
Summary: This study successfully developed radiopaque and hemostatic microspheres by synthesizing barium sulfate nanoparticles with local procoagulant activity. The microspheres demonstrated significant hemostatic capacity and superior embolization effects in both in vitro and in vivo experiments.
BIOACTIVE MATERIALS
(2021)
Review
Microbiology
Alexander I. Netrusov, Elena V. Liyaskina, Irina V. Kurgaeva, Alexandra U. Liyaskina, Guang Yang, Viktor V. Revin
Summary: This review summarizes the importance, properties, and applications of bacterial exopolysaccharides (EPS) in various fields. It provides an overview of the current research progress on EPS, including their biological functions, production methods, and isolation sources of EPS-producing bacterial strains. The review also highlights the latest advances in the study of industrial exopolysaccharides such as xanthan, bacterial cellulose, and levan, as well as discusses current study limitations and future directions.
Review
Chemistry, Multidisciplinary
Biaou O. Ode Boni, Lallepak Lamboni, Tiatou Souho, Mario Gauthier, Guang Yang
MATERIALS HORIZONS
(2019)
Correction
Materials Science, Biomaterials
Ying Li, Hua Jiang, Wenfu Zheng, Niya Gong, Lili Chen, Xingyu Jiang, Guang Yang
JOURNAL OF MATERIALS CHEMISTRY B
(2019)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
