期刊
CARBOHYDRATE POLYMERS
卷 106, 期 -, 页码 101-108出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2014.02.017
关键词
Low-molecular-weight succinoglycans; Sinorhizobium meliloti; Pindolol; Solubility enhancement; Cyclodextrin; Complexation
资金
- Priority Research Centers Program through the National Research Foundation of Korea - Korean Government (Ministry of Education, Science and Technology [NRF2009-0093824, NRF-2013R1A1A2012568]
- National Research Foundation of Korea - Korean Government [NRF-2011-619-E0002]
The low-molecular-weight succinoglycans isolated from Sinorhizobium meliloti are repeating octasaccharide units consisting of monomers, dimers, and trimers. Pindolol is a beta-blocker used to treat cardiovascular disorders. We investigated the formation of complexes between pindolol and lowmolecular-weight succinoglycan monomers (SGs). Even though SGs have a linear structure, the solubility of pindolol in the presence of SGs was increased up to 7-fold compared with methyl-P-cyclodextrin reported as the best solubilizer of pindolol. Complexation of SGs with pindolol was confirmed by nuclear magnetic resonance, Fourier-transform infrared spectroscopy, differential scanning calorimetry, and scanning electron microscopy. Formation constants of complexes were determined from phase solubility diagrams. Conformation of complex was suggested based on a molecular docking study. The present study indicated that formation of pindolol/SGs complexes not only resulted in increased pindolol solubility but also could be useful for improving its clinical application as it did not affect cell viability. (C) 2014 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据