Article
Polymer Science
Xiaoyan Hong, Hao Ding, Jiao Li, Yuanyuan Xue, Luyi Sun, Fuchuan Ding
Summary: A new semi-interpenetrating network hydrogel P(AM-co-AA)/CS with excellent mechanical properties and anti-fatigue characteristics was synthesized, which can be used to manufacture pressure sensors and drug-controlled release carriers.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2021)
Article
Agricultural Engineering
Huazhong Ma, Jianglin Zhao, Ying Liu, Liang Liu, Juan Yu, Yimin Fan
Summary: An interpenetrating network (IPN) hydrogel was developed by crosslinking nanocellulose and sodium alginate through an acetic acid coagulation bath and Ca2+ chelation. The nanofibers in the hydrogel greatly extended the release time of aspirin to 60 hours, thanks to the well-structured network. Carboxyl groups played a role in the release capacity in different pH environments. This study provides a guide for the preparation of physically crosslinked IPN hydrogels with good mechanical properties and cytocompatibility for drug delivery applications.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Polymer Science
Amlika Rungrod, Apichaya Kapanya, Winita Punyodom, Robert Molloy, Anisa Mahomed, Runglawan Somsunan
Summary: The semi-interpenetrating polymer network (semi-IPN) hydrogel synthesized through free radical UV-photopolymerization technique showed increased elasticity and water absorption capacity, while being non-cytotoxic. Efficient encapsulation of the model drug CIP was achieved, with drug loading capacity enhanced by increasing PCL diol and CIP content. Drug release profiles were influenced by the ratios of Na-AMPS to PCL diol and CIP content, showing diffusion and swelling-controlled release mechanisms. The P(Na-AMPS)/PCL diol semi-IPN hydrogels are promising candidates for drug delivery and controlled release applications in biomedicine.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Lihong Zhang, Chengwang Sheng, Chaowen Chen, Jian Luo, Zhengyan Wu, Haiqun Cao
Summary: In this study, a reversible near infrared-responsive polysaccharide-based hydrogel was successfully developed as a carrier for controlled release of pesticides. The hydrogel exhibited exceptional controlled-release performance and could be reused for multiple cycles. Moreover, it enhanced the stability and adhesion of the pesticide, offering potential applications in improving pesticide utilization and environmental safety.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Napaphak Jaipakdee, Thitiphorn Rongthong, Watchara Kanjanakawinkul, Thaned Pongjanyakul
Summary: Complexation of nicotine with magnesium aluminum silicate was achieved through physical blending. The formed complexes demonstrated potential as drug carriers in buccal matrix formulations due to their sustained release capabilities.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Nanoscience & Nanotechnology
Bin Nie, Hong Wang, Chaohui Rao, Yanwei Zhang, Huifang Wang, Xiaojie Lian, Xianghua Gao, Baolong Niu, Wenfeng Li
Summary: The study successfully achieved specific pH responsiveness of ACCP by designing and synthesizing sodium alginate/ACCP composite nanoparticles. The composite nanoparticles showed excellent drug-controlled release performance and good therapeutic effect on A549 cancer cells.
Article
Polymer Science
Wanwisa Khunawattanakul, Napaphak Jaipakdee, Thitiphorn Rongthong, Narin Chansri, Pathomthat Srisuk, Padungkwan Chitropas, Thaned Pongjanyakul
Summary: This study aimed to investigate the effects of quaternary polymethacrylate (QPM), a positively charged water-insoluble polymer, on the properties of sodium alginate (SA) dispersions and calcium alginate (CA) gel beads containing propranolol HCl (PPN). The addition of QPM increased the viscosity of the composite dispersions, resulting in larger particle size, higher drug entrapment efficiency, and improved particle strength of the gel beads. The PPN-loaded CA-QPM gel beads exhibited slower drug release rate compared to the PPN-loaded CA gel beads. These findings suggest that QPM has the potential to be used as a bioactive compound delivery system.
Article
Pharmacology & Pharmacy
Haoran Cheng, Haishan Wu, Ting Guo, Hyun Jin Park, Jinglei Li
Summary: A zinc insulin hexamer-loaded alginate hydrogel was prepared and characterized for oral insulin administration. The hydrogel showed controlled release of insulin in simulated gastric and intestinal fluids, with no cytotoxicity observed. In diabetic mice, the hydrogel demonstrated significant and prolonged hypoglycemic effect.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Polymer Science
Birgul Kalkan, Nermin Orakdogen
Summary: This study presents a simple methodology for designing anionically modified thermosensitive organic-inorganic hybrid gels using silica nanoparticle-mediated semi-interpenetrating polymer networks. The effects of solution environment, salt concentration, and pH change on the swelling and elastic properties of the gels were investigated. It was found that the identity of counterion and salt concentration had a strong influence on the swelling and compression modulus of the gels. The study suggests that semi-IPN hybrid gels with anionic modification have potential applications in controlled release systems and as adsorbents for cationic dyes.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Polymer Science
Birgul Kalkan, Nermin Orakdogen
Summary: The article describes a simple methodology for designing anionically modified thermosensitive organic-inorganic hybrid gels using silica nanoparticle-mediated semi-interpenetrating polymer networks. The study investigates the effect of changes in solution environment on swelling and elastic properties, with sodium salts showing a significant influence on swelling and compression modulus.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Jiaxin Li, Yachao Yan, Yingzhi Chen, Qinglin Fang, Muhammad Irfan Hussain, Lu-Ning Wang
Summary: In this study, a flexible hydrogel composed of sodium alginate and curcumin-loaded metal-organic frameworks was created for long-term drug release and antibacterial activity, offering a new management system for chronic wound dressings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Polymer Science
Chunqing Niu, Xinyu Liu, Yiyu Wang, Xiang Li, Jian Shi
Summary: NIR-responsive hydrogels can remotely regulate drug release, providing a new option for developing delivery vehicles based on natural polymers. These hydrogels exhibit desirable stability and swelling properties, and demonstrate good cellular compatibility in vitro.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Emine Bulut
Summary: The study focused on the preparation of ionically crosslinked beads as semi-interpenetrating polymer networks loaded with ibuprofen. The drug release behaviors and performance parameters of the beads were investigated and optimized for the best release conditions.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Birgul Kalkan, Nermin Orakdogen
Summary: This study synthesized thermoresponsive semi-interpenetrating polymer networks (semi-IPNs) by varying the content of linear polyacrylamide (PAAm), N-isopropylacrylamide (NIPA), and methacrylic acid (MA). The inclusion of linear PAAm chains increased the crosslinking density and compressive elasticity of the P(NIPA-MA) network. The swelling behavior of the semi-IPN gels was sensitive to the presence of linear PAAm chains, and their equilibrium swelling was decreased compared to the copolymer P(NIPA-MA) network. The prepared semi-IPNs exhibited good adsorption properties for the cationic dye Methyl violet (MV).
REACTIVE & FUNCTIONAL POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Aiping Zhang, Yucheng Zou, Yuhang Xi, Peng Wang, Yue Zhang, Liangru Wu, Hui Zhang
Summary: This study explored the feasibility of using unmodified bamboo shoot cellulose to produce composite aerogels with sodium alginate for sustained release of curcumin in a fast and green way. The composite aerogels showed promising potential as biocompatible carriers for drug and nutraceutical delivery, with improved thermal stability and mechanical properties induced by calcium ion-induced cross-linking. The study demonstrated the first use of cellulose from bamboo shoot to develop aerogels for drug delivery purposes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Engineering, Chemical
Swastika Choudhury, Samit Kumar Ray
Summary: The addition of polymer nanoparticles significantly enhances the separation characteristics of polymer membranes for various applications, providing improved flux and selectivity. The use of low cost chitosan-coated polyacrylonitrile nanoparticles presents a promising alternative to expensive inorganic nanoparticles for membrane modification.
JOURNAL OF MEMBRANE SCIENCE
(2021)
Article
Engineering, Chemical
Swastika Choudhury, Samit Kumar Ray
Summary: The organophilic character of PVC membrane was improved through graft copolymerization and further filling with organo clay, for sorption and pervaporation of tetrahydrofuran. Experimental data showed different flux/THF selectivity for PVC membranes grafted with different materials when treating THF.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Engineering, Chemical
Amritanshu Banerjee, Samit Kumar Ray
Summary: The copolymer membrane prepared by emulsion polymerization showed excellent pervaporation performance for methanol, ethanol, and isopropyl alcohol. The incorporation of natural rubber and nitrocellulose into the membrane resulted in optimized composition of 4:1 Sty: AN molar ratio, 7% NR latex, and 2% NC.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Chemistry, Applied
Amritanshu Banerjee, Samit Kumar Ray
Summary: Biopolymer nanoparticles based on chitosan offer a cost-effective, non-toxic alternative to traditional nanoparticles, and are more compatible with polymer membranes. Chitosan, as a cationic polymer surfactant, helps generate polymer nanoparticles for improving the organophilicity of PVC membranes. The membranes prepared with chitosan grafted PMMA nanopolymers showed enhanced performance in terms of acetone flux and selectivity, fitting closely to ENSIC and solution-diffusion model for sorption and pervaporation data, respectively.
CARBOHYDRATE POLYMERS
(2021)
Article
Polymer Science
Himadri Sekhar Samanta, Samit Kumar Ray
Summary: Several composite hydrogels were synthesized by free radical crosslink copolymerization, characterized for their structures; the hydrogel containing NaMMT clay and PEG showed the best drug release properties.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Engineering, Chemical
Swastika Choudhury, Samit Kumar Ray
Summary: Biocomposites synthesized with optimized composition showed high adsorption capacity for dye removal, indicating potential applications in efficient wastewater treatment.
POLYMER ENGINEERING AND SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Himadri Sekhar Samanta, Samit Kumar Ray
Summary: Pectin grafted polyacrylic copolymer hydrogels were prepared by free radical crosslink copolymerization, with in situ incorporation of attapulgite filler. The release kinetics of diltiazem hydrochloride were studied, and the hydrogel formulation was optimized using response surface methodology, achieving optimal performance at a solution pH of 7.4.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Himadri Sekhar Samanta, Samit Kumar Ray
Summary: Interpenetrating network (IPN) hydrogels were successfully prepared by free radical crosslink copolymerization of acrylic acid and guar gum, with varied synthesis variables affecting the properties of the hydrogels. The release kinetics of vitamin B6 from these hydrogels were studied, with the IPN prepared with specific concentrations showing high entrapment efficiency and sustained release rate. The drug release data fitted well to the Korsmeyer-Peppas model.
JOURNAL OF POLYMER RESEARCH
(2021)
Article
Engineering, Chemical
Bidyut Kumar Bhangi, Samit Kumar Ray
Summary: Polymer metal nano-composites (PMNC) were synthesized by incorporating chitosan, crosslinked polymer, and Cu nanoparticles. The properties of the Cu nanoparticles and the composites were evaluated, and the composites showed promising performance in the degradation of dyes and adsorption of ions.
POLYMER ENGINEERING AND SCIENCE
(2022)
Article
Engineering, Chemical
Bidyut Kumar Bhangi, SamitKumar Ray
Summary: In this study, magnetic hydrogels based on iron oxide nanoparticles were prepared by in-situ co-precipitation of ferric/ferrous salts during copolymerization of acrylonitrile and N-vinyl-2-pyrrolidone. The nanocomposite gels showed high adsorption and photocatalytic degradation efficiency for tetracycline removal from water.
POLYMER ENGINEERING AND SCIENCE
(2023)
Article
Engineering, Chemical
Barnali Dutta, Samit Kumar Ray
Summary: In this study, partially neutralized acrylic acid/sodium acrylate and N,N'-methylenebisacrylamide were subjected to intercalative copolymerization in the presence of sodium montmorillonite nano clay in an aqueous solution of polyvinyl alcohol to prepare filled semi-interpenetrating network type composite polymer networks. The filled full IPN composites were prepared by additional crosslinking of PVA with maleic acid crosslinker. The optimized FFIPN composite showed good adsorption capacity for methyl violet and congo red dyes.
POLYMER ENGINEERING AND SCIENCE
(2023)
Article
Engineering, Chemical
Paramita Das, Samit K. Ray
Summary: In this study, NaMMT clay incorporated and maleic acid crosslinked polyvinyl alcohol-chitosan interpenetrating network nanocomposite membranes were prepared for the dehydration of acetone. The membranes were characterized using various analytical techniques, and the effects of clay, chitosan, and maleic acid on water flux and separation factor were statistically optimized. The optimal membrane composition was found to be 39.3 wt% chitosan, 3 wt% maleic acid, and NaMMT nanoclay.
POLYMER ENGINEERING AND SCIENCE
(2023)
Article
Engineering, Chemical
Amritanshu Banerjee, Samit Kumar Ray
Summary: Isopropyl alcohol (IPA) selective membranes were prepared from poly(methyl methacrylate-co-butyl acrylate) copolymers based on their relative solubility parameter values. The effect of MMA molar% and IPA feed concentration on the membrane performance was studied. The results showed that a membrane prepared from a copolymer with 92 M% MMA exhibited high flux and selectivity for IPA in pervaporation.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Engineering, Chemical
Barnali Datta, Samit Kumar Ray
Summary: Iron oxide nanoparticles impregnated crosslinked copolymer composites were synthesized and characterized. The resulting polymer metal nanocomposites exhibited excellent performance in adsorption and photocatalytic degradation.
POLYMER ENGINEERING AND SCIENCE
(2023)
Article
Polymer Science
Barnali Dutta, Samit Kumar Ray
Summary: In this study, crystalline glass-ceramic fillers were prepared and incorporated into natural rubber composites. The effect of the ceramic fillers on the mechanical, thermal, and transport properties of the composites was investigated. It was found that increasing filler loading decreased the diffusion and mass transfer coefficients of benzene, toluene, and p-xylene in the composites.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)