Article
Nanoscience & Nanotechnology
Deni Rahmat, Clairine Devina
Summary: This study focuses on the synthesis of ethyl cellulose (EC) nanoparticles with mucoadhesive and lipophilic properties through thiolation using cysteamine. The nanoparticles exhibited improved drug release, stability, and biocompatibility, while demonstrating low cytotoxicity.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Pharmacology & Pharmacy
Tamas Kiss, Rita Ambrus, Mohamed M. Abdelghafour, Scarlett Zeiringer, Atida Selmani, Eva Roblegg, Maria Budai-Szucs, Laszlo Janovak, Balint Lorinczi, Agota Deak, Andreas Bernkop-Schnurch, Gabor Katona
Summary: A chitosan-cysteine (chit-cyst) conjugate with enhanced mucoadhesive properties was synthesized and characterized. The conjugate showed improved mucoadhesion compared to chitosan, and no residual L-cysteine was detected. Cytotoxicity studies confirmed the safety of the conjugate for nasal application. The prepared nasal powder formulations were found to be suitable for reducing the off periods of Parkinson's disease based on in vitro studies.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Julian David Friedl, Marcel Walther, Pia Katharina Vestweber, Jana Wachter, Patrick Knoll, Arne Matteo Joergensen, Andreas Bernkop-Schnuerch, Maike Windbergs
Summary: To date, buccal administration of lipophilic drugs remains challenging due to poor solubility and limited penetration. In this study, researchers developed mucoadhesive electrospun SEDDS patches to overcome these limitations. The patches showed high encapsulation efficiency, improved drug penetration, and enhanced therapeutic effects, making them a promising approach for oromucosal delivery of lipophilic drugs.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Ruben Varela-Fernandez, Xurxo Garcia-Otero, Victoria Diaz-Tome, Uxia Regueiro, Maite Lopez-Lopez, Miguel Gonzalez-Barcia, Maria Isabel Lema, Francisco Javier Otero-Espinar
Summary: This study describes the preparation and optimization of different PLGA-based nanosystems for the delivery of lactoferrin for ocular diseases. The modified polymeric nanocarriers demonstrated suitable size, uniform distribution, and efficient drug encapsulation. In vitro release studies showed controlled delivery of lactoferrin, and no cytotoxicity was observed. The mucoadhesive properties of the nanoparticles were also confirmed in vitro and in vivo.
Review
Pharmacology & Pharmacy
Beatriz Silva, Berta Sao Braz, Esmeralda Delgado, Lidia Goncalves
Summary: In recent years, there has been a growing scientific interest in topical ocular delivery targeting the posterior segment of the eye, as it is a non-invasive and well-tolerated administration route with fewer side effects. Improving corneal permeability or prolonging precorneal retention time can enhance intraocular bioavailability of drugs. Nanosystems utilizing mucoadhesive polymers or colloidal particles have emerged as promising strategies for more efficient treatment of ocular diseases.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Roman V. Moiseev, Daulet B. Kaldybekov, Sergey K. Filippov, Aurel Radulescu, Vitaliy V. Khutoryanskiy
Summary: Liposomes with different modifications were formulated and their physicochemical characteristics and retention on ex vivo eye tissues were evaluated. The maleimide-decorated liposomes showed the best retention performance on bovine conjunctiva compared to other liposomal formulations.
Article
Engineering, Biomedical
Mitchell Ross, Lindsay Sheardown, Benjamin Muirhead, Jonathan Mofford, Jennifer (JingYuan) Tian, Heather Sheardown
Summary: A platform of mucoadhesive and thermogelling eyedrops was developed for the treatment of various ocular conditions. The materials used were highly tunable, allowing for the delivery of different therapeutic agents. The safety and tolerability of the eyedrops was demonstrated in both in vitro and in vivo studies.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Pharmacology & Pharmacy
Mulazim Hussain Asim, Muhammad Ijaz, Arshad Mahmood, Patrick Knoll, Aamir Jalil, Shumaila Arshad, Andreas Bernkop-Schnuerch
Summary: Thiolated beta-cyclodextrin was synthesized and characterized for its potential use as an auxiliary agent for ocular drug delivery, showing enhanced permeation and mucoadhesive properties. The newly synthesized thiolated oligomer exhibited improved aqueous solubility, viscosity enhancement of mucus, prolonged ocular residence time, and enhanced permeation of sodium fluorescein on various ocular tissues, making it a promising candidate for ocular drug delivery.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Gerard Esteruelas, Lyda Halbaut, Victor Garcia-Torra, Marta Espina, Amanda Cano, Miren Ettcheto, Antoni Camins, Eliana B. Souto, Maria Luisa Garcia, Elena Sanchez-Lopez
Summary: A novel in situ gelling system dispersing RLZ-loaded nanoparticles has been successfully developed as an innovative neuroprotective strategy for potential topical treatment of glaucoma, achieving a more delayed distribution in the posterior eye segment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Fernanda Isadora Boni, Beatriz S. F. Cury, Natalia Noronha Ferreira, Maria Palmira Daflon Gremiao
Summary: Polymer blends of GG/RS and GG/P cross-linked with different cations resulted in microparticles with varied physical-chemical properties and mucoadhesive abilities. Aluminum cross-linking in GG:P blends produced smaller particles, while calcium cross-linking in GG:RS particles reduced size and provided protection against enzymatic degradation in the stomach. The high mucoadhesive ability of the microparticles was evident at both pH values, with stronger interactions observed at pH 6.8.
Article
Chemistry, Medicinal
Aiqin Li, Ifrah Nabi Khan, Ikram Ullah Khan, Abid Mehmood Yousaf, Yasser Shahzad
Summary: This study developed mucoadhesive bilayer films loaded with drug and oil as a potential therapeutic option for periodontitis management. The films showed excellent antibacterial response and pharmaceutical attributes, demonstrating sustained release of drug for up to 48 hours. These films could be effective in combating bacterial infection associated with periodontitis.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Aline Leite de Farias, Maria Isabel Amaya Arbelaez, Andreia Bagliotti Meneguin, Hernane da Silva Barud, Fernanda Lourencao Brighenti
Summary: The study found that morin has good antimicrobial and anti-biofilm activity against polymicrobial biofilms, effectively reducing microbial viability and polysaccharide concentration in the biofilm matrix, and controlling acidogenicity. In addition, morin showed cytotoxicity to oral keratinocytes within a certain concentration range.
Review
Chemistry, Multidisciplinary
Ridhdhi S. Dave, Taylor C. Goostrey, Maya Ziolkowska, Sofia Czerny-Holownia, Todd Hoare, Heather Sheardown
Summary: There is a growing demand for effective treatments for ocular conditions, with topical administration being the preferred method despite its drawbacks. Nanoparticles with tunable mucoadhesion and/or mucopenetration show potential to overcome these drawbacks and improve ocular bioavailability, reduce toxicity, and increase ocular retention. Recent advances in developing nanocarriers with tunable mucoadhesion and mucopenetration for drug delivery to the eye are highlighted in the current review.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Physical
Valeria Maria de Oliveira Cardoso, Natalia Araujo Pereira de Brito, Natalia Noronha Ferreira, Fernanda Isadora Boni, Leonardo Miziara Barboza Ferreira, Suzana Goncalves Carvalho, Maria Palmira Daflon Gremiao
Summary: Nanotechnology has been applied in the development of polymer nanocarriers for oral delivery of biomolecules. This study focused on the preparation of nanoparticles based on gellan gum and chitosan blends, with different polymer mass ratios and addition orders influencing particle size. Encapsulation of polymyxin B reduced particle size, while Fourier transform infrared spectroscopy and X-ray diffraction revealed interactions and organized structures. Scanning electron microscopy showed spherical and uniform nanoparticles with mucoadhesive properties, indicating potential for enhanced oral peptide delivery.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Pharmacology & Pharmacy
Ahmed Adel Ali Youssef, Ruchi Thakkar, Samir Senapati, Poorva H. Joshi, Narendar Dudhipala, Soumyajit Majumdar
Summary: This study aimed to design a MOX-loaded nanoemulsion (MOX-NE) and mucoadhesive agents (MOX-NEM) to sustain MOX release and overcome the drawbacks of commercial ophthalmic formulations. The lead formulations showed desired properties and sustained release profiles of MOX. The permeation and antibacterial activity of the lead MOX-NE formulation were found to be better than those of the commercial eyedrops. MOX-NE and MOX-NEM formulations have the potential to improve treatment outcomes in ocular bacterial infections.
Article
Materials Science, Biomaterials
Jyoti Mundlia, Munish Ahuja, Pradeep Kumar
Summary: The study demonstrated the formation of conjugates of gellan gum and polyphenols, validated by various analytical methods, showing self-assembly of conjugates and improved antioxidant and antibacterial activity, along with higher anti-cancer activity against human ovarian carcinoma cell lines.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2021)
Article
Polymer Science
Manisha Sharma, Jyoti Mundlia, Tarun Kumar, Munish Ahuja
Summary: This study aims to produce luliconazole-loaded solid lipid nanoparticles using microwave-assisted technique. While microwave power and Pluronic F-68 concentration have an impact on particle size and zeta potential, they do not significantly affect the entrapment of luliconazole. The optimized solid lipid nanoparticles show high entrapment efficiency and excellent antifungal activity against Candida albicans and Aspergillus niger.
Article
Materials Science, Textiles
Rashmi, Rimpy, Munish Ahuja
FIBERS AND POLYMERS
(2020)
Article
Polymer Science
Rashmi Sharma, Rimpy Pahwa, Munish Ahuja
Summary: Iodine-loaded poly(silicic acid) gellan nanocomposite film was successfully fabricated and demonstrated enhanced thermal stability, mechanical properties, moisture resistance, antibacterial activity, and mucoadhesive strength, making it a potential candidate for antibacterial applications in pharmaceuticals.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Letter
Public, Environmental & Occupational Health
Pragya D. Yadav, Nivedita Gupta, Dimpal A. Nyayanit, Rima R. Sahay, Anita M. Shete, Triparna Majumdar, Savita Patil, Harmanmeet Kaur, Chaitali Nikam, Jayshri Pethani, Deepak Y. Patil, Neeraj Aggarwal, Neetu Vijay, Jitendra Narayan
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2021)
Article
Virology
Pragya D. Yadav, Dimpal A. Nyayanit, Triparna Majumdar, Savita Patil, Harmanmeet Kaur, Nivedita Gupta, Anita M. Shete, Priyanka Pandit, Abhinendra Kumar, Neeraj Aggarwal, Jitendra Narayan, Neetu Vijay, Usha Kalawat, Attayur P. Sugunan, Ashok Munivenkatappa, Tara Sharma, Sulochna Devi, Tapan Majumdar, Subhash Jaryal, Rupinder Bakshi, Yash Joshi, Rima Sahay, Jayanti Shastri, Mini Singh, Manoj Kumar, Vinita Rawat, Shanta Dutta, Sarita Yadav, Kaveri Krishnasamy, Sharmila Raut, Debasis Biswas, Biswajyoti Borkakoty, Santwana Verma, Sudha Rani, Hirawati Deval, Disha Patel, Jyotirmayee Turuk, Bharti Malhotra, Bashir Fomda, Vijaylakshmi Nag, Amita Jain, Anudita Bhargava, Varsha Potdar, Sarah Cherian, Priya Abraham, Anjani Gopal, Samiran Panda, Balram Bhargava
Summary: The study found that the main virus clades circulating in different parts of India are GH and GR, with GH being predominant in the north and GR in the south. Samples collected from January to August in 2020 showed the presence of single independent mutations from Maharashtra and Southern Indian States.
Article
Virology
Ketki Deshpande, Ullas Pt, Ojas Kaduskar, Neetu Vijay, Aparna Rakhe, Shankar Vidhate, Kirtee Khutwad, Gururaj Rao Deshpande, Bipin Tilekar, Sanskruti Saka, Kshitija Gadekar, Roshni Patil, Pragya Yadav, Varsha Potdar, Yogesh Gurav, Priyanka Gupta, Harmanmeet Kaur, Jitendra Narayan, Gajanan Sapkal, Priya Abraham
Summary: Seven commercially available ELISA kits demonstrated high accuracy in detecting IgG antibodies against SARS-CoV-2, with DiaPro COVID-19 IgG ELISA showing the highest sensitivity. These assays can be valuable in tracing mild infections, cohort studies, and pre-vaccine evaluations due to their good accuracy indices.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Virology
Nivedita Gupta, Harmanmeet Kaur, Pragya Dhruv Yadav, Labanya Mukhopadhyay, Rima R. Sahay, Abhinendra Kumar, Dimpal A. Nyayanit, Anita M. Shete, Savita Patil, Triparna Majumdar, Salaj Rana, Swati Gupta, Jitendra Narayan, Neetu Vijay, Pradip Barde, Gita Nataraj, Amrutha B. Kumari, Manasa P. Kumari, Debasis Biswas, Jyoti Iravane, Sharmila Raut, Shanta Dutta, Sulochana Devi, Purnima Barua, Piyali Gupta, Biswa Borkakoty, Deepjyoti Kalita, Kanwardeep Dhingra, Bashir Fomda, Yash Joshi, Kapil Goyal, Reena John, Ashok Munivenkatappa, Rahul Dhodapkar, Priyanka Pandit, Sarada Devi, Manisha Dudhmal, Deepa Kinariwala, Neeta Khandelwal, Yogendra Kumar Tiwari, Prabhat Kiran Khatri, Anjli Gupta, Himanshu Khatri, Bharti Malhotra, Mythily Nagasundaram, Lalit Dar, Nazira Sheikh, Jayanthi Shastri, Neeraj Aggarwal, Priya Abraham
Summary: The study revealed that the majority of breakthrough COVID-19 cases in India were infected with the Delta variant, with only 9.8% requiring hospitalization and a fatality rate of 0.4%. This suggests that vaccination significantly reduces the risk of hospitalization and mortality.
Review
Pharmacology & Pharmacy
Vinay Kant, Pooja Kumari, Dhaval K. Jitendra, Munish Ahuja, Vinod Kumar
Summary: Wound healing is a complex biological process involving sequential biochemical reactions to restore cellular integrity. The market for wound-care products is vast, with natural bioactive agents showing potential for promoting wound healing. Encapsulating these agents into nano-formulations has helped overcome limitations and improve their applicability in clinical practices.
CURRENT DRUG DELIVERY
(2021)
Article
Pharmacology & Pharmacy
Dhaval J. Kamothi, Vinay Kant, Babu L. Jangir, Vinay G. Joshi, Munish Ahuja, Vinod Kumar
Summary: This study demonstrated the effectiveness of encapsulated bilirubin nanoparticles in promoting wound healing, as compared to native bulk bilirubin. The nanoparticles, formed using Pluronic F-127, showed promising results in accelerating wound closure, reducing inflammation, and promoting tissue regeneration. These findings highlight the potential of encapsulated bilirubin nanoparticles as a novel biomaterial for wound healing in the future.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Rimpy, Munish Ahuja
Summary: The present research uses nanocellulose extracted from rice or wheat straw and modified with tetraethyl orthosilicate (TEOS). The modified nanocellulose scaffolds show improved swelling, porosity, and tensile strength, as well as better drug release and antifungal activity. The cytotoxicity of fluconazole remains unchanged.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rimpy Pahwa, Munish Ahuja
Summary: The objective of this study was to develop a vaginal drug delivery system using lyophilized fluconazole-loaded nanocellulose-gellan scaffolds cross-linked with trisodium trimetaphosphate. The optimal formulation of the cross-linked rice or wheat nanocellulose-gellan based scaffolds contained specific concentrations of polymers and cross-linking agents. The cross-linked scaffolds exhibited higher thermal stability, porosity, tensile strength, and mucoadhesive strength, and slower enzymatic degradation. They also provided sustained release of fluconazole and increased vaginal permeation compared to non cross-linked scaffolds. Additionally, the phosphorylated nanocellulose-gellan based scaffolds showed improved antifungal activity and non-cytotoxicity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Rimpy Pahwa, Munish Ahuja
Summary: The purpose of this research was to evaluate the effectiveness of rice and wheat nanocellulose scaffolds coated with Eudragit E100 for vaginal delivery of fluconazole. The optimal formulation of the scaffolds consisted of nanocellulose and Eudragit E100. The Eudragit-coated nanocellulose scaffolds showed improved thermal stability, swelling, porosity, tensile strength, mucoadhesive strength, and lower enzymatic degradation rate compared to the unmodified scaffolds. The optimal batch of Eudragit-coated nanocellulose scaffolds provided sustained release of fluconazole and higher vaginal permeation.
JOURNAL OF PHARMACEUTICAL INNOVATION
(2023)
Article
Polymer Science
Atul Kaushik, Shashi Yadav, Priya Mudgal, Rimpy Pahwa, Tarun Kumar, Munish Ahuja
Summary: The study focuses on the propyl modification and characterization of Moringa gum for sustained drug delivery. The propylated Moringa gum was evaluated as a matrix tablet and composite beads for sustained release of diclofenac sodium. The propyl modification improved the physicochemical properties of Moringa gum and showed promising potential for sustained drug delivery applications.
Article
Chemistry, Applied
Vikas Dagar, Rimpy Pahwa, Munish Ahuja
Summary: This study aims to improve the efficacy of carboxymethyl tamarind kernel polysaccharide by cross-linking with Ca2+ ion and preparing its diclofenac sodium loaded matrix tablets. The results showed that the cross-linked polysaccharide exhibited changes in thermal property, shape, and surface, while the cross-linking of calcium also altered the drug release behavior, making it suitable for sustained release formulation.
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2023)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
