Review
Chemistry, Physical
Hileia K. S. Souza, Wala Kraiem, Amine Ben Yahia, Adel Aschi, Loic Hilliou
Summary: Hybrid carrageenans, also known as kappa-2 (K2) or weak kappa, are sulfated polysaccharides extracted from specific species of red seaweeds. They have thermo-reversible gelling properties and are gaining interest in industry due to their intermediate texturizing properties. However, further research is needed to fully understand their chemical structure and how it affects their gel formation and rheological properties.
Article
Biotechnology & Applied Microbiology
Melanie H. Hughes, Patricia I. Leonardi, Diego B. Genovese
Summary: This study investigates the effects of carrageenan concentration, salt concentration, and KCl center dot CaCl2 ratio on the gelation properties of carrageenans from Sarcopeltis skottsbergii and Sarcothalia crispata. The results show that higher concentrations of carrageenan and salt increase gel strength but also increase turbidity. Increasing the KCl fraction also increases gel strength. The optimal compositions predicted by the models are in line with the observed responses. Considering the increasing demand for carrageenan in the food industry, S. skottsbergii and S. crispata could be potential sources of these biopolymers.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2023)
Article
Multidisciplinary Sciences
Uma Jingxin Tay, Megan Goh, Jeralyn Ching Wen Hui, Prakash Arumugam
Summary: This paper presents a simple, economical, and miniaturized assay called the Floating Sphere Assay for detecting novel proteins with gelling attributes, accurately estimating the Minimum Gelling Concentrations (MGCs), and accelerating the discovery of gelatin substitutes.
Article
Multidisciplinary Sciences
Uma Jingxin Tay, Megan Goh, Jeralyn Ching Wen Hui, Prakash Arumugam
Summary: The study introduces a simple and economical 'Floating Sphere Assay' method for detecting minimum gelling concentration and high-throughput screening of gelling proteins.
Article
Multidisciplinary Sciences
Kairit Eha, Tonis Pehk, Ivo Heinmaa, Aleksei Kaleda, Katrin Laos
Summary: In this study, short-term heat treatment was found to have a significant impact on the structure, molecular weight, and gel rheology of commercial carrageenans. Heat caused desulphation and degradation of furcellaran galactans, leading to a decrease in viscosity and gel hardness. Storage modulus values of carrageenan gels decreased with increasing treatment temperature, with the greatest decrease seen in kappa/lambda-carrageenan gels.
Article
Polymer Science
Loic Hilliou
Summary: This paper reviews the relationship between carrageenan gel structure and elastic properties, and discusses the comparison of linear and nonlinear elastic models with structural and rheological data, focusing on the concentration scaling of strain hardening exhibited by different types of carrageenan gels.
Article
Biochemistry & Molecular Biology
Milena Alvarez-Vinas, Noelia Gonzalez-Ballesteros, M. Dolores Torres, Lucia Lopez-Hortas, Candida Vanini, Guido Domingo, M. Carmen Rodriguez-Arguelles, Herminia Dominguez
Summary: This study investigates the sustainable extraction and depolymerization of carrageenan from seaweed using hydrothermal treatment with subcritical water. The results show that operating at 140 degrees C yields the highest extraction rate, and the crude carrageenan can be effectively obtained through methods such as ultrafiltration and ethanol precipitation. Additionally, it is found that the crude carrageen fraction can be used to prepare gel materials with excellent mechanical properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Construction & Building Technology
Asma Boukhatem, Kamal Bouarab, Ammar Yahia
Summary: The effect of kappa-iota carrageenan on the rheological behavior, hydration kinetics, and strength development of cement-based materials was investigated. The results showed that the addition of kappa-iota carrageenan increased the flowability and structural stability of cement suspensions. However, when combined with high-range water reducer (HRWR), the effect of kappa-iota carrageenan was reduced. Furthermore, the addition of kappa-iota carrageenan delayed the hardening time of cement suspensions, but had no significant impact on early-age compressive strength development.
ACI MATERIALS JOURNAL
(2022)
Article
Polymer Science
Chen Song, Ying You, Chengrong Wen, Yinghuan Fu, Jingfeng Yang, Jun Zhao, Shuang Song
Summary: Low-molecular-weight carrageenan has advantages in solubility, absorption efficiency, and bioavailability compared to original carrageenan. A photocatalytic degradation method with only TiO2 has been developed to prepare low-molecular-weight carrageenan with high sulfation degree and low viscosity. The study also proposed the degradation rules and provided an effective green method for the degradation of carrageenan.
Article
Food Science & Technology
Yanira Sanchez-Garcia, Nestor Gutierrez-Mendez, Ivan Salmeron, Victor H. Ramos-Sanchez, Martha Y. Leal-Ramos, David R. Sepulveda
Summary: This study aimed to investigate the impact of carrageenans on lactose mutarotation and solubility, revealing that carrageenans can affect the time to reach mutarotation balance and the proportion of beta/alpha isomers at equilibrium, while reducing lactose solubility within a certain temperature range and decreasing the width of the metastable zone.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Polymer Science
Noelia Florez-Fernandez, Elena Falque, Herminia Dominguez, Maria Dolores Torres
Summary: This study successfully isolated hybrid carrageenans from Mastocarpus stellatus red seaweed using subcritical water extraction and investigated the impact of different thermal conditions on the rheological behavior of the recovered carrageenans. The chemical composition of the seaweed and the phytochemical properties of the soluble liquid extracts were also analyzed. Results showed that the highest extraction yields and strongest rheology properties of the hybrid carrageenans were obtained at a hydrothermal treatment of 130 degrees C. Additionally, the inhibitory effect on ovarian carcinoma and lung carcinoma cell lines was the greatest at 130 degrees C as well.
Article
Materials Science, Multidisciplinary
Panchami Patel, Kratika Mujmer, Vinod Kumar Aswal, Sharad Gupta, Prachi Thareja
Summary: In this study, the printing limitation of κ-carrageenan gel ink was overcome by optimizing the ink formulation. It was found that the addition of 25 mM KCl or CaCl2 significantly improved the printability of the gel ink, resulting in thin and continuous filaments. Furthermore, the gel ink showed excellent biocompatibility.
MATERIALS TODAY COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Fang Liu, Guangcai Duan, Haiyan Yang
Summary: Carrageenans are biopolymers derived from red seaweeds and have various applications in the food industry as emulsifiers, stabilizers, and thickeners. They also show potential in biomedical applications, such as hydrogel fabrication, drug delivery systems, and tissue engineering. This review provides insights into the structural characteristics, rheological properties, and biofunctionality of carrageenans, and discusses their potential in biomedicine.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Chemistry, Applied
Arman Jafari, Mojtaba Farahani, Mahsa Sedighi, Navid Rabiee, Houman Savoji
Summary: Biomaterials play a crucial role in tissue engineering, regenerative medicine, and drug delivery, with polymeric biomaterials being the most promising candidates. Carrageenan, derived from red seaweed, possesses unique properties and various biological activities, making it highly attractive for tissue engineering and drug delivery research.
CARBOHYDRATE POLYMERS
(2022)
Review
Food Science & Technology
Fang Liu, Pengfen Hou, Hui Zhang, Qingjuan Tang, Changhu Xue, Robert W. Li
Summary: Carrageenans, commonly used food additives, have been a part of human diets for hundreds of years. Recent studies suggest that certain forms of carrageenans may have adverse effects on gastrointestinal health. The impact of carrageenans on individuals may be structure-dependent and influenced by pre-existing health conditions.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2021)
Article
Food Science & Technology
Maria Florencia Basanta, Sergio Anibal Rizzo, Natalia Szerman, Sergio Ramon Vaudagna, Adriana Maria Descalzo, Lia Noemi Gerschenson, Carolina Daiana Perez, Ana Maria Rojas
FOOD RESEARCH INTERNATIONAL
(2018)
Article
Food Science & Technology
Cinthia Santo Domingo, Ana M. Rojas, Eliana N. Fissore, Lia N. Gerschenson
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2019)
Article
Pharmacology & Pharmacy
Natalia Ehrenhaus Masotta, Manuela R. Martinefski, Silvia Lucangioli, Ana M. Rojas, Valeria P. Tripodi
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2019)
Article
Chemistry, Applied
Alondra M. Idrovo Encalada, Carolina D. Perez, Silvia K. Flores, Luciana Rossetti, Eliana N. Fissore, Ana M. Rojas
Article
Engineering, Chemical
Alondra M. Idrovo Encalada, Carolina D. Perez, Paola Alzate Calderon, Enzo Zukowskia, Lia N. Gerschenson, Ana M. Rojas, Eliana N. Fissore
JOURNAL OF FOOD ENGINEERING
(2019)
Article
Food Science & Technology
Alondra M. Idrovo Encalada, Carolina D. Perez, Lia N. Gerschenson, Ana M. Rojas, Eliana N. Fissore
LWT-FOOD SCIENCE AND TECHNOLOGY
(2019)
Article
Chemistry, Applied
Vanina A. Cosenza, Diego A. Navarro, Carlos A. Stortz, Ana M. Rojas
CARBOHYDRATE POLYMERS
(2020)
Article
Chemistry, Applied
Frank Sznaider, Ana M. Rojas, Carlos A. Stortz, Diego A. Navarro
CARBOHYDRATE POLYMERS
(2020)
Article
Chemistry, Applied
Alondra M. Idrovo Encalada, Carolina D. Perez, Luciana Rossetti, Ana M. Rojas, Eliana N. Fissore
FOOD HYDROCOLLOIDS
(2020)
Article
Food Science & Technology
Cinthia Santo Domingo, Carlos Otalora Gonzalez, Diego Navarro, Carlos Stortz, Ana M. Rojas, Lia N. Gerschenson, Eliana N. Fissore
Summary: A microwave heating procedure is proposed for concentrating polysaccharides in artichoke residues, which is more efficient than the traditionally used convective procedure. Subsequent stages involving buffer/enzymes were able to isolate pectin and inulin enriched fractions. The proposed procedure is important for utilizing vegetable by-products to produce fractions with potential for being used in healthy food formulations in the emerging biorefinery framework.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Natalia Ehrenhaus Masotta, Christian Hocht, Mario Contin, Silvia Lucangioli, Ana M. Rojas, Valeria P. Tripodi
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Article
Food Science & Technology
Carlos M. Otalora Gonzalez, Maria D. De'Nobili, Ana M. Rojas, Maria F. Basanta, Lia N. Gerschenson
Summary: The study developed functional composite edible films based on pectin with beetroot powder and red cabbage powder as fillers. The films showed changes in properties over time and demonstrated enhanced stability of red colour, making them suitable as colouring agents for edible food packaging applications.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Food Science & Technology
Alondra Mariela Idrovo Encalada, Maria Dolores De'Nobili, Andrea Nora M. Ponce, Carlos Arturo Stortz, Eliana Noemi Fissore, Ana Maria Rojas
Summary: A method for preparing calcium-crosslinked films using an orange-coloured carrot pectin-enriched fraction was developed, showing excellent mechanical properties and antioxidant capabilities. CPEF, rich in carotenoids and alpha-tocopherol, can maintain the orange color and partial carotenoid content of the films while providing water resistance.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Applied
Matias R. Villarreal, Diego A. Navarro, Nora M. A. Ponce, Ana M. Rojas, Carlos A. Stortz
Summary: Salicornia, a halophyte plant found on the coast of Argentina, has been identified as a potential source of biopolymers and antioxidants for food applications. Cell wall sequential extraction revealed the presence of pectin fractions, arabinoxylans, proteins, cellulose, lignin, and phenolics in different proportions. The high levels of arabinose in Salicornia suggest its ability to maintain cell wall flexibility in water-deficient environments.
Article
Multidisciplinary Sciences
Dana C. Bernhardt, Nora M. A. Ponce, Maria F. Basanta, Carlos A. Stortz, Ana M. Rojas
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)