期刊
CARBOHYDRATE POLYMERS
卷 91, 期 1, 页码 1-6出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2012.07.067
关键词
Fucoidan; Molecular weight; Anticoagulant activity
资金
- State Oceanic Administration of the People's Republic of China [201005024]
- Doctorial Fund of Shandong Province [BS2011YY066]
- Science and Technology Project of Shandong Province [2011GHY11529]
- Prospective Joint Research Projects of Jiangsu Province [BY2011189]
Seven fucoidans that differed only with respect to the average molecular weight and four fucoidans that differed with respect to both the molar ratio of fucose to galactose and the average molecular weight were obtained. The anticoagulant activities of these fucoidans were determined in order to understand the effects of the average molecular weight and the content of galactose. Fucoidans Y5-Y11, with the average molecular weight in the range of 50.1-8.4 kDa, showed decreasing activity at three concentrations and dose-dependent activity in the APTT and TT assays. Y1-Y4, which differed with respect to the average molecular weight and the molar ratio of fucose to galactose, exhibited complicated results in the APTT and TT assays. It was shown that not only the average molecular weight but also the molar ratio of fucose to galactose affected the anticoagulant activity of fucoidans. (C) 2012 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据