期刊
CARBOHYDRATE POLYMERS
卷 94, 期 2, 页码 940-945出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2013.02.013
关键词
Chitosan; Nanoparticles; Ionic gelation; Static mixer; Drug delivery
资金
- Agency for Science, Technology and Research (A*STAR), Singapore [ICES/07-122B01]
The purpose of this study is to synthesize chitosan (CS) nanoparticles (NPs) by ionic gelation with tripolyphosphate (TPP) as crossslinker in static mixers. The proposed static mixing technique showed good control over the ionic gelation process and 152-376 nm CS NPs were achieved in a continuous and scalable mode. Increasing the flow rates of CS:TPP solution streams, decreasing the CS concentration or reducing the CS:TPP solution volume ratio led to the smaller particles. Sylicylic acid (SA) was used as a model drug and successfully loaded into the CS NPs during the fabrication process. Our work demonstrates that ionic gelation-static mixing is a robust platform for continuous and large scale production of CS NPs for drug delivery. (C) 2013 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据