Article
Chemistry, Physical
Teresa Silvestri, Federica D'Aria, Fabrizio Villapiano, Fernando Scala, Laura Mayol, Danilo Aleo, Nunzio Cardullo, Sossio Fabio Graziano, Marco Biondi, Concetta Giancola
Summary: This study investigated different types of cyclodextrins (CDs) to improve the solubility of hydrocortisone (HC) in aqueous solution. HP beta CD was identified as the most effective CD in enhancing the solubility of HC, which has the potential to improve the formulation of HC-based pharmaceutical products.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Food Science & Technology
Andreia F. R. Silva, Mariana Monteiro, Daniela Resende, Susana S. Braga, Manuel A. Coimbra, Artur M. S. Silva, Susana M. Cardoso
Summary: The study demonstrated that gamma-cyclodextrin (γ-CD) can act as a carrier of resveratrol (RSV), promoting its solubility and protecting its antioxidant stability in lemon juices for at least 28 days.
Article
Thermodynamics
Dzhovidon Kabirov, Teresa Silvestri, Marcella Niccoli, Tatiana Usacheva, Laura Mayol, Marco Biondi, Concetta Giancola
Summary: This study investigates the formation of inclusion complexes between the semisynthetic hydroxypropyl-beta-cyclodextrin (HPβCD) and CURC. Various experimental conditions were tested to evaluate the formation, stability, and efficacy of the complexes.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2022)
Article
Biochemistry & Molecular Biology
Junqiang Guo, Liwei Lin, Yuping Wang, Wang Zhang, Guowang Diao, Yuanzhe Piao
Summary: A water-soluble inclusion complex of DPG and beta-CDP, termed DPG-beta-CDP, was prepared and found to greatly enhance the water solubility of DPG, making it a promising candidate for water-soluble vulcanization accelerators.
Article
Polymer Science
Ine Suharyani, Muchtaridi Muchtaridi, Ahmed Fouad Abdelwahab Mohammed, Khaled M. Elamin, Nasrul Wathoni, Marline Abdassah
Summary: The study aimed to enhance the solubility of alpha-Mangostin in water by forming a complex with Cyclodextrin, resulting in a significant increase in solubility and potential for water-based preparation for clinical applications.
Article
Biochemistry & Molecular Biology
Laura Sbarcea, Ionut-Mihai Tanase, Adriana Ledeti, Denisa Circioban, Gabriela Vlase, Paul Barvinschi, Marinela Miclau, Renata-Maria Varut, Oana Suciu, Ionut Ledeti
Summary: Risperidone, an atypical antipsychotic drug, was encapsulated with randomly methylated beta-cyclodextrin to enhance its solubility and stability. The compatibility study revealed that the inclusion complex of Risperidone with RM-beta-CD showed compatibility with certain pharmaceutical excipients, making it a promising candidate for further research in developing new formulations with enhanced bioavailability and stability.
Review
Medicine, Research & Experimental
Vasanti Suvarna, Bhunesh Bore, Chaitanya Bhawar, Rashmi Mallya
Summary: Bioactive phytochemicals from natural sources have diverse therapeutic activities, but their application is hindered by drawbacks such as poor solubility and bioavailability. However, complexation with cyclodextrins provides a solution to these issues. This article summarizes the complexation of various phytochemicals with cyclodextrins and the impact on their stability and dissolution rate, leading to enhanced bioactivity.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Physical
Shuang Gao, Jingyu Jiang, Xiaoming Li, Fei Ye, Ying Fu, Lixia Zhao
Summary: In this study, an inclusion complex of beta-cyclodextrin and difenoconazole was synthesized to enhance water solubility and antifungal activity. The complex showed increased water solubility and improved fungicidal effect against Gibberella sp., presenting a new formulation idea for the agricultural application of difenoconazole.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Acoustics
Xiaowen Sun, Junxiang Zhu, Chengqin Liu, Dongfeng Wang, Chang-Yun Wang
Summary: In this study, a stable inclusion complex of Fucoxanthin (Fx) and 2-hydroxypropyl-beta-cyclodextrin (2-HP-beta-CD) was prepared with the aid of ultrasound. The complex exhibited good water solubility and stability, and showed excellent antitumor activity. This encapsulation strategy could potentially promote the application of Fx in pharmaceuticals and functional foods.
ULTRASONICS SONOCHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Chulhun Park, Jieyu Zuo, Myung-Chul Gil, Raimar Lobenberg, Beom-Jin Lee
Summary: This study investigated the enhancement of solubility and stability of cannabinoid acids through the formation of inclusion complexes with cyclodextrins. The inclusion complexes showed improved physicochemical and biological performances, making them a promising option for loading lipophilic cannabinoids in drug products derived from cannabis.
Article
Biochemistry & Molecular Biology
Mahendra P. Kapoor, Masamitsu Moriwaki, Katsuhiko Minoura, Derek Timm, Aya Abe, Kento Kito
Summary: This study investigated the preparation, stability, solubility, and spectroscopic features of a hesperetin-7-O-glucoside inclusion complex with beta-cyclodextrin. The results showed that the inclusion complex improved the water solubility and thermal stability of hesperetin-7-O-glucoside, potentially enhancing its health benefits.
Article
Chemistry, Applied
Pinal Chaudhari, Sumit Birangal, Nimisha Mavlankar, Asish Pal, Lakshmi Sruthi Mallela, Sanhita Roy, Arun K. Kodoth, Vivek Ghate, Madhavan Nampoothiri, Shaila A. Lewis
Summary: In this study, sulfobutylether-beta-cyclodextrin based complexes were developed to improve the solubility and corneal permeation of Cyclosporine A (CsA) for the treatment of dry eye disease. The complexes showed improved dissolution and transcorneal permeation, and demonstrated non-irritancy and non-toxicity. The in vivo treatment with the complexes showed better management of dry eye.
CARBOHYDRATE POLYMERS
(2022)
Article
Food Science & Technology
Prakash Chandra Pradhan, Abhishek Mandal, Anirban Dutta, Rohan Sarkar, Aditi Kundu, Supradip Saha
Summary: The inclusion complex of Berberis lycium anthocyanins with beta-cyclodextrin was successfully prepared and demonstrated improved thermal stability and regulated release of anthocyanins. Molecular docking studies revealed the thermodynamic stability of one anthocyanin complex over the other. Molecular dynamics simulations provided insights into the behavior of anthocyanins within the inclusion complex cavity.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Medicine, Research & Experimental
Chihiro Tsunoda, Kanji Hasegawa, Ryosuke Hiroshige, Takahiro Kasai, Hideshi Yokoyama, Satoru Goto
Summary: This study investigates the effect of cyclodextrin (CD) on the solubility of drugs in the presence of multiple drug interactions. The results show that ss CD has a synergistic effect on increasing solubility in drug-drug combinations and can effectively improve the dissolution rate of drugs.
MOLECULAR PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Yue Niu, Lihong Jia, Yuanjie Li, Yinggui Liu, Qiuxiang Yin, Ling Zhou
Summary: The prednisolone/β-cyclodextrin complex with a 1:2 molar ratio was successfully prepared, and its single-crystal structure was determined for the first time. The thermodynamic phase diagram of this complex was established to support the preparation process by solution crystallization. Molecular dynamics simulations were conducted to probe the intermolecular interactions and the formation mechanism of prednisolone/β-cyclodextrin complex.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Chemistry, Applied
Xiu-Qin Zheng, Lei-Xin Song, Zhu-Zhen Han, Ying-Bo Yang, Yi Zhang, Li-Hua Gu, Li Yang, Gui-Xin Chou, Zheng-Tao Wang
Summary: In this study, five new triterpenoids were isolated from the fruit spikes of Prunella vulgaris L., along with 15 known triterpenoids. Their structures were elucidated, and their anti-thyroid cancer activities were evaluated. Three of the compounds showed apparent inhibitory activity against thyroid cancer.
NATURAL PRODUCT RESEARCH
(2023)
Article
Plant Sciences
Hao Qiu, Lei-Xin Song, Ying-Bo Yang, Si-Yu Zhang, Zhu-Zhen Han, Zheng-Tao Wang, Li Yang
Summary: Two undescribed stilbenoid diglycosides, dendrosonside A and dendrosonside B, were isolated from the stems of Dendrobium 'Sonia'. Their structures were elucidated and they showed inhibition of nitric oxide production.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2023)
Article
Chemistry, Analytical
Yuangui Yang, Lvye Liu, Zhengtao Wang, Yan Jin, Yanhai Zhang
Summary: An automated on-line solid-phase extraction (SPE) high-performance liquid chromatography (HPLC) method was developed for the determination of six protoberberine alkaloids in compound Chinese medicines containing Coptidis Rhizoma and Phellodendri Cortex. The method effectively removed interferences from samples and successfully quantified the target alkaloids using ion pair reverse phase high-performance liquid chromatography.
ANALYTICAL LETTERS
(2023)
Article
Chemistry, Applied
Jia-Ying Zhao, Qi Liao, Jian-Wei Zhang, Guo-Qiang Lin, Zhengtao Wang, Dingding Gao, Qing-Hua Li, Ping Tian
Summary: In this study, a metal-free cascade dihalogenation-cyclization reaction was reported for the convenient preparation of dibrominated cis-tetrahydrobenzofuran-5(4H)-ones and cis-dihydrobenzopyran-6(5H)-ones. These products bear 1,4-dibromobut-1-enyl subunit in trans-trans and trans-cis form. The anticancer activity against MDA-MB-468 cells was also observed for the corresponding products.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Review
Chemistry, Analytical
Longchan Liu, Ziying Wang, Qian Zhang, Yuqi Mei, Linnan Li, Huwei Liu, Zhengtao Wang, Li Yang
ANALYTICAL CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Maoqi Hou, Feng Nie, Jianing Zhao, Zhengcai Ju, Li Yang, Qingzhong Wang, Shujuan Zhao, Zhengtao Wang
Summary: In this study, six UGTs were characterized, two of which were novel. PnUGT71A3 catalyzes the glycosylation of protopanaxatriol (PPT) and F1 to form Rh1 and Rg1, respectively, and also the glycosylation of protopanaxadiol (PPD)-type Rg3 to generate Rd. PnUGT94M1 regioselectively catalyzes the rhamnosylation of the C6 glucose of PPT-type ginsenosides Rg1 and Rh1, generating ginsenosides Re and Rg2, respectively, and is UDP-beta-L-rhamnose (UDP-Rha)-dependent.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Yaru Wang, Yunxia Shang, Fengyu Tang, Kun Qiu, Xiaohui Wei, Zhengtao Wang
Summary: In this study, self-double-emulsifying drug delivery system enteric-coated capsules (PNS-SDE-ECC) were used to enhance the oral bioavailability and anti-inflammatory effects of Panax notoginseng saponins (PNS). PNS-SDE-ECC significantly promoted the absorption of PNS in the intestinal tract and exhibited sustained release and stability. Compared to gastric capsules, PNS-SDE-ECC increased the relative bioavailability of NGR1, GRg1, GRe, GRb1, and GRd by 4.83, 10.78, 9.25, 3.58, and 4.63 times, respectively. Furthermore, PNS-SDE-ECC reduced OXZ-induced inflammatory damage in the colon by regulating cytokine expression.
Article
Plant Sciences
Yin Cao, Mingrui Li, Lihua Gu, Xin Zhao, An Zhou, Yuping Miao, Yi Wu, Zunji Ke, Rongfeng Hu, Zhengtao Wang, Xiaojun Wu
Summary: The study investigated the effects of Kaixin San (KXS) on hippocampal neurons and cardiac ferroptosis in mice with rapid-eye-movement (REM) sleep deprivation. The results showed that KXS improved learning and memory, prevented mitochondrial damage, alleviated myocardial injury, and reversed the expression of proteins involved in ferroptosis in the hippocampus and heart tissues.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Chemistry, Physical
Rui Tian, Yufan Guo, Fazhen Luo, Tianshu Yang, Zhenhua Zhou, Zhengtao Wang, Yan Xie
Summary: This paper reports the synthesis of multifunctional carbon dots (CFCDs) using herbal medicine as a precursor, and investigates their fluorescent properties and biological activities. The obtained CFCDs have a graphitic structure, abundant functional groups, high aqueous solubility, and excellent stability. CFCDs exhibit pH-dependent fluorescence properties and low cytotoxicity, making them suitable for cell imaging. Moreover, CFCDs have good hemostatic effects and can promote platelet aggregation. CFCDs have potential for wide application in the medical domain.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Article
Food Science & Technology
Lihua Gu, Yue Jiang, Yuanyuan Han, Li Yang, Zhengtao Wang
Summary: A practical TLC-direct bioassay method was established for screening and evaluating antioxidant activity. The method involved a series of reactions, including the production of lipid peroxides by UV irradiation of linoleic acid and the conversion of peroxides into malondialdehyde. A dot blot test using TLC separation showed that substances with anti-lipid peroxidation activity appeared as white spots/zones on a red background. The method was validated for selectivity, sensitivity, linearity, precision, and recovery, and was successfully used to identify active antioxidant constituents from Perilla fruits.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Deqing Ruan, Jingyi Yang, Qianfei Luo, Yanhong Shi, Lili Ding, Zhengtao Wang, Rui Wang, Li Yang
Summary: In this study, we found that goitrin, an alkaloid from Radix Isatidis, showed protective effects in LPS-induced septic shock by inhibiting caspase-11 non-canonical inflammasome pathway. This finding provides a new therapeutic strategy for the clinical treatment of septic shock.
Article
Biochemistry & Molecular Biology
Yan Chen, Yingying Tang, Pei Liu, Jinyuan Wang, Weiqian Wang, Changhong Wang, Lili Ding, Aizhen Xiong, Li Yang, Zhengtao Wang
Summary: This study investigates the toxicity and toxicokinetic characteristics of a toxic PA N-oxide, senecionine N-oxide, using a UDP-glucuronosyltransferase 1A4 humanized mouse model (hUGT1A4 mouse model) and wild-type mice. Results show that senecionine N-oxide exposure caused less toxicity in hUGT1A4 mice, and N-glucuronidation occurred exclusively in hUGT1A4 mice. There were also differences in toxicokinetic characteristics between hUGT1A4 mice and wild-type mice, with enhanced clearance of senecionine N-oxide and senecionine in hUGT1A4 mice, leading to detoxification.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Plant Sciences
Ruiyang Gao, Zhilun Yu, Cheng Lv, Xiaolong Geng, Yijing Ren, Junyu Ren, Hao Wang, Fangbin Ai, Beibei Zhang, Bei Yue, Zhengtao Wang, Wei Dou
Summary: This study found that a plant called Allium macrostemon Bunge (AMB) promotes hair regrowth in AGA mice and identifies the underlying molecular mechanisms. AMB stimulates proliferation and migration of human hair dermal papilla cells (HDPC) and enhances growth factors expression through the activation of the Wnt/β-catenin signaling pathway. Treatment with AMB extract promotes hair regeneration in AGA mice. These findings contribute to the potential use of AMB in alopecia treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Wei Li, Tongxi Zhuang, Zixuan Wang, Xunjiang Wang, Longchan Liu, Yixuan Luo, Rufeng Wang, Linnan Li, Wendong Huang, Zhengtao Wang, Li Yang, Lili Ding
Summary: Red ginseng extracts (RGS) show potential in treating obesity and insulin resistance by improving glucose and lipid metabolism. This study demonstrated that RGS activates intestinal TGR5 to promote lipolysis and energy consumption by increasing circulating bile acid levels, and facilitates the transport of bile acids by promoting ASBT translocation.
Review
Biochemistry & Molecular Biology
Zhonglian Yu, Mengqin Xia, Jiping Lan, Li Yang, Zhengtao Wang, Rui Wang, Hongxun Tao, Yanhong Shi
Summary: The Lycium genus, including Lycium barbarum L., Lycium chinense Mill., and Lycium ruthenicum Murr., has been used as a source of medicines and nutrient supplements in China for thousands of years. These fruits have been extensively studied and commercialized for their health-related properties, including antioxidant, immunomodulatory, anti-tumor, hepatoprotective, and neuroprotective effects. However, there is limited systematic and comprehensive information available on the Lycium genus.
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
