Article
Chemistry, Applied
Dominik Ruhr, Michael John, Annette Reiche
Summary: Experimental study showed that approximately 50% of BDDE molecules effectively cross-link, and there is a direct correlation between the degree of cross-linking and the decomposition temperature of the cellulose membranes.
CARBOHYDRATE POLYMERS
(2021)
Article
Polymer Science
Pooria Rahmani, Akbar Shojaei
Summary: In this study, superabsorbent and tough hydrophobic associated hydrogels were developed using terpolymerization of poly acrylic acid (PAA), polyacrylamide (PAM), and lauryl methacrylate (LMA) within the micelles formed by sodium dodecyl sulfate (SDS) surfactant. The hydrogels exhibited suitable mechanical properties and outstanding swelling ratio due to the multiple physical interactions inside the hydrogel. This fascinating feature could broaden the applications of hydrogels in various areas.
Article
Engineering, Multidisciplinary
Alexander Pestov, Yuliya Privar, Arseny Slobodyuk, Andrey Boroda, Svetlana Bratskaya
Summary: This study demonstrates the use of acyclic diethylacetal of acetaldehyde (ADA) with low cytotoxicity for the fabrication of hydrogels. The hydrogels were formed via Schiff bases formation between chitosan and acetaldehyde generated in situ from acetals in chitosan acetate solution. The formed hydrogels showed mechanical stability and insolubility in a broad pH range.
Article
Pharmacology & Pharmacy
Mario Saletti, Marco Paolino, Lavinia Ballerini, Germano Giuliani, Gemma Leone, Stefania Lamponi, Marco Andreassi, Claudia Bonechi, Alessandro Donati, Daniele Piovani, Alberto Giacometti Schieroni, Agnese Magnani, Andrea Cappelli
Summary: An easy and viable crosslinking procedure using click-chemistry was developed for hyaluronic acid. The resulting crosslinked materials showed no cytotoxic effects, tunable water affinity, and rheological properties, suggesting potential applications in different biomedical fields.
Review
Polymer Science
He Mengyuan, Wang Changlin, Xu Tong, Dong Ping, Yu Xiaojun, Song Huaying, Liu Congying, Gao Peng, Cong Zhufeng
Summary: Hydrogels have a unique three-dimensional structure and are widely used in drug delivery. Natural hydrogel materials are non-toxic, easily accessible, and abundant. Chemical modification of natural hydrogels improves their properties. Chitosan, hyaluronic acid, gelatin, and sodium alginate are common natural polymers. This review comprehensively summarizes their characteristics, derivatives, mechanisms, and applications in drug delivery systems.
Article
Materials Science, Characterization & Testing
Zhenming Qi, Xiaosai Hu
Summary: This study introduces a novel cross-linker, sulfanilic acid (SA), to improve the mechanical performance of hydrogels. SA overcomes the heterogeneity of cross-links in the topological structure of gels and forms multiple hydrogen bonds with poly(acrylamide) (PAM) chains, resulting in a distinct energy dissipation mode. The PAM/SA gel exhibits good self-recoverability and remarkable fatigue resistance.
Article
Chemistry, Applied
Kaibin Li, Xiaorui Li, Chunyan Li, Yiding Shen, Dan Wang
Summary: The cross-linked polyvinyl alcohol (AZ-CIPVA) prepared with modifiers IBMA and AZ showed improved paper sizing efficiency. The reaction between AZ and carboxyl groups in CIPVA molecules formed a cross-linking structure, enhancing the gel content, cross-linking density, and thermal stability of the film. The maximum tensile strength and modulus of the film were achieved at 3.5% AZ dosage, leading to increased dry and wet tensile indexes of the paper.
PROGRESS IN ORGANIC COATINGS
(2021)
Article
Food Science & Technology
Faezeh Ahrari, Maryam Yousefi, Zohreh Habibi, Mehdi Mohammadi
Summary: The preparation of cross-linked enzymes can be done through enzyme aggregation or crystallization followed by cross-linking using glutaraldehyde as a common linker. Isocyanide-based multi-component reactions (ICMRs) provide a one-step process to directly prepare cross-linked enzymes from their soluble forms. Cysteamine is introduced as a non-toxic alternative cross-linker in ICMR-implemented cross-linking reactions, demonstrating improved immobilization yields and enzyme activities.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jing Chen, Qun Zhao, Hang Gao, Lili Zhao, Huiying Chu, Yichu Shan, Zhen Liang, Yukui Zhang, Lihua Zhang
Summary: Chemical cross-linking mass spectrometry (CXMS) is a powerful technology for analyzing protein complexes. However, in vivo CXMS studies have been limited by cross-linking biocompatibility and data analysis. In this study, a glycosidic bond-based MS-cleavable cross-linker called trehalose disuccinimidyl ester (TDS) was designed and synthesized, which simplified the cross-linked peptides into conventional single peptides via selective cleavage. TDS showed high biocompatibility and accuracy, enhancing the cross-linking identification accuracy and throughput.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Organic
Heli Fan, Xiaohua Peng
Summary: Two small libraries of 2-OMe or 2-NO2-benzene analogues containing various leaving groups were synthesized and characterized, with compounds containing a 2-methoxy substituent showing faster cross-linking reaction rates and higher efficiency. The benzylic leaving groups greatly affected DNA cross-linking efficiency, with compounds containing OCH3, OCH2Ph, or Ph3P+ as leaving groups showing higher ICL yields. The heat stability study indicated that dGs were the preferred alkylation sites in DNA for the benzyl cations produced from certain compounds.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Shuwen Jiang, Eduardo Fuentes-Lemus, Michael J. Davies
Summary: Beta-2-microglobulin (B2M), a component of the major histocompatibility complex, plays a crucial role in cell immunity. Elevated levels of B2M are associated with amyloid formation in certain pathological conditions. This study investigates the chemical and structural changes of B2M induced by oxidative stress, which may contribute to amyloid formation.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Wancheng Chen, Sijie Yuan, Jie Shen, Yongsheng Chen, Yang Xiao
Summary: The composite hydrogel CH-P 40% demonstrated a dense network structure, retained various chemical bonds, cellulose crystal structures, and showed favorable thermal stability. It also exhibited increased cell proliferation rates and no pathological lesions in mouse organs, indicating good biocompatibility. Additionally, the hydrogel-treated liver wounds showed less bleeding within 3 minutes, highlighting its potential as a rapid hemostatic biomedical material.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Physical
Aidan E. Gilchrist, Yueming Liu, Katarina Klett, Yu-Chung Liu, Sofia Ceva, Sarah C. Heilshorn
Summary: Hydrogels cross-linked by dynamic covalent chemistry (DCC) are stiff and remodelable, making them ideal biomimetics for tissue engineering applications. By using small molecule competitors, the formation of hydrogel network can be transiently controlled. Experimental and computational methods are used to find a series of competitors that predictably alter the gelation time and mechanics of hydrogels. The tunable gelation kinetics of recombinant hydrogel are demonstrated using human intestine organoids as a model system.
CHEMISTRY OF MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Melek Pamuk Algi, Rumeysa Sarigol
Summary: In this study, we developed a multifunctional polymeric hydrogel through cross-linker engineering and demonstrated its application in photothermal therapy. The hydrogel showed high efficiency in eliminating cancer cells and sustained release of drugs.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Pengxiang Xu, Jiangfeng Song, Zhuqing Dai, Yayuan Xu, Dajing Li, Caie Wu
Summary: The study investigated the construction of nano-lutein hydrogels with sustained release properties by cross-linking with different concentrations of Ca2+. Results showed that the highest loading capacity for lutein reached 770.88 μg/g, with an encapsulation efficiency of 99.39%. The presence of lutein nanoparticles and increased Ca2+ concentration both affected the physical properties and swelling behavior of the hydrogel. The stability of cross-linked ionic bonds in the hydrogel was reduced by lutein nanoparticles and excessive Ca2+, impacting its thermodynamic stability.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)