Article
Chemistry, Applied
Min Li, Yinan Zhao, Jiao Sun, Huiying Chen, Zhanbiao Liu, Kexin Lin, Pengfei Ma, Wenjun Zhang, Yuhong Zhen, Shufen Zhang, Shubiao Zhang
Summary: Polymer-based prodrug nanocarriers with tumor-targeting and controlled-release properties are highly desirable for improving cancer treatment. Hyaluronic acid (HA), known for its excellent biocompatibility and targeting ability for CD44, has been suggested as a carrier for delivering drugs with poor solubility and high toxicity. In this study, podophyllotoxin (PPT) was conjugated to HA through ester and disulfide linkages to create a pH and reduction-responsive prodrug (HA-S-S-PPT). Micelles self-assembled from HA-S-S-PPT efficiently accumulated at the tumor site due to HA receptor-mediated endocytosis. These micelles exhibited 33.1% higher cumulative release compared to HA-NH-CO-PPT micelles, which were only sensitive to pH. HA-S-S-PPT micelles demonstrated excellent antitumor activity in vivo, with a tumor inhibition rate of 92%, significantly higher than that of HA-NH-CO-PPT micelles (65%), and minimal systemic toxicity. This controllable-targeting nanoparticle system presents a potential platform for the clinical application of PPT.
CARBOHYDRATE POLYMERS
(2022)
Article
Nanoscience & Nanotechnology
Youkabed Kazemi, Sadegh Dehghani, Fatemeh Soltani, Khalil Abnous, Mona Alibolandi, Seyed Mohammad Taghdisi, Mohammad Ramezani
Summary: Nanomaterial-based drug delivery using HA-targeted nanocarrier loaded with DOX showed promising anti-cancer effects in both in vitro and in vivo studies. The smart nanosystem demonstrated controlled drug release in response to ATP content and improved cytotoxicity and cellular uptake. The HA-targeted formulation enhanced survival rate and tumor inhibition in tumor-bearing mice compared to free DOX.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Umeka Nayanathara, Bruna Rossi Herling, Niloufar Ansari, Changhe Zhang, Saskia R. Logan, Maximilian A. Beach, Samuel A. Smith, Nathan R. B. Boase, Angus P. R. Johnston, Georgina K. Such
Summary: We designed dual pH-responsive multicomponent nanoparticles with tunable core polymer architectures to investigate the effect of polymer architecture on intracellular therapeutic delivery. The nanoparticles were assembled using amphiphilic block copolymers and contained doxorubicin (Dox) covalently conjugated to star or linear core polymers. Despite similar physicochemical properties, the nanoparticles with a linear core showed higher toxicity in MCF-7 cells (IC50 = 60 ng/mL) compared to those with a star core (IC50 > 1000 ng/mL), suggesting that polymer architecture influenced drug release behavior.
ACS APPLIED NANO MATERIALS
(2023)
Article
Engineering, Biomedical
Qiang Li, Dongsheng Fu, Jie Zhang, Tianyang Li, Huifang Wang, Wenjuan Hou, Baolong Niu, Ruijie Guo, Yiming Liu
Summary: Encapsulation of DOX and CUR into pH-responsive targeting dual-agent delivery nanoparticles was successfully achieved in this study. The HEPT nanoparticles showed higher cytotoxicity against cancer cells and are promising as a new strategy for cancer treatment.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2021)
Article
Medicine, Research & Experimental
Carolina Henriques Cavalcante, Renata Salgado Fernandes, Juliana de Oliveira Silva, Caroline Mari Ramos Oda, Elaine Amaral Leite, Geovanni Dantas Cassali, Ives Charlie-Silva, Bianca Helena Ventura Fernandes, Lucas Antonio Miranda Ferreira, Andre Luis Branco de Barros
Summary: The developed pH-sensitive micelles encapsulating DOX showed promising results with small diameter, high stability, low toxicity, and significantly better inhibition of tumor growth compared to other forms of DOX.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Morvarid Borhaninia, Mahsa Zahiri, Khalil Abnous, Seyed Mohammad Taghdisi, Mohammad Ramezani, Mona Alibolandi
Summary: In this study, a pH-sensitive polymersome incorporating doxorubicin (DOX) was prepared using a hyaluronic acid-beta-poly (beta-amino ester) (HA-PBAE) diblock copolymer. The DOX was loaded into the aqueous compartment of the HA-PBAE polymersome with high entrapment efficiency and loading content. The DOX-HA-PBAE platform showed accelerated drug release under acidic conditions and exhibited higher cytotoxicity and cellular internalization compared to free DOX in CD44 positive cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Donghun Shin, Seungki Lee, Hyun Sung Jang, Ji Bong Joo, Inhee Choi
Summary: In this study, dual-responsive hollow mesoporous silica nanoparticles (HMSNs) capped with hyaluronic acid (HA) were designed as drug carriers, exhibiting enhanced targeting efficiency and drug release efficiency. This research provides a new possibility for further improving drug delivery efficiency.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Huiting Chen, Zhou Fang, Mengdi Song, Kehai Liu
Summary: The study presents a hierarchical drug delivery system, HA-GDT-Lip, which exhibits high cell uptake efficiency and mitochondrial targeting ability, inducing cell apoptosis and showing excellent antitumor activity and in vivo safety.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Materials Science, Biomaterials
Sensen Zhou, Cheng Li, Yang Yuan, Lei Jiang, Weizhi Chen, Xiqun Jiang
Summary: This study reports a novel tumor-targeted liposome based on the protein-anchored cell membrane architecture. The liposome, called dtDLP, was constructed through the electrostatic interaction between dendritic lipopeptide liposomes and a dual-targeted recombinant protein, and it demonstrated superior tumor homing, cellular endocytotic, and penetration abilities.
BIOMATERIALS SCIENCE
(2022)
Article
Engineering, Biomedical
Lipeng Qiu, Jiamin Xu, Kamel S. S. Ahmed, Mengqin Zhu, Yan Zhang, Miaomiao Long, Weijun Chen, Wenjie Fang, Huijie Zhang, Jinghua Chen
Summary: A dual-functional pH-sensitive drug delivery system was developed for breast cancer therapy. The system showed higher cytotoxicity and cell uptake efficiency compared to other drug-loaded micelles, indicating its potential for reversing multidrug resistance. In vivo experiments demonstrated that the system effectively inhibited tumor growth without significant changes in body weight. The results suggest that the dual gain DNVM can enhance the efficacy of chemotherapy for doxorubicin-resistant tumor cells and has the potential to overcome multiple drug resistance.
ACTA BIOMATERIALIA
(2022)
Article
Biochemistry & Molecular Biology
Wei-Hsiang Hsu, Chien-Liang Ku, You-Ren Lai, Steven S. -S. Wang, Shiu-Huey Chou, Ta-Hsien Lin
Summary: This study aimed to develop DOXO-coupled glycated BSA nanoparticles and improve their targeting capability towards GLUT5 transporters over-expressed on breast cancer cells. The synthesized nanoparticles had a spherical shape with a hydrodynamic diameter of approximately 60.74 nm and a zeta-potential of approximately -42.20 mV. Furthermore, the DOXO-coupled glycated BSA nanoparticles exhibited cytotoxicity towards both MCF-7 and MDA-MB-231 cells. Overall, this research demonstrates the potential of drug-coupled glycated BSA nanoparticles as a targeted drug delivery platform for breast cancer therapy. Rating: 9/10.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biophysics
Shuang Fu, Yinan Zhao, Jiao Sun, Ting Yang, Defu Zhi, Enxia Zhang, Fangli Zhong, Yuhong Zhen, Shufen Zhang, Shubiao Zhang
Summary: RGD-modified liposomes showed excellent active targeting ability for integrin ?v?3 receptors and enhanced DOX release due to their pH-sensitivity, resulting in significant antitumor efficacy with low toxicity. This new approach provides a potential avenue for improved tumor therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Won Jung Kim, Eu Hyun Lee, Yong-Jin Kwon, Sang-Kyu Ye, Kyu Oh Kim
Summary: An amphipathic PAA-POSS@DOX drug delivery system that is sensitive to pH changes in the cancer microenvironment has been developed using a nanoparticle based on inorganic polyhedral oligomeric silsesquioxane (POSS). This system has high loading efficiency and can quickly release the drug to the target area, as confirmed by cell death in the MDA-MB-231 breast cancer line.
Article
Chemistry, Inorganic & Nuclear
Hafez Khodayari, Amir Heydarinasab, Elham Moniri, Mahsasadat Miralinaghi
Summary: pH-sensitive magnetic nanocarrier was developed for doxorubicin delivery by grafting hyaluronic acid/beta-cyclodextrin onto Fe3O4 magnetic nanoparticles. The nanocarrier demonstrated strong pH-dependent release behavior, with higher drug release at pH 5.6 compared to pH 7.4. The release mechanism was determined to be controlled by Fickian diffusion kinetic. The surface modification of the magnetic nanoparticles greatly influenced drug sorption and was more compatible with Langmuir isotherm and pseudo-second-order kinetic models. Thermodynamic parameters indicated that the doxorubicin adsorption was endothermic and spontaneous, suggesting physiochemical sorption. These findings highlight the potential of pH-sensitive nanocarriers for drug delivery.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Nanoscience & Nanotechnology
Qian Xie, Shi Gao, Rui Tian, Guohao Wang, Zainen Qin, Minglong Chen, Wenhui Zhang, Qiang Wen, Qingjie Ma, Lei Zhu
Summary: We developed a hyaluronic acid nanoparticle that carries a chemotherapy drug and a photosensitizer, and demonstrated its efficacy in tumor-bearing mice. This smart drug delivery system improves traditional chemotherapy and enhances photodynamic therapy. The nanoparticles release drugs in the tumor, providing effective treatment.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)