Tacrine–propargylamine derivatives with improved acetylcholinesterase inhibitory activity and lower hepatotoxicity as a potential lead compound for the treatment of Alzheimer’s disease

Novel tacrine–ebselen hybrids with improved cholinesterase inhibitory, hydrogen peroxide and peroxynitrite scavenging activity

(2013) Fei Mao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A novel hybrid of 6-chlorotacrine and metal–amyloid-β modulator for inhibition of acetylcholinesterase and metal-induced amyloid-β aggregation

(2013) Akiko Kochi et al.   Chemical Science

O-Hydroxyl- or o-amino benzylamine-tacrine hybrids: Multifunctional biometals chelators, antioxidants, and inhibitors of cholinesterase activity and amyloid-β aggregation

(2012) Fei Mao et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, design and biological evaluation of novel highly potent tacrine congeners for the treatment of Alzheimer's disease

(2012) Slavka Hamulakova et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Divergent Transformations of Aromatico-Aminonitrile with Carbonyl Compound

(2012) Jianhong Tang et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Tacrine-Silibinin Codrug Shows Neuro- and Hepatoprotective Effects in Vitro and Pro-Cognitive and Hepatoprotective Effects in Vivo

(2012) Xinyu Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tacrine–Ferulic Acid–Nitric Oxide (NO) Donor Trihybrids as Potent, Multifunctional Acetyl- and Butyrylcholinesterase Inhibitors

(2012) Yao Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Multi-target, Neuroprotective and Neurorestorative M30 Improves Cognitive Impairment and Reduces Alzheimer's-Like Neuropathology and Age-Related Alterations in Mice

(2012) Lana Kupershmidt et al.   MOLECULAR NEUROBIOLOGY

BCHE and CYP2D6 genetic variation in Alzheimer’s disease patients treated with cholinesterase inhibitors

(2011) Caterina Chianella et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Use of memantine for the treatment of dementia

(2011) Daphne Lo et al.   Expert Review of Neurotherapeutics

Novel Tacrine−8-Hydroxyquinoline Hybrids as Multifunctional Agents for the Treatment of Alzheimer’s Disease, with Neuroprotective, Cholinergic, Antioxidant, and Copper-Complexing Properties

(2010) María Isabel Fernández-Bachiller et al.   JOURNAL OF MEDICINAL CHEMISTRY

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tacrine-Melatonin Hybrids as Multifunctional Agents for Alzheimer's Disease, with Cholinergic, Antioxidant, and Neuroprotective Properties

(2009) María Isabel Fernández-Bachiller et al.   ChemMedChem

Oxidative stress hypothesis in Alzheimer’s disease: a reappraisal

(2008) Domenico Praticò   TRENDS IN PHARMACOLOGICAL SCIENCES