Article
Chemistry, Applied
Maxime Gautreau, Sylvie Durand, Angeline Paturel, Sophie Le Gall, Loic Foucat, Xavier Falourd, Bruno Novales, Marie-Christine Ralet, Sylvie Chevallier, Antoine Kervoelen, Alain Bourmaud, Fabienne Guillon, Johnny Beaugrand
Summary: The relationship between the mechanical properties, chemical composition, and cellulose structure of flax fibre bundles was investigated in this study using sequential biopolymer extraction. The results showed that the oxalate extract mainly consisted of homogalacturonans and type I rhamnogalacturonans, while the LiCl extract was composed mainly of glucomannans and the KOH extract of xyloglucans. The extraction process led to the disappearance of the middle lamella, resulting in a decrease in the tensile Young's modulus and maximum strength of the fibre bundles.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Applied
Eugenio Spadoni Andreani, Salwa Karboune, Lan Liu
Summary: In this study, cell wall polysaccharides were extracted from Stevens cranberry pomace, revealing a high content of pectic polysaccharides including homogalacturonan, arabinan, and galactan. Various extracts showed differences in composition, with CH extract having the highest yield and mainly consisting of homogalacturonan. Additionally, high molecular weight polysaccharides were identified in all extracts.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Applied
Yang Qiu, Jinfeng Bi, Xin Jin, Lina Hu, Jian Lyu, Xinye Wu
Summary: Protein denaturation plays the most important role in affecting the WHC of rehydrated shiitake mushrooms, while the status of cell wall fibrous material has a relatively weak impact. Loss of cell membrane integrity is unlikely to contribute to WHC changes in rehydrated shiitake mushrooms.
Article
Biochemistry & Molecular Biology
Ana Atanasova, Ani Petrova, Desislava Teneva, Manol Ognyanov, Yordan Georgiev, Nenko Nenov, Petko Denev
Summary: This study investigated the effectiveness of subcritical water extraction (SWE) for the recovery of rosmarinic acid (RA) from lemon balm, as a green alternative to conventional hydro-alcoholic extraction. The results showed that SWE was an efficient technology for the extraction of RA and other antioxidants with reduced extraction time and without the use of toxic organic solvents. Furthermore, by modifying SWE conditions, extracts with different purity and content of RA could be obtained.
Article
Chemistry, Applied
Jelle Van Audenhove, Tom Bernaerts, Novita I. Putri, Sophie Delbaere, Ilke Caveye, Ann M. Van Loey, Marc E. Hendrickx
Summary: This study investigated the influence of pectin depletion on the network forming potential of cell wall material (CWM) from tomato through high-pressure homogenization (HPH). The results showed that the microstructure, water binding capacity, and viscoelastic properties of CWM were affected by the degree and method of pectin extraction before and after HPH functionalization.
FOOD HYDROCOLLOIDS
(2022)
Article
Microbiology
Michael Solvang, Freda M. Farquharson, Dayan Sanhueza, Graham Horgan, Wendy R. Russell, Petra Louis
Summary: This study examined the impact of different dietary fibre sources on gut microbiota growth and metabolite production. The results showed that complex fibres led to greater variation in microbiota compared to pectins. The composition of the plants, such as the levels of arabinan and galactan, were major predictors of bacterial enrichment.
ENVIRONMENTAL MICROBIOLOGY
(2023)
Article
Chemistry, Applied
Yiting Guo, Bengang Wu, Xiuyu Guo, Dandan Liu, Chengcheng Qiu, Haile Ma
Summary: Thermosonication can significantly increase the hardness of carrots and preserve their tissue structure. It damages cell membrane permeability, leading to the migration of water and electrolytes. Thermosonication also affects carrot cell structure by modifying the characteristics of pectin.
Article
Chemistry, Applied
Jean-Claude Boulet, Elissa Abi-Habib, Stephanie Carrillo, Stephanie Roi, Frederic Veran, Arnaud Verbaere, Emmanuelle Meudec, Anais Rattier, Marie-Agnes Ducasse, Bodil Jorgensen, Jeanett Hansen, Sophie Le Gall, Celine Poncet-Legrand, Veronique Cheynier, Thierry Doco, Aude Vernhet
Summary: The concentrations of anthocyanins and tannins extracted from berries in wines and from skin macerations in model solutions were studied for different grape varieties, maturation levels, and vintages. The analysis of cell wall polysaccharides using both the classical method and comprehensive microarray polymer profiling provided a comprehensive understanding of the polysaccharidic composition. The extraction efficiency was higher in wines compared to model solutions, with non acylated anthocyanins having the highest extraction efficiency, followed by tannins and p-coumaroylated anthocyanins. The polysaccharidic composition suggested the involvement of homogalacturonans, rhamnogalacturonans, and extensins in the extraction process.
Article
Chemistry, Applied
Jun Liu, Ziying Hu, Dunhua Liu, Anran Zheng, Qin Ma
Summary: This study investigated the mechanisms by which cold storage affects the water-holding capacity (WHC) of beef through analysis of exudates using an untargeted metabolomics strategy. The findings revealed the presence of ferroptosis during beef storage, which negatively impacted the WHC.
Review
Biochemistry & Molecular Biology
Yi Qiu, Wenbo Song, Ying Yang, Guojie Zhou, Yidan Bai, Toshihiro Akihisa, Feng Ye, Feng Feng, Wangshu Zhang, Jie Zhang
Summary: This article summarizes an important herbal medicine in China, Anoectochilus roxburghii, which has great medicinal and edible value. Polysaccharides, one of the main active components of A. roxburghii, have different structural characteristics and pharmacological activities depending on the sources and extraction methods. The review provides information on the extraction and purification methods, structural features, biological activities, and applications of A. roxburghii polysaccharides, as well as highlighting current research shortcomings and potential focus for future studies.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Yi-Peng Bai, Hui-Ming Zhou, Ke-Rui Zhu, Qin Li
Summary: The present study aimed to investigate the influence of thermal processing on the water-soluble polysaccharides in chickpeas. It was found that thermal processing caused cell wall breakage and increased the extraction rate of polysaccharides. However, it also led to a decrease in branching degree and molecular weights, as well as changes in the structure and thermal stability of polysaccharides. Interestingly, thermal processing enhanced the antioxidant activities of the polysaccharides.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Environmental
Wenxu Zhang, Peng Wang, Yun Deng, Xinyue He, Xiaoming Yang, Rui Chen, Ziqiang Lei
Summary: A superabsorbent polymer (SAP) was successfully synthesized using tap water as a reaction medium, showing great potential in water absorption rate and improving sandy soil properties.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Polymer Science
Amalie Younes, Salwa Karboune, Lan Liu, Eugenio Spadoni Andreani, Sarah Dahman
Summary: Cocoa bean shells were found to be a rich source of carbohydrates, protein, ash, and polyphenols. Cell wall polysaccharides, mainly composed of pectic polysaccharides and hemicellulosic polysaccharides, were extracted and showed prebiotic activity similar to or greater than inulin and rhamnogalacturonan. The short-chain fatty acid profiles were characterized by high amounts of lactic acid, followed by acetic and propionic acid.
Article
Chemistry, Applied
Jingxuan Ke, Yuhao Zhang, Xin Wang, Jing Sun, Siqi Wang, Yanli Ma, Qing Guo, Zhiqing Zhang
Summary: This study extracted two cell-wall polysaccharides, CP-1 and CP-2, from chayote and conducted a structural analysis. CP-1 was identified as galactan, while CP-2 was an anionic heteropolysaccharide. The excellent application characteristics of CP-1 and CP-2 were confirmed, suggesting that chayote cell-wall polysaccharides could be used as new polysaccharide materials.
Article
Chemistry, Applied
Jun Liu, Dunhua Liu, Anran Zheng, Qin Ma
Summary: This study investigated the interrelationships between haem, protein, and lipid oxidation and water holding capacity (WHC) in beef during refrigerated storage. The results showed that haem oxidation resulted in protein structural disruption and a decrease in WHC. Additionally, levels of lipid and protein oxidation products increased significantly over storage time.
Review
Agricultural Engineering
Xinxin Li, Adiphol Dilokpimol, Mirjam A. Kabel, Ronald P. de Vries
Summary: Fungi are important polysaccharide degraders in nature, and they can diversify their carbohydrate-active enzyme combinations to survive in different ecological habitats. This review summarizes the current knowledge on substrate specificity of xylanolytic enzymes and the diversity of enzyme sets in fungi, and reviews the industrial applications of fungal xylanolytic enzymes.
BIORESOURCE TECHNOLOGY
(2022)
Article
Plant Sciences
Lukas Pfeifer, Gijs van Erven, Elizabeth A. Sinclair, Carlos M. Duarte, Mirjam A. Kabel, Birgit Classen
Summary: This study provides a comprehensive overview of the cell wall composition of seagrasses, helping understand their adaptation to the marine environment in an evolutionary context and evaluating their potential in biorefinery incentives.
Article
Chemistry, Multidisciplinary
Peicheng Sun, Christophe V. F. P. Laurent, Vincent J. P. Boerkamp, Gijs van Erven, Roland Ludwig, Willem J. H. van Berkel, Mirjam A. Kabel
Summary: This study discovered a novel type of C4/C6 double oxidized cello-oligosaccharides, generated by C4 and C1/C4 oxidizing LPMOs. Experimental evidence confirmed that the C6 gem-diol structure resulted from oxygenation.
Article
Biochemistry & Molecular Biology
Adiphol Dilokpimol, Bart Verkerk, Xinxin Li, Annie Bellemare, Mathieu Lavallee, Matthias Frommhagen, Emilie Normolle Underlin, Mirjam A. Kabel, Justin Powlowski, Adrian Tsang, Ronald P. de Vries
Summary: In this study, ten novel fungal CE1 enzymes from different subfamilies were heterologously produced and screened for their activity towards model and complex plant biomass substrates. The study found CE1 enzymes with dual feruloyl/acetyl xylan esterase (FXE) activity, expanding the substrate specificity. These new FXEs from CE1 can efficiently release both feruloyl and acetyl residues from feruloylated xylan, making them potentially valuable components in industrial enzyme cocktails for plant biomass degradation.
Article
Food Science & Technology
Joanne W. Siccama, Rianne Oudejans, Lu Zhang, Mirjam A. Kabel, Maarten A. Schutyser
Summary: This study proposed the enzymatic conversion of cellulosic-rich waste streams of white asparagus into cellobiose and cello-oligosaccharides (COS) for producing a natural carrier agent. By optimizing the enzyme loadings, hydrolysis times, and pre-treatment conditions, a high yield/purity enzymatic hydrolysate with a high glass transition temperature (T-g) was obtained. The spray-dried hydrolysates of asparagus fiber showed potential usage as a carrier agent due to their high T-g.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Peicheng Sun, Xinxin Li, Adiphol Dilokpimol, Bernard Henrissat, Ronald P. de Vries, Mirjam A. Kabel, Miia R. Makela
Summary: This article introduces xyloglucanases (XEGs) and the GH44 family, which have been found in bacteria and fungi. Through genome analysis, GH44 enzymes from Dichomitus squalens and Pleurotus ostreatus were discovered and characterized. The study reveals that these fungal GH44 XEGs have different cleavage patterns during cellulose hydrolysis, indicating their potential for plant biomass conversion and utilization.
Review
Agriculture, Dairy & Animal Science
C. Lannuzel, A. Smith, A. L. Mary, E. A. Della Pia, M. A. Kabel, S. de Vries
Summary: This study focuses on the degradation of fibers in rapeseed meal (RSM), sunflower seed meal (SFM), and soybean meal (SBM). It is found that RSM and SFM are more difficult to degrade compared to SBM, and the degradation is often incomplete. The addition of multi-carbohydrases can improve the degradation of fibers in RSM, while mechanical, (hydro)thermal, or chemical treatments have limited effect.
ANIMAL FEED SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemical Research Methods
Xinxin Li, Dimitrios Kouzounis, Mirjam A. Kabel, Ronald P. de Vries, Adiphol Dilokpimol
Summary: Efficient bioconversion of agro-industrial side streams requires a wide range of enzyme activities. This study focused on the GH30 family of enzymes and identified novel enzyme activities within this diverse family. A phylogenetic tree was constructed, showing that GH30 enzymes cluster into four subfamilies with distinct polysaccharide specificities and high potential for the production of short non-digestible di- and oligosaccharides.
Review
Agricultural Engineering
Hector A. Ruiz, William Gustavo Sganzerla, Valeria Larnaudie, Romy J. Veersma, Gijs van Erven, Shiva, Leopoldo J. Rios-Gonzalez, Rosa M. Rodriguez-Jasso, Gilver Rosero-Chasoy, Mario Daniel Ferrari, Mirjam A. Kabel, Tania Forster-Carneiro, Claudia Lareo
Summary: The development and sustainability of second-generation biorefineries are crucial for producing high-value compounds and biofuels at an industrial scale. Hydrothermal pretreatment, specifically liquid hot water (LHW) and steam explosion (SE), is considered the most promising process for biomass fractionation, hydrolysis, and structural modifications. This review focuses on the plant cell wall architecture, hydrothermal pretreatment fundamentals, process design integration, techno-economic parameters, and profitability indicators, highlighting the implementation of biorefineries in a circular economy framework. The review also analyzes the environmental sustainability aspects of hydrothermal pretreatments.
BIORESOURCE TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dimitrios Kouzounis, Gijs van Erven, Natalia Soares, Mirjam A. Kabel, Henk A. Schols
Summary: Supplementing enzymes for insoluble fiber degradation has been shown to enhance fermentation in poultry and potentially disrupt cereal cell wall matrix for improved nutrient digestion. However, the current study found that enzyme supplementation did not affect the extractability of arabinoxylan by alkali. Instead, it mainly resulted in the release of arabinoxylo-oligosaccharides without altering the cell wall architecture.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Caio de Oliveira Gorgulho Silva, Marlene Vuillemin, Mirjam A. A. Kabel, Willem J. H. van Berkel, Anne S. S. Meyer, Jane W. W. Agger
Summary: Polyphenol oxidases (PPOs) catalyze the conversion of monophenols to diphenols, which act as reducing agents for lytic polysaccharide monooxygenases (LPMOs). The role of the catalytic products of the PPO MtPPO7 in priming and fueling the activity of the LPMO NcAA9C is investigated. It is found that the catalytic products of MtPPO7 provide the initial electron for the reduction of Cu(II) to Cu(I), but cannot provide sufficient reducing power for continuous fueling of the LPMO activity. This priming reaction occurs with low amounts of MtPPO7 products and does not generate significant levels of H2O2 to fuel the LPMO peroxygenase activity.
Article
Agriculture, Multidisciplinary
Jeimmy Paola Lancheros, Charmaine D. Espinosa, Roelant Hilgers, Mirjam A. Kabel, Hans H. Stein
Summary: This study aimed to quantify the concentrations of ferulic acid and p-coumaric acid in a diet based on corn and soybean meal (SBM) and in feces from pigs fed this diet, as well as in a diet based on corn, SBM, and distillers' dried grains with solubles (DDGS) and in feces from pigs fed this diet. The results showed that the concentration of bound ferulic and p-coumaric acids was higher in the corn-SBM-DDGS diet and feces from pigs fed this diet compared to the corn-SBM diet and feces from pigs fed that diet.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Chemistry, Physical
Peicheng Sun, Zhiyu Huang, Sanchari Banerjee, Marco A. S. Kadowaki, Romy J. Veersma, Silvia Magri, Roelant Hilgers, Sebastian J. Muderspach, Christophe V. F. P. Laurent, Roland Ludwig, David Cannella, Leila Lo Leggio, Willem J. H. van Berkel, Mirjam A. Kabel
Summary: In this study, two new fungal oxidoreductases from the AA16 family were characterized. These enzymes were found to be capable of producing H2O2 by oxidizing low-molecular-weight reductants. The interplay between AA16 proteins and MtLPMO9 proteins significantly enhanced cellulose degradation. These findings provide new insights into the functions of copper-dependent enzymes and the interplay of oxidative enzymes within fungal systems to degrade lignocellulose.
Article
Biochemistry & Molecular Biology
Katharina Duran, Jeanne Miebach, Gijs van Erven, Johan J. P. Baars, Rob N. J. Comans, Thomas W. Kuyper, Mirjam A. Kabel
Summary: Fungi, especially the edible white button mushroom, have the ability to degrade lignin and utilize it for growth. By analyzing the mycelial growth of Agaricus bisporus, researchers found that the mushroom is capable of extensive lignin degradation and identified the specific changes in lignin structure during this process. This study provides valuable insights into the mechanisms of fungal lignin conversion and contributes to our understanding of lignin decomposition.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Multidisciplinary Sciences
Katharina Duran, Joris Magnin, Antoine H. P. America, Mao Peng, Roelant Hilgers, Ronald P. de Vries, Johan J. P. Baars, Willem J. H. van Berkel, Thomas W. Kuyper, Mirjam A. Kabel
Summary: Proteomic analysis revealed that the secretomes of Agaricus bisporus showed significant changes during its 15-day growth in the substrate, with a decrease in β-xylosidase and glucosidase activities and an increase in laccase and oxidoreductase activities. These secretomes were also able to modify lignin models, promoting biomass valorization.
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
