Article
Biochemistry & Molecular Biology
Nagi M. El-Shafai, Mamdouh S. Masoud, Mohamed M. Ibrahim, Mohamed S. Ramadan, Gaber A. M. Mersal, Ibrahim M. El-Mehasseb
Summary: This study focuses on improving the loading and release efficiency of sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV) by combining it with beta-cyclodextrin (beta CD) basket to form a novel self-assembly beta CD-SOF. The drug is then loaded onto chitosan nanoparticles (Cs NPs) to create a hybrid composite named Cs@beta CD-SOF. Through various characterization methods, it is confirmed that Cs@beta CD-SOF has a loading efficiency of 94.54% and exhibits high release efficiency.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Medicinal
Yingqi Mi, Jingjing Zhang, Wenqiang Tan, Qin Miao, Qing Li, Zhanyong Guo
Summary: In this study, chitosan nanoparticles with good antioxidant activity, pH-sensitive sustained controlled release, and enhanced antitumor activity were successfully synthesized. These nanoparticles can serve as drug carriers and have broad application prospects.
Review
Medicine, Research & Experimental
Melika Hosseini, Mahnaz Amiri, Mojgan Ghanbari, Makarim A. Mahdi, Waleed K. Abdulsahib, Masoud Salavati-Niasari
Summary: Medicine/nanotechnology is gaining great attention as a new and applicable technique for cancer treatment through drug delivery systems. Polysaccharides, such as cellulose, beta-cyclodextrin, sodium carboxymethyl cellulose, and chitosan, are natural bio-materials that are suitable for designing and formulating nanosystems due to their exceptional advantages. An intelligent drug delivery platform based on these hybrids has been developed for dual-responsive dual-drug delivery. The combination of nanotechnology and biological molecules has been actively explored to overcome the limitations of conventional cancer treatments. This review discusses and investigates the latest developments in the field of biomedical therapeutics and cancer therapy using hybrid platforms of anticancer drugs/nanoparticles/Polysaccharides, highlighting their biocompatibility, large surface area, and promising future prospects.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Polymer Science
Bingren Tian, Yumei Liu, Jiayue Liu
Summary: The paper discusses the different forms of anticancer drug carriers using chitosan as the basic material, highlighting their role in cancer treatment and the release of anticancer drugs from these carriers. It also proposes the application prospects of chitosan-based delivery systems for anticancer drugs by comparatively evaluating the role of chitosan in anticancer drug delivery.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Georgia Michailidou, Dimitrios N. Bikiaris
Summary: In this study, printable inks for three-dimensional printing were prepared using blends of CS and Vanillin-CS derivative (VACS). The addition of iota-carrageenan (iCR) as a thickening agent was found to be necessary. Viscosity analysis and drug loading experiments were conducted for characterization and evaluation.
Article
Polymer Science
Safa Ouerghemmi, Stephanie Degoutin, Mickael Maton, Nicolas Tabary, Frederic Cazaux, Christel Neut, Nicolas Blanchemain, Bernard Martel
Summary: This study focuses on the preparation of core-sheath nanofibers using chitosan and cyclodextrin polymer, and investigates the stability, release behavior, and antibacterial activity of triclosan-loaded nanofibers in aqueous medium. The results indicate that the type of nanofibers directly affects the release and antibacterial activity of triclosan.
Article
Pharmacology & Pharmacy
Parbeen Singh, Yongli Chen, Deependra Tyagi, Li Wu, Xiaohong Ren, Jinglong Feng, Andrew Carrier, Tiangang Luan, Yongjun Tang, Jiwen Zhang, Xu Zhang
Summary: 13-Cyclodextrin was grafted onto hyaluronic acid in a single step to create a supramolecular biopolymer, HA-13-CD, which showed high loading capacity for drugs doxorubicin and Rhodamine B. The polymer also exhibited targeted drug delivery to cancerous cells with a high level of CD44 receptor expression, potentially making it a promising cancer-cell-targeting drug carrier.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Nanoscience & Nanotechnology
Edurne Marin, Neha Tiwari, Marcelo Calderon, Jose-Ramon Sarasua, Aitor Larranaga
Summary: Polymer capsules fabricated via the layer-by-layer approach show promise for controlled enzymatic reactions and drug release in response to biologically relevant stimuli, with the potential to target multiple mediators of inflammatory diseases.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Ana Ciric, Dorde Medarevic, Bojan Calija, Vladimir Dobricic, Milena Rmandic, Tanja Barudzija, Andelija Malenovic, Ljiljana Djekic
Summary: The entrapment procedure of a poorly water soluble drug was studied to investigate its effect on the physicochemical and drug release performances of chitosan/xanthan polyelectrolyte complexes (PECs). Different drug entrapment procedures and chitosan-to-xanthan mass ratios were observed to affect the formation of PECs, leading to controlled drug release with zero-order kinetics.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Physical
Yong Hu, Guojing Mo, Ying Wang, Juan Guo, Chao Huang
Summary: The study prepared TPP-beta-cyclodextrin/chitosan nanoparticles loaded with curcumin and vitamin C through controllable self-assembly, which showed enhanced chemical stability and antioxidant properties compared to individual ingredients. Release kinetics varied under different pH conditions, with Fickian diffusion dominating at pH 1.2 and non-Fickian or anomalous diffusion at pH 7.4. Additionally, the release rate of curcumin was faster than that of vitamin C, confirming the synergistic nutraceutical effect of each active ingredient.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Biochemistry & Molecular Biology
Yuting Yuan, Zhenhua Wang, Shengjia Su, Yingqi Mi, Qing Li, Fang Dong, Wenqiang Tan, Zhanyong Guo
Summary: Amphiphilic low molecular weight chitosan-lipoic acid (LC-LA) conjugates with different degrees of substitution (DS) of LA were synthesized by N, N'-carbonyldiimidazole (CDI) catalysis to self-assemble into redox-sensitive micelles. The blank micelles showed excellent biocompatibility and redox-sensitive behavior with low critical micelle concentration (CMC), nano-scale size, and positive zeta potential. Doxorubicin (Dox) loaded micelles exhibited redox-trigger behavior, strong antitumor activity, and increased cellular uptake efficiency against A549 cell.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Nihan Saracogullari, Dilara Gundogdu, Fatma Neslihan Ozdemir, Yesim Soyer, Irem Erel-Goktepe
Summary: The study found that the biological properties of chitosan LbL films are influenced by the type of polyacid, thickness, surface morphology, etc. TA/CHI films are suitable for antiadhesive surfaces, while PAA/CHI multilayers are suitable for preparing antibacterial surfaces.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Pharmacology & Pharmacy
Sony Priyanka Bandi, Deepanjan Datta, Venkata Vamsi Krishna Venuganti
Summary: We developed a multi-layered mucoadhesive gastric patch that can deliver chemotherapeutic agent continuously for 8 days after oral administration. The patch consists of a core layer containing the drug, a mucoadhesive layer made of chitosan-hydrocaffeic acid conjugate, and a backing layer made of hydrophobic polycaprolactone-polydimethylsiloxane composite. The patch showed sustained release of the drug in simulated gastric fluid and remained stable during long-term storage. In animal studies, the patch provided constant plasma concentration of the drug for 8 days and did not cause significant histological changes in the gastric tissue. The patch also demonstrated significant reduction in tumor volume in a mouse model. Therefore, the multi-layered mucoadhesive gastric patch has potential as a long-acting oral drug delivery system.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Fangzhe Liu, Zihan Wang, Hui Guo, Haichao Li, Yulan Chen, Shuang Guan
Summary: This study introduced a double-layer hydrogel with a drug release layer and a mechanical support layer. By incorporating beta-cyclodextrin polymer (beta-CDP), poly(vinyl alcohol) (PVA), and carboxymethyl cellulose sodium (CMC), the hydrogel exhibited improved drug release rate and mechanical strength. The dual-layer structure provides a feasible solution for fabricating high-performance hydrogel dressings with sustained drug release properties.
Article
Chemistry, Applied
Huaying He, Caixia Sun, Yunxiang Weng, Hongjian Huang, Peng Ni, Yan Fang, Renfeng Xu, Zhengchao Wang, Haiqing Liu
Summary: A novel chitosan-catechol hemostatic gauze with impressive hemostatic performance on rat injuries has been developed through surface modification, demonstrating biodegradability and non-cytotoxicity while integrating three structure and function effects.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Julie Meimoun, Yupin Phuphuak, Remi Miyamachi, Yong Miao, Marc Bria, Cyril Rousseau, Guilherme Nogueira, Andreia Valente, Audrey Favrelle-Huret, Philippe Zinck
Summary: Cyclodextrins (CDs) are cyclic oligosaccharides widely used in various fields. This study successfully achieved quantitative functionalization of various types of CDs using 4-dimethylaminopyridine (DMAP) as a catalyst. The inclusion complex formed between DMAP and β-CD was characterized for the first time, and its association constant was estimated.
Article
Biochemical Research Methods
Camille Malburet, Laurent Leclercq, Jean-Francois Cotte, Jerome Thiebaud, Herve Cottet
Summary: The development of combination vaccines is crucial for reducing the number of injections, shortening vaccination schedules, and increasing vaccination coverage. This study optimized the capillary zone electrophoresis method and utilized specific coatings and additives to enhance protein separation efficiency, enabling the study of antigen-adjuvant interactions.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Article
Biochemical Research Methods
Xiaoling Leclercq, Laurent Leclercq, Alexis Guillard, Laurent Rodriguez, Olivier Braun, Cedrick Favero, Herve Cottet
Summary: Taylor dispersion analysis (TDA) was successfully utilized to determine the broad distribution and ultrahigh molar masses of industrial anionic polyacrylamides (IPAMs), surpassing the limitations of Size Exclusion Chromatography (SEC). By optimizing the experimental protocols and data processing methods, TDA allows for rapid and accurate characterization of polymer hydrodynamic radii and diffusion coefficients, providing essential data for further research and applications.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Review
Chemistry, Multidisciplinary
Sebastien Roca, Laura Dhellemmes, Laurent Leclercq, Herve Cottet
Summary: Capillary electrophoresis is an effective analytical method for separating compounds based on their charge to size ratios. However, solute adsorption on the capillary wall remains a major obstacle to achieving high separation efficiency. Polyelectrolyte multilayer coatings provide a versatile approach to control and minimize solute adsorption in capillary electrophoresis.
Article
Polymer Science
Safa Ouerghemmi, Stephanie Degoutin, Mickael Maton, Nicolas Tabary, Frederic Cazaux, Christel Neut, Nicolas Blanchemain, Bernard Martel
Summary: This study focuses on the preparation of core-sheath nanofibers using chitosan and cyclodextrin polymer, and investigates the stability, release behavior, and antibacterial activity of triclosan-loaded nanofibers in aqueous medium. The results indicate that the type of nanofibers directly affects the release and antibacterial activity of triclosan.
Article
Polymer Science
Ekkachai Martwong, Nathapong Sukhawipat, Jatupol Junthip
Summary: This study used functional textile as an effective adsorbent for removing paraquat from water. The coating of anionic cyclodextrin polymer on cotton cord was successfully investigated. The results showed that the coating had a high adsorption capacity for paraquat and good reusability.
Article
Polymer Science
Dounya Merah, Lamia Bedjaoui, Nouh Zeggai, Zohra Bouberka, Johan Sarazin, Donna Boutalbi, Ana Barrera, Hana Boughrara, Frederic Dubois, Frederic Cazaux, Philippe Supiot, Ulrich Maschke
Summary: Polymerization kinetics and thermal properties of acrylic copolymers containing IBOA and 2-EHA units were investigated. High conversion rates of the acrylic double bonds were achieved, and a single glass transition temperature was observed over a large temperature range, possibly due to hydrogen bonding interaction. Several degradation processes were observed, with the thermal stability of the copolymers increasing with higher IBOA content.
JOURNAL OF POLYMER RESEARCH
(2022)
Article
Polymer Science
Jiraporn Phojaroen, Thitirat Jiradechakorn, Suchata Kirdponpattara, Malinee Sriariyanun, Jatupol Junthip, Santi Chuetor
Summary: This study evaluated the performance of hydrothermal-mechanical pretreatment of corncob for biofuels and biochemical production. The results showed that this combined pretreatment process can achieve high energy efficiency and low waste generation.
Article
Polymer Science
Ekkachai Martwong, Nathapong Sukhawipat, Jatupol Junthip
Summary: Contamination from hazardous organic compounds in water is a significant problem. In this study, a modified textile coated with anionic cyclodextrin polymer was used to remove cationic pollutants from aqueous solutions. The physicochemical properties of the modified textile were characterized, and it showed a high removal efficiency for paraquat, methylene blue, and crystal violet. The kinetics and isotherm of the adsorption process were also studied. The modified textile exhibited good recyclability performance.
Article
Polymer Science
Jatupol Junthip, Natchapat Chaipalee, Yada Sangsorn, Chanannat Maspornpat, Juthamas Jitcharoen, Sittichai Limrungruengrat, Thana Chotchuangchutchaval, Ekkachai Martwong, Nathapong Sukhawipat
Summary: A novel waste-based plasticizer derived from modified used palm oil (mUPO) has been developed and used as a plasticizer to improve the properties of non-glutinous thermoplastic starch foam. The addition of mUPO has a direct effect on mechanical and thermal properties, increasing impact strength and reducing glass transition temperature. It also reduces shrinkage and moisture absorption in the starch foam. The utilization of mUPO as a waste-based material shows promise as a green alternative plasticizer for starch components, especially in foam applications.
Article
Chemistry, Multidisciplinary
Nathalia Oderich Muniz, Sarah Gabut, Mickael Maton, Pascal Odou, Michele Vialette, Anthony Pinon, Christel Neut, Nicolas Tabary, Nicolas Blanchemain, Bernard Martel
Summary: The search for effective protective masks against the 2019 coronavirus outbreak and air pollution has led to the development of advanced filtering textiles with antimicrobial properties. This study successfully produced a filtering electrospun membrane that combines optimal filtration efficiency with fast deactivation of viruses and bacteria. The membrane, composed of polyvinyl alcohol nanofibers stabilized with a biocidal agent, showed promising results against various pathogens, including a human coronavirus strain.
Article
Pharmacology & Pharmacy
Marie-Stella M'Bengue, Thomas Mesnard, Feng Chai, Mickael Maton, Valerie Gaucher, Nicolas Tabary, Maria-Jose Garcia-Fernandez, Jonathan Sobocinski, Bernard Martel, Nicolas Blanchemain
Summary: Three-dimensional printing of thermoplastic polyurethane is gaining interest in the medical industry due to its tunable properties and the advantages of 3D printing processes. This study investigated the implementation of medical grade TPU by FDM for manufacturing implantable medical devices, including the effects of gamma sterilization. The results showed that TPU underwent degradation during the fabrication process, but mechanical properties and biocompatibility were not significantly impacted by gamma sterilization.
Article
Pharmacology & Pharmacy
Basma Moutamenni, Nicolas Tabary, Alexandre Mussi, Jeremy Dhainaut, Carmen Ciotonea, Alexandre Fadel, Laurent Paccou, Jean-Philippe Dacquin, Yannick Guinet, Alain Hedoux
Summary: Mesoporous silica (MPS) carriers have potential in increasing drug solubility and stabilizing amorphous drug delivery. A solvent-free method called milling-assisted loading (MAL) allows manipulation of the drug's physical state within the pores. This study investigated the effects of milling intensity and pore architecture on drug state and release. The results showed that decreasing milling intensity promoted nanocrystallization of the confined drug, and the chemical modification of the pore surface also enhanced nanocrystallization. The particle size of the composites had the greatest influence on the drug release profile.
Article
Polymer Science
Henry Chijcheapaza-Flores, Nicolas Tabary, Feng Chai, Mickael Maton, Jean-Noel Staelens, Frederic Cazaux, Christel Neut, Bernard Martel, Nicolas Blanchemain, Maria Jose Garcia-Fernandez
Summary: This study aims to combine the properties of hydrogels based on chitosan (CHT) and the polymer of beta cyclodextrin (PCD) for local delivery of cinnamaldehyde (CN) in diabetic foot ulcers. The results demonstrated the successful development of a cytocompatible (ISO 10993-5) injectable hydrogel with antibacterial and antibiofilm activity. Furthermore, a partial active molecule release and an increase in hydrogel elasticity were observed in the presence of CN.
Article
Pharmacology & Pharmacy
Hay Man Saung Hnin Soe, Jatupol Junthip, Supakarn Chamni, Chaisak Chansriniyom, Patanachai Limpikirati, Thanundorn Thanusuwannasak, Rathapon Asasutjarit, Patamaporn Pruksakorn, Rinrapas Autthateinchai, Sirawit Wet-osot, Thorsteinn Loftsson, Phatsawee Jansook
Summary: In this study, water-soluble anionic beta-cyclodextrin derivatives were synthesized to improve the aqueous solubility of miconazole for the treatment of fungal keratitis. The results showed that the prepared complex significantly increased the solubility of miconazole and exhibited good antifungal efficacy.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
