Article
Pharmacology & Pharmacy
Atul Garkal, Amelia Avachat
Summary: This study developed a novel pH-responsive in-situ gelling sustained-release nevirapine pediatric suspension (SRNPS) for the treatment and prevention of mother-to-child transmission of HIV. The SRNPS demonstrated good in-situ gelling behavior and sustained drug release, leading to improved patient compliance.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Hetal Thakkar, Darshan Vaghela, Brijesh Pradipkumar Patel
Summary: The study demonstrated that intranasal gel spray delivery of paroxetine can increase the drug concentration in the brain and provide a quicker onset of action. Additionally, the formulation was found to be non-toxic to the nasal mucosa, showing potential as a new approach for treating depression and anxiety disorders.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Hani Abdeltawab, Scott M. Bolam, Jagdish K. Jaiswal, Sue R. McGlashan, Simon W. Young, Andrew Hill, Darren Svirskis, Manisha Sharma
Summary: A thermoresponsive in situ gelling system based on poloxamer was developed for sustained delivery of bupivacaine hydrochloride and ketorolac tromethamine. The system demonstrated prolonged drug release and potential clinical benefits.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Gabor Katona, Bence Sipos, Maria Budai-Szucs, Gyorgy Tibor Balogh, Szilvia Veszelka, Ilona Grof, Maria A. Deli, Balazs Volk, Piroska Szabo-Revesz, Ildiko Csoka
Summary: The aim of this study was to develop an intranasal in situ thermo-gelling meloxicam-human serum albumin (MEL-HSA) nanoparticulate formulation applying poloxamer 407 (P407) to improve drug absorption. The optimized formulation (MEL-HSA-P14%) showed enhanced permeability through the blood-brain barrier-specific lipid fraction and promise for overcoming challenges of nasal drug delivery.
Article
Pharmacology & Pharmacy
Mahmoud H. H. Teaima, Doaa A. Helal, Jihad M. Alsofany, Mohamed A. El-Nabarawi, Mohamed Yasser
Summary: This study developed niosomal nanocarriers for improved intranasal delivery of dronedarone hydrochloride. The optimized niosomes showed enhanced bioavailability compared to the oral suspension, with significant increases in C-max, AUC(0-72), and AUC(0-infinity). The niosomal in situ gel formulation resulted in almost twofold amplification of relative bioavailability after intranasal administration.
Article
Biochemistry & Molecular Biology
Ahmad Hivechi, Mohammad Taghi Joghataei, S. Hajir Bahrami, Peiman B. Milan, Moein Amoupour, Noorahmad Latifi, S. Mohammad Amin Haramshahi, Soheila Naderi Gharahgheshlagh, Saeed Nezari
Summary: In this study, an in situ gelling hydrogel based on oxidized carboxymethyl cellulose (OCMC) and gelatin (Gel) was used to accelerate the healing rate of diabetic wounds. The hydrogel demonstrated excellent biocompatibility, antibacterial, and antioxidant activity, promoting faster tissue regeneration. In vivo experiments on rats and mice showed that the OCMC-Gel hydrogel significantly improved the healing rate of both non-diabetic and diabetic wounds, with better skin tissue regeneration observed in the treated groups.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Srushti M. Tambe, Divya D. Jain, Chetan Hasmukh Mehta, T. Ashwini, Usha Yogendra Nayak, Purnima D. Amin
Summary: In this study, a novel ophthalmic solution called MeltDrops was successfully developed using hot-melt extrusion technology. MeltDrops showed improved retention time and bioavailability compared to marketed eyedrops. It also exhibited better physical and chemical uniformity and sustained drug release for over 12 hours in vitro. In vivo studies in rabbits confirmed the superior effectiveness and safety of MeltDrops.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Manasa Moganti, H. N. Shivakumar
Summary: A novel sol-gel system of calcium carbonate (CC) was developed to prolong gastric residence time and improve bioavailability. Through optimization of formulation composition, the optimized batch displayed significantly higher gastric retention time and controlled release compared to the marketed suspension, showing promise for improving the bioavailability of nutrients with absorption window in the upper gastrointestinal tract.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Yiwen Zhang, Chen Jiang
Summary: The prevention of tumor recurrence after surgery involves eliminating residual tumor cells and changing the microenvironments that induce recurrence. Establishing an appropriate drug delivery system is crucial for treatment plans, and in-situ drug delivery systems (ISDDS) are considered effective for postoperative use, improving drug delivery efficiency and reducing side effects. New understanding of postoperative recurrence mechanisms and advancements in drug delivery materials have significantly enhanced ISDDS technology.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Polymer Science
Eileen Hulambukie, Hani Abdeltawab, Sanjukta Duarah, Darren Svirskis, Manisha Sharma
Summary: This study aims to develop an NRT formulation that offers sustained nicotine release. Thermoresponsive in situ gelling systems containing nicotine were successfully prepared using poloxamer. The optimized formulation demonstrated prolonged release of nicotine.
Article
Instruments & Instrumentation
Chandra Teja Uppuluri, Punna Rao Ravi, Avantika V. Dalvi, Shafik Shakil Shaikh, Suvarna R. Kale
Summary: Methyl cellulose (MC) based nasal in situ gels were developed to enhance brain delivery of the anti-Parkinson's drug piribedil (PBD). NaCl was found to be an effective solute, and formulations with higher gel strength resulted in slower drug release and prolonged intranasal residence, improving brain availability of PBD.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Integrative & Complementary Medicine
Abbas Raisi, Omid Dezfoulian, Farshid Davoodi, Shayan Taheri, Soroush Afshar Ghahremani
Summary: The research showed that Salvia miltiorrhiza hydroalcoholic extract effectively reduces the occurrence of peritoneal adhesions due to its antioxidant and anti-inflammatory properties. A higher dose of the extract demonstrated better results in reducing peritoneal adhesions, proinflammatory and mesenchymal cell markers, and oxidative stress.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2021)
Article
Infectious Diseases
Patricia Rocha de Araujo, Giovana Maria Fioramonti Calixto, Victor Hugo Sousa Araujo, Mariana Rillo Sato, Camila Fernanda Rodero, Joao Augusto Oshiro-Junior, Tais Maria Bauab, Marlus Chorilli
Summary: The study demonstrates that HYP-LCPS can be used for the treatment of VVC and provides localized treatment on the superficial layers of porcine vaginal mucosa, showing effective therapeutic potential.
Review
Pharmacology & Pharmacy
Oluwadamilola M. Kolawole, Michael T. Cook
Summary: In situ gelling formulations are liquid drug delivery systems that can transform into gel state upon application to the body. Incorporating drug nanoparticles into in situ gelling systems can improve drug release and therapeutic outcomes. The composition of in situ gelling formulations affects various performance factors. This review article discusses evaluation techniques and clinical properties of in situ gelling systems for drug delivery.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Instruments & Instrumentation
Purva Khare, Manasi M. Chogale, Pratik Kakade, Vandana B. Patravale
Summary: This article proposes a transmucosal ocular delivery system of Posaconazole using a gellan gum-based in situ gelling nano-suspension. The nanosuspension demonstrated enhanced antibacterial properties and drug release compared to a marketed itraconazole nanosuspension. The developed nanosuspension showed good mucoadhesion and minimal irritancy.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)