期刊
CARBOHYDRATE POLYMERS
卷 90, 期 4, 页码 1428-1436出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2012.07.011
关键词
Dextran; Oxidization; Gelatin; Tissue adhesive; Photocrosslinking
资金
- National Natural Science Foundation of China [50803004]
- Beijing Natural Science Foundation [2112033]
- Fundamental Research Funds for the Central Universities [ZZ1115]
A two-component tissue adhesive based on biocompatible and bio-degradable polymers (oxidized urethane dextran (Dex-U-AD) and gelatin) was prepared and photocrosslinked under the ultraviolet (UV) irradiation. The adhesive could adhere to surface of gelatin, which simulated the human tissue steadily. The structures of above Dex-U-AD were characterized by FTIR, H-1 NMR spectroscopy and XRD. The adhesion property of result products was evaluated by lap-shear test. The maximum adhesion strength could reach to 4.16 +/- 0.72 MPa which was significantly higher than that of fibrin glue. The photopolymerization process of Dex-U-AD/gelatin was monitored by real time infrared spectroscopy (RTIR). It took less than 5 min to complete the curing process. The cytotoxicity of Dex-U-AD/gelatin also was evaluated which indicated that Dex-U-AD/gelatin gels were nontoxic to L929 cell. The relationship between all the above-mentioned properties and degree of oxidization of Dex-U-AD was assessed. The obtained products have the potential to serve as tissue adhesive in the future. (c) 2012 Elsevier Ltd. All rights reserved.
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