期刊
CARBOHYDRATE POLYMERS
卷 89, 期 1, 页码 138-145出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2012.02.062
关键词
Nanocomposite hydrogels; Modified kappa-carrageenan; Nanoparticles; Controlled drug release
资金
- Food and Biomaterial Engineering lab
- Research Management Centre UTM [01H31]
In this article, silver and magnetite nanofillers were synthesized in modified kappa-carrageenan hydrogels using the in situ method. The effect of metallic nanoparticles in gastro-intestinal tract (GIT) release of a model drug (methylene blue) has been investigated. The effect of nanoparticles loading and genipin cross-linking on GIT release of nanocomposite is also studied to finally provide the most suitable drug carrier system. In vitro release studies revealed that using metallic nanocomposites hydrogels in GIT studies can improve the drug release in intestine and minimize it in the stomach. It was found that cross-linking and nanofiller loading can significantly improve the targeted release. Therefore, applying metallic nanoparticles seems to be a promising strategy to develop GIT controlled drug delivery. (C) 2012 Elsevier Ltd. All rights reserved.
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