期刊
CARBOHYDRATE POLYMERS
卷 86, 期 4, 页码 1595-1601出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2011.06.069
关键词
Alginate; Periodate oxidation; Degradation; beta-Elimination; Biomaterial; Tissue engineering
资金
- Research Council of Norway [1459457/120, 146974/130]
Limited periodate oxidation (0-8%) of alginates results in enhanced degradability, extending the range of applications of alginates as biomaterials, e.g. in tissue engineering. Oxidation produces dialdehydes that are highly sensitive to alkaline beta-elimination, even under physiological conditions (pH 7.4, 37 degrees C). Although all periodate is consumed during limited oxidation, not all of the resulting dialdehydes are equally degradable, leading to a characteristic level off in molecular weight upon prolonged degradation. A significant fraction (20-50%) of the oxidized residues were resistant even at pH 10.4. We tentatively assign this finding to the presence of particularly stable intramolecular hemiacetals known to form in periodate oxidized alginates (PGA). The enhanced degradation of POA persists into the gel state, allowing tailoring of more biodegradable alginate gels. The activation energy for beta-elimination of dialdehydes was 88 kJ/mol compared to 113 kJ/mol for unoxidized residues, presumably reflecting the absence of strain in the non-cyclic transition state of the former. (C) 2011 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据