Article
Polymer Science
Dongmei Liu, Susu Zhao, Yujie Jiang, Chuanhui Gao, Yumin Wu, Yuetao Liu
Summary: Hydrogels with good biocompatibility and moisture-preserving properties can be used as medical materials for wound dressings. By copolymerizing blood serum albumin (BSA) with various monomers, double network hydrogels were synthesized, which significantly improved the mechanical strength of natural protein-based hydrogels and showed good biocompatibility and stable drug release properties. In vitro evaluation in a mouse skin incision model demonstrated that the hydrogels had a high wound closure effect, offering a feasible strategy for rapid skin wound healing.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Engineering, Biomedical
Yunfan Zhang, Xueyu Dou, Lingyun Zhang, Hufei Wang, Ting Zhang, Rushui Bai, Qiannan Sun, Xing Wang, Tingting Yu, Decheng Wu, Bing Han, Xuliang Deng
Summary: In this study, a semi-interpenetrating network composite gel was prepared to fulfill the mechanical and cell compatibility requirements of hydrogels. The gel successfully encapsulated ASA via electrostatic interactions and achieved sustained release, promoting stem cell proliferation and differentiation. In vivo studies confirmed the potential of this gel in bone tissue engineering.
BIOACTIVE MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Hyunki Kim, Saehan Choi, Yunhwa Hong, Jinhyo Chung, Jinhyeok Choi, Woong-Ku Choi, In Woo Park, Sang Hyeok Park, Hyeok Park, Woo-Jae Chung, Kwang Heo, Minbaek Lee
Summary: This study developed a simple and efficient method to prepare pure and cross-linked HA hydrogel films, and fabricated biocompatible, biodegradable, and high-performance triboelectric nanogenerators based on these films. The HA hydrogel film showed only minor degradation after long-term use and exhibited no cytotoxicity, even promoting cell proliferation.
APPLIED MATERIALS TODAY
(2021)
Article
Materials Science, Biomaterials
Xin Li, Tristan T. Y. Tan, Qianyu Lin, Chen Chuan Lim, Rubayn Goh, Ken-ichi Otake, Susumu Kitagawa, Xian Jun Loh, Jason Y. C. Lim
Summary: In recent years, there has been increasing interest in multidrug therapy due to its potential for synergistic drug action and sequential drug delivery. However, the combination of metal-organic frameworks (MOFs) with temperature-responsive hydrogels (or thermogels) in composite materials for simultaneous multidrug delivery has received limited attention. In this study, we conducted a systematic investigation of different MOFs embedded within PEG-containing thermogel matrices, and identified that UiO-66 can achieve temporally differentiated yet sustained simultaneous drug release.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Review
Chemistry, Multidisciplinary
Arpita Roy, Kalipada Manna, Sagar Pal
Summary: This review article focuses on the modern advances and developments of stimuli-responsive polymeric hydrogels and nanogels. Different synthetic designs and physicochemical tuning of stimuli sensitive hydrogels/nanogels are summarized. Stimuli-responsive hydrogels find extensive uses in the healthcare sector, including biosensing, controlled/sustained drug delivery, tissue and bone regeneration. These materials have significant properties and benefits for the healthcare sector.
MATERIALS CHEMISTRY FRONTIERS
(2022)
Article
Materials Science, Multidisciplinary
Elena V. Parfenyuk, Ekaterina S. Dolinina
Summary: Silica hydrogels have potential applications in the development of new soft drug formulations and cosmetic products. In this study, hydrogel drug-silica composites were synthesized under different synthesis conditions and their mechanical properties, thixotropic behavior, and drug release kinetics were investigated. The results showed that the synthesis conditions significantly influenced the properties of the hydrogels.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Morteza Eskandani, Hossein Derakhshankhah, Soheila Zare, Rana Jahanban-Esfahlan, Mehdi Jaymand
Summary: A pH-responsive magnetic hydrogel-based drug delivery system was designed and developed using a novel strategy based on horseradish peroxidase-mediated crosslinking. It showed promising synergistic effects for in vitro chemo/hyperthermia therapy of human breast cancer cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Laszlo Seres, Edit Csapo, Norbert Varga, Adam Juhasz
Summary: This paper investigates the assembly process of colloidal hyaluronic acid (HyA) based hydrogel particles, with a focus on the formation of surfactant-neutralized polysaccharide networks. By measuring various indicators, such as rheology, light scattering, zeta potential, turbidity, and charge titration, it is found that the preparation of HyA-CTAB particles can be well controlled. The results show that a higher amount of negative charges can be detected on the polymer chain at smaller initial amounts of HyA, and the pH has negligible effect on the formation process.
Article
Biochemistry & Molecular Biology
Yongchao Jiang, Yingying Guo, Haonan Wang, Xiaofeng Wang, Qian Li
Summary: A double-layered hydrogel coating with spatiotemporal drug release capacity was applied on a poly-caprolactone (PCL) fibrous scaffold to promote quick endothelialization on vascular grafts. The composite coating consisted of dopamine-modified hyaluronic acid (HA) hydrogel and gelatin hydrogel, with heparin and chondroitin sulfate introduced for drug release behavior. The coating improved the surface properties of the PCL scaffold and enhanced endothelial cell proliferation and angiogenesis behaviors. In vitro tests confirmed the long-term anticoagulation property of the modified scaffold. This research provides a universal strategy for promoting endothelialization and anticoagulation in vascular grafts.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Chemical
Badr-Eddine Channab, Chiraa Elidrissi Elhassani, Younes Essamlali, Salah Eddine Marrane, Achraf Chakir, Mohamed Zahouily
Summary: Nitrogen is the most widely used macronutrient for soil fertility. Conventional nitrogen fertilizers have low use efficiency due to loss through leaching and volatilization. Developing slow-release nitrogen fertilizers is an advanced solution to address these issues. This study aims to develop new slow-release nitrogen fertilizers using modified natural hydroxyapatite hybrid nanocomposites as carriers. The developed fertilizers displayed a slow-release property and required 18 days for complete nitrogen release in water.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Dariush Nikjoo, Ires van der Zwaan, Jonas Ruden, Goran Frenning
Summary: This study aimed to produce microparticles of hyaluronic acid hydrogel loaded with salbutamol sulphate for controlled release in the lung. The drug-loaded microparticles were successfully prepared and showed improved aerodynamic properties compared to unloaded microparticles. In vitro drug release studies confirmed the potential of these particles to release the drug in a sustained manner.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Polymer Science
Fabio Pizzetti, Anna Maspes, Arianna Rossetti, Filippo Rossi
Summary: Hydrogels have shown promise in various medical applications, such as controlled drug delivery systems and tissue engineering scaffolds. Careful material design is crucial for achieving desired properties. By modifying the 3D network of agarose-carbomer hydrogels with hyaluronic acid chains as degradable cross-links, the degradation kinetics of the hydrogels can be tuned to improve tissue regrowth.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Chemistry, Applied
Huazhong Ma, Juan Yu, Liang Liu, Yimin Fan
Summary: This study prepared TEMPO-oxidized nanocellulose and nanochitin-based hydrogels, demonstrating the diversity of release capacity of the hydrogels in different pH environments, with potential applications in specific areas such as drug delivery, wound dressing, and food packaging.
CARBOHYDRATE POLYMERS
(2021)
Article
Food Science & Technology
Hui Wang, Jinming Liu, Xu Fan, Jing Ren, Qian Liu, Baohua Kong
Summary: In this study, high strength sodium alginate (NaAlg) hydrogel films were obtained using natural crab-shell particles (CSP) and deacetylated crab-shell particles (dCSP) as crosslinking agents. The bi-crosslinked NaAlg hydrogel films demonstrated superior surface hydrophobicity, gel properties, mechanical strength, and thermal stabilities compared to neat NaAlg film and mono-crosslinked NaAlg hydrogel films. Additionally, these hydrogel films exhibited sustained release activity for diclofenac sodium for over 36 hours. This green crosslinking technique shows promise for the development of high-performance NaAlg hydrogel films for food packaging and medical wound dressing applications.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Hanieh Gholizadeh, Emelie Landh, Dina M. Silva, Antonella Granata, Daniela Traini, Paul Young, Ali Fathi, Simin Maleknia, Terence Abrams, Fariba Dehghani, Hui Xin Ong
Summary: A synthetic and thermo-responsive polymer, TP, is used as a universal carrier platform for sustained drug release. The polymer can be dissolved in an aqueous solution without the addition of surfactants or organic solvents. After injection, TP undergoes a phase transition to form a hydrogel matrix, which allows sustained elusion and controlled delivery of therapeutics. In vitro and in vivo studies confirm the high potential of TP as a carrier for localized and sustained drug delivery.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Polymer Science
Betul Ari, Mehtap Sahiner, Sahin Demirci, Nurettin Sahiner
Summary: The combination of PVA with TA and Cur in cryogel composites showed high antioxidant and antibacterial activities, with potential for blood contacting applications. Release of TA and Cur from the composites was quantified at different pH conditions, showing concentration-dependent enzyme inhibition against alpha-glucosidase.
Article
Chemistry, Analytical
Selin S. Suner, Sahin Demirci, Duygu S. Sutekin, Selehattin Yilmaz, Nurettin Sahiner
Summary: A new thiourea hexamethylene diisocyanate covalent organic framework (TH COF) with adjustable surface charge and area was successfully synthesized, exhibiting excellent acid-base absorption capability and reusability.
Review
Biochemistry & Molecular Biology
Mehtap Sahiner, A. Sanem Yilmaz, Buket Gungor, Yasmin Ayoubi, Nurettin Sahiner
Summary: The prevalence of cardiovascular disease, oxidative stress-related complications, and chronic age-related illnesses is increasing worldwide. Traditional medicinal treatments often have limitations, such as ineffectiveness, toxicity, and the need for multiple drugs in certain chronic diseases. Therefore, alternative treatment methods are necessary. Polyphenolic compounds have been shown to possess cardioprotective, ROS scavenging, anti-aging, and anticancer properties, and they have the potential to be used as alternative therapeutic agents.
Article
Polymer Science
Mehtap Sahiner, Selin S. Suner, Aynur S. Yilmaz, Nurettin Sahiner
Summary: Polyelectrolyte microgels derived from chondroitin sulfate (CS) are promising therapeutic carriers for long-term drug delivery applications. In this study, chemically crosslinked CS microgels were synthesized and then transformed into polyelectrolyte CS-[NH4](+) microgels through a cation exchange reaction. These microgels exhibited injectability, controllable degradation capability, and enhanced drug loading capacity compared to CS microgels. The loaded drug was sustainably released for a long-term period, and the RA-loaded CS-[R](+) microgels showed excellent antioxidant activity.
Article
Pharmacology & Pharmacy
Mehtap Sahiner, Aynur S. S. Yilmaz, Ramesh S. S. Ayyala, Nurettin Sahiner
Summary: Poly(glycerol) (p(Gly)) particles were successfully synthesized using the micro-emulsion method, with an average size of 14.5+/-5.6 μm. The particles showed good biocompatibility and non-toxicity, making them promising vehicles for drug delivery systems. Loading the flavonoid quercetin into the p(Gly) particles demonstrated their improved bioavailability and sustained release profiles.
Review
Engineering, Biomedical
Mehtap Sahiner, Aynur Sanem Yilmaz, Buket Gungor, Nurettin Sahiner
Summary: Neurodegenerative diseases are characterized by the progressive loss and death of nerve cells, and efforts are being made to understand their pathogenesis. This review focuses on Alzheimer's disease, which has a high prevalence and lacks radical treatment, and explores the potential neurological effects of phytochemicals as therapeutic agents. The survey highlights the inhibitory effects of herbal compounds on acetylcholinesterase, an enzyme with significant value in AD treatment. It has been shown that phytopharmaceuticals can have long-term effects in protecting nervous system health, reducing inflammation, improving cognitive damage, and alleviating dementia sequelae. Herbal-based therapeutics offer advantages as new generation or complementary agents with high compliance, fewer adverse effects, and lower cost compared to traditional pharmaceutical agents in the fight against AD.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Chemistry, Physical
Sultan Butun Sengel, Hatice Deveci, Harun Bas, Vural Butun
Summary: In this study, carbon sphere (CS) was successfully synthesized using starch via a hydrothermal process. The optimized CS was modified and used as a catalyst for hydrogen production through the dehydrogenation of sodium borohydride in methanol. The factors affecting the H2 production rate, such as reaction temperature, catalyst type and amount, and NaBH4 amount, were investigated.
CATALYSIS COMMUNICATIONS
(2023)
Article
Polymer Science
Cihan Aktas, Osman Polat, Mohamadreza Beitollahpoor, Melika Farzam, Noshir S. Pesika, Nurettin Sahiner
Summary: In this study, the effect of plasma treatment on the wetting properties of LDPE films was investigated. The contact angle and surface energy values of LDPE films changed after plasma treatment. Kinetic friction force measurements proved to be more sensitive than contact angle measurements in differentiating the wetting properties of different LDPE films.
Article
Chemistry, Physical
Seyda Somakli, Sultan Butun Sengel
Summary: Silica aerogels with interpenetrating network structures were synthesized and used as catalysts for the dehydrogenation of NaBH4 in methanol. The addition of nano- and micro-sized SiO2 and carbon particles, as well as the modification with -NH2 functional group and protonation with HCl treatment, enhanced the catalytic activity and allowed for repeated use.
Article
Chemistry, Medicinal
Selin S. Suner, Mehtap Sahiner, Evrim Umut, Ramesh S. Ayyala, Nurettin Sahiner
Summary: Chondroitin sulfate (CS) was physically crosslinked with Fe(III), Gd(III), Zn(II), and Cu(II) ions to obtain CS-metal ion-containing particles. These particles have the potential for use as injectable materials for intravenous administration, with excellent blood compatibility and low cytotoxicity. Additionally, CS-Zn(II) and CS-Cu(II) particles show strong antibacterial activity, and the CS-metal ion particles can enhance contrast in magnetic resonance imaging (MRI), making them versatile biomaterials.
Article
Polymer Science
Mehtap Sahiner, Aynur S. Yilmaz, Ramesh S. Ayyala, Nurettin Sahiner
Summary: In this study, water-soluble microgels of glycol chitosan (GC) were synthesized and their blood and cell compatibility were tested. The results showed that the microgels exhibited good blood compatibility and cell viability. Furthermore, the microgels were used for drug delivery of tannic acid (TA), and they exhibited strong antioxidant activity.
Article
Engineering, Environmental
Kutalmis Gokkus, Sultan Butun Sengel, Yeliz Yildirim, Soner Hasanbeyoglu, Vural Butun
Summary: To protect aquatic ecosystems, dyes need to be treated in situ and/or in vivo due to their widespread use and pollution in wastewater. In this study, we synthesized PGMA-NH2 hydrogels containing different amino groups and lengths, which showed significant potential for efficient adsorption of CR dye, an anionic indicator dye. The adsorption capacity of PGMA-DETA and PGMA-TEPA reached 196 and 147 mg/g, respectively, with a contact time of 40 minutes. Isotherm and kinetic experiments confirmed that the adsorption followed the Freundlich isotherm and pseudo-second-order equation.
JOURNAL OF ENVIRONMENTAL ENGINEERING AND SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Merve Nur Soykan, Burcugul Altug, Harun Bas, Hamed Ghorbanpoor, Huseyin Avci, Sertac Eroglu, Sultan Butun Sengel, Ayla Eker Sariboyaci, Sibel Gunes Bagis, Onur Uysal, Eray Atalay
Summary: A PRP-laden GelMA hydrogel contact lens is developed to support and protect limbal stem cells after ocular surface injuries.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Chemistry, Physical
Selin S. Suner, Venkat R. Bhethanabotla, Ramesh S. Ayyala, Nurettin Sahiner
Summary: Photo-activated antipathogenic carbon dots were prepared by modifying arginine carbon dots with fluorescent dyes, leading to enhanced antimicrobial potency. These modified carbon dots showed excellent fluorescence properties and broad-spectrum antimicrobial activity, with the photosensitive arginine-riboflavin carbon dots exhibiting the strongest antibacterial effect.
Article
Polymer Science
Mehtap Sahiner, Aynur S. Yilmaz, Ramesh S. Ayyala, Nurettin Sahiner
Summary: Carboxymethyl chitosan microgels show excellent biocompatibility and drug-loading ability, making them important in antibacterial applications. These microgels, synthesized in a microemulsion environment, have tailored size and zeta potential values, and possess a spherical structure.
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
