Article
Biochemistry & Molecular Biology
Zunjiang Zhao, Xuan Zhang, Dalun Lv, Lei Chen, Baode Zhang, Dejin Wu
Summary: Due to the unsatisfactory response of most types of cancer to current treatment methods, research on producing drugs with less toxicity and greater efficiency is ongoing. This study presents a green procedure for producing Ag nanoparticles supported on magnetic nanoparticles, and evaluates their biological and chemical performance. The synthesized nanocomposite showed cytotoxic and anti-cutaneous squamous cell carcinoma potentials, as well as high antioxidant activity. Clinical trials are needed to further explore the application of this nanocomposite in treating cutaneous squamous cell carcinoma.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Pedro Adao, Joao Reboleira, Marco Teles, Beatriz Santos, Nadia Ribeiro, Carlos M. Teixeira, Mafalda Guedes, Joao Costa Pessoa, Susana Bernardino
Summary: The study aimed at enhancing the antioxidant and antimicrobial activities of porphyran hydrocolloid through chemical modification. The resulting sulfated galactan porphyran, treated with N-(2-hydroxy-3,5-di-tert-butyl-benzyl)-L-tyrosine derivative, POR-L2, exhibited superior radical scavenging and antimicrobial activities compared to native porphyran, POR. Surface morphology analysis showed potential applicability of both POR and POR-L2 in the production of films and washable coatings for improved food packaging protection.
Article
Acoustics
Zhenjie Tang, Yanrong Wang, Gangliang Huang, Hualiang Huang
Summary: According to the response surface methodology, the optimized conditions for ultrasound-assisted extraction of polysaccharide from Garcinia mangostana L. rinds were determined. Acetylation significantly improved the antioxidant activity of the polysaccharide. Chemical modification is an effective method to improve the properties of polysaccharides, indicating the great research value and potential of Garcinia mangostana L. polysaccharide.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Chemistry, Medicinal
Waraporn Sakaew, Jenjiralai Phanphak, Somsuda Somintara, Wiphawi Hipkaeo, Kanokpan Wongprasert, Jose Kovensky, Choowadee Pariwatthanakun, Tawut Rudtanatip
Summary: This study investigated the antioxidant and antiurolithiatic activities of sulfated polysaccharides. The results showed that sulfated galactans exhibited pronounced antioxidant activities and the highest antiurolithiatic activity, as well as improved cell survival and increased anti-apoptotic protein in kidney cells.
Article
Polymer Science
Ahmed Al-Harrasi, Saurabh Bhtaia, Mohammed Said Al-Azri, Hafiz A. Makeen, Mohammed Albratty, Hassan A. Alhazmi, Syam Mohan, Ajay Sharma, Tapan Behl
Summary: Research on composite edible films using chitosan and porphyran loaded with ginger essential oil has shown significant improvements in physical and chemical properties, with enhanced antioxidant potential. This suggests their potential use as packaging materials in the food industry.
Article
Food Science & Technology
Zehong Chen, Yuxuan Liu, Dan Wang, Niuniu Wu, Kaiping Wang, Yu Zhang
Summary: In this study, sulfated modification was performed on Grifola frondosa polysaccharide (GFP) using the chlorosulfonic acid-pyridine method. The sulfated GFP (S-GFP) exhibited alpha-glucosidase inhibitory activity and changed the conformation of the enzyme. The results suggest that sulfation alters the structure and inhibitory mechanism of polysaccharides.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Chemistry, Applied
Lihua Geng, Quanbin Zhang, Qishan Suo, Jing Wang, Yingxia Wang, Cong Wang, Ning Wu
Summary: The oligo-porphyran OP145, isolated from Pyropia yezoensis, shows potential in inhibiting SARS-CoV-2. Through experiments and simulations, it is found that OP145 can bind to Spike glycoprotein and prevent viral infection.
CARBOHYDRATE POLYMERS
(2023)
Article
Food Science & Technology
Yingyun Peng, Jiehan Zhang, Huangling Yang, Zhifeng Yang, Haibo Xue, Fan Wu, Zeyujin Wang, Lin Xie, Yiyong Chen
Summary: Polysaccharides from Agrocybe cylindracea were chemically acetylated to improve their antioxidant activities. The optimized acetylation process resulted in Ac-ACPs with higher antioxidant capacity, suggesting their potential applications in the food and pharmaceutical industries.
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2022)
Article
Agricultural Engineering
Yi Han, Meng Zhao, Kehui Ouyang, Si Chen, Yang Zhang, Xin Liu, Qi An, Zitong Zhao, Wenjun Wang
Summary: The sulfation derivative of Cyclocarya paliurus polysaccharides showed stronger antioxidant activity compared to the original polysaccharides. The antioxidant effect may be performed via the Keap1-Nrf2 pathway, with Nrf2 proteins increased and Keap1 proteins decreased in response to polysaccharide stimulation.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Review
Chemistry, Medicinal
Mauricio T. Tavares, Alan P. Kozikowski, Sida Shen
Summary: Histone deacetylase 6 (HDAC6) is a zinc-dependent enzyme that regulates the acetylation of non-histone substrates, impacting various cellular processes. The discovery of mercaptoacetamide (MCA)-based HDAC6 inhibitors has shown promising potential due to their selectivity and lack of mutagenicity. Further research on the structure-activity relationships, selectivity, and pharmacological properties of MCA-based HDAC6 inhibitors could lead to improved drug-like properties.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Food Science & Technology
Krittika Srisuksai, Kongphop Parunyakul, Pitchaya Santativongchai, Narumon Phaonakrop, Sittiruk Roytrakul, Phitsanu Tulayakul, Wirasak Fungfuang
Summary: Crocodile oil is rich in monounsaturated fatty acids and polyunsaturated fatty acids, which have antioxidant and cognitive effects. This study investigated the effect of crocodile oil on antioxidant activity and cognitive function in rats. The results showed that crocodile oil significantly decreased triglyceride levels and had stronger free radical scavenging ability compared to olive oil. It also improved memory function in rats without causing a decline in cognitive function. Therefore, crocodile oil can be considered as an alternative dietary oil with hypolipidemic and antioxidant effects.
Article
Biochemistry & Molecular Biology
Quan Chen, Wenting Zhang, Gangliang Huang
Summary: Acetylated mung bean peel polysaccharides were prepared by extraction and acetylation, and their structural characteristics and activity were preliminarily understood through infrared and ultraviolet methods. Acetylation modification improved the structure of polysaccharides, resulting in changes in their properties. The acetylated product showed new characteristic absorption peaks at 1732 cm(-1), and the scavenging ability of hydroxyl radicals was enhanced. Therefore, acetylation modification of mung bean peel polysaccharides can enhance activity by improving the structure, providing an experimental basis for their application.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Biochemistry & Molecular Biology
Jaber A. Alshehri, Daniel M. Gill, Alan M. Jones
Summary: The treatment of common steroids with TBSAB allows for convenient conversion to corresponding steroidal organosulfates without the need for ion-exchange chromatography. This method was further explored in estradiol and pregnanediol systems, along with the application of deuterium labeling for mass-spectrometric quantification in biological studies.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Chemistry, Applied
Huifang Wang, Meiyu Yuan, Gaoheng Li, Yuxin Tao, Xuanyu Wang, Sheng Ke, Min Zhuang, Anqi Wang, Zhongkai Zhou
Summary: This research characterized the structure of Cyperus esculentus polysaccharide (CEP) and its acetylated form (ACEP), and investigated the effects of acetylation on various properties. The results showed that both CEP and ACEP were heteropolysaccharides consisting of multiple sugars. Acetylation improved thermal stability and exhibited greater antioxidant activity. Furthermore, CEP and ACEP protected cells against inflammation. This study highlights the potential of C. esculentus for the functional food industry.
Article
Polymer Science
Dae Young Jeong, Eung Take Lee, Jisun Lee, Dae Cheol Shin, Yong Hyun Lee, Jae Kweon Park
Summary: The immunological effects of chitosan purified from Hermetia illucens larvae were investigated based on the difference in the degree of deacetylation (DD) and molecular weight (MW). Our results showed that the DD of purified high molecular weight chitosan (Hi-CTSN) from H. illucens larvae was 87.2%. The study also examined the effects of different chitooligosaccharides (CTS) on the expression of inflammatory cytokines in macrophage cells.
MACROMOLECULAR RESEARCH
(2023)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)